The Private Facility Has Installed A Pair Of Result6 Compact Nearfield Monitors To Complement Its Existing Range Of Recording And Mixing Equipment.

International Society for Structural Health Monitoring of Intelligent Infrastracture will host Tenth International Conference on Structural Health Monitoring of Intelligent Infrastructure on June 30 - July 2, 2021 in Porto, Portugal. TRB is pleased to cosponsor this event. The conference provides a forum for idea exchanges, knowledge sharing, and technology-need matchmaking in the global Structural Health Monitoring and Nondestructive Testing community. It serves as a unique venue to showcase U.S. and gl...

The production of formate from CO2 is considered an attractive strategy for the long-term storage of solar renewable energy in chemical form.

U.S. Financial System “Monitor” Failed to Flash Warning as Fed Pumped $6 Trillion Emergency Liquidity into Wall Street

By Pam Martens and Russ Martens: May 8, 2020 ~  The Office of Financial Research (OFR) was created under the Dodd-Frank financial reform legislation of 2010 to keep the Financial Stability Oversight Council (F-SOC) informed on emerging threats that have the potential to implode the financial system — as occurred in 2008 in the worst financial crash since the Great Depression. The Trump administration has gutted both its funding and staff. One of the early warning systems of an impending financial crisis that OFR was supposed to have created is the heat map above. Green means low risk; yellow tones mean moderate risk; while red tones flash a warning of a serious problem. On September 17, 2019, liquidity was so strained on Wall Street that the Federal Reserve had to step in and began providing hundreds of billions of dollars per week in repo loans. By January 27, 2020 (before … Continue reading →

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AN ALIEN hunter believes he has spotted a UFO over Spain, which he claims intelligent extraterrestrials are using to monitor the coronavirus situation.

A service highlighting the riches of the daily press.

Margaret Thatcher's ability to kick off what Mrs Merton used to call a heated debate, is apparent on today's front pages.

The Sun has commissioned a poll of Britain's favourite prime ministers. "Maggie wins again!" it cries. Margaret Thatcher pushes Churchill into second place, and Clement Attlee can only manage 5%, behind Tony Blair and Harold Wilson.

In the YouGov poll of 1,893 adults, poor old Ted Heath and David Cameron finish with nil points. Pitt the younger doesn't get a look in either although that's because the poll confines itself to post-war leaders.

The Times strikes a conciliatory note. "Royal respect as Queen leads Thatcher mourners." The paper says that whatever misgivings the Queen may have had about Thatcherism have been put to one side. "The conjecture that the Queen was fundamentally opposed to much of what her longest-serving prime minister stood for will be forgotten in the significance of the moment."

"Operation True Blue: Thatcher funeral in security clampdown," warns the Guardian about fears that the funeral service may foment civic unrest and terrorist attacks.

The ipaper risks not only spreading alarm and confusion but enraging pedants. "Britain at war over Thatcher funeral". Erm, tanks on the streets, pitched battles? Oh, not literally.

The Daily Mirror goes in hard but with better grammar. "The £10m goodbye. Why is Britain's most divisive Prime Minister getting a ceremonial funeral fit for a Queen?"

It may not come as a total surprise to find that the Daily Mail is angry. Very angry. "The flames of hatred: 30 years of Left wing loathing for Lady T explodes in sick celebrations of her death." (There's also a medium range ballistic missile launched from page 10 at the good people of this parish...)

The Daily Telegraph tries to calm things down. "No gushing hysteria, just quiet, dignified respect" is the headline over Michael Deacon's report from Finchley, the Iron Lady's constituency for 33 years. A local recalls how she had a soft spot for a bar called Cheers.

"She would pop in and have a drink. Denis would have gin and tonic and I think she would have a glass of wine...She was very approachable and friendly." It's cosy and sepia tinted, like the credits of Coronation Street relocated to prosperous middle class suburbia.

But amidst all the gentle colour, the writer can't resist one pot shot at those celebrating Thatcher's death. "For those who insist that Left-wing ideology is motivated above all by compassion for others, this must be a difficult week." Ouch!

Which leaves one paper not doing Thatcher on its front page. Come in Daily Express, your taste for bathos knows no bounds. (Yes, even the Daily Star splashes on the funeral costs). "Gel to wipe out arthritic pain" runs the headline.

And on that bombshell...

A service highlighting the riches of the daily press.

Sometimes an incongruous detail is all you need for a great story. Like putting Madonna and Gary Neville in the same headline.

"Madonna's very rude...Gary Neville has equally dazzling stature but better manners", goes the Daily Mirror headline.

The story is badged "It's Official" suggesting there may be an element of tongue in cheek. As might the picture of Neville wearing an England tracksuit, captioned "Dazzler", on one side of the page with Madge in a Panama hat on the other.

The paper reports that the Malawian government made an "astonishing attack" on the US artiste after she visited her charity in the southern African country last week.

The reason for the spat remains vague. The paper reports that she was "left fuming after being snubbed by president Joyce Banda and having to queue with economy passengers at the airport as she flew out of the capital Lilongwe".

The government statement accuses her of wanting Malawi "to be for ever chained to the obligation of gratitude".

Other papers note though that the government diatribe follows the sacking of the president's sister as head of Raising Malawi, Madonna's charity there.

But the story's real joy is in the ill-assorted mix of celebs the government lists.

"It is worth making her aware that Malawi has hosted many international stars, including Chuck Norris, Bono, David James, Rio Ferdinand and Gary Neville who have never demanded state attention or decorum despite their equally dazzling stature."

Paper Monitor guesses that the Mirror subs had a little chat about which of the three footballers to pair with Madge in the headline.

Which would jar most incongruously next to the "Queen of Pop"? Somehow, ineffably, Gary Neville wins every time.

A service highlighting the riches of the daily press.

If you're a woman, it may be worth reading the Times before getting dressed this morning.

The paper reports how Professor Jean-Denis Rouillon, an academic at the University Hospital of Besancon in eastern France, has broken the post-war consensus.

Bras may not be necessary for holding up breasts. Or "norks" as Carol Midgley calls them in her commentary.

The Frenchman tracked 320 women's breasts over 15 years. I'll bet he did, a wag might mutter.

"Our first results validate the hypothesis that the bra is a false need," the professor says, adopting a most unpage 3 lexicon.

"Medically, physiologically and anatomically, the breast derives no benefit from being deprived of gravity. If it is, the tissues that support it are going to decline and the breast will progressively suffer damage."

Prof Rouillon is not one to shirk the detail. He notes that after a year of not wearing a bra, the nipples of women aged between 18 and 35 rose by 7mm on average.

Older and underweight women might need a bra but for the young it could be damaging, he argues in a technocratic idiom that comes naturally to a Francophone scientist.

"If a woman puts on a bra when her breasts first appear, the suspensory apparatus does not work properly and tissues of the bra distend."

It's left to Midgely to shoot his theory down with some anecdotal evidence of a less professorial tone. "Going without them gives you backache, a dowager's hump and the impression that two labrador puppies are tussling under your jumper."

Paper Monitor, who cannot confirm or deny the presence of a bra about its person, is keeping an open mind until Monsieur Rouillon's full research is published.

A service highlighting the riches of the daily press.

The electronic Daily Telegraph is now behind a paywall. Paper Monitor has effected an old-school breach of that wall - buying a copy of the actual paper.

It's almost like going undercover. Reading an actual paper edition of a newspaper.

Page two has the gratifying news that Carol Vorderman's nose is better. She fell down and broke it. She did not have a nose job. That was speculation.

Page six reveals that cheats in school games are copying footballers. For clarity, in Telegraphland a common equation is footballers=bad.

But you have to wait until page 11 for the really serious news.

"Here's to you, Mrs Robinson. Why more 40-somethings are dating younger men".

That's the headline. And there's a massive picture of Helen McCrory. Massive.

The anchor on the same page is Catherine Deneuve saying flat shoes are sexier than "twisted" and impossible high heels.

Further on there's a leader. It quotes the Song of Solomon.

Oh, to wear one's erudition so lightly.

A service highlighting the riches of the daily press.

There's crime stories. And then there's quirky crime stories.

The Daily Telegraph headline gives you a clue that this is a nice, light story about how crime doesn't pay.

"Happiness is... a burglar wasting three days for pouch of tobacco."

The ne'er-do-well spent three nights chiselling away at the wall of Medway Motorcycles in Rochester to make a hole big enough to squeeze into. Finally he breached the 2ft-thick wall. The high performance bikes were to be his. And then he realised he'd forgotten about the alarm.

"One false move towards the bikes would have sent the alarm ringing," the paper reports. "So the thief crept up to the first floor instead, looking for items to steal."

In the end he left with just a packet of rolling tobacco worth £3.

"When I got here the next morning the place was in a right state but all I can see he has nicked is my Golden Virginia," the owner says.

The proprietor's surname is Eastwood. If only he'd caught the burglar in the act.

Imagine the scene, burglar holding the Golden Virginia, Eastwood - first name Jez but we'll gloss over that - reaching for his pretend, concealed .44 Magnum: "You've got to ask yourself one question: Do I feel lucky? Well, do ya, punk?"

It took Paper Monitor a while to work out the happiness allusion of the headline.

A clue - it depends how many TV ads you remember from the 1980s that used Bach's Air on a G string to conjure up plumes of sensuous tobacco smoke. Answers to the usual place.

A service highlighting the riches of the daily press.

Hair we go again. Sorry, Paper Monitor couldn't resist.

Yes, it's another hair story, and yes, there's a picture of Jennifer Aniston.

This time, however, the Daily Mail reports that the Friends star has finally fallen out of favour. At least, her hairstyle has anyway.

It says a survey on the best onscreen hairstyles reveals her locks are no longer the most influential.

"Sorry, Jen... Anne's top of the crops," is its headline, revealing that Anne Hathaway's crowning glory has outshone the competition.

The elfin cut was first sported in the 2011 adaptation of David Nicholls's hit novel One Day. But it was her Oscar-winning turn in Les Miserables, as Fantine, which saw her cut it off for an extended period.

The actress was said to be "inconsolable" after the chop so it's quite a turnaround.

For those interested in which other celebrities made the cut, Miss Aniston's long curly style in Along Came Polly was in second place. And Audrey Hepburn's "up do" from 1963 film Charade in third.

Frank Reich has worked hard to find ways to teach the Colts virtually, including bringing in an NBA legend to inspire the team.

At Swoop we use Redis extensively for caching, message processing and analytics. The Redis documentation can be pithy at times and recently I found myself wanting to look in more depth at the Redis wire protocol. Getting everything set up … Continue reading →

Frank Reich has worked hard to find ways to teach the Colts virtually, including bringing in an NBA legend to inspire the team.

• Dockworkers in Belgium are wearing bracelets to enforce social distancing.
• The bracelets were already used to detect if someone fell into the water, but now they will sound an alarm if workers get to close to each other.
• Manufacturers say there is no privacy issue and the bracelets don't track workers' locations, despite concerns.
• Visit Business Insider's homepage for more stories.

Quarantine and social distancing are going high-tech as countries and companies embrace wearables. In Antwerp, Belgium, dockworkers are instructed to wear bracelets that enforce social distancing rules while they work.

Europe, where more than 100,000 people have died from COVID-19, is slowly starting to reopen in some places. Stay at home orders are expiring in many countries, while nonessential travel has stopped across the EU, and countries look towards the summer to anticipate what kind of travel might be possible. 

People are beginning to go back to work, which in some sectors means inevitable close contact, especially in many essential jobs. Social distancing bracelets in Belgium are one idea bing tested to see what the future of work might look like after coronavirus.

Here's how it works. 

SEE ALSO: People arriving in Hong Kong must wear tracking bracelets for 2 weeks or face jail time. Here's how they work.

The black, plastic bracelets are worn on the wrist like a watch.

They're made by Belgian company Rombit, which says that they are "a fully integrated personal safety and security device, specifically designed for highly industrial environments."

Source: Romware

Rombit already made bracelets useful in the port setting, which could be used to call for help if a worker fell into the water or another accident occurred.

Europe is slowly starting to go back to work, but fears of a second wave are making officials cautious.

Contact tracing is one solution being explored around the world, and the manufacturers of the bracelet believe it could also be used for contact tracing.

Source: The Associated Press

European health guidances say to wash hands, wear masks, and keep at least 1.5 meters, or about five feet, apart.

When two workers are less than five feet apart, the bracelets will sound warnings.

Rombit CEO John Baekelmans told Reuters that the bracelets won't allow companies to track employees' locations, because the devices are only connected to each other. He says there is no central server.

Source: Reuters

Workers in the control tower will be the first to test the bracelets early this month.

Then, the Port of Antwerp will likely expand the devices to tug boat workers.

Baekelmans told Reuters that Rombit already had hundreds of requests in 99 countries, and is hoping to ramp up production to 25,000 in a few weeks.

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Wellness is a buzzy word lately. Over the past few years, we’ve seen a surge in all things health, wellness, and spirituality. Juice bars are popping up, boutique studios are becoming more accessible, and essential oils are chilling us out. Self-care is becoming more of the norm too, but amidst all this hype, it can be challenging to find the right routine that promotes good exercise, sleep, vitals, and mindset.  Read more...

Amelia C. Peterson
Nov 1, 2012; 11:1475-1488
Technological Innovation and Resources

Leigh Anderson
Apr 1, 2006; 5:573-588
Research

Problems might occur when using SAS Enterprise Guide with dual monitors. For example, it might appear there is a performance problem with the query builder or other task, or it might appear that code or a task is hung, or

Shwetha K. Shetty
Apr 1, 2020; 61:546-559
Methods

Protein tyrosine kinases (PTKs) play key roles in cellular signal transduction, cell cycle regulation, cell division, and cell differentiation. Dysregulation of PTK-activated pathways, often by receptor overexpression, gene amplification, or genetic mutation, is a causal factor underlying numerous cancers. In this study, we have developed a parallel reaction monitoring (PRM)-based assay for quantitative profiling of 83 PTKs. The assay detects 308 proteotypic peptides from 54 receptor tyrosine kinases and 29 nonreceptor tyrosine kinases in a single run. Quantitative comparisons were based on the labeled reference peptide method. We implemented the assay in four cell models: 1) a comparison of proliferating versus epidermal growth factor (EGF)-stimulated A431 cells, 2) a comparison of SW480Null (mutant APC) and SW480APC (APC restored) colon tumor cell lines, and 3) a comparison of 10 colorectal cancer cell lines with different genomic abnormalities, and 4) lung cancer cell lines with either susceptibility (11-18) or acquired resistance (11-18R) to the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib. We observed distinct PTK expression changes that were induced by stimuli, genomic features or drug resistance, which were consistent with previous reports. However, most of the measured expression differences were novel observations. For example, acquired resistance to erlotinib in the 11-18 cell model was associated not only with previously reported upregulation of MET, but also with upregulation of FLK2 and downregulation of LYN and PTK7. Immunoblot analyses and shotgun proteomics data were highly consistent with PRM data. Multiplexed PRM assays provide a targeted, systems-level profiling approach to evaluate cancer-related proteotypes and adaptations. Data are available through Proteome eXchange Accession PXD002706.

Niemann-Pick disease type C (NPC) disease is a lipid-storage disorder that is caused by mutations in the genes encoding NPC proteins and results in lysosomal cholesterol accumulation. 2-Hydroxypropyl-β-cyclodextrin (CD) has been shown to reduce lysosomal cholesterol levels and enhance sterol homeostatic responses, but CD’s mechanism of action remains unknown. Recent work provides evidence that CD stimulates lysosomal exocytosis, raising the possibility that lysosomal cholesterol is released in exosomes. However, therapeutic concentrations of CD do not alter total cellular cholesterol, and cholesterol homeostatic responses at the ER are most consistent with increased ER membrane cholesterol. To address these disparate findings, here we used stable isotope labeling to track the movement of lipoprotein cholesterol cargo in response to CD in NPC1-deficient U2OS cells. Although released cholesterol was detectable, it was not associated with extracellular vesicles. Rather, we demonstrate that lysosomal cholesterol trafficks to the plasma membrane (PM), where it exchanges with lipoprotein-bound cholesterol in a CD-dependent manner. We found that in the absence of suitable extracellular cholesterol acceptors, cholesterol exchange is abrogated, cholesterol accumulates in the PM, and reesterification at the ER is increased. These results support a model in which CD promotes intracellular redistribution of lysosomal cholesterol, but not cholesterol exocytosis or efflux, during the restoration of cholesterol homeostatic responses.

The hydrolysis of triglycerides in triglyceride-rich lipoproteins by LPL is critical for the delivery of triglyceride-derived fatty acids to tissues, including heart, skeletal muscle, and adipose tissues. Physiologically active LPL is normally bound to the endothelial cell protein glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1 (GPIHBP1), which transports LPL across endothelial cells, anchors LPL to the vascular wall, and stabilizes LPL activity. Disruption of LPL-GPIHBP1 binding significantly alters triglyceride metabolism and lipid partitioning. In this study, we modified the NanoLuc® Binary Technology split-luciferase system to develop a novel assay that monitors the binding of LPL to GPIHBP1 on endothelial cells in real time. We validated the specificity and sensitivity of the assay using endothelial lipase and a mutant version of LPL and found that this assay reliably and specifically detected the interaction between LPL and GPIHBP1. We then interrogated various endogenous and exogenous inhibitors of LPL-mediated lipolysis for their ability to disrupt the binding of LPL to GPIHBP1. We found that angiopoietin-like (ANGPTL)4 and ANGPTL3-ANGPTL8 complexes disrupted the interactions of LPL and GPIHBP1, whereas the exogenous LPL blockers we tested (tyloxapol, poloxamer-407, and tetrahydrolipstatin) did not. We also found that chylomicrons could dissociate LPL from GPIHBP1 and found evidence that this dissociation was mediated in part by the fatty acids produced by lipolysis. These results demonstrate the ability of this assay to monitor LPL-GPIHBP1 binding and to probe how various agents influence this important complex.

Continuous glucose monitor (CGM) readings are delayed relative to blood glucose, and this delay is usually attributed to the latency of interstitial glucose levels. However, CGM-independent data suggest rapid equilibration of interstitial glucose. This study sought to determine the loci of CGM delays. Electrical current was measured directly from CGM electrodes to define sensor kinetics in the absence of smoothing algorithms. CGMs were implanted in mice, and sensor versus blood glucose responses were measured after an intravenous glucose challenge. Dispersion of a fluorescent glucose analog (2-NBDG) into the CGM microenvironment was observed in vivo using intravital microscopy. Tissue deposited on the sensor and nonimplanted subcutaneous adipose tissue was then collected for histological analysis. The time to half-maximum CGM response in vitro was 35 ± 2 s. In vivo, CGMs took 24 ± 7 min to reach maximum current versus 2 ± 1 min to maximum blood glucose (P = 0.0017). 2-NBDG took 21 ± 7 min to reach maximum fluorescence at the sensor versus 6 ± 6 min in adipose tissue (P = 0.0011). Collagen content was closely correlated with 2-NBDG latency (R = 0.96, P = 0.0004). Diffusion of glucose into the tissue deposited on a CGM is substantially delayed relative to interstitial fluid. A CGM that resists fibrous encapsulation would better approximate real-time deviations in blood glucose.

Joseph Tran
Oct 1, 2012; 30:173-178
Practical Pointers

Evan M. Benjamin
Jan 1, 2002; 20:
Practical Pointers

Tadej Battelino
Aug 1, 2019; 42:1593-1603
International Consensus Report

Dorothee Deiss
Dec 1, 2006; 29:2730-2732
BR Emerging Treatments and Technologies

Thomas Danne
Dec 1, 2017; 40:1631-1640
Continuous Glucose Monitoring and Risk of Hypoglycemia

William L Clarke
Sep 1, 1987; 10:622-628
Technical Article

David C. Klonoff
Aug 1, 2018; 41:1681-1688
Emerging Technologies: Data Systems and Devices

Kirstine J. Bell
Jun 1, 2015; 38:1008-1015
Type 1 Diabetes at a Crossroads

Richard M. Bergenstal
Nov 1, 2018; 41:2275-2280
Perspectives in Care

Guillermo E. Umpierrez
Aug 1, 2018; 41:1579-1589
Diabetes Care Symposium

Thomas Danne
Dec 1, 2017; 40:1631-1640
Continuous Glucose Monitoring and Risk of Hypoglycemia

Tadej Battelino
Aug 1, 2019; 42:1593-1603
International Consensus Report

OBJECTIVE

To determine if temporal glucose profiles differed between 1) women who were randomized to real-time continuous glucose monitoring (RT-CGM) or self-monitored blood glucose (SMBG), 2) women who used insulin pumps or multiple daily insulin injections (MDIs), and 3) women whose infants were born large for gestational age (LGA) or not, by assessing CGM data obtained from the Continuous Glucose Monitoring in Women With Type 1 Diabetes in Pregnancy Trial (CONCEPTT).

Evan M. Benjamin
Jan 1, 2002; 20:
Practical Pointers

James Chamberlain
Jul 1, 2013; 31:106-109
Feature Articles

London : S. Highley, 1848.

Chicago, Ill. : Joint Commission on Accreditation of Healthcare Organizations, 1987.

Surveys provide secure, anonymous feedback from staff at all levels of healthcare organizations

(PRWeb May 06, 2020)

Read the full story at https://www.prweb.com/releases/health_worker_data_alliance_monitoring_emotional_physical_and_occupational_health_of_healthcare_workers_during_covid_19/prweb17101008.htm

Zhenguo Gao, Pang Du, Ran Jin, John L. Robertson.

Source: The Annals of Applied Statistics, Volume 14, Number 1, 143--159.

Abstract:
Liver procurement experiments with surface-temperature monitoring motivated Gao et al. ( J. Amer. Statist. Assoc. 114 (2019) 773–781) to develop a variance change-point detection method under a smoothly-changing mean trend. However, the spotwise change points yielded from their method do not offer immediate information to surgeons since an organ is often transplanted as a whole or in part. We develop a new practical method that can analyze a defined portion of the organ surface at a time. It also provides a novel addition to the developing field of functional data monitoring. Furthermore, numerical challenge emerges for simultaneously modeling the variance functions of 2D locations and the mean function of location and time. The respective sample sizes in the scales of 10,000 and 1,000,000 for modeling these functions make standard spline estimation too costly to be useful. We introduce a multistage subsampling strategy with steps educated by quickly-computable preliminary statistical measures. Extensive simulations show that the new method can efficiently reduce the computational cost and provide reasonable parameter estimates. Application of the new method to our liver surface temperature monitoring data shows its effectiveness in providing accurate status change information for a selected portion of the organ in the experiment.

Paul J. Birrell, Lorenz Wernisch, Brian D. M. Tom, Leonhard Held, Gareth O. Roberts, Richard G. Pebody, Daniela De Angelis.

Source: The Annals of Applied Statistics, Volume 14, Number 1, 74--93.

Abstract:
A prompt public health response to a new epidemic relies on the ability to monitor and predict its evolution in real time as data accumulate. The 2009 A/H1N1 outbreak in the UK revealed pandemic data as noisy, contaminated, potentially biased and originating from multiple sources. This seriously challenges the capacity for real-time monitoring. Here, we assess the feasibility of real-time inference based on such data by constructing an analytic tool combining an age-stratified SEIR transmission model with various observation models describing the data generation mechanisms. As batches of data become available, a sequential Monte Carlo (SMC) algorithm is developed to synthesise multiple imperfect data streams, iterate epidemic inferences and assess model adequacy amidst a rapidly evolving epidemic environment, substantially reducing computation time in comparison to standard MCMC, to ensure timely delivery of real-time epidemic assessments. In application to simulated data designed to mimic the 2009 A/H1N1 epidemic, SMC is shown to have additional benefits in terms of assessing predictive performance and coping with parameter nonidentifiability.

The Computer Emergency Response Team of Mauritius (CERT-MU) in collaboration with the Command and Control Centre of Kenya organised a 3-day training programme on Cyber Defense Monitoring and Forensics at Voilà Hotel, Bagatelle from the 27^th February – 1^st March 2018. The training course provided an introduction to Network Security Monitoring (NSM), Security Information and Events Management (SIEM), Malware Analysis and Digital Forensics. Major part of the course was hands-on case studies and analysis exercises using real world data. The main focus of the training programme was on intensive hands-on sessions on addressing key challenges faced by local organizations in all sectors/industries. A wide range of commercial and open source tools were used to equip cyber defenders with the necessary skills to anticipate, detect, respond and contain adversaries. The training programme was followed by 23 participants from the public and private sector.