MIC2595R

PIC24FJ256GA705 Family Flash programming Specification

PIC24FJ256GA412/GB412 Family Flash Programming Specification

EMC1825

EVB-USB7252 Evaluation Kit User's Guide

PIC18F25/45/55Q43 Silicon Errata and Data Sheet Clarifications

PIC32MM0256GPM064 Family Silicon Errata and Data Sheet Clarification

MCP1525

This paper documents the Chair's Summary of the Development Effectiveness Committee (DEC) discussion held on 25 March 2020. The commitee discussed the sector-wide evaluation report ADB Support for Transport, 2010-2018.

Gentex Purchases Microchip’s 25 Billionth MCU, Advancing its HomeLink Interface

EVB-LAN9252-SAMD51 HEX ImageFiles

EVB-LAN9252-SAMD51 ESI File

ATmega640/1280/1281/2560/2561 - Complete Datasheet

AT25010B/AT25020B/AT25040B SPI Automotive Temperature Serial EEPROM Data Sheet

AT25128B/256B Automotive - Complete Datasheet

ATM90E25

Bangalore/Mumbai: HDFC Property Fund, the private equity arm of Housing Development Finance Corp. Ltd, has raised $250 million (around `1,500 crore today) through an offshore fund. It hopes to raise another $150 million by the end of the year, said a person directly familiar with the development who did not want to be named. On Friday, HDFC Property Fund informed the BSE that it had raised the capital through its second international fund, saying “the recently closed fund will focus on investing primarily in residential property developments in major cities across India”. The cumulative assets under management now exceed $1 billion, the statement added. The new fund, which started raising […]

PIC32MZ2025DAK169

PIC32MZ1025DAL176

PIC32MZ1025DAK176

PIC32MZ1025DAL169

PIC32MZ1025DAK169

PIC32MZ2025DAK176

ATA6025

ATA664251

TC1025

PIC24FJ256GU410

PIC24FJ256GU408

PIC24FJ256GU406

PIC24FJ256GU405

NEW DELHI: One would imagine that office rents would go down with a strong bounceback in demand for space from corporates. Pure economics, one would think? Not really. Office rentals are likely to climb up in the coming months because of a shortage of quality spaces in key business districts around the country. “In certain key locations, rentals could go up 20-25 per cent in the next 12 months,” says Sanjay Dutt, executive managing director for South Asia at property consultancy Cushman & Wakefield. The situation has been brought on by the fact that most developers and even private equity players have chosen to focus on the residential property market […]

MCP2557FD

MCP2517FD

MCP2542WFD

MCP2544WFD

MCP2518FD

23A256

NEW DELHI: Realty firm Logix group plans to raise Rs 250 crore from foreign investors for the development of its ongoing mixed-use commercial project in Noida. The company is developing this commercial project at an investment of Rs 1,000 crore and is looking to raise FDI to complete this project. The 6-acre project ‘Noida City Center’ includes a 7 lakh sq ft shopping mall, 2.5 lakh sq ft office towers, two hotels with combined 400 rooms and 100 service apartments. “Total project cost of this commercial project is Rs 1,000 crore,” Logix group CMD Shakti Nath said. The investments are largely met through internal accruals, he said, adding that the […]

The genomes of 2514 new viruses have been identified in DNA recovered from human and animal cells, many of them belonging to wholly new families

History is witness to the many scientific leaders and technology visionaries who all tried to predict what innovations will exist in the future. While not all predictions come to fruition, others were not so far off. We may not have flying cars like The...

Legionella pneumophila, the etiological agent of Legionnaires’ disease, employs an arsenal of hundreds of Dot/Icm-translocated effector proteins to facilitate replication within eukaryotic phagocytes. Several effectors, called metaeffectors, function to regulate the activity of other Dot/Icm-translocated effectors during infection. The metaeffector Lpg2505 is essential for L. pneumophila intracellular replication only when its cognate effector, SidI, is present. SidI is a cytotoxic effector that interacts with the host translation factor eEF1A and potently inhibits eukaryotic protein translation by an unknown mechanism. Here, we evaluated the impact of Lpg2505 on SidI-mediated phenotypes and investigated the mechanism of SidI function. We determined that Lpg2505 binds with nanomolar affinity to SidI and suppresses SidI-mediated inhibition of protein translation. SidI binding to eEF1A and Lpg2505 is not mutually exclusive, and the proteins bind distinct regions of SidI. We also discovered that SidI possesses GDP-dependent glycosyl hydrolase activity and that this activity is regulated by Lpg2505. We have therefore renamed Lpg2505 MesI (metaeffector of SidI). This work reveals novel enzymatic activity for SidI and provides insight into how intracellular replication of L. pneumophila is regulated by a metaeffector.

Thematic collection: This article is part of the Exploration 17 collection available at: https://www.lyellcollection.org/cc/exploration-17

OBJECTIVE

With rising health care costs and finite health care resources, understanding the population needs of different type 2 diabetes mellitus (T2DM) patient subgroups is important. Sparse data exist for the application of population segmentation on health care needs among Asian T2DM patients. We aimed to segment T2DM patients into distinct classes and evaluate their differential health care use, diabetes-related complications, and mortality patterns.

RESEARCH DESIGN AND METHODS

Latent class analysis was conducted on a retrospective cohort of 71,125 T2DM patients. Latent class indicators included patient’s age, ethnicity, comorbidities, and duration of T2DM. Outcomes evaluated included health care use, diabetes-related complications, and 4-year all-cause mortality. The relationship between class membership and outcomes was evaluated with the appropriate regression models.

RESULTS

Five classes of T2DM patients were identified. The prevalence of depression was high among patients in class 3 (younger females with short-to-moderate T2DM duration and high psychiatric and neurological disease burden) and class 5 (older patients with moderate-to-long T2DM duration and high disease burden with end-organ complications). They were the highest tertiary health care users. Class 5 patients had the highest risk of myocardial infarction (hazard ratio [HR] 12.05, 95% CI 10.82–13.42]), end-stage renal disease requiring dialysis initiation (HR 25.81, 95% CI 21.75–30.63), stroke (HR 19.37, 95% CI 16.92–22.17), lower-extremity amputation (HR 12.94, 95% CI 10.90–15.36), and mortality (HR 3.47, 95% CI 3.17–3.80).

CONCLUSIONS

T2DM patients can be segmented into classes with differential health care use and outcomes. Depression screening should be considered for the two identified classes of patients.

Whether low plasma 25-hydroxyvitamin D concentrations cause osteoporotic fractures is unclear. We tested the hypothesis that low plasma 25-hydroxyvitamin D concentrations are associated with increased risk of osteoporotic fractures using a Mendelian randomization analysis.We genotyped 116 335 randomly chosen white Danish persons aged 20–100 years in 2 population-based cohort studies for plasma 25-hydroxyvitamin D decreasing genotypes in CYP2R1 (rs117913124 and rs12794714), DHCR7 (rs7944926 and rs11234027), GEMIN2 (rs2277458), and HAL (rs3819817); 35 833 had information on plasma 25-hydroxyvitamin D. We assessed risk of total, osteoporotic, and anatomically localized fractures from 1981 through 2017. Information on fractures and vital status was obtained from nationwide registries.During up to 36 years of follow-up, we observed 17 820 total fractures, 10 861 osteoporotic fractures, and 3472 fractures of hip or femur. Compared with individuals with 25-hydroxyvitamin D ≥ 50nmol/L, multivariable adjusted hazard ratios (95% CIs) for total fractures were 1.03 (0.97–1.09) for individuals with 25–49.9 nmol/L, 1.19 (1.10–1.28) for individuals with 12.5–24.9 nmol/L, and 1.39 (1.21–1.60) for individuals with 25-hydroxyvitamin D < 12.5 nmol/L. Corresponding hazard ratios were 1.07 (1.00–1.15), 1.25 (1.13–1.37), and 1.49 (1.25–1.77) for osteoporotic fractures and 1.09 (0.98–1.22), 1.37 (1.18–1.57), and 1.41 (1.09–1.81) for fractures of hip or femur, respectively. Hazard ratios per 1 increase in vitamin D allele score, corresponding to 3.0% (approximately 1.6 nmol/L) lower 25-hydroxyvitamin D concentrations, were 0.99 (0.98–1.00) for total fractures, 0.99 (0.97–1.00) for osteoporotic fractures, and 0.98 (0.95–1.00) for fractures of hip or femur.Low plasma 25-hydroxyvitamin D concentrations were associated with osteoporotic fractures; however, Mendelian randomization analysis provided no evidence supporting a causal role for vitamin D in the risk for osteoporotic fractures.

Cần bán căn shop đẹp nhất phía Đông Hà Nội tại Chân tòa chung cư Sky Oasis Ecopark. DT: Tổng 163m2 (2 tầng). Tầng 1: 82,4m2 - tầng 2: 81,1 m2. Hai tầng KD (tầng 1 cao 5m, tầng 2 cao 5.9m). Hình thức sở hữu: Sổ lâu dài, linh hoạt tách 2 sổ chuyển nhượng được. Đặc điểm: Gần bể bơi ...

Ecopark. Shop khối đế chung cư ở vị trí kim cương -. Sở hữu căn shop đẹp nhất phía Đông Hà Nội. DT: Từ 53m - 104m2. Hai tầng KD (tầng 1 cao 5m, tầng 2 cao 5.9m). Hình thức sở hữu: Sổ lâu dài, linh hoạt tách 2 sổ chuyển nhượng được. Đặc điểm: Gần bể bơi lớn tầng 3, nằm trong đô th...