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Essai sur la leucorrhée et les causes diverses qui la produisent / par A.M. Bureaud Riofrey.

Londres : L’Auteur, 1834.




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Essai sur les moyens de perfectionner et d'étendre l'art de l'anatomiste, présenté et soutenu à l'Ecole de médecine de Paris le lundi 11 fructidor an XI / par Constant Dumeril.

Paris : Baudouin, 1803.




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Caravan of decorated cars bring joy to high school seniors




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Idaho district to graduate seniors at drive-in theater




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W. Va. Governor Fires Sen. Joe Manchin's Wife From State Education Post

The legislature sent a proposal last week to Gov. Jim Justice's desk to shutter the state's advisory education and the arts department, leaving the Gayle Manchin and her staff in the lurch.




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West Virginia Teachers Continue to Strike After State Senate Trims Pay Raise

The West Virginia Senate trimmed the proposed pay raise for teachers from 5 percent to 4 percent, prompting union officials to declare that the strike will continue indefinitely.




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Supreme Court to Weigh 'Incorrigible' Bar for Juvenile Life Without Parole Sentences

The justices agreed to decide whether the Eighth Amendment requires a trial court to find that a juvenile is permanently incorrigible before imposing a sentence of life without parole.




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A rich man and a woman who has visited him for tea gossip about an impoverished gentleman's daughter who is present in his house as a governess: the visitor looks at the governess with a supercilious expression. Engraving by R. Hatfield, 1842, after R

London (No. 4, Hanover Street) : Published ... for the proprietor by T.G. March ; [London] (Threadneedle Street) : Sold also by F. G. Moon ; [London] (Strand) : [Sold also by] Ackermann & Co., April 10, 1842 ([London?] : Printed by R. Lloyd)




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Cybele, accompanied by Bacchus and Ceres, is carried on a chariot drawn by lions, surrounded by ancillary deities and followers; representing the element earth. Engraving by C. Dupuis, 1721, after Louis de Boullogne the younger.

Paris (rue de la Vannerie a l'image St. Michel) : Dupuis graveur du Roy, [1721]




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A man, a woman, and two children; representing Isaiah. Engraving by P. Savorelli, 1805, after Michelangelo.

Romae [Rome] (ad Pasquinum) : Venit ... apud Montagnani-Mirabili, [1805?]




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A nymph seated on a rock and holding a lyre, surrounded by water and fish; representing a Rhinemaiden (Die Lorelei, nymph of the Rhine). Stipple engraving by J.H. Baker after F.R. Roffe after L.M. von Schwanthaler.

London : Published for the proprietors, [between 1800 and 1899]




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A fight between two men is interrupted by a woman representing mercy, pleading on behalf of the losing party. Engraving by G.T. Doo, 1848, after W. Etty.

London (5 Haymarket) : Published ... by J. Hogarth, June 1 1849.




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Panthers strike deal with 2018 draft pick Grigori Denisenko

The Florida Panthers finally have a deal with Russian forward Grigori Denisenko. The Panthers announced Tuesday that Denisenko has agreed to a three-year entry level contract - though it remains unclear when that contract will be officially signed and begin to take effect, given the uncertainty of the current NHL season because of the coronavirus pandemic. Denisenko was the 15th overall pick by the Panthers in the 2018 draft.




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Sharks' Marcus Sorensen still skating, keeping routine while in Sweden

Marcus Sorensen is using his connections in Sweden to stay ready in case the NHL season resumes.




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Tuberculosis statistics : summary of the report / addressed by Dr. S. Rosenfeld (Vienna) to the Health Committee of the Leage of Nations.

England : League of Nations, 1925.




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Das Apothekenwesen in Baden von 1945 bis 1960 / Ilse Denninger ; mit einem Geleitwort von Christoph Friedrich.

Stuttgart : In Kommission: Wissenschaftliche Verlagsgesellschaft mbH, 2019.




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Antike Naturwissenschaft und ihre Rezeption : Band XXIX / Jochen Althoff, Sabine Föllinger, Georg Wöhrle (Hg.)

Trier : WVT Wissenschaftlicher Verlag Trier, 2017.




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Illuminated address presented to Andrew Lynch, 1925




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Aari McDonald on returning for her senior year at Arizona: 'We're ready to set the bar higher'

Arizona's Aari McDonald and Pac-12 Networks' Ashley Adamson discuss the guard's decision to return for her senior season in Tucson and how she now has the opportunity to be the face of the league. McDonald, the Pac-12 Defensive Player of the Year, was one of the nation's top scorers in 2019-20, averaging 20.6 points per game.




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Ruthy Hebard, Sabrina Ionescu 'represent everything that is great about basketball'

Ruthy Hebard and Sabrina Ionescu have had a remarkable four years together in Eugene, rewriting the history books and pushing the Ducks into the national spotlight. Catch the debut of "Our Stories Unfinished Business: Sabrina Ionescu and Ruthy Hebard" at Wednesday, April 15 at 7 p.m. PT/ 8 p.m. MT on Pac-12 Network.




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Kentucky women add guards Massengill, Benton as transfers

LEXINGTON, Ky. (AP) -- Sophomore guards Jazmine Massengill and Robyn Benton transferred to Kentucky from Southeastern Conference rivals Wednesday.




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Parseval inequalities and lower bounds for variance-based sensitivity indices

Olivier Roustant, Fabrice Gamboa, Bertrand Iooss.

Source: Electronic Journal of Statistics, Volume 14, Number 1, 386--412.

Abstract:
The so-called polynomial chaos expansion is widely used in computer experiments. For example, it is a powerful tool to estimate Sobol’ sensitivity indices. In this paper, we consider generalized chaos expansions built on general tensor Hilbert basis. In this frame, we revisit the computation of the Sobol’ indices with Parseval equalities and give general lower bounds for these indices obtained by truncation. The case of the eigenfunctions system associated with a Poincaré differential operator leads to lower bounds involving the derivatives of the analyzed function and provides an efficient tool for variable screening. These lower bounds are put in action both on toy and real life models demonstrating their accuracy.




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Learning Linear Non-Gaussian Causal Models in the Presence of Latent Variables

We consider the problem of learning causal models from observational data generated by linear non-Gaussian acyclic causal models with latent variables. Without considering the effect of latent variables, the inferred causal relationships among the observed variables are often wrong. Under faithfulness assumption, we propose a method to check whether there exists a causal path between any two observed variables. From this information, we can obtain the causal order among the observed variables. The next question is whether the causal effects can be uniquely identified as well. We show that causal effects among observed variables cannot be identified uniquely under mere assumptions of faithfulness and non-Gaussianity of exogenous noises. However, we are able to propose an efficient method that identifies the set of all possible causal effects that are compatible with the observational data. We present additional structural conditions on the causal graph under which causal effects among observed variables can be determined uniquely. Furthermore, we provide necessary and sufficient graphical conditions for unique identification of the number of variables in the system. Experiments on synthetic data and real-world data show the effectiveness of our proposed algorithm for learning causal models.




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Switching Regression Models and Causal Inference in the Presence of Discrete Latent Variables

Given a response $Y$ and a vector $X = (X^1, dots, X^d)$ of $d$ predictors, we investigate the problem of inferring direct causes of $Y$ among the vector $X$. Models for $Y$ that use all of its causal covariates as predictors enjoy the property of being invariant across different environments or interventional settings. Given data from such environments, this property has been exploited for causal discovery. Here, we extend this inference principle to situations in which some (discrete-valued) direct causes of $ Y $ are unobserved. Such cases naturally give rise to switching regression models. We provide sufficient conditions for the existence, consistency and asymptotic normality of the MLE in linear switching regression models with Gaussian noise, and construct a test for the equality of such models. These results allow us to prove that the proposed causal discovery method obtains asymptotic false discovery control under mild conditions. We provide an algorithm, make available code, and test our method on simulated data. It is robust against model violations and outperforms state-of-the-art approaches. We further apply our method to a real data set, where we show that it does not only output causal predictors, but also a process-based clustering of data points, which could be of additional interest to practitioners.




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Exact Guarantees on the Absence of Spurious Local Minima for Non-negative Rank-1 Robust Principal Component Analysis

This work is concerned with the non-negative rank-1 robust principal component analysis (RPCA), where the goal is to recover the dominant non-negative principal components of a data matrix precisely, where a number of measurements could be grossly corrupted with sparse and arbitrary large noise. Most of the known techniques for solving the RPCA rely on convex relaxation methods by lifting the problem to a higher dimension, which significantly increase the number of variables. As an alternative, the well-known Burer-Monteiro approach can be used to cast the RPCA as a non-convex and non-smooth $ell_1$ optimization problem with a significantly smaller number of variables. In this work, we show that the low-dimensional formulation of the symmetric and asymmetric positive rank-1 RPCA based on the Burer-Monteiro approach has benign landscape, i.e., 1) it does not have any spurious local solution, 2) has a unique global solution, and 3) its unique global solution coincides with the true components. An implication of this result is that simple local search algorithms are guaranteed to achieve a zero global optimality gap when directly applied to the low-dimensional formulation. Furthermore, we provide strong deterministic and probabilistic guarantees for the exact recovery of the true principal components. In particular, it is shown that a constant fraction of the measurements could be grossly corrupted and yet they would not create any spurious local solution.




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Representation Learning for Dynamic Graphs: A Survey

Graphs arise naturally in many real-world applications including social networks, recommender systems, ontologies, biology, and computational finance. Traditionally, machine learning models for graphs have been mostly designed for static graphs. However, many applications involve evolving graphs. This introduces important challenges for learning and inference since nodes, attributes, and edges change over time. In this survey, we review the recent advances in representation learning for dynamic graphs, including dynamic knowledge graphs. We describe existing models from an encoder-decoder perspective, categorize these encoders and decoders based on the techniques they employ, and analyze the approaches in each category. We also review several prominent applications and widely used datasets and highlight directions for future research.




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Bayesian modeling and prior sensitivity analysis for zero–one augmented beta regression models with an application to psychometric data

Danilo Covaes Nogarotto, Caio Lucidius Naberezny Azevedo, Jorge Luis Bazán.

Source: Brazilian Journal of Probability and Statistics, Volume 34, Number 2, 304--322.

Abstract:
The interest on the analysis of the zero–one augmented beta regression (ZOABR) model has been increasing over the last few years. In this work, we developed a Bayesian inference for the ZOABR model, providing some contributions, namely: we explored the use of Jeffreys-rule and independence Jeffreys prior for some of the parameters, performing a sensitivity study of prior choice, comparing the Bayesian estimates with the maximum likelihood ones and measuring the accuracy of the estimates under several scenarios of interest. The results indicate, in a general way, that: the Bayesian approach, under the Jeffreys-rule prior, was as accurate as the ML one. Also, different from other approaches, we use the predictive distribution of the response to implement Bayesian residuals. To further illustrate the advantages of our approach, we conduct an analysis of a real psychometric data set including a Bayesian residual analysis, where it is shown that misleading inference can be obtained when the data is transformed. That is, when the zeros and ones are transformed to suitable values and the usual beta regression model is considered, instead of the ZOABR model. Finally, future developments are discussed.




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A note on the “L-logistic regression models: Prior sensitivity analysis, robustness to outliers and applications”

Saralees Nadarajah, Yuancheng Si.

Source: Brazilian Journal of Probability and Statistics, Volume 34, Number 1, 183--187.

Abstract:
Da Paz, Balakrishnan and Bazan [Braz. J. Probab. Stat. 33 (2019), 455–479] introduced the L-logistic distribution, studied its properties including estimation issues and illustrated a data application. This note derives a closed form expression for moment properties of the distribution. Some computational issues are discussed.




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On the Nielsen distribution

Fredy Castellares, Artur J. Lemonte, Marcos A. C. Santos.

Source: Brazilian Journal of Probability and Statistics, Volume 34, Number 1, 90--111.

Abstract:
We introduce a two-parameter discrete distribution that may have a zero vertex and can be useful for modeling overdispersion. The discrete Nielsen distribution generalizes the Fisher logarithmic (i.e., logarithmic series) and Stirling type I distributions in the sense that both can be considered displacements of the Nielsen distribution. We provide a comprehensive account of the structural properties of the new discrete distribution. We also show that the Nielsen distribution is infinitely divisible. We discuss maximum likelihood estimation of the model parameters and provide a simple method to find them numerically. The usefulness of the proposed distribution is illustrated by means of three real data sets to prove its versatility in practical applications.




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L-Logistic regression models: Prior sensitivity analysis, robustness to outliers and applications

Rosineide F. da Paz, Narayanaswamy Balakrishnan, Jorge Luis Bazán.

Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 3, 455--479.

Abstract:
Tadikamalla and Johnson [ Biometrika 69 (1982) 461–465] developed the $L_{B}$ distribution to variables with bounded support by considering a transformation of the standard Logistic distribution. In this manuscript, a convenient parametrization of this distribution is proposed in order to develop regression models. This distribution, referred to here as L-Logistic distribution, provides great flexibility and includes the uniform distribution as a particular case. Several properties of this distribution are studied, and a Bayesian approach is adopted for the parameter estimation. Simulation studies, considering prior sensitivity analysis, recovery of parameters and comparison of algorithms, and robustness to outliers are all discussed showing that the results are insensitive to the choice of priors, efficiency of the algorithm MCMC adopted, and robustness of the model when compared with the beta distribution. Applications to estimate the vulnerability to poverty and to explain the anxiety are performed. The results to applications show that the L-Logistic regression models provide a better fit than the corresponding beta regression models.




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A design-sensitive approach to fitting regression models with complex survey data

Phillip S. Kott.

Source: Statistics Surveys, Volume 12, 1--17.

Abstract:
Fitting complex survey data to regression equations is explored under a design-sensitive model-based framework. A robust version of the standard model assumes that the expected value of the difference between the dependent variable and its model-based prediction is zero no matter what the values of the explanatory variables. The extended model assumes only that the difference is uncorrelated with the covariates. Little is assumed about the error structure of this difference under either model other than independence across primary sampling units. The standard model often fails in practice, but the extended model very rarely does. Under this framework some of the methods developed in the conventional design-based, pseudo-maximum-likelihood framework, such as fitting weighted estimating equations and sandwich mean-squared-error estimation, are retained but their interpretations change. Few of the ideas here are new to the refereed literature. The goal instead is to collect those ideas and put them into a unified conceptual framework.




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Primal and dual model representations in kernel-based learning

Johan A.K. Suykens, Carlos Alzate, Kristiaan Pelckmans

Source: Statist. Surv., Volume 4, 148--183.

Abstract:
This paper discusses the role of primal and (Lagrange) dual model representations in problems of supervised and unsupervised learning. The specification of the estimation problem is conceived at the primal level as a constrained optimization problem. The constraints relate to the model which is expressed in terms of the feature map. From the conditions for optimality one jointly finds the optimal model representation and the model estimate. At the dual level the model is expressed in terms of a positive definite kernel function, which is characteristic for a support vector machine methodology. It is discussed how least squares support vector machines are playing a central role as core models across problems of regression, classification, principal component analysis, spectral clustering, canonical correlation analysis, dimensionality reduction and data visualization.




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Discrete variations of the fractional Brownian motion in the presence of outliers and an additive noise

Sophie Achard, Jean-François Coeurjolly

Source: Statist. Surv., Volume 4, 117--147.

Abstract:
This paper gives an overview of the problem of estimating the Hurst parameter of a fractional Brownian motion when the data are observed with outliers and/or with an additive noise by using methods based on discrete variations. We show that the classical estimation procedure based on the log-linearity of the variogram of dilated series is made more robust to outliers and/or an additive noise by considering sample quantiles and trimmed means of the squared series or differences of empirical variances. These different procedures are compared and discussed through a large simulation study and are implemented in the R package dvfBm.




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An n-dimensional Rosenbrock Distribution for MCMC Testing. (arXiv:1903.09556v4 [stat.CO] UPDATED)

The Rosenbrock function is an ubiquitous benchmark problem for numerical optimisation, and variants have been proposed to test the performance of Markov Chain Monte Carlo algorithms. In this work we discuss the two-dimensional Rosenbrock density, its current $n$-dimensional extensions, and their advantages and limitations. We then propose a new extension to arbitrary dimensions called the Hybrid Rosenbrock distribution, which is composed of conditional normal kernels arranged in such a way that preserves the key features of the original kernel. Moreover, due to its structure, the Hybrid Rosenbrock distribution is analytically tractable and possesses several desirable properties, which make it an excellent test model for computational algorithms.




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Plan2Vec: Unsupervised Representation Learning by Latent Plans. (arXiv:2005.03648v1 [cs.LG])

In this paper we introduce plan2vec, an unsupervised representation learning approach that is inspired by reinforcement learning. Plan2vec constructs a weighted graph on an image dataset using near-neighbor distances, and then extrapolates this local metric to a global embedding by distilling path-integral over planned path. When applied to control, plan2vec offers a way to learn goal-conditioned value estimates that are accurate over long horizons that is both compute and sample efficient. We demonstrate the effectiveness of plan2vec on one simulated and two challenging real-world image datasets. Experimental results show that plan2vec successfully amortizes the planning cost, enabling reactive planning that is linear in memory and computation complexity rather than exhaustive over the entire state space.




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The evolution of feathers : from their origin to the present

9783030272234 electronic book




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Salt, fat and sugar reduction : sensory approaches for nutritional reformulation of foods and beverages

O'Sullivan, Maurice G., author
9780128226124 (electronic bk.)




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QoS routing algorithms for wireless sensor networks

Venugopal, K. R., Dr., author
9789811527203 (electronic bk.)




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Human behavior analysis : sensing and understanding

Yu, Zhiwen, author
9789811521096 (electronic bk.)




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Handbook of immunosenescence : basic understanding and clinical implications

9783319645971 (electronic bk.)




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Ethnoveterinary medicine : present and future concepts

9783030322700 (electronic bk.)




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Essential current concepts in stem cell biology

9783030339234 (electronic bk.)




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Epidemics and society : from the Black Death to the present

Snowden, Frank M. (Frank Martin), 1946- author.
9780300249149 (electronic book)




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Correction: Sensitivity analysis for an unobserved moderator in RCT-to-target-population generalization of treatment effects

Trang Quynh Nguyen, Elizabeth A. Stuart.

Source: The Annals of Applied Statistics, Volume 14, Number 1, 518--520.




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Objective Bayes model selection of Gaussian interventional essential graphs for the identification of signaling pathways

Federico Castelletti, Guido Consonni.

Source: The Annals of Applied Statistics, Volume 13, Number 4, 2289--2311.

Abstract:
A signalling pathway is a sequence of chemical reactions initiated by a stimulus which in turn affects a receptor, and then through some intermediate steps cascades down to the final cell response. Based on the technique of flow cytometry, samples of cell-by-cell measurements are collected under each experimental condition, resulting in a collection of interventional data (assuming no latent variables are involved). Usually several external interventions are applied at different points of the pathway, the ultimate aim being the structural recovery of the underlying signalling network which we model as a causal Directed Acyclic Graph (DAG) using intervention calculus. The advantage of using interventional data, rather than purely observational one, is that identifiability of the true data generating DAG is enhanced. More technically a Markov equivalence class of DAGs, whose members are statistically indistinguishable based on observational data alone, can be further decomposed, using additional interventional data, into smaller distinct Interventional Markov equivalence classes. We present a Bayesian methodology for structural learning of Interventional Markov equivalence classes based on observational and interventional samples of multivariate Gaussian observations. Our approach is objective, meaning that it is based on default parameter priors requiring no personal elicitation; some flexibility is however allowed through a tuning parameter which regulates sparsity in the prior on model space. Based on an analytical expression for the marginal likelihood of a given Interventional Essential Graph, and a suitable MCMC scheme, our analysis produces an approximate posterior distribution on the space of Interventional Markov equivalence classes, which can be used to provide uncertainty quantification for features of substantive scientific interest, such as the posterior probability of inclusion of selected edges, or paths.




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Estimating the rate constant from biosensor data via an adaptive variational Bayesian approach

Ye Zhang, Zhigang Yao, Patrik Forssén, Torgny Fornstedt.

Source: The Annals of Applied Statistics, Volume 13, Number 4, 2011--2042.

Abstract:
The means to obtain the rate constants of a chemical reaction is a fundamental open problem in both science and the industry. Traditional techniques for finding rate constants require either chemical modifications of the reactants or indirect measurements. The rate constant map method is a modern technique to study binding equilibrium and kinetics in chemical reactions. Finding a rate constant map from biosensor data is an ill-posed inverse problem that is usually solved by regularization. In this work, rather than finding a deterministic regularized rate constant map that does not provide uncertainty quantification of the solution, we develop an adaptive variational Bayesian approach to estimate the distribution of the rate constant map, from which some intrinsic properties of a chemical reaction can be explored, including information about rate constants. Our new approach is more realistic than the existing approaches used for biosensors and allows us to estimate the dynamics of the interactions, which are usually hidden in a deterministic approximate solution. We verify the performance of the new proposed method by numerical simulations, and compare it with the Markov chain Monte Carlo algorithm. The results illustrate that the variational method can reliably capture the posterior distribution in a computationally efficient way. Finally, the developed method is also tested on the real biosensor data (parathyroid hormone), where we provide two novel analysis tools—the thresholding contour map and the high order moment map—to estimate the number of interactions as well as their rate constants.




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Rates of convergence in de Finetti’s representation theorem, and Hausdorff moment problem

Emanuele Dolera, Stefano Favaro.

Source: Bernoulli, Volume 26, Number 2, 1294--1322.

Abstract:
Given a sequence ${X_{n}}_{ngeq 1}$ of exchangeable Bernoulli random variables, the celebrated de Finetti representation theorem states that $frac{1}{n}sum_{i=1}^{n}X_{i}stackrel{a.s.}{longrightarrow }Y$ for a suitable random variable $Y:Omega ightarrow [0,1]$ satisfying $mathsf{P}[X_{1}=x_{1},dots ,X_{n}=x_{n}|Y]=Y^{sum_{i=1}^{n}x_{i}}(1-Y)^{n-sum_{i=1}^{n}x_{i}}$. In this paper, we study the rate of convergence in law of $frac{1}{n}sum_{i=1}^{n}X_{i}$ to $Y$ under the Kolmogorov distance. After showing that a rate of the type of $1/n^{alpha }$ can be obtained for any index $alpha in (0,1]$, we find a sufficient condition on the distribution of $Y$ for the achievement of the optimal rate of convergence, that is $1/n$. Besides extending and strengthening recent results under the weaker Wasserstein distance, our main result weakens the regularity hypotheses on $Y$ in the context of the Hausdorff moment problem.




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Strictly weak consensus in the uniform compass model on $mathbb{Z}$

Nina Gantert, Markus Heydenreich, Timo Hirscher.

Source: Bernoulli, Volume 26, Number 2, 1269--1293.

Abstract:
We investigate a model for opinion dynamics, where individuals (modeled by vertices of a graph) hold certain abstract opinions. As time progresses, neighboring individuals interact with each other, and this interaction results in a realignment of opinions closer towards each other. This mechanism triggers formation of consensus among the individuals. Our main focus is on strong consensus (i.e., global agreement of all individuals) versus weak consensus (i.e., local agreement among neighbors). By extending a known model to a more general opinion space, which lacks a “central” opinion acting as a contraction point, we provide an example of an opinion formation process on the one-dimensional lattice $mathbb{Z}$ with weak consensus but no strong consensus.




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Smart research for HSC students: Essential Library resources for your research and study

This session brings together the key resources for HSC subjects, including those that are useful for studying Advanced and Extension courses.




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Heteromodal Cortical Areas Encode Sensory-Motor Features of Word Meaning

The capacity to process information in conceptual form is a fundamental aspect of human cognition, yet little is known about how this type of information is encoded in the brain. Although the role of sensory and motor cortical areas has been a focus of recent debate, neuroimaging studies of concept representation consistently implicate a network of heteromodal areas that seem to support concept retrieval in general rather than knowledge related to any particular sensory-motor content. We used predictive machine learning on fMRI data to investigate the hypothesis that cortical areas in this "general semantic network" (GSN) encode multimodal information derived from basic sensory-motor processes, possibly functioning as convergence–divergence zones for distributed concept representation. An encoding model based on five conceptual attributes directly related to sensory-motor experience (sound, color, shape, manipulability, and visual motion) was used to predict brain activation patterns associated with individual lexical concepts in a semantic decision task. When the analysis was restricted to voxels in the GSN, the model was able to identify the activation patterns corresponding to individual concrete concepts significantly above chance. In contrast, a model based on five perceptual attributes of the word form performed at chance level. This pattern was reversed when the analysis was restricted to areas involved in the perceptual analysis of written word forms. These results indicate that heteromodal areas involved in semantic processing encode information about the relative importance of different sensory-motor attributes of concepts, possibly by storing particular combinations of sensory and motor features.

SIGNIFICANCE STATEMENT The present study used a predictive encoding model of word semantics to decode conceptual information from neural activity in heteromodal cortical areas. The model is based on five sensory-motor attributes of word meaning (color, shape, sound, visual motion, and manipulability) and encodes the relative importance of each attribute to the meaning of a word. This is the first demonstration that heteromodal areas involved in semantic processing can discriminate between different concepts based on sensory-motor information alone. This finding indicates that the brain represents concepts as multimodal combinations of sensory and motor representations.