He was archbishop of Antioch at the time of the wicked Emperor Numerian. Once the Emperor came to Antioch and attempted to enter a church where Babylas was serving. Coming to the door, the Archbishop forbade the Emperor, as a pagan and a shedder of innocent blood, to enter the house where the True God was worshipped. Retreating in humiliation, the Emperor determined to take his revenge. Shortly after he had Babylas imprisoned along with several Christian children. Babylas was made to watch the beheading of each of the children. Having given them encouragement he submitted himself to beheading. At his own request he was buried in the chains with which he had been bound.   After the establishment of Christianity in the Roman Empire, the Emperor Gallus had a church built in honor of Babylas near the site of a temple to Apollos at Daphne, outside Antioch. (This was where, according to pagan legend, the maiden Daphne had been turned into a tree to escape the lust of Apollos). When Julian the Apostate came to Antioch in 362 to consult a famous oracle there, he found that the oracle had been deprived of its power by the presence of a Christian church nearby. He ordered the relics of St Babylas to be dug up and removed from the Church. As soon as this had been done a thunderbolt destroyed the shrine of Apollo, which Julian did not dare to rebuild. Saint John Chrysostom, then Archbishop of Antioch, preached a sermon on these events within a generation after their occurrence.

She lived in Rome during the reigns of the Emperors Decius and Valerian. At an early age she left all to embrace a life of unceasing prayer, entering a small monastery in Rome, directed by a nun named Sophia. For her Christian faith, she was seized and brought before the governor Probus and, when she boldly confessed Christ and refused to honor the idols, was subjected to a series of vicious tortures, under which she died. An angel led Sophia to retrieve her holy relics, which are now venerated at the monastery of Grigoriou on Mt Athos.   We are sometimes told that monasticism developed in the Church after Christianity became accepted and grew more worldly. The story of St Anastasia is one of many evidences in the lives of the Saints that what we now call monasticism was present from the earliest days of the Church.

A pagan couple, Cleitophon and Leucippe, who lived in Emesa in the reign of the Emperor Decius, were grieved that they were unable to have children. One day a monk named Onuphrius came to their door seeking alms to give to the poor, and seeing Leucippe's downcast face, asked her what was wrong. When she replied that she was barren, Onuphrius told her that this was by God's providence, to prevent their child from being given over to idolatry, and that if they accepted Christ she would bear a child. Leucippe was baptized into the Faith and bore a son not long after, which in turn brought her husband to faith in Christ. The son was named Galaction in baptism.   Years later, Galaction's father, now widowed, decided that Galaction should marry a pagan maiden named Episteme. Galaction married out of obedience, but would not approach Episteme's bed since she was a pagan. In time, he convinced her of the truth of the Faith and baptised her himself. Not long after she was told in a dream of the glory that awaits those who consecrate themselves wholly to God. When she told her husband of the dream, they both resolved to remain in virginity, settling in separate monastic communities near to one another.   In one of the Emperor's persecutions of Christians, Galaction was seized by imperial soldiers and taken away to be killed. Episteme, told in a vision of his arrest, asked the blessing of her abbess to join him in martyrdom. Receiving it, she hurried to Galaction's place of imprisonment, boldly announced her faith in Christ, and after many tortures and humiliations husband and wife were beheaded together.