ive IKEA: Partnering with Australia’s largest delivery provider allows us to enhance our accessibility By postandparcel.info Published On :: Tue, 13 Aug 2024 08:14:43 +0000 Australia Post and IKEA have today announced a new strategic partnership, entering into a three-year agreement to further expand IKEA’s delivery footprint in Australia. Full Article Post Retail
ive Starship Technologies: bringing autonomous food delivery to even more customers in Tallinn By postandparcel.info Published On :: Tue, 15 Oct 2024 11:21:42 +0000 Starship Technologies and Bolt have announced the launch of a new food delivery service. Full Article Innovation Retail
ive Driver dies after crashing on hurricane-damaged highway in North Carolina By www.yahoo.com Published On :: 2024-11-12T20:10:10Z Full Article
ive Driver jumps from overpass into Trinity River after crash on I-35 in Fort Worth, causing heavy traffic By www.yahoo.com Published On :: 2024-11-12T12:49:59Z Full Article
ive See it: Vehicle falls into North Carolina gorge after driver disregards I-40 closure following Helene By www.yahoo.com Published On :: 2024-11-11T16:39:36Z Full Article
ive Miss Universe contestant expelled from competition over ‘personal’ scandal as rumors swirl By www.yahoo.com Published On :: 2024-11-11T16:33:00Z Full Article
ive Beehive Mountain, Alberta and British Columbia, 82j/2 e1/2 By geoscan.nrcan.gc.ca Published On :: Tue, 02 Feb 2016 00:00:00 EDT Re-release; Norris, D K. no. 58-5, 1958, 25 pages (1 sheet), https://doi.org/10.4095/101214 Full Article
ive CRISPR Immune Cells Not Only Survive, They Thrive After Infusion Into Cancer Patients By scienceblogs.com Published On :: Thu, 06 Feb 2020 19:52:53 +0000 CRISPR Immune Cells Not Only Survive, They Thrive After Infusion Into Cancer Patients In the first-ever (sanctioned) investigational use of multiple edits to the human genome, a study found that cells edited in three specific ways and then removed from patients and brought back into the lab setting were able to kill cancer months after their original manufacturing and infusion. This is the first U.S. clinical trial to test the gene editing approach in humans, and the publication of this new data today follows on the initial report last year that researchers were able to use CRISPR/Cas9 technology to successfully edit three cancer patients' immune cells. The ongoing study is a cooperative between Tmunity Therapeutics, the Parker Institute for Cancer Immunotherapy, and the University of Pennsylvania. Patients on this trial were treated by Edward A. Stadtmauer, MD, section chief of Hematologic Malignancies at Penn, co-lead author on the study. The approach in this study is closely related to CAR T cell therapy, in which patient immune cells are engineered to fight cancer, but it has some key differences. Just like CAR T, researchers in this study began by collecting a patient's T cells from blood. However, instead of arming these cells with a receptor against a protein such as CD19, the team first used CRISPR/Cas9 editing to remove three genes. The first two edits removed a T cell's natural receptors so they can be reprogrammed to express a synthetic T cell receptor, allowing these cells to seek out and destroy tumors. The third edit removed PD-1, a natural checkpoint that sometimes blocks T cells from doing their job. Once the three genes are knocked out, a fourth genetic modification was accomplished using a lentivirus to insert the cancer-specific synthetic T cell receptor, which tells the edited T cells to target an antigen called NY-ESO-1. Previously published data show these cells typically survive for less than a week, but this new analysis shows the edited cells used in this study persisted, with the longest follow up at nine months. Several months after the infusion, researchers drew more blood and isolated the CRISPR-edited cells for study. When brought back into the lab setting, the cells were still able to kill tumors. The CRISPR-edited T cells used in this study are not active on their own like CAR T cells. Instead, they require the cooperation of a molecule known as HLA-A*02:01, which is only expressed in a subset of patients. This means that patients had to be screened ahead of time to make sure they were a match for the approach. Participants who met the requirements received other clinically-indicated therapy as needed while they waited for their cells to be manufactured. Once that process was completed, all three patients received the gene-edited cells in a single infusion after a short course of chemotherapy. Analysis of blood samples revealed that all three participants had the CRISPR-edited T cells take root and thrive in the patients. While none responded to the therapy, there were no treatment-related serious adverse events. CRISPR technology has not previously been tested in humans in the U.S. so the research team had to move through a comprehensive and rigorous series of institutional and federal regulatory approval steps, including approval by the National Institutes of Health's Recombinant DNA Research Advisory Committee and review by the U.S. Food and Drug Administration, as well as Penn's institutional review board and institutional biosafety committee. The entire process required more than two years. Researchers say these new data will open the door to later stage studies to investigate and extend this approach to a broader field beyond cancer, several of which are already planned at Penn. sb admin Thu, 02/06/2020 - 14:52 Categories Life Sciences Full Article
ive Bernie Sanders tests positive for COVID-19 amid nationwide spike By www.washingtonexaminer.com Published On :: Thu, 28 Dec 2023 20:46:20 GMT Sen. Bernie Sanders (I-VT) revealed Thursday that he contracted COVID-19 during the Senate's holiday break amid an increase in infections nationwide. Full Article
ive Home economics: The alternative to mortgages with sky-high rates By www.washingtonexaminer.com Published On :: Thu, 07 Dec 2023 11:00:05 GMT Mortgage rates are at their highest levels in 22 years and house prices are at record highs. Hardworking people cannot get on the property ladder, and retirees are struggling to sell in order to downsize. The Biden administration has done little to help alleviate the problem. This Washington Examiner series, Home Economics, will investigate how we got here, the toll on people around the country, and the alternatives people are embracing to survive the market. The last part of this four-part series focuses on the alternatives to traditional fixed-rate mortgages gaining new consideration among prospective home buyers. Full Article
ive WATCH LIVE: Glenn Youngkin announces sports arena project in Alexandria, Virginia By www.washingtonexaminer.com Published On :: Wed, 13 Dec 2023 14:00:38 GMT Gov. Glenn Youngkin (R-VA) and Monumental Sports are announcing a $2 billion sports arena and entertainment district set to be built in the Potomac Yard neighborhood of Alexandria, Virginia. Full Article
ive This Is the Best Place to Live in Virginia By www.washingtonexaminer.com Published On :: Sun, 07 Jan 2024 13:09:31 GMT The number of Americans who relocate each year has been trending downward for decades. According to the U.S. Census Bureau, only 28.2 million people moved to a new home in 2022, down from 41.1 million 20 years earlier. Of those who did move in 2022, the vast majority - an estimated 78% - stayed within the same state. Full Article
ive How parents and caregivers can evaluate the research on MERT and other potential treatments By www.latimes.com Published On :: Thu, 5 Sep 2024 10:00:46 GMT For parents considering autism interventions for their children, evaluating treatments can be daunting. Experts talked to The Times about what to watch for. Full Article
ive 'Grief into action.' Philanthropists give historic $150 million donation to City of Hope for pancreatic cancer research By www.latimes.com Published On :: Tue, 17 Sep 2024 09:30:06 GMT Entrepreneur Emmet Stephenson and his daughter are giving $150 million to City of Hope to fund an award for innovation research in pancreatic cancer. It's the largest single gift the center has received. Full Article
ive 30 years later, a family's loss gives life to others By www.latimes.com Published On :: Fri, 20 Sep 2024 10:00:16 GMT Nicholas Green's organ donation legacy lives on 30 years later. Full Article
ive The Tijuana River smells so bad, the CDC is coming to investigate By www.latimes.com Published On :: Fri, 4 Oct 2024 15:46:18 GMT The CDC plans to knock on the doors of randomly selected homes in the Tijuana River Valley later this month to ask them about how the sewage crisis has affected their wellbeing. Full Article
ive Key takeaways from our investigation into the science behind an alternative autism therapy By www.latimes.com Published On :: Thu, 24 Oct 2024 17:50:49 GMT Here are the key takeways from The Times' yearlong investigation into the science behind magnetic resonance therapy, or MERT, as a therapy for autism. Full Article
ive Jim Williams: D.C. native Lindsay Czarniak set to host coverage of Indianapolis 500 By www.washingtonexaminer.com Published On :: Sat, 25 May 2013 04:00:00 GMT Sunday is the single biggest motorsports day in broadcast television history. NBC has the Grand Prix of Monaco at 7 a.m., coverage of the Indianapolis 500 starts at 11 a.m. on ABC and the nightcap at 6 p.m. will be the Coca Cola 600 from Charlotte on Fox. That means over 18 hours of live Formula 1, IndyCar and NASCAR action, making the Memorial Day weekend must-see TV for motorsports fans. Full Article
ive Five Washington Nationals players will sit out opening day due to COVID-19 concerns By www.washingtonexaminer.com Published On :: Wed, 31 Mar 2021 22:07:53 GMT Five Washington Nationals players will miss Thursday's opening game after one player tested positive for COVID-19. Full Article
ive Caps 2, Rangers 1 (OT): Five Observations By www.washingtonexaminer.com Published On :: Sun, 12 May 2013 04:00:00 GMT 1. So here we are again. Last year the Capitals and the New York Rangers were tied 2-2 in a best-of-seven Stanley Cup playoff series and Washington was moments away from securing Game 5. Instead, a late Joel Ward penalty led to a game-tying goal by Brad Richards with just seconds remaining. Madison Square Garden exploded and Washington wilted in a devastating overtime loss. The Caps survived Game 6 at home, but ultimately were dispatched in a bitter Game 7 loss in New York. Full Article
ive Rangers 1, Caps 0: Five Observations By www.washingtonexaminer.com Published On :: Mon, 13 May 2013 04:00:00 GMT 1. And so for the seventh time in their last nine Stanley Cup playoff series the Caps will play a Game 7. The Rangers assured that with a 1-0 victory at Madison Square Garden on Sunday evening. Washington’s checkered history in those games will leave its fans gasping for air for the next 24 hours. It’s why we love this sport – and hate it, too. Full Article
ive Maryland teachers union representative suspended for antisemitic posts targeting local wealthy Jews By www.washingtonexaminer.com Published On :: Tue, 05 Dec 2023 01:00:24 GMT A Maryland teacher has reportedly been suspended after being accused of spreading antisemitic social media posts. Full Article
ive US Open: Inside the exclusive Los Angeles Country Club drawing the sporting world's attention this weekend By www.washingtonexaminer.com Published On :: Thu, 15 Jun 2023 19:00:25 GMT The U.S. Open is being hosted at the exclusive Los Angeles Country Club for the first time in the club's history, with the world getting an up-close look at one of the most mysterious golf courses in the country. Full Article
ive How YouTube became must-see TV: Shorts, sports and Coachella livestreams By www.latimes.com Published On :: Thu, 16 May 2024 10:00:34 GMT YouTube said more people are watching live events like Coachella and short form videos on TV sets. Sports, including the NFL, are also boosting viewership. Full Article
ive California lawmakers revive debate over bill requiring tech platforms to pay for news By www.latimes.com Published On :: Tue, 11 Jun 2024 02:09:31 GMT New amendments to the California Journalism Preservation Act aim to make it more like a similar law in Canada. Full Article
ive Uber will add driverless Cruise vehicles to its fleet in 2025 By www.latimes.com Published On :: Fri, 23 Aug 2024 01:22:26 GMT The autonomous vehicle company Cruise, which lost its California operating license last year after one of its cars struck a pedestrian, announced a partnership this week with the ride-hail service Uber. Full Article
ive This is what's missing in our sex lives in 2024, according to Esther Perel By www.latimes.com Published On :: Thu, 5 Sep 2024 10:00:27 GMT In "Mating in Captivity" and "The State of Affairs," Esther Perel dissects our hidden desires and impulses with intellectual rigor. Full Article
ive In 'liberal' San Francisco, the sole progressive vying for mayor is an underdog By www.latimes.com Published On :: Tue, 17 Sep 2024 10:00:49 GMT San Franciscans have rejected the city's far-left image in recent years, pulling it toward the center. Aaron Peskin says he wants to be the next "progressive" mayor. Full Article
ive California's digital driver's licenses now work with Apple Wallet By www.latimes.com Published On :: Fri, 20 Sep 2024 10:00:22 GMT Californians can now securely add their digital driver's license or state ID to the Apple Wallet app on their iPhone and Apple Watch, the company announced Thursday. Full Article
ive Facing skepticism, Elon Musk unveils prototype for driverless robotaxi By www.latimes.com Published On :: Fri, 11 Oct 2024 15:01:30 GMT Elon Musk unveiled the Cybercab on Thursday night at a highly anticipated event, where he also showed off new protoypes of a robovan and humanoid robot. Full Article
ive Stay on Target: Overcoming Challenges in Precision Drug Delivery By www.the-scientist.com Published On :: Thu, 24 Oct 2024 14:24:54 GMT Explore how on-target precision therapies improve patient outcomes and drug tolerability. Full Article Sponsored eBooks
ive Gene Proximity to Nuclear Speckles Drives Efficient mRNA Splicing By www.the-scientist.com Published On :: Wed, 30 Oct 2024 04:00:42 GMT Nuclear architecture investigation provides insights into the role of nuclear bodies in RNA processing. Full Article News News & Opinion
ive Creating Effective Scientific Posters By www.the-scientist.com Published On :: Wed, 30 Oct 2024 13:24:42 GMT Posters need to incorporate scientific communication and graphic design principles to reach their full potential. Full Article The Scientist University
ive Collaborative Research Aims to Discover Effective Treatments for Marine Mammals Poisoned by Toxic Algae By www.the-scientist.com Published On :: Wed, 30 Oct 2024 15:32:49 GMT Zymo Research, Unravel Biosciences, and Channel Islands Marine & Wildlife Institute team up to combat increasing cases of domoic acid poisoning in sea lions. Full Article The Scientist The Marketplace
ive Unlocking the Metabolic Drivers of Alzheimer’s Disease By www.the-scientist.com Published On :: Fri, 01 Nov 2024 04:00:27 GMT Cellular oxygen consumption in the brain may shed new light on Alzheimer’s disease onset, progression, and treatment. Full Article Magazine Issue
ive From Marmosets to Menopause: A Primate Perspective By www.the-scientist.com Published On :: Fri, 01 Nov 2024 04:00:32 GMT Agnès Lacreuse investigates cognitive aging and women’s health in nonhuman primates. Full Article Magazine Issue
ive Live Imaging Intracellular Parasites Reveals Changes to Host Metabolism By www.the-scientist.com Published On :: Wed, 06 Nov 2024 08:00:48 GMT Researchers found that Toxoplasma gondii increased the host cell’s metabolic activity, offering insights into potential treatment strategies. Full Article News News & Opinion
ive What Drives the "Wet Dog Shakes" Reflex in Furry Animals? By www.the-scientist.com Published On :: Thu, 07 Nov 2024 19:01:14 GMT Scientists discovered a mechanoreceptor that triggers the distinctive shake-off behavior observed in mice when they become wet. Full Article News News & Opinion
ive Study finds DC least festive in the US By www.washingtonexaminer.com Published On :: Sun, 10 Dec 2023 17:43:46 GMT The nation's capital Washington, D.C., is the least festive of the United States, according to a study. Full Article
ive Caps 2, Rangers 1 (OT): Five Observations By www.washingtonexaminer.com Published On :: Fri, 10 May 2013 04:00:00 GMT 1. So here we are again. Last year the Capitals and the New York Rangers were tied 2-2 in a best-of-seven Stanley Cup playoff series and Washington was moments away from securing Game 5. Instead, a late Joel Ward penalty led to a game-tying goal by Brad Richards with just seconds remaining. Madison Square Garden exploded and Washington wilted in a devastating overtime loss. The Caps survived Game 6 at home, but ultimately were dispatched in a bitter Game 7 loss in New York. Full Article
ive The conservative kids are all right By www.washingtonexaminer.com Published On :: Fri, 23 Sep 2022 03:00:20 GMT Run GenZ advises young Republican candidates on everything from website building to fundraising plans. Full Article
ive WATCH LIVE: House Transportation and Infrastructure Committee holds hearing on FBI headquarters relocation By www.washingtonexaminer.com Published On :: Tue, 12 Dec 2023 14:00:45 GMT The House Transportation and Infrastructure Committee is holding a hearing examining the General Service Administration's site selection for the FBI's new headquarters. Full Article
ive Metro budget proposal includes massive layoffs and service cuts to address $750 million deficit By www.washingtonexaminer.com Published On :: Tue, 12 Dec 2023 20:52:04 GMT On Tuesday, Metro General Manager and CEO Randy Clarke proposed a budget for the next fiscal year that includes massive layoffs and dozens of service cuts as the agency faces a $750 million deficit. Full Article
ive Driverless cars in California can get out of almost any ticket: Report By www.washingtonexaminer.com Published On :: Tue, 02 Jan 2024 22:01:30 GMT California will ticket a driver for violating the rules of the road, but for driverless vehicles, there is reportedly no mechanism to ticket the person responsible because of a loophole in some jurisdictions. Full Article
ive 'It takes away from the Native Americans': Son of Redskins logo designer denounces rebranding By www.washingtonexaminer.com Published On :: Thu, 16 Jul 2020 13:50:50 GMT The Washington Redskins branding change isn’t sitting well with everyone. Full Article
ive Native American organization wants to make ‘Redskins’ name great again By www.washingtonexaminer.com Published On :: Wed, 16 Aug 2023 17:20:41 GMT Left-wing activists may have fueled the movement to change the name of Washington’s NFL franchise. However, an indigenous organization known as the Native American Guardian’s Association is trying to resurrect its former moniker and make Washington’s football team the “Redskins” again. Now known as the Commanders, the team changed its name in 2020 to appease a fanatical mob of social justice warriors and white guilt apologists who claimed the name and logo were racist. Full Article
ive Native American group files lawsuit against Washington Commanders over 'fake' group claims By www.washingtonexaminer.com Published On :: Mon, 25 Sep 2023 18:24:51 GMT A Native American group filed a lawsuit against the Washington Commanders after the team alleged the group, which is advocating that the team revert to its "Redskins" title, was "fake." Full Article
ive Human Skeletal Remains of the Mary Rose Shipwreck Give Insight to Health of the Crew By www.discovermagazine.com Published On :: Fri, 01 Nov 2024 18:15:00 GMT New application of Raman spectroscopy imaging allows scientists to probe the chemical composition of sailors lost at sea over 500 years ago. Full Article The Sciences
ive Modernizing .NETpad: .NET 9 Arrives with a Few (More) Small Improvements for WPF (Premium) By www.thurrott.com Published On :: Tue, 12 Nov 2024 17:14:34 +0000 I was excited to see Microsoft bring the Windows Presentation Foundation (WPF) back from the dead this past year: At Build 2024 back in May, it announced that it would continue investing in this 20-year-old technology, starting with support for Windows 11 theming that would arrive as part of .NET 9. In fact, I was so excited about this that I brought my .NETpad project back from the dead as well, and I spent much of the summer modernizing my Notepad clone with the new features. I wrote 24 articles documenting this work, but I was stymied by the half-assed nature of the improvements. Microsoft released exactly one WPF update during the several months of .NET 9 development, and it never added any of the features I discovered were missing. And so as we headed into today's release of .NET 9, my excitement was somewhat diminished. My assumption was that we wouldn't see those missing features implemented until .NET 10, if ever. Well, Microsoft just released .NET 9. As part of that release, it published updated documentation for WPF (and all the other .NET technologies). And to my surprise, there are some updates to WPF that address at least one of those missing features. So let's take a look. To add support for Windows 11 theming to a WPF project, you need to add a reference to the new Fluent theme resource dictionary in its App.xml file. It looks like so: <Application.Resources> <ResourceDictionary> <ResourceDictionary.MergedDictionaries> <ResourceDictionary Source="pack://application:,,,/PresentationFramework.Fluent;component/Themes/Fluent.xaml" /> </ResourceDictionary.MergedDictionaries> </ResourceDictionary> </Application.Resources> But with the shipping version of .NET 9, there's a second, more elegant way to add Windows 11 theming support. Now, you can access a new Application.ThemeMode property of a new styling API to toggle the app's theme mode between Light, Dark, System, and None. And that's fantastic, because it addresses one of those missing features: To date, .NETpad has adapted itself to the system theme (Light or Dark), but there was no way to let the user pick a theme mode. (For example, if the system was set to Dark and the user wanted the app to use Light mode.) With this change, I can implement that feature. Fortunately, .NETpad is ready for this change, too: If you followed along with my work this past summer, you may remember that I implemented the user interface for switching the app theme into its settings interface, but left the UI hidden because it didn't do anything. But I always felt that Microsoft would need to implement this features, so I left the code in there. Granted, I didn't think it would happen this quickly. The shipping version of .NET 9 also adds explicit support for the Windows 11 accent color (as configured by the user in the Settings app in Personalization > Accent color). As it is, .NETpa... The post Modernizing .NETpad: .NET 9 Arrives with a Few (More) Small Improvements for WPF (Premium) appeared first on Thurrott.com. Full Article Dev Premium .NETpad WPF Windows Presentation Foundation Modernizing .NETpad (2024)
ive Vote No Initiative Measure No. 2109 By www.thestranger.com Published On :: Fri, 01 Nov 2024 10:00:00 -0700 Stop the Cuts to Child Care and Education by Stranger Election Control Board This crackpot initiative would repeal the state’s new capital gains tax and cut $2.2 billion for education, early learning services, and child care at a time when schools across the state face huge deficits. Aside from dramatically reducing funding for schools, passing this initiative would help restore Washington’s status as the state with the most unfair tax code for poor people, all in the service of helping our wealthiest residents dodge a tax that their accountants might mistake as a rounding error. Full Article Elections 2024