Formula 1 is to introduce a device to cool drivers when conditions become too extreme in hot weather, in response to scenes at last year’s Qatar Grand Prix.

Irish mixed martial artist Conor McGregor claimed to have had consensual sex with a woman who is accusing him of rape, a court has heard.

1. John Krasinski reveals wife Emily Blunt's reaction to his Sexiest Man Alive title  Hindustan Times
2. Actor John Krasinski Named 'Sexiest Man Alive' Of 2024 By People Magazine  NDTV
3. Is Jim from The Office really the sexiest man in the world?  The Guardian
4. Not Shah Rukh Khan, Hrithik Roshan, Leonardo Dicaprio, Chris Evans, or Tom Cruise, THIS actor is the sexiest  India.com
5. John Krasinski Is PEOPLE's 2024 Sexiest Man Alive!  PEOPLE

Filed under: Food and Drink, North America, United States

• Regardless of the area's suitability for growing grapes, plop down a vineyard or winery and travelers will come for a taste and buy a sympathy bottle (pro tip: go for the ice wine as it's harder to mess up)
• Ski resorts looking to attract off-season dollars or stale attractions looking to draw media coverage and visitors hook up a zipline

Continue reading Vineyard and Zipline Trends Collide at the Pinot Express

Vineyard and Zipline Trends Collide at the Pinot Express originally appeared on Gadling on Wed, 11 Dec 2013 16:54:00 EST. Please see our terms for use of feeds.

With new faces on the team, Spring Training is a time for excitement, but the Rockies had October in mind with their one big offseason signing: Daniel Murphy for two years and $24 million.

Rockies left-hander Kyle Freeland plans to expand his arsenal and attack hitters in every quadrant of the strike zone this season.

The prefrontal cortex is critical for decision-making across species, with its activity linked to choosing between options. Drift diffusion models (DDMs) are commonly employed to understand the neural computations underlying this behavior. Studies exploring the specific roles of regions of the rodent prefrontal cortex in controlling the decision process are limited. This study explored the role of the prelimbic cortex (PLC) in decision-making using a two-alternative forced-choice task. Rats first learned to report the location of a lateralized visual stimulus. The brightness of the stimulus indicated its reward value. Then, the rats learned to make choices between pairs of stimuli. Sex differences in learning were observed, with females responding faster and more selectively to high-value stimuli than males. DDM analysis found that males had decreased decision thresholds during initial learning, whereas females maintained a consistently higher drift rate. Pharmacological manipulations revealed that PLC inactivation reduced the decision threshold for all rats, indicating that less information was needed to make a choice in the absence of normal PLC processing. μ-Opioid receptor stimulation of the PLC had the opposite effect, raising the decision threshold and reducing bias in the decision process toward high-value stimuli. These effects were observed without any impact on the rats’ choice preferences. Our findings suggest that PLC has an inhibitory role in the decision process and regulates the amount of evidence that is required to make a choice. That is, PLC activity controls "when," but not "how," to act.

Basolateral amygdala (BLA) neurons are engaged by emotionally salient stimuli. An area of increasing interest is how BLA dynamics relate to evolving reward-seeking behavior, especially under situations of uncertainty or ambiguity. Here, we recorded the activity of individual BLA neurons in male rats across the acquisition and extinction of conditioned reward seeking. We assessed ongoing neural dynamics in a task where long reward cue presentations preceded an unpredictable, variably time reward delivery. We found that, with training, BLA neurons discriminated the CS+ and CS– cues with sustained cue-evoked activity that correlated with behavior and terminated only after reward receipt. BLA neurons were bidirectionally modulated, with a majority showing prolonged inhibition during cued reward seeking. Strikingly, population-level analyses revealed that neurons showing cue-evoked inhibitions and those showing excitations similarly represented the CS+ and behavioral state. This sustained population code rapidly extinguished in parallel with conditioned behavior. We next assessed the contribution of the orbitofrontal cortex (OFC), a major reciprocal partner to the BLA. Inactivation of the OFC while simultaneously recording in the BLA revealed a blunting of sustained cue-evoked activity in the BLA that accompanied reduced reward seeking. Optogenetic disruption of BLA activity and OFC terminals in the BLA also reduced reward seeking. Our data indicate that the BLA represents reward-seeking states via sustained, bidirectional cue-driven neural encoding. This code is regulated by cortical input and is important for the maintenance of vigilant reward-seeking behavior.

OM teaches East London youth about the persecuted Christians in the world, as well as trains them in street ministry.

Subic Bay, Philippines :: Local volunteers share their stories and experiences on Logos Hope.

Women caught in the sex industry find new life through Nea Zoi, a partner organisation, which reaches out to sex workers in Athens.

An OM Greece worker explains, while she is babysitting, how she helps ladies involved in human trafficking and the sex industry.

OM uses an educational programme called KidsGames to share Bible stories in a public school.

The Mena Travelling Team has their first outreach, travelling throughout the MENA region and doing whatever it takes to share the Gospel with the unreached.

How God called Andrea from Italy to leave his comfort zone during the Transform conference and his experience with OM Lifehope in the UK.

A new OM Italy team member participates in an English Scout Camp, which brings the Gospel to children and gives her new cultural insight.

Penang, Malaysia :: A group of youngsters come to Logos Hope for a three day youth camp.

The varied teaching styles at Teenstreet Malaysia 2016 helped teens to connect with the theme of discovering their identity.

OM Czech Republic participates in Mission Weekend, an annual event to encourage Czech Christians to engage in missions.

The ministry of helping women involved in the sex industry aims to support those trafficked in Czech Republic by building relationships and prayer

As OM Czech Republic team members reach out to sex workers by visiting a brothel regularly, they are able to establish friendships and talk about God and His care for the women there, and offer them Christmas gifts, which touch hearts.

Three hundred people interested in sports ministry gathered in Ecuador in April for a forum organised by the Coalición Internacional del Deporte.

Cartagena, Colombia :: Logos Hope partners with Youth With A Mission (YWAM) in an outreach to a troubled community.

OM Belgium and OM Arts creatively connect with the local community through drawings, song, poetry and flowers.

Gujarat Titans have entrusted former India keeper-batter Parthiv Patel with the dual responsibility of serving as their assistant and batting coach in the upcoming IPL

Indian cricket team star batters Virat Kohli and Rohit Sharma faced a lot of criticism from fans as well as experts following their poor show in the Test series against New Zealand.

If you don't know about the role and make-up of a digital team, and how it can impact customer experience and brand success, Matt Harris of Sendwithus has the answers

Here's a collection of recent DMN content that exemplifies successful omnichannel strategies, as well as a few tips to help bring omnichannel mainstream

1. John Krasinski revealed as People magazine's Sexiest Man Alive after Benny Blanco confusion; fans are relieved  Hindustan Times
2. John Krasinski reveals wife Emily Blunt's reaction to his Sexiest Man Alive title  Hindustan Times
3. Not Shah Rukh Khan, Hrithik Roshan, Leonardo Dicaprio, Chris Evans, or Tom Cruise, THIS actor is the sexiest  India.com
4. Actor John Krasinski Named 'Sexiest Man Alive' Of 2024 By People Magazine  NDTV
5. Is Jim from The Office really the sexiest man in the world?  The Guardian

Officials of Biñan City have been ordered to respond to a complaint filed by residents regarding a reclamation project in Laguna de Bay.

The Sandiganbayan has acquitted former Food and Drug Administration chief Nela Charade Puno of graft, which stemmed from a raid and closure by the FDA of a pharmacy and wellness center in Tarlac.

Vitals inquiry expert Miroslava Milenović faces heated scrutiny over qualifications and methods for her role in uncovering complex financial links

The index was designed to quantify the specific vulnerabilities faced by countries, especially small island developing states

MANILA, Philippines — Former President Rodrigo Duterte has defied the appeal made by her daughter—Vice President Sara Duterte—that the ex-leader be excused from the House of Representatives’ quad committee hearing as it is already getting late. When the quad committee hearing on Wednesday was suspended at 9:10 p.m., Vice President Duterte approached lead presiding officer and Surigao del Norte Rep. Robert Ace Barbers, Santa Rosa City Rep. Dan Fernandez, Senior Deputy Speaker Aurelio Gonzales Jr., and Deputy Speaker David Suarez to discuss something. READ: Ex-President Duterte shows up at House quad comm drug war hearing After some time, Barbers asked […]...

Keep on reading: Duterte defies VP Sara’s appeal to excuse him from hearing

MANILA, Philippines — A specialist from the state weather bureau pointed to the ridge of a high pressure area located north of the country as a factor behind the recent string of tropical cyclones to strike Northern Luzon. The region saw Severe Tropical Kristine (International name: Trami) make landfall in Isabela on Oct. 24, Typhoon Marce (Yinxing) in Cagayan on Nov. 7, and Typhoon Nika (Toraji) in Aurora on Nov. 11. Further, while Super Typhoon Leon (Kong-rey) made landfall in Taiwan, the cyclone brought inclement weather over Northern Luzon until it exited the Philippine area of responsibility (PAR) on Nov. […]...

Keep on reading: Pagasa explains why recent typhoons tend to only hit Northern Luzon

Opponents of the bill claimed it would have targeted pro-Palestinian organizations that facilitate aid to Gaza.

Hezbollah’s drones were “ultimately,” the terrorist organization’s “trump card,” despite rockets being employed as their “main weapons.”

The Al-Quds Brigades, the military wing of the Palestinian Islamic Jihad, published the video in multiple groups on Telegram.

Mojtaba Amani, the Islamic Republic’s ambassador to Lebanon, himself badly injured by the pager incident, justified the purchase by quoting the ‘weakness of the Lebanese state’.

• Govt objects to repeal of prison rules for PTI founder
• Imran booked in 54 cases across Punjab, LHC told

LAHORE/ISLAMABAD: An anti-terrorism court (ATC) on Tuesday disposed of pre-arrest bail petitions of eight PTI activists in the case regarding an attack on the Lahore corps commander’s residence after police declared them innocent in the investigation.

ATC-I Judge Manzer Ali Gill was hearing the bail petitions of 32 activists when a prosecutor stated that a joint investigation team (JIT), formed to probe the May 9 incidents, had exonerated eight of the petitioners for lack of evidence.

At this, the lawyer for the activists sought the court permission to withdraw their bail petitions.

The judge adjourned the bail petitions of other activists till Dec 11 and 13, asking them to join the JIT investigation.

The judge allowed the request and disposed of the petitions of Tanzila Imran, Ri­­zwana Ghazanfar, Makiya Saeed, Shah­baz Amir Ali, Farooq Ahmad, Usman Naveed, Zirk Khan and Mian Ahmad Rehman.

Sarwar Road police of Lahore had registered a case against PTI leaders and workers for attacking the Lahore corps commander house, also known as Jinnah House, on May 9 last year.

Separately, ATC-III Judge Arshad Javed adjourned the hearing of post-arrest bail petitions by the PTI leaders, including Shah Mahmood Qureshi, Dr Yasmin Rashid and Mian Mehmoodur Rasheed, in May 9 cases.

The judge directed the petitioners’ lawyers to conclude their arguments on the next hearing; otherwise, the petitions would be decided on the basis of police record.

The judge postponed the pleas of Rasheed till Nov 12, Dr Yasmin till Nov 13 & 16, and Qureshi till Nov 19.

The bench, comprising Chief Justice Aamer Farooq and Justice Saman Rafat Imtiaz, issued a notice to Advocate Sher Afzal Marwat on whose petition the section was set aside, seeking his response.

Prison rules

Meanwhile, a two-member division bench of the Islamabad High Court (IHC) took up the petition of the chief commissioner Islamabad against setting aside of Section 265 of the Punjab Prison Rules that prohibits political discussion during prisoner meetings with visitors.

The plea contested Justice Sardar Ejaz Ishaq Khan’s verdict, which had struck down Section 265.

Advocate General Islamabad Ayaz Shaukat argued that the IHC lacked jurisdiction to intervene in Punjab’s laws and maintained that the single bench did not have the authority to nullify provisions in the Punjab Prison Rules.

Chief Justice Farooq asked, “So, you are saying that the Islamabad High Court cannot interfere in any provincial law?”

Justice Imtiaz noted that the Punjab Prison Rules are also applicable to prisoners in Isla­mabad, suggesting an overlap in jurisdiction.

The CJ inquired whether a formal notice under Section 27A was issued to the attorney general or the advocate general by the single bench, a requirement before declaring any law invalid.

While the advocate general said he had been summoned, he acknowledged that a formal notice was not issued.

Advocate General Shaukat requested the immediate suspension of the single bench’s decision, but Chief Justice Farooq scheduled a formal hearing for the next week.

Justice Farooq Haider was hearing a petition filed by Imran’s sister, Noreen Niazi, challenging the non-disclosure of the cases’ details against her brother.

Cases against Imran

Also on Tuesday, Punjab Police told the La­­­hore High Court that 54 criminal cases, in­­cluding those related to May 9, had been registered against PTI founding chairman Imran Khan in different cities of the province.

An additional advocate general presented a report on behalf of the inspector general of police, revealing that 21 cases were registered in Lahore, 19 in Rawalpindi, seven in Sheikhupura, five in Faisalabad and one each in Gujranwala and Mianwali.

The cases include attacks on the Jinnah House, Askari Tower at Liberty Roundabout, General Headquarters in Rawalpindi and office of an intelligence agency in Faisalabad. A law officer for the Federal Investigation Agency (FIA) sought additional time to provide details of the cases, if any, against Imran Khan.

The judge allowed the request and adjourned further hearing till Nov 20.

Published in Dawn, November 13th, 2024

1. Actor John Krasinski Named 'Sexiest Man Alive' Of 2024 By People Magazine  NDTV
2. Celebs crowned Sexiest Man Alive in last ten years: John Krasinski, Patrick Dempsey, Paul Rudd, to Idris Elba  Hindustan Times
3. Is Jim from The Office really the sexiest man in the world?  The Guardian
4. John Krasinski Is PEOPLE's 2024 Sexiest Man Alive!  PEOPLE
5. John Krasinski chosen as Sexiest Man Alive but fans have declared these stars as Sexiest Musician and Sexi  The Economic Times

1. Oncologist stabbed at Chennai govt hospital ‘by 26-year-old whose mother is undergoing cancer treatment’  The Indian Express
2. Video: Chennai man calmly walks away after stabbing doctor, wipes knife  India Today
3. Indian Medical Association condemns brutal attack on doctor in Chennai  The New Indian Express
4. Daylight assault on doctor inside Chennai hospital leaves medical fraternity in shock  The Hindu
5. 'No law and order': BJP, AIADMK attack ruling DMK after government doctor stabbed in Chennai  The Times of India

Background

Asthma exacerbations in children pose a significant burden on healthcare systems and families. While traditional risk assessment tools exist, artificial intelligence (AI) offers the potential for enhanced prediction models.

Background

Lung cancer ranks as the leading cause of cancer-related deaths worldwide. There is evidence that second-hand smoke (SHS) exposure is a risk factor for the development of lung cancer in never-smokers. This systematic review and meta-analysis aims to provide the most accurate quantification of the association between SHS exposure and lung cancer risk in never-smokers.

Extracellular vesicles (EVs) released by various cells play crucial roles in intercellular communication within the respiratory system. This review explores the historical context and significance of research into extracellular vesicles. Categorised into exosomes (sized 30–150 nm), microvesicles (sized 50–1000 nm) and apoptotic bodies (sized 500–2000nm), based on their generation mechanisms, extracellular vesicles carry diverse cargoes of biomolecules, including proteins, lipids and nucleic acids. Respiratory ailments are the primary contributors to both mortality and morbidity across various populations globally, significantly impacting public health. Recent studies have underscored the pivotal role of extracellular vesicles, particularly their cargo content, in mediating intercellular communication between lung cells in respiratory diseases. This comprehensive review provides insights into extracellular vesicle mechanisms and emphasises their significance in major respiratory conditions, including acute lung injury, COPD, pulmonary hypertension, pulmonary fibrosis, asthma and lung cancer.

Scammers are using increasingly sophisticated ways to lure unsuspecting victims, and some are impersonating an email help desk or support team.

Stay up to date on the latest AI technology advancements and learn about the challenges and opportunities AI presents now and for the future.

1. Garena Free Fire MAX Redeem Codes for November 12: Claim Exclusive Rewards Today!  The Hans India
2. Garena Free Fire MAX redeem codes for November 12: Win free diamonds, skins, and more  The Times of India
3. Garena Free Fire MAX Redeem Codes Today, November 13: Win Free Gifts, Skins And Much More  Jagran English
4. Free Fire Mystery Shop: Rewards, duration, and more  Sportskeeda
5. Garena Free Fire MAX redeem codes for November 13, 2024: Win bundles, new outfits, and more rewards...  Moneycontrol

1. Market crash: Investors become poorer by ₹13 lakh crore; Sensex tanks 2.27% in two days  The Hindu
2. Bloodbath on D-street: Investors lose Rs 13 lakh crore in last 2 days- Top reasons why market is falling  The Times of India
3. Nifty Drops 2,718 Points From Record High, Hits Below 200-DEMA; What Is Next Target And How To Invest?  Goodreturns
4. 'Everything is being cut,' says Basant Maheshwari as market goes into correction phase; key reasons behind today's fall  Business Today
5. Ahead of Market: 10 things that will decide stock action on Thursday  The Economic Times

1. COP29: Small victory as nations approve new carbon market rules, standards  The Indian Express
2. COP29 begins in Azerbaijan: Everything you need to know  The Indian Express
3. Developed nations need to triple their contribution to make climate finance credible: Avinash Persaud  The Hindu
4. COP29 gets momentum with consensus on creation of carbon credits standards, India wants to conclude work  The Times of India
5. UN Climate Draft Shows Deep Divide On Funding For Poorer Nations At COP29  NDTV