London (No. 90, Cheapside, & 8, Pall Mall) : Published ... by Hurst, Robinson & Co., March 1st. 1824.

[London], [1824]

[Paris] : [de l'Imprimerie de Clousier], [between 1780 and 1789]

[London] : [Wellcome Trust], [2009]

How to tune in to Tom Wilson's best games on Sunday.

Alex Ovechkin can lay claim as the best Capitals player to wear No. 8, but what about the rest of the jersey numbers? Who are the best Caps for every number?

Alex Ovechkin can lay claim as the best Capitals player to wear No. 8, but what about the rest of the jersey numbers? Who are the best Caps for every number?

The Washington Capitals on Friday placed Brendan Leipsic on unconditional waivers to terminate his contract after he made disparaging comments about women and teammates in a private social media chat. In a conversation involving his brother and Florida Panthers minor leaguer Jack Rodewald, Leipsic commented on the physical appearances of Vancouver forward Tanner Pearson's wife and Edmonton captain Connor McDavid's girlfriend. The NHL called it ''inexcusable conduct'' and said it would address the matter with the Capitals and Panthers.

The Washington Capitals have placed former Winterhawks wing Brendan Leipsic on unconditional waivers with the intention of his contract being terminated after private messages revealed misogynistic comments. > The Washington Capitals have placed Brendan Leipsic on unconditional waivers for purposes of terminating his contract.https://t.co/UnADibu2yQ

The Washington Capitals decided to part ways with forward Brendan Leipsic on Friday after he made vulgar and disparaging comments on an social media chat group. The 25-year old Canadian was placed on waivers by the NHL club after his Instagram group chat messages were leaked earlier this week. The chat included inappropriate remarks about Edmonton Oilers forward Connor McDavid's girlfriend and the wife of Vancouver Canucks player Tanner Pearson.

Troy Brouwer scored the game-winning goal as the Capitals beat the Blackhawks at Nationals Park on Jan. 1, 2015. Relive the excitement with Monday night's replay.

Washington announced it is terminating the contract of forward Brendan Leipsic after his mysogynistic comments on Instagram were leaked.

2019

Rockville, Maryland : National Institute on Drug Abuse, 1978.

Gregory J. Matthews, Ofer Harel

Source: Statist. Surv., Volume 5, 1--29.

Abstract:
There is an ever increasing demand from researchers for access to useful microdata files. However, there are also growing concerns regarding the privacy of the individuals contained in the microdata. Ideally, microdata could be released in such a way that a balance between usefulness of the data and privacy is struck. This paper presents a review of proposed methods of statistical disclosure control and techniques for assessing the privacy of such methods under different definitions of disclosure.

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The next seminar in the 2017–18 History of Pre-Modern Medicine seminar series takes place on Tuesday 7 November. Speaker: Dr Michael Brown (University of Roehampton), ‘Anxiety and compassion: emotions and the surgical encounter in early 19th-century Britain’ The historical study of the… Continue reading

The next seminar in the 2017–18 History of Pre-Modern Medicine seminar series takes place on Tuesday 30 January. Speaker: Professor Guido Alfani (Bocconi University, Milan) Plague in Italy and Europe during the 17th century: epidemiology and impact Abstract: After many years of relative… Continue reading

Chengchun Shi, Rui Song, Wenbin Lu.

Source: The Annals of Statistics, Volume 47, Number 4, 2348--2377.

Abstract:
Precision medicine is an emerging medical paradigm that focuses on finding the most effective treatment strategy tailored for individual patients. In the literature, most of the existing works focused on estimating the optimal treatment regime. However, there has been less attention devoted to hypothesis testing regarding the optimal treatment regime. In this paper, we first introduce the notion of conditional qualitative treatment effects (CQTE) of a set of variables given another set of variables and provide a class of equivalent representations for the null hypothesis of no CQTE. The proposed definition of CQTE does not assume any parametric form for the optimal treatment rule and plays an important role for assessing the incremental value of a set of new variables in optimal treatment decision making conditional on an existing set of prescriptive variables. We then propose novel testing procedures for no CQTE based on kernel estimation of the conditional contrast functions. We show that our test statistics have asymptotically correct size and nonnegligible power against some nonstandard local alternatives. The empirical performance of the proposed tests are evaluated by simulations and an application to an AIDS data set.

Armin Schwartzman, Andrew J. Schork, Rong Zablocki, Wesley K. Thompson.

Source: The Annals of Applied Statistics, Volume 13, Number 4, 2509--2538.

Abstract:
Analysis of genome-wide association studies (GWAS) is characterized by a large number of univariate regressions where a quantitative trait is regressed on hundreds of thousands to millions of single-nucleotide polymorphism (SNP) allele counts, one at a time. This article proposes an estimator of the SNP heritability of the trait, defined here as the fraction of the variance of the trait explained by the SNPs in the study. The proposed GWAS heritability (GWASH) estimator is easy to compute, highly interpretable and is consistent as the number of SNPs and the sample size increase. More importantly, it can be computed from summary statistics typically reported in GWAS, not requiring access to the original data. The estimator takes full account of the linkage disequilibrium (LD) or correlation between the SNPs in the study through moments of the LD matrix, estimable from auxiliary datasets. Unlike other proposed estimators in the literature, we establish the theoretical properties of the GWASH estimator and obtain analytical estimates of the precision, allowing for power and sample size calculations for SNP heritability estimates and forming a firm foundation for future methodological development.

Lisa Schlosser, Torsten Hothorn, Reto Stauffer, Achim Zeileis.

Source: The Annals of Applied Statistics, Volume 13, Number 3, 1564--1589.

Abstract:
To obtain a probabilistic model for a dependent variable based on some set of explanatory variables, a distributional approach is often adopted where the parameters of the distribution are linked to regressors. In many classical models this only captures the location of the distribution but over the last decade there has been increasing interest in distributional regression approaches modeling all parameters including location, scale and shape. Notably, so-called nonhomogeneous Gaussian regression (NGR) models both mean and variance of a Gaussian response and is particularly popular in weather forecasting. Moreover, generalized additive models for location, scale and shape (GAMLSS) provide a framework where each distribution parameter is modeled separately capturing smooth linear or nonlinear effects. However, when variable selection is required and/or there are nonsmooth dependencies or interactions (especially unknown or of high-order), it is challenging to establish a good GAMLSS. A natural alternative in these situations would be the application of regression trees or random forests but, so far, no general distributional framework is available for these. Therefore, a framework for distributional regression trees and forests is proposed that blends regression trees and random forests with classical distributions from the GAMLSS framework as well as their censored or truncated counterparts. To illustrate these novel approaches in practice, they are employed to obtain probabilistic precipitation forecasts at numerous sites in a mountainous region (Tyrol, Austria) based on a large number of numerical weather prediction quantities. It is shown that the novel distributional regression forests automatically select variables and interactions, performing on par or often even better than GAMLSS specified either through prior meteorological knowledge or a computationally more demanding boosting approach.

South Australia -- Genealogy.

The Round Rock Independent School District in Texas is looking for a digital curriculum and blended learning program. Baltimore is looking for a comprehensive high school literacy program.

The post Austin-Area District Looks for Digital/Blended Learning Program; Baltimore Seeks High School Literacy Program appeared first on Market Brief.

The military is preparing to deploy to the region to try to stop illegal logging and mining.

Ioannis Ntzoufras, Claudia Tarantola, Monia Lupparelli.

Source: Bayesian Analysis, Volume 14, Number 3, 797--823.

Abstract:
We introduce a novel Bayesian approach for quantitative learning for graphical log-linear marginal models. These models belong to curved exponential families that are difficult to handle from a Bayesian perspective. The likelihood cannot be analytically expressed as a function of the marginal log-linear interactions, but only in terms of cell counts or probabilities. Posterior distributions cannot be directly obtained, and Markov Chain Monte Carlo (MCMC) methods are needed. Finally, a well-defined model requires parameter values that lead to compatible marginal probabilities. Hence, any MCMC should account for this important restriction. We construct a fully automatic and efficient MCMC strategy for quantitative learning for such models that handles these problems. While the prior is expressed in terms of the marginal log-linear interactions, we build an MCMC algorithm that employs a proposal on the probability parameter space. The corresponding proposal on the marginal log-linear interactions is obtained via parameter transformation. We exploit a conditional conjugate setup to build an efficient proposal on probability parameters. The proposed methodology is illustrated by a simulation study and a real dataset.

Thomas Staudt, Timo Aspelmeier, Oskar Laitenberger, Claudia Geisler, Alexander Egner, Axel Munk.

Source: Statistical Science, Volume 35, Number 1, 92--111.

Abstract:
Super-resolution microscopy is rapidly gaining importance as an analytical tool in the life sciences. A compelling feature is the ability to label biological units of interest with fluorescent markers in (living) cells and to observe them with considerably higher resolution than conventional microscopy permits. The images obtained this way, however, lack an absolute intensity scale in terms of numbers of fluorophores observed. In this article, we discuss state of the art methods to count such fluorophores and statistical challenges that come along with it. In particular, we suggest a modeling scheme for time series generated by single-marker-switching (SMS) microscopy that makes it possible to quantify the number of markers in a statistically meaningful manner from the raw data. To this end, we model the entire process of photon generation in the fluorophore, their passage through the microscope, detection and photoelectron amplification in the camera, and extraction of time series from the microscopic images. At the heart of these modeling steps is a careful description of the fluorophore dynamics by a novel hidden Markov model that operates on two timescales (HTMM). Besides the fluorophore number, information about the kinetic transition rates of the fluorophore’s internal states is also inferred during estimation. We comment on computational issues that arise when applying our model to simulated or measured fluorescence traces and illustrate our methodology on simulated data.

[London?], [6th June 1990]

Svetlana Mastitskaya
Apr 8, 2020; 40:3052-3062
Systems/Circuits

JS Taube
Feb 1, 1990; 10:420-435
Articles

Thomas Schikorski
Aug 1, 1997; 17:5858-5867
Articles

Gregor Thut
Sep 13, 2006; 26:9494-9502
BehavioralSystemsCognitive

Jessica A. Gorski
Aug 1, 2002; 22:6309-6314
BRIEF COMMUNICATION

Italian translation of the BIS Press Release on the presentation of the Annual Report (25 June 2017)

Italian translation of the BIS press release on the presentation of the Annual Economic Report 2018, 24 June 2018. Le autorità possono fare in modo che l'attuale ripresa economica si mantenga oltre il breve termine avviando riforme strutturali, ridando margine di manovra alle politiche monetarie e di bilancio per affrontare eventuali future minacce, e incoraggiando la pronta attuazione delle riforme regolamentari, scrive la Banca dei Regolamenti Internazionali (BRI) nella sua Relazione economica annuale. ...

Spanish version of executive summary of report on Central bank digital currencies published by the Committee on Payments and Market Infrastructures (CPMI) and the Markets Committee, March 2018.

Spanish version of Press release about CPMI and the Markets Committee issuing a report on "Central bank digital currencies" (12 March 2018)

Spanish translation of "Frequently asked questions on market risk capital requirements" by the Basel Committee, March 2018.

To view more press releases, please visit http://www.snl.com/irweblinkx/news.aspx?iid=1024452.

The Linux Foundation will host ToIP, a cross-industry effort to ensure more secure data handling over the Internet. This new foundation is an independent project enabling trustworthy exchange and verification of data between any two parties on the Internet. The ToIP Foundation will provide a robust common standard to instill confidence that data is coming from a trusted source.