Rawalpindi : Four suspects allegedly involved in the killing of a newlywed couple, in apparently an honour killing case, were arrested here on Friday from the jurisdiction of Airport Police Station.Junaid and Sidra were murdered few days back in apparently an honour killing case after they tied...

The Special Investigation Unit of the Criminal Investigation Agency busted on Friday three suspected criminals running a gang. In a separate raid, they apprehended analleged robber.According to SIU police chief SSP Irfan Bahadur, three gang members were involved in various criminal cases,...

Hundreds of protesters gathered in front of a Georgia courthouse on Friday to decry the killing of an unarmed black man in February and the delay in charging two white men in a shooting captured on video that was released earlier this week. This report produced by Jillian Kitchener.

Hundreds of protesters gathered in front of a Georgia courthouse on Friday to decry the killing of an unarmed black man in February and the delay in charging two white men in a shooting captured on video that was released earlier this week.

A white former police officer and his son were arrested in Georgia on Thursday and charged with murder in the death of an unarmed black man, an incident that has sparked furor in the community and among civil rights activists across the United States. Gloria Tso reports.

Hundreds of protesters gathered in front of a Georgia courthouse on Friday to decry the killing of an unarmed black man in February and the delay in charging two white men in a shooting captured on video that was released earlier this week. This report produced by Jillian Kitchener.

Title: Second Man Arrested in Tainted Letter Case, Officials Report
Category: Health News
Created: 4/27/2013 6:35:00 PM
Last Editorial Review: 4/29/2013 12:00:00 AM

Title: Dispatcher-Assisted CPR Boosts Cardiac Arrest Survival in Kids: Study
Category: Health News
Created: 4/30/2014 4:36:00 PM
Last Editorial Review: 5/1/2014 12:00:00 AM

Title: Out-of-Hospital Cardiac Arrests On the Rise During COVID-19 Crisis
Category: Health News
Created: 4/30/2020 12:00:00 AM
Last Editorial Review: 5/1/2020 12:00:00 AM

Kei Jokura, Junko M. Nishino, Michio Ogasawara, and Atsuo Nishino

Ciliary movement is a fundamental process to support animal life, and the movement pattern may be altered in response to external stimuli under the control of nervous systems. Juvenile and adult ascidians have ciliary arrays around their pharyngeal gill slits (stigmata), and continuous beating is interrupted for seconds by mechanical stimuli on other parts of the body. Although it has been suggested that neural transmission to evoke ciliary arrest is cholinergic, its molecular basis has not yet been elucidated in detail. We herein attempted to clarify the molecular mechanisms underlying this neurociliary transmission in the model ascidian Ciona. Acetylcholinesterase histochemical staining showed strong signals on the laterodistal ciliated cells of stigmata, hereafter referred to as trapezial cells. The direct administration of acetylcholine (ACh) and other agonists of nicotinic ACh receptors (nAChRs) onto ciliated cells reliably evoked ciliary arrest that persisted for seconds in a dose-dependent manner. Only one isoform among all nAChR subunits encoded in the Ciona genome, called nAChR-A7/8-1, a relative of vertebrate α7 nAChRs, was expressed by trapezial cells. Exogenously expressed nAChR-A7/8-1 on Xenopus oocytes responded to ACh and other agonists with consistent pharmacological traits to those observed in vivo. Further efforts to examine signaling downstream of this receptor revealed that an inhibitor of phospholipase C (PLC) hampered ACh-induced ciliary arrest. We herein propose that homomeric α7-related nAChR-A7/8-1 mediates neurociliary transmission in Ciona stigmata to elicit persistent ciliary arrest by recruiting intracellular Ca²⁺ signaling.

Arrestin-1 is the arrestin family member responsible for inactivation of the G protein–coupled receptor rhodopsin in photoreceptors. Arrestin-1 is also well-known to interact with additional protein partners and to affect other signaling cascades beyond phototransduction. In this study, we investigated one of these alternative arrestin-1 binding partners, the glycolysis enzyme enolase-1, to map the molecular contact sites between these two proteins and investigate how the binding of arrestin-1 affects the catalytic activity of enolase-1. Using fluorescence quench protection of strategically placed fluorophores on the arrestin-1 surface, we observed that arrestin-1 primarily engages enolase-1 along a surface that is opposite of the side of arrestin-1 that binds photoactivated rhodopsin. Using this information, we developed a molecular model of the arrestin-1–enolase-1 complex, which was validated by targeted substitutions of charge-pair interactions. Finally, we identified the likely source of arrestin's modulation of enolase-1 catalysis, showing that selective substitution of two amino acids in arrestin-1 can completely remove its effect on enolase-1 activity while still remaining bound to enolase-1. These findings open up opportunities for examining the functional effects of arrestin-1 on enolase-1 activity in photoreceptors and their surrounding cells.

Proteinase-activated receptors (PARs) are a four-member family of G-protein–coupled receptors that are activated via proteolysis. PAR4 is a member of this family that is cleaved and activated by serine proteinases such as thrombin, trypsin, and cathepsin-G. PAR4 is expressed in a variety of tissues and cell types, including platelets, vascular smooth muscle cells, and neuronal cells. In studying PAR4 signaling and trafficking, we observed dynamic changes in the cell membrane, with spherical membrane protrusions that resemble plasma membrane blebbing. Since nonapoptotic membrane blebbing is now recognized as an important regulator of cell migration, cancer cell invasion, and vesicular content release, we sought to elucidate the signaling pathway downstream of PAR4 activation that leads to such events. Using a combination of pharmacological inhibition and CRISPR/CRISPR-associated protein 9 (Cas9)–mediated gene editing approaches, we establish that PAR4-dependent membrane blebbing occurs independently of the Gα_q/11- and Gα_i-signaling pathways and is dependent on signaling via the β-arrestin-1/2 and Ras homolog family member A (RhoA) signaling pathways. Together these studies provide further mechanistic insight into PAR4 regulation of cellular function.

Hundreds of protesters gathered in front of a Georgia courthouse on Friday to decry the killing of an unarmed black man in February and the delay in charging two white men in a shooting captured on video that was released earlier this week.

Former Los Angeles Lakers player Shannon Brown was arrested last week for allegedly firing a gun at two people who entered his Georgia home that was listed for sale.

Read our live coronavirus updates HERE

A 43-year-old man has been arrested on suspicion of attempted murder after a police officer was attacked on Easter Sunday.

Follow our live updates here Coronavirus: the symptoms

Read our live updates on coronavirus HERE Coronavirus: The symptoms

A sick child died after their mother was kept on hold by the NHS 111 helpline for more than an hour as she desperately sought medical help.

Follow our live coronavius updates HERE Coronavirus: The symptoms

Detectives investigating a gang responsible for trafficking young women from Brazil to work in brothels in north London have made two arrests.

Police in Hong Kong have arrested at least 14 veteran pro-democracy activists accused of joining unlawful protests last year.

Police have launched an investigation after an officer was filmed threatening to "make something up" in order to arrest a man.

Three men have been arrested on suspicion of firearms offences after failing to stop for police.

Northumbria Police warn such behaviour will be treated 'incredibly seriously' after Charlene Merrifield sent to prison for four months

A seven-year-old boy accidentally killed his three-year-old sister after shooting her with an unsecured shotgun in Colorado, police said.

A man in his 30s has been arrested in Chatham following reports of gunshots being fired from the balcony of an apartment block.

Police have arrested six people and seized about £1m in assets from brothels in Westminster as part of a major crackdown operation.

The 47-year-old officer was knifed in the abdomen while attending reports of disorder at an address in St Vincent Road, Newport, during the early hours of Thursday.

An average of 100 people a day are being arrested for domestic violence offences during the coronavirus lockdown in London, Scotland Yard has revealed.

A teenager who allegedly spat at a bus driver in south-east London during the coronavirus lockdown has been arrested.

A man has been arrested on suspicion of murder after two children were stabbed to death in Ilford.

41-year-old Temisan Oritsejafor facing 'significant prison term' over 'vulgar' incident, West Midlands Police force says

Two teenagers have been arrested on suspicion of murder after a young NHS worker was stabbed to death in east London.

Police have arrested 13 people and issued 11 more with fines after breaking up two parties in Liverpool during coronavirus lockdown.

Two teenagers have been arrested after a young boy was shot in east London and left with potentially life-changing injuries.

A man has been arrested on suspicion of murder after a woman was shot inside a house during the coronavirus lockdown.

A New York police officer caught on video pointing a stun gun at a man and grappling him to the ground over an alleged social distancing violation has been stripped of his badge.

A 13-year-old girl has been arrested on suspicion of attempted murder after a woman was left fighting for her life following reports of a street fight.

The wife of former Premier League footballer Kevin Phillips has been released without charge after being arrested on suspicion of attempted murder following a stabbing.

A man has been jailed after he viciously bit down on an officer's finger in a "sustained attack" to avoid being arrested.

A man has been found dead after suffering suspected stab wounds in west London.

A man has been arrested on suspicion of attempted murder after a police officer was attacked in north west London.

Georgia State Bureau of Investigation has arrested suspects in the shooting death of an unarmed black jogger, Ahmaud Arbery. It would have been Arbery's 26th birthday on Friday.

The chief prosecutor will seek capture of Jordan Goudreau as well as two US-based advisers to opposition leader Juan Guaidó

• How the plot to invade Venezuela fell apart

Venezuela’s chief prosecutor has ordered the arrest of a former Green Beret and two opposition figures living in the United States for their purported role in a botched operation aimed at removing Nicolás Maduro from power.

Tarek William Saab said Venezuela will seek the capture of Jordan Goudreau, a military veteran who has claimed responsibility for the attack, as well as Juan José Rendón and Sergio Vergara, two US-based advisers to the opposition leader Juan Guaidó.

Bad Company frontman Brian Howe has died at the age of 66, a family member has confirmed.