Background: ⁶⁸Ga PSMA PET CT (PSMA) is increasingly used in men with biochemical recurrence (BCR) post radical prostatectomy (RP), but its longer term prognostic / predictive potential in these men is unknown. The aim of this study was to evaluate the predictive value of PSMA PET for 3 year freedom from progression (FFP) in men with BCR post RP undergoing salvage radiotherapy (sRT). Methods: This prospective multi-center study enrolled 260 men between 2015 and 2017. Eligible patients were referred for PSMA with rising PSA following RP. Management following PSMA was recorded but not mandated. PSMA protocols were standardised across sites and reported prospectively. Clinical, pathological and surgical information, sRT, timing and duration of androgen deprivation (ADT), 3 year PSA results and clinical events were documented. FFP was defined as a PSA rise ≤ 0.2ng/mL above nadir post sRT, with no additional treatment. Results: The median PSA was 0.26ng/mL (IQR 0.15 - 0.59) and follow-up 38 months (IQR 31-43). PSMA was negative in 34.6% (90/260), confined to prostate fossa 21.5% (56/260), pelvic nodes 26.2% (68/260), and distant disease 17.7% (46/260). 71.5% (186/260) received sRT, 38.2% (71/186) to the fossa only, 49.4% (92/186) fossa + pelvic nodes and 12.4% (23/186) nodes alone/SBRT. PSMA was highly predictive of FFP at 3 years following sRT. Overall, FFP was achieved in 64.5% (120/186) of those who received sRT, 81% (81/100) with negative/fossa confined vs. 45% (39/86) for extra fossa disease (p<0.0001). On logistic regression PSMA was more independently predictive of FFP than established clinical predictors, including PSA, T-stage, surgical margin status or Gleason score (P < 0.002). 32% of men with a negative PSMA PET did not receive treatment. Of these, 66% (19/29) progressed, with a mean rise in PSA of 1.59ng/mL over the 3 years. Conclusion: PSMA PET result is highly predictive of FFP at 3 years in men undergoing sRT for BCR following RP. In particular, men with negative PSMA PET or disease identified as still confined to the prostate fossa demonstrate high FFP, despite receiving less extensive radiotherapy and lower rates of additional ADT than those with extra fossa disease.

As policymakers look for ways to address the drivers of illegal immigration, many have called for migration aims to be incorporated into development work and development tools into migration partnerships. This policy brief analyzes the benefits and risks of heightened cooperation between actors in these fields, and identifies areas where joint initiatives may prove fruitful.

WASHINGTON — Latinos and immigrants are at least twice as likely to lack health insurance coverage as the overall population in three central Kansas City metro counties, a new Migration Policy Institute (MPI) study reveals. In fact, they are four times as likely to be uninsured in Johnson County, Kansas. 

WASHINGTON — The U.S. immigration system was dramatically reshaped by the terrorist attacks of September 11, 2001, which shone a harsh spotlight on weaknesses in visa and immigration screening processes. From the creation of the Department of Homeland Security (DHS) to expanded national security protections in immigration and tourism policies, countless changes in the immigration arena have unfolded over the past 19 years.

Female teachers, principals, and superintendents in Pennsylvania earn significantly less money than their male counterparts, a new study shows.

United States. Central Intelligence Agency -- History.

A school leader outlines how research findings on reducing achievement gaps are reflected in practice at her New Mexico school.

Doron's experience on Logos Hope shows him God's faithfulness and uncovers leadership abilities he is using today in a new role.

The Bank for International Settlements (BIS) today announced two key appointments to the BIS Innovation Hub, a new initiative designed to support central bank collaboration on new financial technology. (Press release, 19 February 2020)

The number of cases of COVID-19 in First Nations reserves continues to rise this week, with 161 confirmed positive cases reported as of May 5.

Doron's experience on Logos Hope shows him God's faithfulness and uncovers leadership abilities he is using today in a new role.

Advanced preliminary release for Q4 2019 quarterly data on credit-to-GDP gaps covering 44 economies have been updated. These time-series data show the difference between the credit-to-GDP ratio and its long-run trend, which can serve as an early warning indicator of financial crises. As input, the data used are the credit-to-GDP ratio as published in the BIS database of total credit to the private non-financial sector. The credit series capture total borrowing by the private non-financial sector (ie households and non-financial corporations) from all sources.

SA faces its gravest test in over 70 years, to rebuild an economy that was already in a protracted slump after the ravages of the Covid-19 pandemic. Yet, one could be forgiven for believing there's a wedge between the state's main actors tasked with the job of resurrecting a country that may see its jobless rate rise as high as 50%.

Schools need help from the federal government to prepare millions of U.S. students for remote learning this fall and beyond.

Schools and tech companies in the U.S. and abroad have experience deploying virtual learning should a coronavirus emergency arise.

As black-white achievement gaps widen in schools, so, too, do disparities in discipline rates between black and white students, according to a study published Wednesday of 2,000 schools.

Teachers coming from alternative programs leave the profession at higher rates than their traditionally certified peers, and that gap is growing, a study finds.

Doron's experience on Logos Hope shows him God's faithfulness and uncovers leadership abilities he is using today in a new role.

Academic gender gaps in reading and math follow different paths as American students move from their school years into adulthood, according to new federal data.

Female teachers, principals, and superintendents in Pennsylvania earn significantly less money than their male counterparts, a new study shows.

In spite of stereotypes, gender gaps in math and reading aren't universal. The most comprehensive study to date on gender gaps suggests the size and even the direction of the gaps vary from one school district to another.

A growing number of students have experienced a brain injury that could affect their ability to learn in school. Yet most teachers aren't prepared to work with these students.

Doron's experience on Logos Hope shows him God's faithfulness and uncovers leadership abilities he is using today in a new role.

Doron's experience on Logos Hope shows him God's faithfulness and uncovers leadership abilities he is using today in a new role.

Doron's experience on Logos Hope shows him God's faithfulness and uncovers leadership abilities he is using today in a new role.

Doron's experience on Logos Hope shows him God's faithfulness and uncovers leadership abilities he is using today in a new role.

A new study finds that extracurricular activities have differing positive effects for rural boys compared to girls.

Doron's experience on Logos Hope shows him God's faithfulness and uncovers leadership abilities he is using today in a new role.

Doron's experience on Logos Hope shows him God's faithfulness and uncovers leadership abilities he is using today in a new role.

While it won't be ready until 2022, it will create hundreds of jobs, run on 100 percent renewable energy, and be the first data center to take advantage of a new StatePoint Liquid Cooling system that promises a 50 percent reduction in water use.

Doron's experience on Logos Hope shows him God's faithfulness and uncovers leadership abilities he is using today in a new role.

The United States has gained ground against other countries in a global assessment of teenagers' reading, math, and science skills. That's ironic, though, considering this country has been running in place for years in all three subjects.

Underprivileged kids learn about Jesus through a weekly football programme.

Achievement gaps in math between Latino students and their white counterparts set in before kindergarten, says a new report by Child Trends' Hispanic Institute.

White teachers are generally less optimistic about their black students' chances of obtaining a four-year degree than black teachers—and those lowered expectations could become "self-fulfilling prophecies" when students internalize them or when teachers change their approach to students as a result,

A recent blog post by Walt Gardner ("The Hard Truth About the Achievement Gap," placed the blame for the achievement gap on one group above others: parents.

The non-marital birth rate to women age 24 and under was 71 percent in 2017. Here's what that means for educational outcomes and schools, according to guest blogger Ian Rowe.

Flipped classrooms have been getting attention as a way for teachers to find more time for activities and individual support during the regular school day, but a new study cautions that the model could trade short-term gains for wider achievement gaps.

Does a student have a fixed or a growth mindset? That's the wrong question for us to measure, argues researcher Dave Paunesku.

In 50 years, the achievement gap has been unchanged, with the poorest 10 percent of students performing three to four years behind the wealthiest 10 percent of peers, finds a new study in the journal Education Next.

As black-white achievement gaps widen in schools, so, too, do disparities in discipline rates between black and white students, according to a study published Wednesday of 2,000 schools.

What we call education inequality defines how—and even if—we solve it, write three researchers.

A new analysis finds that high-poverty schools are the least effective. But why those schools stifle achievement is harder to figure out.