Previous studies have shown that concomitant administration of the quadrivalent human papillomavirus vaccine with MCV4 and Tdap was generally well tolerated and did not interfere with the immune responses to the respective vaccines.

Concomitant administration of the novel 9-valent human papillomavirus vaccine with MCV4 and Tdap, 2 vaccines that are currently recommended for routine vaccination of adolescents, did not compromise the safety, tolerability, and immunogenicity of the individual vaccines. (Read the full article)

Previous studies found that 2010–2011 trivalent inactivated influenza vaccine (TIV) and 13-valent pneumococcal conjugate vaccine (PCV13) were associated with statistically significant increased risks of febrile seizures (FS) in the United States.

Estimated FS relative risks after TIV or PCV13 adjusted for DTaP were >1, although not statistically significant and lower than previous estimates. Same-day administration of TIV and PCV13 did not result in more FS compared with separate-day vaccination. (Read the full article)

HPV is the most common sexually transmitted infection in the United States. More than 50% of sexually active men and women will acquire HPV infection in their lifetime. In 2011, HPV was recommended for routine use among male adolescents.

(Read the full article)

Men were also more likely to request a transfer to a school with a male principal.

A new brief from the Brookings Institution poses the question: Is overrepresentation of women in the teaching force negatively affecting boys' achievement?

Lineup is subject to change. Please see our masthead for editorial contacts.

The Valencia CF starlet gives you his formula for finishing when running in on goal.

The UK and the European Union are on course to miss a key milestone on the road to a Brexit deal after talks hit a roadblock. Negotiations are now paused, putting pressure on leaders to step into the breach later this week.

La fièvre des élections s’empare de l’Afrique centrale. Pour la seconde fois depuis la fin des guerres qui ont dévasté la région, les scrutins s’enchaînent au Burundi, au Rwanda, en République centrafricaine et au Congo.

Vu du centre de l’Afrique – Tchad, République centrafricaine (RCA) et RD Congo –, le cinquantenaire des indépendances est un anniversaire à l’envers : on en parle davantage à Paris et Bruxelles qu’à N’Djamena, Bangui et Kinshasa. Sans doute parce que, en Europe, il s’agit avant tout de gérer des diasporas turbulentes et une relation bilatérale devenue épineuse tandis que, dans les capitales africaines, il s’agit d’éviter à tout prix le droit d’inventaire.

Dans de nombreux pays, le pétrole suscite des débats controversés sur son rôle de moteur de changements économiques, sociaux et géopolitiques. Depuis quelques années, les réflexions sur la question du pétrole ont démontré une corrélation négative entre son exploitation, le développement socioéconomique, la gouvernance et le regain des conflits dans les pays producteurs.

La rechute est le risque majeur des pays post-conflit et l'une des principales raisons de cette rechute s'appelle la corruption.

Incapable d’agir quand Crisis Group et d’autres organisations envoyaient des signaux d’alerte et qualifiaient la Centrafrique d’Etat fantôme, la communauté internationale doit dorénavant s’impliquer massivement, à des coûts largement supérieurs, suite aux pertes humaines considérables et aux déplacements massifs de population, et avec des chances de succès beaucoup plus faibles.

Gepotidacin, a triazaacenaphthylene bacterial type II topoisomerase inhibitor, is in development for treatment of uncomplicated urinary tract infection (uUTI). This Phase 2a study in female participants with uUTI evaluated the pharmacokinetics (primary objective), safety, and exploratory efficacy of gepotidacin. Eligible participants (N = 22) were confined to the clinic at baseline, received oral gepotidacin 1,500 mg twice daily for 5 days (on-therapy; Days 1 to 5), and returned to the clinic for test-of-cure (Days 10 to 13) and follow-up (Day 28±3). Pharmacokinetic, safety, clinical, and microbiological assessments were performed. Maximum plasma concentrations were observed approximately 1.5 to 2 hours postdose. Steady state was attained by Day 3. Urinary exposure over the dosing interval increased from 3,742 μg.h/ml (Day 1) to 5,973 μg.h/ml (Day 4), with trough concentrations of 322 to 352 μg/ml from Day 3 onward. Gepotidacin had an acceptable safety-risk profile with no treatment-limiting adverse events and no clinically relevant safety trends. Clinical success was achieved in 19 (86%) and 18 (82%) of 22 participants at test-of-cure and follow-up, respectively. Eight participants had a qualifying baseline uropathogen (growth; ≥10⁵ CFU/ml). A therapeutic (combined clinical and microbiological [no growth; <10³ CFU/ml]) successful response was achieved in 6 (75%) and 5 (63%) of 8 participants at test-of-cure and follow-up, respectively. Plasma area under the free-drug concentration-time curve over 24 hours at steady state divided by the MIC (fAUC_0-24/MIC) and urine AUC_0-24/MIC ranged from 6.99 to 90.5 and 1,292 to 121,698, respectively. Further evaluation of gepotidacin in uUTI is warranted. (NCT03568942)

A total of 2,283 Salmonella spp. isolates were recovered from 18,334 samples including patients with diarrhea, food of animal origin and pets across 5 provinces of China. The highest prevalence of Salmonella spp. was detected in chicken meats (39.3%, 486/1,237). Fifteen serogroups and 66 serovars were identified, with Typhimurium and Enteritidis being the most dominant. Most (85.5%, 1,952/2,283) isolates exhibited resistant to ≥ 1 antimicrobial and 56.4% were multi-drug resistant (MDR). A total of 222 isolates harbored extended-spectrum β-lactamases (ESBLs), 200 of which were CTX-M-type that were mostly detected from chicken meat and turtle fecal. Overall, eight bla_CTX-M genes were identified, with bla_CTX-M-65, bla_CTX-M-123, bla_CTX-M-14, bla_CTX-M-79, and bla_CTX-M-130 being the most prevalent. Totally, 166 of the 222 ESBL-producing isolates had amino acid substitutions in GyrA (S83Y, S83F, D87G, D87N, and D87Y) and ParC (and S80I), whilst the PMQR-encoding genes oqxA/B, qepA, and qnrB/S were detected in almost all isolates. Of the fifteen sequence types (STs) identified in the 222 ESBLs, ST17, ST11, ST34, and ST26 ranked among the top 5 in the number of isolates. Our study revealed considerable serovars diversity, high prevalence of co-occurrence of MDR determinants, including CTX-M-type ESBLs, QRDRs mutations and PMQR genes. This is the first report of CTX-M-130 Salmonella spp. from patients with diarrhea and QRDRs mutations from turtle fecal samples. Our study emphasizes the importance of actions, both in the health care settings and in the veterinary medicine sector, to control the dissemination of MDR, especially the CTX-M Salmonella spp. isolates.

Although it's pricey, the intuitive Salesforce Pardot offers standout features, making it a leader among today's marketing automation platforms.

Valencia will need to must a remarkable home recovery to turn round their tie against Atalanta after a 4-1 first-leg defeat.

Mauritians are Africa's wealthiest individuals, while Zimbabweans count as the poorest, according to the latest Africa Wealth Report.

Save $30 on this Editors' Choice fitness tracker, which is safe to wear in the pool and shower. It's normally $149.95, but you can grab it now for just $119.95 with free shipping.

Tickets are now on sale for UEFA Futsal EURO 2018 at Stožice Arena in Ljubljana with the first one bought by UEFA President Aleksander Čeferin, who was born in the Slovenian capital.

Tickets for the UEFA Futsal Cup finals at Zaragoza's Pabellón Príncipe Felipe on 20, 22 April are on sale.

"It's the same as an iPod except it sounds like God," Young said here at CES.

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U19 EURO kicks off in Armenia on Sunday and we pick out a player from each team to keep an eye on.

UEFA's 'Women's football across the national associations 2017' report shows how the female game has evolved over the past five years, and offers a snapshot of the sport in each of UEFA's 55 member associations.

Giving users of smart assistants the option to adjust settings for privacy or content delivery, or both, doesn’t necessarily increase their trust in the platform, according to a team of Penn State researchers. In fact, for some users, it could have an unfavorable effect.

St. Joseph Medical Center has begun using an experimental treatment program called convalescent plasma therapy with a growing number of its COVID-19 positive patients.

Former Vice President Joe Biden has approved a series of new hires that will significantly expand his campaign ahead of the general election fight with President Trump.

Four Portugal players, three from Germany and two each representing France and Wales have made the official UEFA EURO 2016 Team of the Tournament.

• Football stadiums made available to National Health Service (NHS) for emergency facilities
• Ryan Giggs, Gareth Bale and Sophie Ingle spread NHS stay at home message
• Domestic league clubs raise funds for health care services

Source: mashable.com - Friday, May 08, 2020
Whether you're having a weird Mother's Day weekend or not, mom just feels extra far away, right? Even if you live far away and didn't see your mom (or mom figure) that often before social distancing, keeping in touch feels more imperative than ever. Watching a movie over FaceTime or Zoom isn't the same as hanging out IRL, but the whole "quality time" thing being your idea will be enough to make her smile. And this doesn't require a special mom holiday, you know — choosing one night a week for a movie night with mom would do a world of good for everyone's sense of normalcy.  Set it in stone with a new 4K TV on sale for Mother's Day weekend: Read more... More about 4k Tv , Oled , Mashable Shopping , Tech , and Consumer Tech

General public can apply for tickets on UEFA.com as of 14 June 12.00CET

Security expert Max Eddy explains how Apple banning an app used by pro-democracy protesters shows how even the best consumer security polices fail when there's a lack of will to enforce them appropriately.

Royole is known for being the first to show off a flexible phone, and at CES 2020, it has an Alexa-based smart speaker with a wraparound touch-screen display and a smart notebook that translates your handwriting into typed text.

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Source: www.youtube.com - Monday, April 27, 2020

Freshsales CRM is another small business-oriented offering from Freshworks, and the company's SMB expertise shows up clearly with an easy to use interface and a nicely pared feature set.

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Washington D.C., Mar 22, 2020 / 04:00 am (CNA).- The Syrian civil war has led to one of the largest refugee crises of modern times, and presented unique problems for Syria’s ancient Christian communities. Marginalized for centuries, persecuted by ISIS, afraid to attract any attention from the West, Syrian Christians remain, by most accounts, the war’s most invisible victims.

Seta Kale, a Syrian with a Syriac and Armenian descent, was born and raised in Qamishli and fled to Sweden at the age of 16. Today, as a 23-year-old, she’s studying business and economics at Jönköping International Business School, while working part-time as a cashier at a supermarket called Coop, and as a saleswoman at Rituals Cosmetics. Kale likes to sing to cope with her stress, and she likes to read poetry.

In partnership with the Philos Project, CNA sat down with Seta Kale:

When and how did you flee to Sweden?

I moved to Sweden seven years ago in December 2012, a couple of days before Christmas. We flew from Syria to Armenia, and from there we came to Sweden as tourists. We are some of the lucky ones as there were not many who could flee safely. But it was not as easy as it sounds. My family and I had to split up and travel on different dates in order to avoid the suspicion that we were refugees. We had no idea how we were going to be treated upon our arrival in Sweden, and therefore did not want to take any risks by travelling together.

We have seven people in our family. My mom, two of my brothers and I went first. After six months my older sister and third brother came, and a year later my dad arrived. My dad had to take the most difficult route, one that was filled with risks. He couldn’t get a tourist visa, so he had to travel between countries (Turkey, Italy, Greece and France) to be able to come to Sweden. At one point, he had to cross the sea in a small boat together with 30 other people and walk through a forest for several days. Some days he was unreachable, and I’ve never felt that kind of fear ever before. It was a kind that I will never forget.

When did you start feeling the war?

As I mentioned before, I lived in Qamishli. It is a city in northeast Syria, and it was one of the cities that was least affected by war in the beginning unlike, for example, Aleppo and Raqqa. There still were bombs and shootings. The violence started when our bread factory was bombed. It then escalated to hospitals, schools and many public places. Everything became more expensive and there was no access to electricity and clean water 24/7. People were afraid to go to work and children were afraid to go to school. Qamishli felt like a haunted city.

It was when my school was bombed only minutes after my sister and I had left that my dad decided that we had to flee Syria. I will never forget the memory of that day. The ground was shaking under our feet as my mom and aunt ran towards us. After that, people became desperate to flee the war. Houses and apartments were quickly emptied. The feelings and stories that Syria has carried together with her people since 2011 is indescribable.

Tell me about your hometown in Syria.

In Qamishli, Syriacs, Armenians, Assyrians, Arabs, Kurds, Christians, Muslims all lived together. There were as many churches as there were mosques. People worked alongside one another. They were humble, loving, loyal and respectful towards each other. We felt secure because we knew that if we ever were in danger, the whole city would come and help. Religion and ethnicity did not matter to us, and this was the case in the whole country, not only in my hometown. We never thought “he’s Muslim” or “she’s Christian.”

The social life never stopped in Qamishli. There were things to do 24/7 with friends and family. Christians and Muslims celebrated Christmas, Eid al-fitr, Easter and Eid al-adha together.

When I came to Sweden, everyone thought I lived in a tent in the desert. But the more they got to know me, they were surprised by my knowledge and all the languages I could speak. Unfortunately, people tend to believe things about Syria that are not true. We had access to development, education, jobs and more. People say that nothing is perfect, but Syria was perfect in my eyes. We were very rich, but not in a materialistic way. We were rich in culture, religion, knowledge, history, tradition, peoples and so much more. Everything had a reason and I am the way I am today mostly because of what and who Syria is.

What are your best and worst memories from Qamishli?

Wow, I don’t know where to begin. I have so many good memories imprinted in my heart. I cannot choose one because there are so many; from silly things in school with friends, to mini trips with the family throughout Syria, to celebrations of Christmas and Easter.

The worst memory I have was a time when I was on my way from Qamishli to Aleppo while we were fleeing the war. It was a 9-hour drive by bus. Before, it used to be a beautiful ride with beautiful buildings, houses, people and restaurants on the road. But that day I saw a completely different scene. It was filled with sorrow, and the beautiful buildings were reduced to stones on the ground. There were no houses, no restaurants and no people. During the trip to Aleppo the bus had to stop more than five times at checkpoints. Some checkpoints belonged to the Syrian military and some were controlled by ISIS. Once, my sister and I had to hide under the seats so the ISIS soldiers wouldn’t take us. Another horrible memory is simply when I realized that this is it, I will never go back to my country. I cried the entire flight.

Have you lost any friends or family members during the war?

I was one of the lucky ones who didn’t lose any friends or family members. But in Qamishli, everyone knows everyone, and we heard a lot of incredibly sad stories about people who disappeared during bombings and shootings. I had family members and friends, both boys and girls, who were drafted to the military. It was during the worst time in the war and the military needed as many people as possible. When these people would return, they were very different. What they witnessed during their time in the military changed them. In that way, I’ve lost loved ones.

If you could go back, would you stay in Sweden or move back to Syria?

I would definitely go back. Besides the fact that I miss it, I want to help rebuild what the war has destroyed. I want to see my country back on its feet and stronger than ever. I want to start a family there and I want my children to grow up in the country that I grew up in.

If you could send a message to Christians in the West, what would you want them to know about Syria?

I want people not to only think of war when they hear “Syria,” because it’s so much more. I want them to know that the Syrian people are struggling and fighting for the country to remain. But most of all, I want them to continue to pray every day for the people there and know that any contribution is an enormous help for the Syrians.

 

 

CNA Staff, Apr 6, 2020 / 01:00 pm (CNA).- Unable to lead the traditional Palm Sunday procession through Jerusalem, Archbishop Pierbattista Pizzaballa, OFM, apostolic administrator of the Latin Patriarchate of Jerusalem, blessed the city with a relic of the True Cross on April 5.

The annual procession, which recalls Christ’s entry into the city and the beginning of Holy Week, was cancelled in line with international efforts to curb the spread of COVID-19, with public gatherings and events suspended in Israel. 

“We decided since we cannot have the palm procession, to have anyway a moment of prayer this afternoon,” said Pizzaballa on Sunday. The archbishop led a short, multi-lingual “moment of prayer” at Dominus Flevit, a church located on the Mount of Olives.

The church, which is shaped like a teardrop, overlooks the city, and was built to mark the Gospel account of Jesus weeping as he envisioned the destruction of Jerusalem.

The prayer service ended with Pizzaballa raising a relic of the True Cross over the city in benediction. 

Jerusalem, said Pizzaballa, “is a symbol of the church, the symbol also of humanity. It is the house of prayer for all the people, according to the scriptures.”

“So when we cry [over] Jerusalem, together with Jesus, we cry [over] all our human fraternity, for this difficult moment we are living, for this sad Palm Sunday, this Easter we have to celebrate.”

Pizzaballa said that sadness over being unable to celebrate the liturgical feasts of Holy Week is real, but “maybe, in a way also very true, very essential.” 

“Today we have not celebrated the solemn and beautiful entrance of Jesus to the city of Jerusalem like every year, with faithful from all the parishes of the diocese and with pilgrims from all over the world,” Pizzaballa said during the prayer service.

“We have not raised our palms and olive branches to cry out ‘Hosanna’ to our king, Jesus the Christ.” 

Instead, the archbishop asked Catholics in the Holy Land and around the world to consider what the Lord may be trying to say during these times.

He noted that, while the people of Jerusalem in the Gospel greeted him with cheers on Palm Sunday, Jesus knew that “He came to Jerusalem, not to be on the throne like David, but to be put to death.” 

“The meaning that Jesus attributes to his ‘triumphal entry’ is different from the meaning that the people of Jerusalem saw in it,” he said.

“Perhaps this is the lesson that Jesus wants to teach us today. We turn to God when there is something that harms us. When we are in trouble, suddenly we all want to ask big and difficult questions.”

While people may be praying for an end to the COVID-19 pandemic as we often do for solutions  to other problems, the archbishop said that  “Jesus responds in His own way” to these prayers. 

“Precisely because Jesus says ‘yes’ to our deepest desires, He will have to say ‘no’ to our immediate desires,” he said.

Drawing comparisons between this year's Palm Sunday and the biblical Palm Sunday during Christ's earthly life, Pizzaballa said the story of Jesus’ entrance into Jerusalem “is a lesson on the discrepancy between our expectations and God’s response.” 

The crowd who greeted Jesus was disappointed that their salvation was not immediate, said Pizzaballa, but “Jesus’ entry into Jerusalem is truly the moment when salvation is born.” 

“The ‘Hosannas’ were justified, even if not for the reasons the Jerusalemites had supposed,” he said. 

This remains true today, he explained. Although it may seem as though God is not answering prayers and leaves people “disappointed,” this is in part because “our expectations remain without an apparent response.”

Christianity, he said, “is based on hope and love, not certainty,” and that while God will not answer all problems with certainty, “He won’t leave us alone.” 

“And here, today, despite everything, at the gates of His and our city, we declare that we really want to welcome Him as our King and Messiah, and to follow Him on His way to His throne, the cross,” he said.  

“But we also ask Him to give us the strength necessary to carry it with His own, fruitful love.”

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