The Implication of Greater Use of Investment Screening 26 June 2020 — 9:00AM TO 10:30AM Anonymous (not verified) 11 February 2021 Online

What is driving the trend towards greater use of investment screening by nation states and regional economic groupings?

• How is the COVID-19 crisis affecting this trend?
• What will the economic implications be?
• Will this help or hinder inclusivity and transparency in investment governance?
• Is there a role for international safeguards and/or international coordination of national/regional approaches to investment screening?

This event is part of the Inclusive Governance Initiative, which is examining how to build more inclusive models and mechanisms of global governance fit for purpose in today’s world.

How can the investor community address the ‘S’ in ESG? – the role of social purpose values 16 November 2021 — 1:30PM TO 2:30PM Anonymous (not verified) 18 October 2021 Online

This webinar highlights the crucial relationship between an open civic space and a profitable business environment.

2020 was a tipping point for investors to think and act more responsibly, galvanized by catalysts like the killing of George Floyd and the pandemic. There is increasing investor support for social and environmental causes. Younger investors are placing increasing emphasis on values and social issues in their investment decisions.

The ‘S’ in the Environment Social and Governance (ESG) agenda is clearly gaining traction, but how far does it extend to civil and political liberties i.e. the right of citizens, NGOs and journalists to speak freely, assemble and associate which are increasingly shrinking around the world?

While there is increasing focus on human rights issues such as modern slavery and supply chains, civil society space issues often fall between the cracks when investors consider ESG.

This webinar also explores opportunities and challenges that arise for the investor community in terms of factoring civic space issues into their political risk and ESG analysis.

• To what extent are civic space issues being factored into ESG social purpose values, especially by younger investors?
• What is the best methodology for assessing these issues in order to ensure a common and coherent set of global standards in this area?
• And how can investors mitigate the risks of their activities to civic space in practice?

Lipoprotein (a) [Lp(a)] is a well-known risk factor for cardiovascular disease, but analysis on Lp(a) and renal dysfunction is scarce. We aimed to investigate prospectively the association of serum Lp(a) with the risk of reduced renal function, and further investigated whether diabetic or hypertensive status modified such association. Six thousand two hundred and fifty-seven Chinese adults aged ≤40 years and free of reduced renal function at baseline were included in the study. Reduced renal function was defined as estimated glomerular filtration rate <60 ml/min/1.73 m². During a mean follow-up of 4.4 years, 158 participants developed reduced renal function. Each one-unit increase in log₁₀-Lp(a) (milligrams per deciliter) was associated with a 1.99-fold (95% CI 1.15–3.43) increased risk of incident reduced renal function; the multivariable-adjusted odds ratio (OR) for the highest tertile of Lp(a) was 1.61 (95% CI 1.03–2.52) compared with the lowest tertile (P for trend = 0.03). The stratified analysis showed the association of serum Lp(a) and incident reduced renal function was more prominent in participants with prevalent diabetes [OR 4.04, 95% CI (1.42–11.54)] or hypertension [OR 2.18, 95% CI (1.22–3.89)]. A stronger association was observed in the group with diabetes and high Lp(a) (>25 mg/dl), indicating a combined effect of diabetes and high Lp(a) on the reduced renal function risk. An elevated Lp(a) level was independently associated with risk of incident reduced renal function, especially in diabetic or hypertensive patients.

The neuronal basis of complex social behavior is still poorly understood. In honeybees, reproductive investment decisions are made at the colony-level. Queens develop from female-destined larvae that receive alloparental care from nurse bees in the form of ad-libitum royal jelly (RJ) secretions. Typically, the number of raised new queens is limited but genetic breeding of "royal jelly bees" (RJBs) for enhanced RJ production over decades has led to a dramatic increase of reproductive investment in queens. Here, we compare RJBs to unselected Italian bees (ITBs) to investigate how their cognitive processing of larval signals in the mushroom bodies (MBs) and antennal lobes (ALs) may contribute to their behavioral differences. A cross-fostering experiment confirms that the RJB syndrome is mainly due to a shift in nurse bee alloparental care behavior. Using olfactory conditioning of the proboscis extension reflex, we show that the RJB nurses spontaneously respond more often to larval odors compared with ITB nurses but their subsequent learning occurs at similar rates. These phenotypic findings are corroborated by our demonstration that the proteome of the brain, particularly of the ALs differs between RJBs and ITBs. Notably, in the ALs of RJB newly emerged bees and nurses compared with ITBs, processes of energy and nutrient metabolism, signal transduction are up-regulated, priming the ALs for receiving and processing the brood signals from the antennae. Moreover, highly abundant major royal jelly proteins and hexamerins in RJBs compared with ITBs during early life when the nervous system still develops suggest crucial new neurobiological roles for these well-characterized proteins. Altogether, our findings reveal that RJBs have evolved a strong olfactory response to larvae, enabled by numerous neurophysiological adaptations that increase the nurse bees' alloparental care behavior.

In eukaryotic DNA replication, DNA polymerase ε (Polε) is responsible for leading strand synthesis, whereas DNA polymerases α and δ synthesize the lagging strand. The human Polε (hPolε) holoenzyme is comprised of the catalytic p261 subunit and the noncatalytic p59, p17, and p12 small subunits. So far, the contribution of the noncatalytic subunits to hPolε function is not well understood. Using pre-steady-state kinetic methods, we established a minimal kinetic mechanism for DNA polymerization and editing catalyzed by the hPolε holoenzyme. Compared with the 140-kDa N-terminal catalytic fragment of p261 (p261N), which we kinetically characterized in our earlier studies, the presence of the p261 C-terminal domain (p261C) and the three small subunits increased the DNA binding affinity and the base substitution fidelity. Although the small subunits enhanced correct nucleotide incorporation efficiency, there was a wide range of rate constants when incorporating a correct nucleotide over a single-base mismatch. Surprisingly, the 3'→5' exonuclease activity of the hPolε holoenzyme was significantly slower than that of p261N when editing both matched and mismatched DNA substrates. This suggests that the presence of p261C and the three small subunits regulates the 3'→5' exonuclease activity of the hPolε holoenzyme. Together, the 3'→5' exonuclease activity and the variable mismatch extension activity modulate the overall fidelity of the hPolε holoenzyme by up to 3 orders of magnitude. Thus, the presence of p261C and the three noncatalytic subunits optimizes the dual enzymatic activities of the catalytic p261 subunit and makes the hPolε holoenzyme an efficient and faithful replicative DNA polymerase.

President-elect Donald Trump wants legal authorities to investigate what he said were possibly illegal rumors he is going to sell his majority stock stake in Trump Media. He claims he won't sell.

WASHINGTON, Oct. 30, 2024 — The U.S. Department of the Treasury (Treasury) today issued a final rule (Final Rule) to implement Executive Order 14105 of August 9, 2023, “Addressing United […]

The post US Treasury Issues Final Rule Addressing Investments in Certain National Security Technologies and Products appeared first on HPCwire.

The U.S. Army is investigating the suspected suicides of three soldiers based at New York's Fort Drum.

Billionaire financier John Paulson has declined a likely appointment as U.S Treasury Secretary by President-elect Donald Trump, he announced.

In this fourth installment on the growth in dual-language learning, the director of dual-language education in Portland, Ore., says schools must have a clear reason for why they are offering dual-language instruction.

The student newspaper at duPont Manual High School in Louisville, Ky., first reported on the state's problematic police training material.

Low-intensity transcranial focused ultrasound stimulation (TUS) is a novel technique for noninvasive brain stimulation (NIBS). TUS delivered in a theta (5 Hz) burst pattern (tbTUS) induces plasticity in the human primary motor cortex (M1) for 30–60 min, showing promise for therapeutic development. Metaplasticity refers to activity-dependent changes in neural functions governing synaptic plasticity; depotentiation is the reversal of long-term potentiation (LTP) by a subsequent protocol with no effect alone. Metaplasticity can enhance plasticity induction and clinical efficacy of NIBS protocols. In our study, we compared four NIBS protocol combinations to investigate metaplasticity on tbTUS in humans of either sex. We delivered four interventions: (1) sham continuous theta burst stimulation with 150 pulses (cTBS150) followed by real tbTUS (tbTUS only), (2) real cTBS150 followed by sham tbTUS (cTBS only), (3) real cTBS150 followed by real tbTUS (metaplasticity), and (4) real tbTUS followed by real cTBS150 (depotentiation). We measured motor-evoked potential amplitude, short-interval intracortical inhibition, long-interval intracortical inhibition, intracortical facilitation (ICF), and short-interval intracortical facilitation before and up to 90 min after plasticity intervention. Plasticity effects lasted at least 60 min longer when tbTUS was primed with cTBS150 compared with tbTUS alone. Plasticity was abolished when cTBS150 was delivered after tbTUS. cTBS150 alone had no significant effect. No changes in M1 intracortical circuits were observed. Plasticity induction by tbTUS can be modified in manners consistent with homeostatic metaplasticity and depotentiation. This substantiates evidence that tbTUS induces LTP-like processes and suggests that metaplasticity can be harnessed in the therapeutic development of TUS.

Social protection and decent jobs are cornerstones of agrifood systems transformation, but they require strong political commitment

Forensic anthropologist Doug Owsley discusses the skeletal specimens in a new exhibit at the Natural History Museum (Meredith Bragg). Read more at: https://www.smithsonianmag.com/smithsonian-institution/meet-the-scientist-who-reads-bones-40315000/

Renaissance paintings, medieval archives, cloistered orchards—how one Italian scientist is uncovering secrets that could help combat a growing agricultural crisis

RCMP are investigating after officers discovered human remains in an abandoned, burned vehicle in Greenhill, N.S.

Elections Nova Scotia is investigating PC candidate Susan Corkum-Greek's campaign to determine whether it broke the law by handing out gift cards on Saturday outside a Tim Hortons in Lunenburg, N.S. 

Saskatchewan's Serious Incident Response Team (SIRT) is investigating the role the Moose Jaw Police Service played in a crash that killed a 31-year-old man.

Public Schools Branch director Tracy Beaulieu speaks with CBC News: Compass host Steve Bruce about the money for schools in the new capital budget the province presented last week, and about the work that lies ahead.

A 43-year-old man is dead after being shot by police at a west-end Hamilton apartment building Saturday, in an incident which also sent an officer to hospital, Ontario's police watchdog says. 

Investor pricing reveals expectations for rates, dividends, and inflation.

Ontario Provincial Police (OPP) have released dashcam footage of a crash that sent two people to hospital in life-threatening condition, linked to an ongoing investigation into rocks being thrown at moving vehicles in the GTA.

North American market leader speeds innovation and customization

OM New Zealand builds relationships with churches and cares for the 50-some New Zealanders serving in cross-cultural missions.

Lincoln and Manna from Hong Kong are two of the four candidates to participate in OM EAP’s first Timothy Trek training programme this year.

A News24 reader looks to an expert for guidance on the best investment vehicles for each of her children.

The South African Association of Treasury Advisors highlights the importance of dealing only with an authorised financial services provider when making any investment.

An investment writer at Allan Gray discusses how investors can overcome the fear of losing money.

Gold remains at record highs, but there are various ways to get exposure to the metal that are less cumbersome and more investor-friendly than holding physical gold.

The latest investment insights and market developments.

The latest investment insights and market developments.

The latest investment insights and market developments.

The latest investment insights and market developments.

The Penn State DuBois Office of Student Engagement will welcome students and members of the public to Hiller Auditorium on Thursday, Oct. 17, when paranormal investigator John Zaffis visits campus.

It took less than a week for one of Citigroup's recommended Trump trades to sink under water.

The Government Employees' Pension Fund delivered a return of 4.9% on investments for its members in the year to end-March.

For Roberto Ramirez, serving God in missions has been one step of faith after another.

Governor John Carney, Lt. Governor Bethany Hall-Long and the Department of Services for Children, Youth and Their Families (DSCYF) on Tuesday announced a $16 million investment to renovate and remodel Wharton Hall on the DSCYF campus.

Bitget Wallet and Foresight Ventures have collaborated to invest $20 million (roughly Rs. 168 crore) in Telegram, aiming to accelerate the growth of its Mini Apps initiative, as announced on Monday, November 11.

The 14th Global Investment Immigration Summit at the Shangri-la Hotel in New Delhi on February 10, 2024 marked a significant milestone in India's quest for international opportunities.

Division of Small Business Launches Request for Proposals (RFP) for Travel, Tourism, and Outdoor Recreation Industries WILMINGTON, Del. – Governor John Carney and the Delaware Division of Small Business on Monday announced that the State of Delaware will be investing over $7 million as part of the recovery effort in travel, tourism, and outdoor recreation industries.  […]

Wilmington, Del. (January 26, 2022) – The Delaware Division of the Arts is pleased to announce the launch of the Arts Incubator Project, an assessment, training, and planning initiative built on the principles of Inclusion, Diversity, Equity and Access (IDEA) for the state’s arts industry with a $1.25 million investment in the initiative. “A diverse […]

Funding will link library collections, broaden student access to books and materials DOVER – Students will gain greater access to quality books through school libraries across Delaware with a $1 million state investment announced Tuesday by House Majority Leader Valerie Longhurst and officials from the Delaware Library Consortium. The funds, allocated to the Delaware Division […]

A New Castle County grand jury has indicted a New Castle woman for 53 felonies following the alleged murder of an infant and the abuse of four other children at a Bear daycare facility. Dejoynay Ferguson, 20, is alleged to have suffocated a 4-month-old child to death and to have abused that child and four other children between July […]

Attorney General Jennings announced Tuesday that the Delaware Department of Justice’s Investor Protection Unit is participating in a consolidated nationwide enforcement action to disrupt a fraudulent precious metals scheme that has solicited more than $180 million from seniors and other investors. The Delaware Department of Justice, the U.S. Commodity Futures Trading Commission, and 29 other […]