tea To teach or not to teach climate change education - the perceptions of sixth-graders in northern Israel. By ezproxy.scu.edu.au Published On :: Fri, 01 Dec 2023 00:00:00 -0500 Children's Geographies; 12/01/2023(AN 174964054); ISSN: 14733285Academic Search Premier Full Article ISRAEL CLIMATE change education CLIMATE change adaptation ATTITUDES toward the environment RESEARCH questions CLIMATE change ENVIRONMENTAL activism
tea Reconfiguring school learning spaces: students' and teachers' voices on well-being. By ezproxy.scu.edu.au Published On :: Thu, 01 Feb 2024 00:00:00 -0500 Children's Geographies; 02/01/2024(AN 175911767); ISSN: 14733285Academic Search Premier Full Article TURKEY HIGH school teachers SCHOOL children SELF-determination theory STUDENT well-being LEARNING SCHOOL environment
tea Breaking the barriers: the capacity to aspire for higher education of Bangladesh tea workers' children. By ezproxy.scu.edu.au Published On :: Sat, 01 Jun 2024 00:00:00 -0400 Children's Geographies; 06/01/2024(AN 178088796); ISSN: 14733285Academic Search Premier Full Article BANGLADESH APPADURAI Arjun 1949- BOURDIEU Pierre 1930-2002 HIGHER education EMPLOYEE education CULTURAL capital TEA RURAL children SOCIAL capital
tea Facets of Team Equity: A Scoping Review By ifp.nyu.edu Published On :: Mon, 04 Nov 2024 03:42:11 +0000 Small Group Research, Ahead of Print. This article presents the findings of a scoping review looking at conceptualizations of team equity in academic literature between 2017 and 2021. A search and filter process produced a set of 42 publications containing discussion of equity or equality at the team level. A qualitative thematic analysis was carried […] The post Facets of Team Equity: A Scoping Review was curated by information for practice. Full Article Meta-analyses - Systematic Reviews
tea Key facts about public school teachers in the U.S. By ifp.nyu.edu Published On :: Tue, 22 Oct 2024 20:39:23 +0000 The post Key facts about public school teachers in the U.S. was curated by information for practice. Full Article Infographics
tea NIHR launches pipeline of Mental Health Research Groups across England [ £27 million to support mental health research teams in nine regions ] By ifp.nyu.edu Published On :: Sat, 02 Nov 2024 13:39:06 +0000 The post NIHR launches pipeline of Mental Health Research Groups across England [ £27 million to support mental health research teams in nine regions ] was curated by information for practice. Full Article Funding
tea Using Legitimation Code Theory to explore knowledge building in English medium higher education teaching: methodological challenges and innovations By ifp.nyu.edu Published On :: Tue, 05 Nov 2024 09:29:38 +0000 Volume 29, Issue 7, October 2024. Read the full article › The post Using Legitimation Code Theory to explore knowledge building in English medium higher education teaching: methodological challenges and innovations was curated by information for practice. Full Article Journal Article Abstracts
tea Where is the Public Service in Career Plateau Research? By ifp.nyu.edu Published On :: Tue, 05 Nov 2024 12:07:43 +0000 Canadian Public Administration, Volume 67, Issue 3, Page 420-428, September 2024. Read the full article › The post Where is the Public Service in Career Plateau Research? was curated by information for practice. Full Article Journal Article Abstracts
tea Don't destroy Portland, help people instead By www.portlandmercury.com Published On :: Wed, 06 Nov 2024 12:49:00 -0800 by Anonymous Hi. Last time this happened, we marched across the Broadway Bridge and it was this magical moment of solidarity and righteous protest. Then someone smashed windows and set dumpsters on fire. The rage is real, but all this accomplished was economic devastation for small businesses downtown (just cuz you smashed a Wells Fargo, doesn't mean the lunch shop next door didn't suffer). If you need to protest, what about a good old fashioned die-in? Physically destroying Portland hurts our neighbors, to the point it almost seems like MAGA plants are trying to discredit legit protesters. Please instead reach out to organizations that are working to help immigrants, LGBTQ+ people, women in need of health care, or whoever you love and will suffer under this administration. Let's thrive, Portland. Fuck the rest of the US, we're what we've got and we need to show up for each other. Full Article I Anonymous
tea 2018 Quantrell and Graduate Teaching Awards By www.uchicago.edu Published On :: Tue, 29 May 2018 10:41 -0500 Faculty members recognized for outstanding teaching and mentoring Full Article
tea A Hungry Anteater Enjoys Several Lovely Treats at the Miller Rehab Zoo in Quebec, Canada By laughingsquid.com Published On :: Sat, 09 Nov 2024 16:24:19 +0000 A hungry anteater named Tammy who lives at the Miller Rehabilitation Zoo in Quebec, Canada enjoyed several lovely treats. Full Article Blog
tea Minnesota Lynx GM, associate head coach leave the WNBA team By www.mprnews.org Published On :: Tue, 12 Nov 2024 01:44:00 +0000 General Manager Clare Duwelius is headed to Unrivaled, the new women’s three-on-three basketball league started by Napheesa Collier and Breanna Stewart. And associate head coach Katie Smith is headed to Ohio State, where she’ll be the assistant coach for the women’s basketball team. Full Article
tea Brain Teasers 2 Exhibit (8/20/2010) By calendar.rsvpa.com Published On :: Fri, 20 Aug 2010 04:00:00 GMT Start Date: 8/20/2010 All DayEnd Date: 8/20/2010Lancaster County - North Museum of Natural History & ScienceGain new appreciation for your brain and what it can do when Brain Teasers 2 opens at the North Museum of Natural History & Science on June 26. This exhibit offers 21 challenges for puzzle enthusiasts of all ages and is designed to sharpen problem-solving skills and provide plenty of fun at the same time. Brain twisters include unraveling mathematical conundrums, separating linked objects and reassembling them, arranging geometric shapes to form new ones and much more. To solve these puzzles, use creative thinking and program solving strategies. This brightly colored exhibit appeals to visitors of all ages and encourages parent-child interaction as families can team up to solve the brain teasers. Visitors have been known to come back and try again if they don’t solve all the puzzles on their first visit! Brain Teasers 2 is sponsored by Lancaster NeuroScience & Spine Associates and will be on display at the North Museum through September 12. Full Article 08/20/2010
tea Brain Teasers 2 Exhibit (8/19/2010) By calendar.rsvpa.com Published On :: Thu, 19 Aug 2010 04:00:00 GMT Start Date: 8/19/2010 All DayEnd Date: 8/19/2010Lancaster County - North Museum of Natural History & ScienceGain new appreciation for your brain and what it can do when Brain Teasers 2 opens at the North Museum of Natural History & Science on June 26. This exhibit offers 21 challenges for puzzle enthusiasts of all ages and is designed to sharpen problem-solving skills and provide plenty of fun at the same time. Brain twisters include unraveling mathematical conundrums, separating linked objects and reassembling them, arranging geometric shapes to form new ones and much more. To solve these puzzles, use creative thinking and program solving strategies. This brightly colored exhibit appeals to visitors of all ages and encourages parent-child interaction as families can team up to solve the brain teasers. Visitors have been known to come back and try again if they don’t solve all the puzzles on their first visit! Brain Teasers 2 is sponsored by Lancaster NeuroScience & Spine Associates and will be on display at the North Museum through September 12. Full Article 08/19/2010
tea Christian attorney warns 'tearing down' religious freedom in US is 'spirit of the age' By www.christianpost.com Published On :: Mon, 04 Nov 2024 17:54:11 -0500 An attorney dedicated to upholding religious freedom stated that he is “greatly disturbed” to see what Michigan has become, warning of a “growing hostility” in the state toward the exercise of religion in the public square. Full Article
tea Chaplain blacklisted by CofE for teaching Christian views on gender identity takes archbishop to court By www.christianpost.com Published On :: Mon, 11 Nov 2024 07:24:04 -0500 The Rev. Bernard Randall, an ordained Church of England chaplain, has taken legal action against Archbishop of Canterbury Justin Welby for blocking a disciplinary case against the Bishop of Derby who labeled him a safeguarding risk due to his traditional Christian views on gender identity.. Full Article
tea Fast-Paced Offense Leads OSU Women's Basketball Team Resurgence By radio.wosu.org Published On :: Thu, 21 Jan 2016 12:28:35 +0000 The Ohio State women's basketball team is having a great season. The Buckeyes are ranked seventh in the country ,, they just routed Big Ten power Purdue, and they take on rival Michigan Thursday night. For WOSU's sports show After the Score , Steve Brown and Thomas Bradley spoke with head coach Kevin McGuff. Full Article
tea Forget Globull Warming: Instead, Save the Endangered African Wild Dog By english.pravda.ru Published On :: Thu, 04 Nov 2021 13:41:00 +0300 Regarding my choice for the first part of my titular line, it is what it is: The weather. Nothing more. All else, is buell sheet. Let us leave it at that. Besides, have not we all had enough of the progressive Wokies and Fake News Media the world over waxing on ad hominem about it already? Climate hysteria has been going on for decades now. Even with their newest iteration, ‘The Green New Deal’ this climate hoax still comes up smelling of well, sulfur. It really stinks. What is the adage again? Right: Lipstick on a pig… It does not hide the fact that a real pig, still resides behind the shiny lip-gloss. Climatologist progressives As of this writing, the dog whistling climatologist progressives are attending their annual gas lighting meeting in Scotland. As usual Sweet Child of Sweden, Great Thunberg is there. No surprise either that the pudgy yute girl, now teenager, is leading the “How dare you!’ vanguard charge. No big surprise either, that the world’s billionaire oligarchs attended. All, without exception arrived in their own private Lear jets; leaving their biggest carbon footprints in their wake. As many of you know, that is the wealth mongers’ signature move. Full Article Science
tea Russian figure skating team falls under doping shadow By english.pravda.ru Published On :: Wed, 09 Feb 2022 16:49:00 +0300 Alexei Zheleznyakov, who is part of the team of Russian figure skating coach Eteri Tutberidze, responded to recent reports about a suspicious doping test that one of the skaters of the Russian national team had at the Beijing Olympics. Zheleznyakov said that he did not believe that anyone from the Russian team could violate anti-doping rules. "The guys took samples before the Games, most likely when they arrived and after their performances. We were staying at the hotel without getting out, but now they suddenly found something, and it happened right after the gold medal,” Alexei Zheleznyakov, who choreographs the Russian figure skaters in Beijing wrote on his Facebook account. Full Article Sport
tea Formula 1 looks to synthetic fuels as the future, Instead of going electric By english.pravda.ru Published On :: Fri, 03 Mar 2023 17:05:00 +0300 Formula 1 (F1) has been striving to become more environmentally friendly in recent years while still remaining relevant beyond the race track. The series has included more technology that is seen in street cars, such as small-displacement engines with turbos and hybridization. However, F1's CEO, Stefano Domenicali, has said in an interview with an Italian paper that the series will "never go electric." F1 sees synthetic fuels, also known as e-fuels, as the future of the series. These lab-created fuels are already in limited production but come with an extreme cost. However, this is not a problem for motorsport. F1's goal is to have e-fuels powering the grid by 2026 and then working towards finding a way to use them in passenger cars as combustion bans start to take effect in nations in the 2030s, just as F1 hopes to become carbon neutral. Full Article Sport
tea Dreamteam Albania By english.pravda.ru Published On :: Tue, 25 Jun 2024 19:30:00 +0300 Albania’s football team is to be congratulated on some very entertaining football, taking the game to their powerful opponents in the most difficult group at UEFA 2024 Group B, the Group of Death. Spain, Italy, Croatia, and…Albania, present in the UEFA finals for only the second time (2016 was the first). Along with everyone else, when I saw the group, I groaned and said “Poor Albania, they are going to get thrashed”. Well, they didn’t. The game against Italy surprised and shocked everyone as the reigning champions were outplayed by a spirited Albania for much of the game, managing to hold on to their 2-.1 lead in a game which Albania should have drawn. Spirit and grit For those who thought this was a fluke, they were wrong. This was already obvious in the first game with Albania’s passing and movement off the ball, the team spirit and what we call grit, saw wave after wave of Albanian attacks, intelligent attacks favouring incursions down both flanks or through the middle, depending on where there were better positioned players with all the Albanian team able to read the game as it developed. The passing was not only intelligent, it was accurate, fast-paced and sophisticated, denoting remarkable maturity. Full Article Opinion
tea Man steals bottle of vodka for his hangover and goes to fight in Ukraine By english.pravda.ru Published On :: Fri, 01 Nov 2024 18:33:00 +0300 A resident of Syktyvkar is going to serve in the zone of the special military operation after stealing a bottle of vodka. The man stole it from a grocery store, became a defendant in a criminal case and agreed to sign a contract for military service. The 39-year-old man, named only as Vitaly, had a hangover in the morning of October 27. He went to the nearest grocery store to get a "remedy." He took a small bottle of vodka from a shelf and went home without paying for it. Store employees noticed the missing bottle, looked through CCTV footage and called the police that found the man quickly. Full Article Society
tea PPDS and software firm Telelogos team up to bring advanced content and device management solutions to Philips Tableaux By www.retailtechnologyreview.com Published On :: PPDS, the exclusive global provider of Philips professional displays, has announced that Telelogos software has been approved as the very first remote device management solution for the new Philips Tableaux range of Advanced Colour ePaper displays. Full Article Mobile Computers
tea Co-op teams up with Quadient to deliver parcel locker convenience in communities in the UK By www.retailtechnologyreview.com Published On :: Quadient (Euronext: QDT), a global automation platform powering secure and sustainable business connections, has partnered with Co-op in the UK to deliver further parcel locker growth and added convenience to its communities. Full Article Retail Supply Chain
tea Retail payroll teams struggling with seasonal hiring, but too few are leveraging technology to alleviate the burden By www.retailtechnologyreview.com Published On :: Mon, 13 Nov 2000 17:31:40 +0000 With the holiday season fast approaching, retail payroll teams around the world are bracing for the strain of seasonal hiring. The influx of workers means added payroll runs, and yet too few are turning to technology to ease the pressure. Full Article Retail Supply Chain Critical Issues
tea New Russian McDonald's to have books instead of toys in Kids Combos By english.pravda.ru Published On :: Tue, 29 Nov 2022 19:49:00 +0300 Russia's Vkusno i Tochka (Tasty and That's It) fast food chain, which appeared n the country instead of McDonald's, will have meal combos for children similarly to Happy Meal, the company's press service told RBC. The sets will be called "Kids Combos." The company will remove toys from the sets to replace them with books. The new products will be available at restaurants of the network from December 12 in Novokuznetsk, Novosibirsk, Berdsk, Barnaul, Tomsk, Kemerovo and Krasnoyarsk. Kids Combos will be available throughout Russia starting from January. Kids Combos will include nuggets, cheese snacks, classic burgers, salads, carrot sticks and apple wedges, as well as a drink of choice, a representative of Tasty and That's It said. Full Article Business
tea Russian billionaire: Sell dollars quickly, buy euro, yuan and gold instead By english.pravda.ru Published On :: Tue, 14 Mar 2023 16:12:00 +0300 Russians should start selling dollars and buy euros, yuan and gold instead, businessman Oleg Deripaska believes. In his recent post on Telegram, Deripaska reacted to the statement from the author of the best-selling book "Rich Dad Poor Dad" Robert Kiyosaki about the future economic crisis in the United States. Kiyosaki, who predicted the collapse of Lehman Brothers in 2008, encouraged investors to buy more gold, silver and bitcoin. In his post, Deripaska published a link to Kiyosaki's interview with Fox Business. Full Article Business
tea Belarus bans most of Russian tea products By english.pravda.ru Published On :: Tue, 09 Apr 2024 15:01:00 +0300 Belarus suddenly banned the sale of Russian-made tea. According to the Ministry of Health of Belarus, the reason for this decision was a violation of requirements for microbiological indicators of product safety. Sanitary services of Belarus found traces of fungus in several types of tea produced by Orimi LLC, a Russian legal entity. Belarus banned all brands of tea produced by this company, their import into Belarus was restricted as well. The list of prohibited products includes such tea brands as: Greenfield, TESS, Princess Nuri, Princess Java, as well as some types of Jardin and Jockey coffee. Orimi LLC is taking necessary measures to prove the stability of production processes and effectiveness of the safety control system, the Belarusian Ministry of Health added. Restrictions on the sale of products may be lifted as soon as the company meets all relevant requirements of the Health Ministry of Belarus. Full Article Business
tea How To Use Shopify Staff Roles And Permissions To Manage Your Growing Team By www.retailtechnologyreview.com Published On :: Mon, 13 Nov 4620 17:06:52 +0000 By Jeremy Landau, freelance writer.It’s no secret that when your business begins to grow, you will need to add staff to accommodate the increased sales and other demands on store operations. This tends to become more complex as your business gets larger, and staff roles and responsibilities may need to be diversified and identified, so everyone knows what they should be doing. Full Article EPoS Systems Critical Issues
tea New Look and ZigZag Global team up to introduce convenient drop-off kiosks at selected stores By www.retailtechnologyreview.com Published On :: New Look has rolled out return kiosks in partnership with ZigZag Global, provider of technology-driven retail returns solutions, across a selection of New Look stores. Full Article Kiosk Technology Internet Retailing
tea Ibanera teams up with Visa to drive digital payment solutions By www.retailtechnologyreview.com Published On :: Digital banking platform Ibanera, spearheaded by CEO Michael Carbonara, has entered into a collaboration with Visa, the digital payment solutions provider. This opportunity will enable Ibanera to leverage Visa’s card issuing capabilities to support its clientele’s banking and finance needs. Full Article Data Capture EPoS Systems Payment Technology
tea Study: Student Absenteeism Crisis May Be Hurting Teacher Job Satisfaction By www.newswise.com Published On :: Tue, 12 Nov 2024 09:30:00 EST As student absenteeism reaches record highs in schools across the United States, new research finds that student absences are linked to lower teacher job satisfaction, raising concerns that this may exacerbate growing teacher shortages. Full Article
tea Turning a Blind Eye to Team Members' Unethical Behavior: The Role of Reward Systems By www.newswise.com Published On :: Fri, 08 Nov 2024 09:15:26 EST Full Article
tea Defense Chief: Sending Observation Team Does Not Constitute Overseas Deployment By world.kbs.co.kr Published On :: Mon, 11 Nov 2024 15:28:36 +0900 [Politics] : Defense Minister Kim Yong-hyun on Monday reiterated that sending an observation team to Ukraine is necessary for protecting national interest. During a National Assembly National Defense Committee session, Minister Kim said sending an observation team differs from troop deployment. He explained that a ...[more...] Full Article Politics
tea Ex-National Football Team Player Receives Permanent Ban from Chinese Football Association By world.kbs.co.kr Published On :: Tue, 10 Sep 2024 16:43:39 +0900 [Sports] : Former national football team member Son Jun-ho has been permanently banned by the Chinese Football Association(CFA). The CFA on Tuesday announced the disciplinary action against Son, accusing the football player of engaging in match-fixing and bribery. With the latest decision, Son is permanently ...[more...] Full Article Sports
tea Gov't to Announce Interim Results from Audit into KFA, Nat'l Team Head Coach Appointment By world.kbs.co.kr Published On :: Tue, 24 Sep 2024 17:26:45 +0900 [Sports] : The government is expected to announce next Wednesday interim results from an audit into the Korea Football Association's(KFA) appointment of Hong Myung-bo as head coach of the men's national team. Yu In-chon, minister of culture, sports and tourism, told the parliamentary culture and sports ...[more...] Full Article Sports
tea National Football Team to Keep Tab on Son's Injury Ahead of World Cup Qualifiers By world.kbs.co.kr Published On :: Mon, 30 Sep 2024 15:22:27 +0900 [Sports] : Men's national football team head coach Hong Myung-bo has cast doubt over captain Son Heung-min's availability in the upcoming World Cup qualifiers next month. During a press conference on Monday, Hong announced the roster for October's World Cup qualifiers, which included the Tottenham Hotspur star ...[more...] Full Article Sports
tea Men's Football Team to Face Jordan in World Cup Qualifier without Captain Son By world.kbs.co.kr Published On :: Thu, 10 Oct 2024 14:54:45 +0900 [Sports] : The South Korean men's national football team is set to face Jordan in the third round of 2026 FIFA World Cup qualifiers. The qualifying match between the national team, led by head coach Hong Myung-bo, and Jordan at Amman International Stadium is scheduled to begin at 11 p.m. Thursday, Korea time. While ...[more...] Full Article Sports
tea Men's National Football Team Face Iraq in World Cup Qualifier By world.kbs.co.kr Published On :: Tue, 15 Oct 2024 15:15:11 +0900 [Sports] : The South Korean men's national football team faces Iraq in the World Cup qualifier match on Tuesday night at home. Considered the toughest opponent for South Korea in the third round of the Asian qualifiers, a win against the Middle Eastern squad will give the Taegeuk Warriors a huge boost in their ...[more...] Full Article Sports
tea Son Heung-min Returns as National Team Faces Kuwait, Palestine in World Cup Qualifiers By world.kbs.co.kr Published On :: Mon, 04 Nov 2024 15:51:08 +0900 [Sports] : The men’s national football team is set to face Kuwait and Palestine in mid-November in the third round of 2026 FIFA World Cup qualifiers with the return of captain Son Heung-min, who sat out matches in October due to a hamstring injury. Head coach Hong Myung-bo announced the 26-member roster on Monday, ...[more...] Full Article Sports
tea KFA Revises Rules on Selecting Head Coach of Nat'l Football Team By world.kbs.co.kr Published On :: Tue, 12 Nov 2024 17:56:28 +0900 [Sports] : The Korea Football Association(KFA) has revised its regulations on selecting the head coach of the national football team in a bid to boost the competitiveness and efficiency in operating the team. Following a meeting of its board of directors in Seoul on Tuesday, the association said that in order to ...[more...] Full Article Sports
tea Trump Moves Fast to Form Nat’l Security, Foreign Policy Teams By world.kbs.co.kr Published On :: Wed, 13 Nov 2024 14:50:17 +0900 [International] : Anchor: U.S. President-elect Donald Trump is moving fast to complete appointments for his national security and foreign policy teams, with his latest pick being veteran-turned-conservative news host Pete Hegseth to head the Pentagon. The incoming administration faces a number of foreign policy challenges, ...[more...] Full Article International
tea What Does a Catalytic Converter Do and Why Do People Steal Them? By auto.howstuffworks.com Published On :: Thu, 14 Mar 2024 10:49:58 -0400 Catalytic converters are one of the most important parts of a car's emissions control system. Learn about catalytic converters and catalytic converter laws. Full Article
tea What Is Boba? Everything to Know About Bubble Tea By recipes.howstuffworks.com Published On :: Tue, 30 Apr 2024 10:19:10 -0400 You're not alone if you've ever found yourself wondering, "What is boba?" This food trend has taken the drink market by storm, enchanting tea enthusiasts and curious foodies alike. Full Article
tea Animations, videos and 3D models for teaching space-group symmetry By journals.iucr.org Published On :: Animations, videos and 3D models have been designed to visualize the effects of symmetry operators on selected cases of crystal structures, pointing out the relationship with the diagrams published in International Tables for Crystallography, Vol. A. Full Article text
tea Animations, videos and 3D models for teaching space-group symmetry By journals.iucr.org Published On :: 2024-10-16 A series of animations, videos and 3D models that were developed, filmed or built to teach the symmetry properties of crystals are described. At first, these resources were designed for graduate students taking a basic crystallography course, coming from different careers, at the National Autonomous University of Mexico. However, the COVID-19 pandemic had the effect of accelerating the generation of didactic material. Besides our experience with postgraduate students, we have noted that 3D models attract the attention of children, and therefore we believe that these models are particularly useful for teaching children about the assembled arrangements of crystal structures. Full Article text
tea Teaching about the birth of synchrotron light: the role of Frascati and a missed opportunity By journals.iucr.org Published On :: 2024-05-21 The users of synchrotron light are now tens of thousands throughout the world. Paradoxically, many of them do not know much about the early history of their domain. This is regrettable, since education about the initial developments makes it easier to fully understand synchrotron radiation and effectively use its amazing features. Scarcely known, in particular, is the key role of scientists working in Frascati, Italy. Partly based on his personal experiences, the author reports here relevant aspects of this story, including a pioneering French–Italian experiment that started in the early 1960s, and the Frascati contributions in the 1970s and 1980s to the birth of synchrotron light research. Finally, the unwise strategic decisions that prevented Italy from achieving absolute leadership in this domain – in spite of its unique initial advantages – are analyzed. Full Article text
tea Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket By journals.iucr.org Published On :: 2024-01-30 To identify starting points for therapeutics targeting SARS-CoV-2, the Paul Scherrer Institute and Idorsia decided to collaboratively perform an X-ray crystallographic fragment screen against its main protease. Fragment-based screening was carried out using crystals with a pronounced open conformation of the substrate-binding pocket. Of 631 soaked fragments, a total of 29 hits bound either in the active site (24 hits), a remote binding pocket (three hits) or at crystal-packing interfaces (two hits). Notably, two fragments with a pose that was sterically incompatible with a more occluded crystal form were identified. Two isatin-based electrophilic fragments bound covalently to the catalytic cysteine residue. The structures also revealed a surprisingly strong influence of the crystal form on the binding pose of three published fragments used as positive controls, with implications for fragment screening by crystallography. Full Article text
tea Structural multiplicity in a solvated hydrate of the antiretroviral protease inhibitor Lopinavir By journals.iucr.org Published On :: 2024-10-24 Lopinavir is a potent protease inhibitor that is used as a first-line pharmaceutical drug for the treatment of HIV. The multi-component solvated Lopinavir crystal, systematic name (2S)-N-[(2S,4S,5S)-5-[2-(2,6-dimethylphenoxy)acetamido]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide–ethane-1,2-diol–water (8/3/7) 8C37H48N4O5·3C2H6O2·7H2O, was prepared using evaporative methods. The crystalline material obtained from this experimental synthesis was characterized and elucidated by single-crystal X-ray diffraction (SC-XRD). The crystal structure is unusual in that the unit cell contains 18 molecules. The stoichiometric ratio of this crystal is eight Lopinavir molecules [8(C37H48N4O5)], three ethane-1,2-diol molecules [3(C2H6O2)] and seven water molecules [7(H2O)]. The crystal packing features both bi- and trifurcated hydrogen bonds between atoms. Full Article text
tea Mastercard teams up with Tap Payments By thepaypers.com Published On :: Wed, 13 Nov 2024 08:12:00 +0100 Mastercard has entered into a partnership with Tap Payments to launch a Click to Pay with Payment Passkey service for optimised ecommerce transactions. Full Article