ISLAMABAD: The Centre will have to face serious challenges to support day to day expenditures after paying defence and debt servicing bills from available resources, as the fiscal budget 2020-21 is...

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ISLAMABAD: Prime Minister Imran Khan Friday said out-of-box solutions were needed to meet the present day economic challenges in the wake of COVID-19 situation.He was chairing a meeting to review the economic situation and future outlook of economy in the wake of COVID-19 situation. A detailed...

ISLAMABAD: Prime Minister Imran Khan Friday said out-of-box solutions were needed to meet the present day economic challenges in the wake of COVID-19 situation.He was chairing a meeting to review the economic situation and future outlook of economy in the wake of COVID-19 situation.A detailed...

ISLAMABAD: Prime Minister Imran Khan Friday said out-of-box solutions were needed to meet the present day economic challenges in the wake of COVID-19 situation.He was chairing a meeting to review the economic situation and future outlook of economy in the wake of COVID-19 situation.A detailed...

Crafting small business support efforts to specific country circumstances could help save millions of livelihoods in poor communities and fortify economies against future shocks.

Microchip Solves Interoperability Challenges of Delivering up to 90 Watts of Power Over Ethernet Wiring

ADB has provided several targeted interventions to support its developing member countries in combating the effects of the COVID-19 pandemic from its early stages. In support of ADB’s effort, the Government of Japan is...

Nepal has 2.7% of the earth’s freshwater, yet the people of Kathmandu, Nepal’s most developed region, struggle with scarce water supply.

ADB is formulating an aggressive set of actions to protect the poor, the vulnerable, and wider populations across Asia and the Pacific. And to ensure economies will rebound as swiftly as possible.

Title: Study Challenges Salt Guidelines for Kids
Category: Health News
Created: 4/27/2015 12:00:00 AM
Last Editorial Review: 4/28/2015 12:00:00 AM

A child psychologist advises parents to address the threat of internet challenges with continual, preemptive conversations with kids -- and with special phone settings.

Phenotypic plasticity is defined as the property of organisms to produce distinct phenotypes in response to environmental variation. While for more than a century, biologists have proposed this organismal feature to play an important role in evolution and the origin of novelty, the idea has remained contentious. Plasticity is found in all domains of life, but only recently has there been an increase in empirical studies. This contribution is intended as a fresh view and will discuss current and future challenges of plasticity research, and the need to identify associated molecular mechanisms. After a brief summary of conceptual, theoretical, and historical aspects, some of which were responsible for confusion and contention, I will formulate three major research directions and predictions for the role of plasticity as a facilitator of novelty. These predictions result in a four-step model that, when properly filled with molecular mechanisms, will reveal plasticity as a major factor of evolution. Such mechanistic insight must be complemented with comparative investigations to show that plasticity has indeed created novelty and innovation. Together, such studies will help develop a true developmental evolutionary biology.

Despite significant advances in therapies for pediatric type 1 diabetes, achievement of glycemic targets remains elusive, and management remains burdensome for patients and their families. This article identifies common challenges in diabetes management at the patient-provider and health care system levels and proposes practical approaches to overcoming therapeutic inertia to enhance health outcomes for youth with type 1 diabetes.

As COVID-19 continues to surge, cancer scientists engaged in basic research face unique challenges. At centers throughout the United States, investigators are confronting difficult decisions about which experiments to continue, while securing supplies and creating contingency plans for a complete shutdown.

We report the diagnostic challenges and the clinical course of a patient with an extraordinary presentation of B-lymphoblastic leukemia (B-ALL) with eosinophilia. We identified a novel ZBTB20-JAK2 gene fusion as a chimeric RNA transcript using the Archer platform. This gene fusion from the same patient was recently identified by Peterson et al. (2019) at the genomic level using a different sequencing technology platform. The configuration of this gene fusion predicts the production of a kinase-activating JAK2 fusion protein, which would normally lead to a diagnosis of Philadelphia chromosome–like B-ALL (Ph-like B-ALL). However, the unusual presentation of eosinophilia led us to demonstrate the presence of this gene fusion in nonlymphoid hematopoietic cells by fluorescence in situ hybridization (FISH) studies with morphologic correlation. Therefore, we believe this disease, in fact, represents blast crisis arising from an underlying myeloid neoplasm with JAK2 rearrangements. This case illustrates the difficulty in differentiating Ph-like B-ALL and myeloid/lymphoid neoplasm with eosinophilia and gene rearrangements (MLN-EGR) in blast crisis. As currently defined, the diagnosis of MLN-EGR relies on the hematologic presentations and the identification of marker gene fusions (including PCM1-JAK2, ETV6-JAK2, and BCR-JAK2). However, these same gene fusions, when limited to B-lymphoblasts, also define Ph-like B-ALL. Yet, our case does not conform to either condition. Therefore, the assessment for lineage restriction of gene rearrangements to reflect the pathophysiologic difference between B-ALL and MLN-EGR in blast crisis is likely a more robust diagnostic approach and allows the inclusion of MLN-EGR with novel gene fusions.

It all boils down to how resilient the region is, says an urban planner and designer based in Manila.

Tens of thousands of new apartments enter the Ho Chi Minh City market every year, putting pressure on investors who want to reap returns from rental apartments.

If you didn’t feel challenged enough by Indivisible‘s main platforming and punching campaign, here’s some good news for ya. Lab Zero have released a new DLC for their turn-ish-based RPG today that promises the “forty specially crafted levels await to test your platforming and combat skills.” The Razmi’s Challenges DLC is available now, so you […]

Bill Maher said Republicans "don't care" about Tara Reade's sexual assault allegations, saying such claims are simply used as a "unilateral weapon" against Democrats.

Smithsonian Secretary Lonnie G. Bunch III says: ‘It’s time to put our heads down, and work’

Low staff numbers and a lack of PPE are among the challenges facing schools as they draw together plans to reopen.

NASA has awarded the University of Washington a $499,864 grant to develop a competition that calls on students to turn a simulated lava tube into a habitat suitable for harboring humans on the moon or Mars. The exploration and habitation skills competition will be funded as part of NASA's Artemis Student Challenges program, which plays off the themes of the Artemis moon program to inspire the next generation of explorers and engineers. The competition will involve navigating a rover through a facsimile lava tube and surface structures, generating maps, identifying valuable resources and deploying an airtight barrier to seal the… Read More

Adam Silver outlined a potentially grim future for the NBA in a call with players, calling the pandemic the "single greatest challenge of all our lives."

With sport in lockdown across the globe , more and more sports stars are turning to social media to entertain themselves - and their fans.

With sport in lockdown across the globe , more and more sports stars are turning to social media to entertain themselves - and their fans.

Mikel Arteta insists summer signing Kieran Tierney will bring Arsenal "something special" when the Premier League restarts following its suspension due to the coronavirus pandemic.

With sport in lockdown across the globe , more and more sports stars are turning to social media to entertain themselves - and their fans.

First-generation headsets helped magnify objects for people with impaired vision, but they also prompted motion sickness. A redesign is aimed at fixing this, but problems persist as patients adjust.
Medscape Medical News

Canberra petrol retailers will need to meet weekly fuel price targets to avoid the ACT Government regulating the market, despite prices dropping to about $1 per litre after the Chief Minister threatened to cap margins.

New Zealand's careful climb out of Covid-19 restrictions has been a tale of two journeys.To envious overseas eyes, we have been a smooth success story and a source of hope to others. At home, the reaction has been a lot more mixed.We...

Supercar engineers are taking their skills from the racetrack to the ICU ward by creating a ventilator prototype to help during the coronavirus crisis.

The NRL has a number of crucial questions it must answer if it wants to restart its premiership season on May 28 as planned following the coronavirus-forced suspension of the competition, writes David Mark.

Junior participation numbers in sport may face long-term effects caused by the coronavirus shutdown, meaning it's crucial community clubs act now so the battle isn't lost, writes Richard Hinds.

Governors across the U.S. are encouraging people to continue practicing social distancing amid summer weather

The pandemic is amplifying nearly every disadvantage that women in STEM already face. But institutions and the scientific community can help

-- Read more on ScientificAmerican.com

The Association of Clinical Research Organizations (ACRO) highlights contributions to health and economy (Leeds, UK) – Facing unprecedented challenges associated with Brexit,...

The Association of Clinical Research Organizations (ACRO) convenes discussion series that seeks to advance an industry with important health and economic impacts...

The Department of Justice challenged the state of Arizona’s recently passed immigration law, S.B. 1070, in federal court today. The Department said the Arizona law unconstitutionally interferes with the federal government’s authority to set and enforce immigration policy.

The Department of Justice challenged the state of Alabama’s recently passed immigration law, H.B. 56, in federal court today.

The Department of Justice challenged South Carolina’s recently passed immigration law, Act No. 69, in federal court today.

The Department of Justice today challenged Utah’s immigration law, which comes after recent lawsuits in Arizona, Alabama and South Carolina.

The Department of Justice announced today that it has reached a settlement that will require the Oklahoma State Chiropractic Independent Physicians Association (OSCIPA) and its executive director to stop jointly determining prices and negotiating contracts with insurers on behalf of competing chiropractors in Oklahoma.

"Our Declaration of Independence declared in 1776 that “all men are created equal,” but it took 100 years and a civil war that took hundreds of thousands of lives to end slavery; another hundred years to create legal equality for African Americans; and we struggle to this day to make equality a reality. I see this every day in my work as the chief civil rights law enforcement official for the United States," said Assistant Attorney General Perez.

The U.S. Department of Justice announced today that it has reached a settlement with Chiropractic Associates Ltd. of South Dakota (CASD), an association comprising approximately 80 percent of all practicing chiropractors in South Dakota. The settlement prohibits CASD from jointly determining prices and negotiating contracts with insurers on behalf of competing chiropractors.

Malaysia, incoming host of APEC, will rally the forum to ensure that the ‘”benefits from trade, investment, and economic cooperation are felt and enjoyed by our people,” said Prime Minister Dr Mahathir Mohamad as he launched APEC Malaysia 2020.

Stronger cooperation is essential for APEC as economies address inequality, environmental health, and the digital economy – the region’s critical challenges – said the APEC Secretariat’s Executive Director Dr Rebecca Sta Maria.