AlphaPept: a modern and open framework for MS-based proteomics  Nature.com

Decrypting the molecular basis of cellular drug phenotypes by dose-resolved expression proteomics  Nature.com

Cell-selective proteomics reveal novel effectors secreted by an obligate intracellular bacterial pathogen  Nature.com

A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell  Nature.com

Imputation of label-free quantitative mass spectrometry-based proteomics data using self-supervised deep learning  Nature.com

Identifying proteomic risk factors for cancer using prospective and exome analyses of 1463 circulating proteins and risk of 19 cancers in the UK Biobank  Nature.com

quantms: a cloud-based pipeline for quantitative proteomics enables the reanalysis of public proteomics data  Nature.com

Extended Street Closure at W. Balmoral Avenue between N. Broadway and N. Winthrop Avenue for street and sidewalk restoration.

Extended alley closure for the alley behind 5300 thru 5358 N. Winthrop Avenue (W. Berwyn Avenue to W. Balmoral Avenue)

CTA will be providing added capacity, so whether you plan to run or cheer on the runners, take a train or bus to avoid the headaches of traffic and parking near the route of the 2024 Bank of America Chicago Marathon and Abbott Health and Fitness Expo at McCormick Place. For details about marathon service, you can find it here on CTA’s dedicated Bank of America Chicago Marathon webpage.

The Chicago Transit Authority (CTA) today proposed a $2.16 billion operating budget that keeps fares at current levels, delivers more bus and rail service hours than provided in 2019, and fuels new and ongoing investments to either expand or modernize existing infrastructure, while also evolving current systems to meet modern transit riding needs.

Updated Dates for Extended Alley Closure for The alley behind 5300 thru 5358 N. Winthrop Avenue (W. Berwyn Avenue to W. Balmoral Avenue) for alley reconstruction.

Updated Dates and Extended Street Closure at W. Balmoral Avenue between N. Broadway and N. Winthrop Avenue for street and sidewalk restoration.

The alley behind 5300 – 5358 N. Winthrop Avenue will be closed through Oct. 26 for reconstruction as part of the Red and Purple Modernization Project.

Access to garages in alleys between W Ardmore and W Thorndale by the CTA tracks will be maintained during this work.

Lead paint abatement and painting of CTA track structure will occur on the west side of the tracks.

Updated Dates and Extended Street Closure for W. Balmoral Avenue between N. Broadway and N. Winthrop Avenue for Street and Sidewalk Restoration.

(Thu, Nov 7 2024 2:54 PM to TBD) The Orange, Pink, Purple and 63rd-bound Green Line platform elevator at Washington/Wabash is temporarily out-of-service.

(Thu, Nov 7 2024 2:54 PM to TBD) The Orange, Pink, Purple and 63rd-bound Green Line platform elevator at Washington/Wabash is temporarily out-of-service.

The post BNP Paribas enhances employee rights globally appeared first on Personnel Today.

The post Direct Line to cut 550 jobs globally appeared first on Personnel Today.

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Last year, one of the biggest banks accidentally paid off a client's loan to its lenders — a $900 million mistake. Some of the recipients wouldn't give the money back. And then a surprising court ruling affirmed their no give-back. | Subscribe to our weekly newsletter here.

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The $1.2 trillion infrastructure bill has passed Congress, but what exactly is in it? Today, the important, surprising, delightful line items. | Subscribe to our weekly newsletter here.

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Hormel Foods makes SPAM, and for generations, the company also created jobs for families in Austin, Minnesota. Today, the story of a labor strike that threatened to tear one small town apart. (This episode was made in collaboration with The Experiment podcast.) | Subscribe to our weekly newsletter here.

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Two stories about the effects of inflation on the economy. We meet a gig worker who's seen an increase in wages, but because of inflation, how much of that increase in earnings is an illusion? Then, we break down how the Federal Reserve is planning to fight inflation. | Subscribe to our weekly newsletter here.

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In the 1800s, populist president Andrew Jackson went head-to-head with the most powerful banker in America over who should control the country's money. This clash ended in disastrous results.

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It was just another day at the office. Then the phone started ringing and the caseload kept growing...on today's show, your favorite Planet Money gumshoes investigate your listener questions. | Fill out our listener survey here.

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The last few months have made us acutely aware of inflation. We all agree that it's making our lives harder, but economists disagree about what's causing it. | Fill out our listener survey: npr.org/podcastsurvey

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In the early 90s, Subaru was struggling to stand out in a crowded automobile market. In their greatest time of need, they turned to an unlikely ally: lesbians | Subscribe to our weekly newsletter here.

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It's macro time! Today: Keynes vs. Hayek.

Season 3 of summer school is here asking the biggest economic questions about what makes an entire economy grow or contract? Things like, is there a "right" level of unemployment? Who gains from trade? What rhymes with 'paradox of thrift'? Also, inflation, we'll get to inflation.

Episode 1 begins with the rise of macroeconomics as a field, with one of the great economic debates of the 20th century: what causes booms and busts, and what can the government do about it? How free should a free market be?

It's a debate (over beats and with an actual rap battle) between John Maynard Keynes and F.A Hayek.

Watch this Tik Tok to learn more. | Subscribe to our weekly newsletter here. | Listen to past seasons of Summer School here. | Listen to our econ songs of the summer on Spotify. |

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Eddie Oygur is an Australian businessman who's sold sheepskin ugg boots for years. But one day, he was hit with a lawsuit for breaking American trademark law. On today's show — what's in the name ugg?

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It's fall, so on this episode, we're taking you back to school. First, what sorority rush can teach us about a particular kind of market. Then, how two economists fixed the way macroeconomics was taught in high schools. It's econ, inside and outside the classroom.

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Sam Bankman-Fried built a reputation as the one reliable crypto bro. But within the span of days, his empire came crashing down. What the rise and fall of crypto's 30-year-old elder statesman says about the story of crypto so far.

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Anyone who has tried shopping for day care knows that it is tough out there.

For one, it is hard even to get your hands on information about costs, either online or over the phone – day cares will often only share their prices after you have taken a tour of their facilities. Even once you find a place you like, many day cares have waitlists stretching 6 months, 9 months, a year.

Waitlists are a classic economic sign that something isn't right, that prices are too low. But ask any parent and they will tell you that prices for day cares are actually too high. According to a recent report from the U.S. Treasury, more than 60% of families can't afford the full cost of high quality day care. Meanwhile, day care owners can barely afford to stay open. No one is happy.

On today's show, we get into the very weird, very broken market for day care. We will try to understand how this market can simultaneously strain parents' budgets and underpay its workers. And we will look at a few possible solutions.

This show was produced by Sam Yellowhorse Kesler. Emma Peaslee helped book the show. It was mastered by Gilly Moon. Keith Romer edited this episode. Jess Jiang is our acting Executive Producer.

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Silicon Valley Bank was the 16th largest bank in America, the bank of choice for tech startups and big-name venture capitalists. Then, in the span of just a few days, it collapsed. Whispers that SVB might be in trouble spread like wildfire through group texts and Twitter posts. Depositors raced to empty their accounts, withdrawing $42 billion in a single day. Last Friday, after regulators declared that SVB had failed, the FDIC seized the bank.

As the dust settles on the biggest bank failure — and bank rescue — in recent memory, we're still figuring out what happened. But poor investment choices, weak regulation, and customer panic all played their parts. We'll look into the bank's collapse to understand what it can teach us about the business of banking itself.

This episode was produced by Willa Rubin, with help from Dave Blanchard. It was edited by Keith Romer, and engineered by Brian Jarboe. Fact-checking by Sierra Juarez. Our acting executive producer is Jess Jiang.

Music: "I Don't Do Gossip," "Groovy Little Penguins" and "Vision."

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Sometimes you hear these stories about an airplane that suddenly nosedives. Everyone onboard thinks this is it, and then the plane levels out and everything is fine. For about 72 hours, people and companies that had deposited millions of dollars at the Silicon Valley Bank — many of whom were in the tech industry — thought they had lost absolutely everything to a bank collapse.

Two weeks later, the situation at Silicon Valley Bank has leveled off. The FDIC seized the bank and eventually made all of its depositors whole. But to understand what that financial panic felt like, we retrace the Silicon Valley Bank run and eventual collapse. We hear from four people who were part of the bank run — when they realized early rumblings, what it felt like in the full stampede, what hard decisions they faced, and what the aftermath felt like. And along the way, we uncover the lessons you can only learn when you think the entire world is ending.

This episode was reported by Kenny Malone, produced by Alyssa Jeong Perry with help from Dave Blanchard, engineered by Brian Jarboe, fact-checked by Sierra Juarez, and edited by Jess Jiang.

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Richard J. Lonsinger is a member of the Ponca tribe of Oklahoma, who was adopted at a young age into a white family of three. He eventually reconnected with his birth family, but when his birth mother passed away in 2010, he wasn't included in the distribution of her estate. Feeling both hurt and excluded, he asked a judge to re-open her estate, to give him a part of one particular asset: an Osage headright.

An Osage headright is a share of profits from resources like oil, gas, and coal that have been extracted from the Osage Nation's land. These payments can be sizeable - thousands or even tens of thousands of dollars a year. Historically, they were even larger – in the 1920s the Osage were some of the wealthiest people in the world. But that wealth also made them a target and subject to paternalistic and predatory laws. Over the previous century, hundreds of millions of dollars in oil money have been taken from the Osage people.

On today's show: the story of how Richard Lonsinger gradually came to learn this history, and how he made his peace with his part of a complicated inheritance.

This episode was produced by Willa Rubin with help from Alyssa Jeong Perry and Emma Peaslee. It was engineered by Brian Jarboe and fact-checked by Sierra Juarez. It was edited by Keith Romer, with help from Shannon Shaw Duty from Osage News.

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Earlier this month, we saw the largest bank collapse since the 2008 financial crisis. For many of us, seeing Silicon Valley Bank's meltdown brought us right back to that time 15 years ago, at the beginning of what would become the Great Recession.

In early 2009, one or two banks were failing every week. That's when Planet Money reporter Chana Joffe-Walt went inside one of those banks: the Bank of Clark County, in Washington State. Her reporting on the inner workings of a bank collapse and government takeover helps explain exactly what happens when a bank goes under, minute-by-minute.

This story originally aired in March 2009 on This American Life, from WBEZ Chicago. We're airing it for the first time in full on our podcast.

This version of the story was produced by Dylan Sloan and edited by Dave Blanchard. It was fact-checked by Sierra Juarez and engineered by Katherine Silva. Jess Jiang is Planet Money's acting executive producer.

Music: "Butter" "Bassline Motion" and "Fantasmi."

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In the first half of March, three banks - Silicon Valley Bank, Signature Bank, and Silvergate - all had relatively classic bank runs and collapsed. Which sparked some major banking stress. As a result, the Federal Reserve got a lot of requests to use one of its oldest and most important tools for soothing such troubles: the discount window.

The discount window is like a safety net for banks. And recently, a lot of banks have needed it. So, what is the discount window, where did it come from, and how does it work? And, amidst all the recent banking turmoil, has it been working the way it should? In this episode, we crack open the discount window.

This episode was produced by Emma Peaslee with help from Willa Rubin. It was engineered by Katherine Silva. It was fact-checked by Sierra Juarez and edited by Sally Helm. Jess Jiang is our acting executive producer.

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Puerto Rico's beaches are an integral part of life on the island, and by law, they're one of the few places that are truly public. In practice, the sandy stretch of land where the water meets the shore is one of the island's most contested spaces.

Today we're featuring an episode of the podcast La Brega from WNYC Studios and Futuro Studios, a show about Puerto Rico and the Puerto Rican experience. On the island, a legal definition dating back to the Spanish colonial period dictates what counts as a beach. But climate change, an influx of new residents and a real estate boom are all threatening legal public access to some of Puerto Rico's most cherished spaces. The debate all comes down to one question: what counts as a beach?

You can listen to the rest of La Brega (in English and Spanish) here. They have two full seasons out, which explore the Puerto Rican experience through history and culture. Check it out.

This episode was reported by Alana Casanova-Burgess and produced by Ezequiel Rodriguez Andino and Joaquin Cotler, with help from Tasha Sandoval. It was edited by Mark Pagan, Marlon Bishop, and Jenny Lawton and engineered by Joe Plourde. The zona maritimo terrestre was sung as a bolero by Los Rivera Destino.

The Planet Money version was produced by Dave Blanchard, fact checked by Sierra Juarez, edited by Keith Romer, and engineered by Brian Jarboe.

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It's been a month since the collapse of Silicon Valley Bank touched off the worst episode of banking turmoil since 2008. While the financial system appears to have stabilized, we're still reckoning with what happened. Regulators are getting dragged before Congress. The Federal Reserve and the FDIC have promised reports on what went wrong with bank oversight. And judging by our inbox, you, our listeners, have a lot of lingering questions.

Questions like: Was it a bailout? Where were the regulators? Is it over yet? And what about those other banks that were teetering on the edge?

Today on the show, some answers for you.

This episode was produced by Sam Yellowhorse Kesler with help from Willa Rubin. It was engineered by Brian Jarboe. It was fact-checked by Sierra Juarez and edited by Molly Messick. Jess Jiang is our acting executive producer.

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When a group of amateur investors rallied around the stock for GameStop back in 2021, the story blew up the internet. News outlets around the world, including us here at Planet Money, rushed in to explain why the stock for this retail video game company was suddenly skyrocketing, at times by as much as 1700% in value, and what that meant for the rest of us.

When movie producer Aaron Ryder saw the GameStop story — an army of scrappy underdogs, banding together to strike back against a financial system they felt was rigged against them — he knew it had the makings for a great movie. The only problem: so did a bunch of other movie producers and Hollywood studios. So Aaron found himself in the middle of a fast and furious race to make the first Game Stop movie.

On today's show, one producer's quest to claim the hottest ticket in Tinseltown and the whole hidden machinery dedicated to turning a news story into box office gold. You'll never read the word 'based on a true story' the same way again.

Today's episode was reported and hosted by Alexi Horowitz-Ghazi. It was produced by Willa Rubin, edited by Jess Jiang, engineered by James Willetts, and fact-checked by Cooper Katz McKim and James Sneed. Alex Goldmark is our executive producer.

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Note: There is swearing in this episode.

In 2017, The University of Minnesota asked comedian Maria Bamford to give their commencement speech. But the University may not have known what it was in for. In her speech, Bamford told the crowd of graduates how much the university offered to pay her (nothing), her counteroffer ($20,000), and the amount they settled on ($10,000), which (after taxes and fees, etc.) she gave away to students in the audience to pay down their student loans.

Maria Bamford is a big believer in full disclosure of her finances, a philosophy she's adopted after decades in a Debtors Anonymous support group. In meetings, she learned important financial tips and tricks to go from thousands of dollars in debt to her current net worth of $3.5 million (a number which, true to her philosophy, she will share with anyone).

She spoke with us about her financial issues, how she recovered, and why she believes in total financial transparency, even when it makes her look kinda bad.

Disclaimer: Planet Money is not qualified or certified to give financial advice. And Maria is not a spokesperson for Debtors Anonymous in any way.

This show was hosted by Kenny Malone and Mary Childs. It was produced by Emma Peaslee, edited by Jess Jiang, fact-checked by Sierra Juarez, and engineered by Neisha Heinis. Alex Goldmark is Planet Money's executive producer.

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There's this fundamental question in economics that has proven really hard to answer: What's a good way to help people out of poverty? The old-school way was to fund programs that would support very particular things, like buying cows for a village, giving people business training, or building schools.

But over the past few decades, there has been a new idea: Could you help people who don't have money by ... just giving them money? We covered this question in a segment of This American Life that originally ran in 2013. Economists who studied the question found that giving people cash had positive effects on recipients' economic and psychological well-being. Maybe they bought a cow that could earn them money each week. Maybe they could replace their grass roofs with metal roofs that didn't need fixing every so often.

The success of just giving people in poverty cash has spawned a whole set of new questions that economists are now trying to answer. Like, if we do just give money, what's the best way to do that? Do you just give it all at once? Or do you dole it out over time? And it turns out... a huge new study on giving cash was just released and it's got a lot of answers.

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After very high inflation, the United States is finally feeling some relief in the form of "disinflation." But, why exactly has inflation slowed down?

Three Planet Money hosts try to answer that question while competing to be the winner of our very own reporting challenge: Econ Battle Zone!

It's economics journalism meets high-stakes reality TV competition! Will our contestants be able to impress our celebrity judges? How will they manage to incorporate their mystery ingredients? Who will take home the championship belt? Tune in for the inaugural episode of...Econ Battle Zone!

This episode was hosted by Keith Romer, Amanda Aronczyk, Erika Beras, and Alexi Horowitz-Ghazi. James Sneed produced this episode with help from Emma Peaslee. The show was edited by Molly Messick, engineered by Cena Loffredo, and fact checked by Sierra Juarez. Alex Goldmark is our executive producer.

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On today's episode, we have three big economic ideas for your consideration – ideas that could potentially improve the economy and make us more efficient.

First, what if we ban left turns on roads? Then, what if we gave every new baby ... a trust fund? And lastly, what if we completely got rid of U.S. congressional districts?

That's all on today's episode.

This show was hosted by Sarah Gonzalez. It was produced by Willa Rubin and Emma Peaslee with help from Sam Yellowhorse Kesler. It was edited by Dave Blanchard and engineered by Robert Rodriguez. It was fact-checked by Sierra Juarez. Alex Goldmark is Planet Money's executive producer.

Help support Planet Money and get bonus episodes by subscribing to Planet Money+ in Apple Podcasts or at plus.npr.org/planetmoney.

Always free at these links: Apple Podcasts, Spotify, Google Podcasts, the NPR app or anywhere you get podcasts.

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It's Groundhog Day, and the eyes of the nation have turned to a small town in western Pennsylvania. And, just like last year, all anyone can talk about is Punxsutawney Phil! It is impossible to find a news story that is not about one furry prognosticator.

Well, almost impossible...

Once again, our Planet Money hosts find themselves trapped in the endless Groundhog Day news cycle, and their only way out is to discover an economics story from Groundhog Day itself interesting enough to appease the capricious Groundhog Gods!

So rise and shine campers (and don't forget your booties) as hosts Kenny Malone and Amanda Aronczyk scour the news of February 2nds past, to try to find the perfect story.

This episode was hosted by Kenny Malone and Amanda Aronczyk. It was produced by Sam Yellowhorse Kesler. It was edited by Keith Romer, and engineered by Valentina Rodríguez Sánchez. It was fact-checked by James Sneed. Our executive producer is Alex Goldmark.

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For the last year and a half, the story of FTX has focused largely on the crimes and punishment of Sam Bankman-Fried. But in the background, the actual customers he left behind have been caught in a financial feeding frenzy over the remains of the company.

On today's show, we do a deep dive into the anatomy of the FTX bankruptcy. We meet the vulture investors who make markets out of risky debt, and hear how customers fare in the secretive world of bankruptcy claims trading.

This episode was hosted by Alexi Horowitz-Ghazi and Amanda Aronczyk. It was produced by James Sneed and Sam Yellowhorse Kesler. It was edited by Jess Jiang, and fact-checked by Sierra Juarez. It was engineered by Cena Loffredo. Alex Goldmark is Planet Money's executive producer.

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Karen McDonough of Quincy, Mass., was enjoying her tea one morning in the dining room when she saw something odd outside her window: a group of people gathering on her lawn. A man with a clipboard told her that her home no longer belonged to her. It didn't matter that she'd been paying her mortgage for 17 years and was current on it. She was a nurse with a good job and had raised her kids there. But this was a foreclosure sale, and she was going to lose her house.

McDonough had fallen victim to what's called a zombie second mortgage. Homeowners think these loans are long dead. But then the loans come back to life because they get bought up, sometimes for pennies on the dollar, by debt collectors that then move to collect and foreclose on people's homes.

On today's episode: An NPR investigation reveals the practice to be widespread. Also, what are zombie mortgages? Is all this legal? And is there any way for homeowners to fight the zombies?

You can read more about zombie second mortgages online at: npr.org/zombie

Correction: An earlier version of this episode description misspelled Karen McDonough's last name as MacDonough.

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