Gov. Cuomo is down with Robert De Niro portraying him in a movie about the coronavirus pandemic, should there be one, and he also took a moment to play the role of the Manhattan-born actor.

Elon Musk is in a bind — perhaps the tightest bind of his business career.

Less than two months after touting a plan to put driverless taxis on the road, Tesla Chief Executive Elon Musk on Tuesday walked back the ambitious timetable.

Waymo wants to deploy a robotaxi service for the general public in parts of California as soon as possible.

What's on TV Monday, April 27: Season finale of 'Breeders' on FX; coronavirus; Axios returns; Movies on TV; TV Talk Shows; 'Dispatches From Elsewhere' season finale

On 17 February 2020 Express.co.uk published an article headlined "Amazon withdraws several child car seats from UK sale after safety risk revealed".

FLUFFY bedding, bowls of treats and a dog shammy awaited our Labrador, Tehya, when we rolled up at Dominoes holiday home in Stoke Gabriel, South Devon - and it wasn't too shabby for Tehya's two-legged friends either, having been luxuriously refurbished just a couple of years ago.

A union representing taxi drivers estimates 80,000 "are in danger of becoming destitute" in lockdown.

The SeaBubble is a new form of urban transportation that could offer Parisians a watery alternative to hailing a taxi, driving a car or hopping on an electric scooter.

Viviane Baladi and Mark F. Demers
J. Amer. Math. Soc. 33 (2020), 381-449.
Abstract, references and article information

Jürgen Cox
Sep 1, 2014; 13:2513-2526
Technological Innovation and Resources

Researcher: Hamsa Balakrishnan, MIT. Hamsa Balakrishnan talks about her work to shorten airport runway queues.

Takahito Kashiwabara and Tomoya Kemmochi
Math. Comp. 89 (2020), 1647-1679.
Abstract, references and article information

Changfeng Gui, Kelei Wang and Jucheng Wei
Trans. Amer. Math. Soc. 373 (2020), 3649-3668.
Abstract, references and article information

L. Bernal-González, H. J. Cabana-Méndez, G. A. Muñoz-Fernández and J. B. Seoane-Sepúlveda
Trans. Amer. Math. Soc. 373 (2020), 3063-3083.
Abstract, references and article information

S. S. Lohvinenko and K. V. Ralchenko
Theor. Probability and Math. Statist. 99 (2020), 149-168.
Abstract, references and article information

Shi-Zhong Du
Proc. Amer. Math. Soc. 148 (2020), 2631-2643.
Abstract, references and article information

Naoya Hiramatsu and Ryo Takahashi
Proc. Amer. Math. Soc. 148 (2020), 2359-2369.
Abstract, references and article information

(Queensland University of Technology) Your house number could be the key to the safe relaxation of COVID-19-related restrictions if governments follow a new exit strategy proposal published today in the British Medical Journal. Co-authored by QUT statistician Professor Adrian Barnett, the paper proposes the use of an 'odds-and-evens' approach to allowing people to head back to work and enjoy other activities after weeks of lockdown.

(University of Arkansas) Giant elliptical galaxies are not as likely as disk-shaped galaxies, such as our own Milky Way, to be cradles of technological civilizations, according to a recent paper by a University of Arkansas astrophysicist.

Matt Egan takes us where no other pod has dared gone before (September 2000) and asks Digital Arts Editor Neil Bennett if anyone cares that Nokia is rereleasing the famous 3310. Is it cool to rock one now? Then Techworld Audience Development Editor Christina Mercer lets us know that the future is already here with self driving drone taxis. Would you hitch a lift round Dubai on a massive quadcopter? Finally Deputy Editor at Macworld David Price ruminates on Apple's forecast foray into the world of snackable media content - will it challenge Netflix or try to buy it?  

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GPR120 is implicated as a lipid receptor in the oro-sensory detection of dietary fatty acids. However, the effects of GPR120 activation on dietary fat intake or obesity are not clearly understood. We investigated to determine whether the binding of TUG891, a novel GPR120 agonist, to lingual GPR120 modulates fat preference in mice. We explored the effects of TUG891 on obesity-related hormones and conducted behavioral choice tests on mice to better understand the physiologic relevance of the action of TUG891. In cultured mouse and human taste bud cells (TBCs), TUG891 induced a rapid increase in Ca²⁺ by acting on GPR120. A long-chain dietary fatty acid, linoleic acid (LA), also recruited Ca²⁺ via GPR120 in human and mouse TBCs. Both TUG891 and LA induced ERK1/2 phosphorylation and enhanced in vitro release of glucagon-like peptide-1 from cultured human and mouse TBCs. In situ application of TUG891 onto the tongue of anesthetized mice triggered the secretion of pancreatobiliary juice, probably via the tongue-brain-gut axis. Furthermore, lingual application of TUG891 altered circulating concentrations of cholecystokinin and adipokines, associated with decreased circulating LDL, in conscious mice. In behavioral tests, mice exhibited a spontaneous preference for solutions containing either TUG891 or LA instead of a control. However, addition of TUG891 to a solution containing LA significantly curtailed fatty acid preference. Our study demonstrates that TUG891 binds to lingual GPR120 receptors, activates the tongue-brain-gut axis, and modulates fat preference. These findings may support the development of new fat taste analogs that can change the approach to obesity prevention and treatment.

Lipid droplets (LDs) are frequently increased when excessive lipid accumulation leads to cellular dysfunction. Distinct from mouse beta cells, LDs are prominent in human beta cells, however, the regulation of LD mobilization (lipolysis) in human beta cells remains unclear. We found that glucose increases lipolysis in non-diabetic human islets, but not in type 2 diabetic (T2D) islets, indicating dysregulation of lipolysis in T2D islets. Silencing adipose triglyceride lipase (ATGL) in human pseudoislets (shATGL) increased triglycerides, and the number and size of LDs indicating that ATGL is the principal lipase in human beta cells. In shATGL pseudoislets, biphasic glucose-stimulated insulin secretion (GSIS) and insulin secretion to IBMX and KCl were all reduced without altering oxygen consumption rate compared with scramble control. Like human islets, INS1 cells showed visible LDs, glucose responsive lipolysis, and impairment of GSIS after ATGL silencing. ATGL deficient INS1 cells and human pseudoislets showed reduced Stx1a, a key SNARE component. Proteasomal degradation of Stx1a was accelerated likely through reduced palmitoylation in ATGL deficient INS1 cells. Therefore, ATGL is responsible for LD mobilization in human beta cells and supports insulin secretion by stabilizing Stx1a. The dysregulated lipolysis may contribute to LD accumulation and beta cell dysfunction in T2D islets.

Lipid droplets (LDs) are frequently increased when excessive lipid accumulation leads to cellular dysfunction. Distinct from mouse beta cells, LDs are prominent in human beta cells, however, the regulation of LD mobilization (lipolysis) in human beta cells remains unclear. We found that glucose increases lipolysis in non-diabetic human islets, but not in type 2 diabetic (T2D) islets, indicating dysregulation of lipolysis in T2D islets. Silencing adipose triglyceride lipase (ATGL) in human pseudoislets (shATGL) increased triglycerides, and the number and size of LDs indicating that ATGL is the principal lipase in human beta cells. In shATGL pseudoislets, biphasic glucose-stimulated insulin secretion (GSIS) and insulin secretion to IBMX and KCl were all reduced without altering oxygen consumption rate compared with scramble control. Like human islets, INS1 cells showed visible LDs, glucose responsive lipolysis, and impairment of GSIS after ATGL silencing. ATGL deficient INS1 cells and human pseudoislets showed reduced Stx1a, a key SNARE component. Proteasomal degradation of Stx1a was accelerated likely through reduced palmitoylation in ATGL deficient INS1 cells. Therefore, ATGL is responsible for LD mobilization in human beta cells and supports insulin secretion by stabilizing Stx1a. The dysregulated lipolysis may contribute to LD accumulation and beta cell dysfunction in T2D islets.

Maximum Powerful Obat Kuat Pria adalah ramuan herbal alami yang berkhasiat sebagai obat kuat tahan lama,serta mengatasi ejakulasi dini, impotensi dan dll

With the emergence of sofobuvir, a new direct acting antiviral, treatment for Hepatitis C infection is currently undergoing it's greatest change since the discovery of the virus 25 years ago. However Gilead, who manufacture the treatment, are under fire for the cost of the druge - around $90 000 for a course of treatment. Victor Roy, doctoral...

Many taxi and bus operators in sections of Kingston and St Andrew are seemingly adhering to social-distancing guidelines outlined by the Government for the sector, in terms of the number of passengers they are allowed to transport at a time. These...

A report release and presentation of first-ever U.S. estimates on the actual economic costs of skill underutilization for immigrants, their families, and the U.S. economy, in terms of forgone earnings and unrealized federal, state, and local taxes.

OBJECTIVE

To examine differences in myocardial blood flow (MBF) at rest and during stress between patients with type 2 diabetes and controls, and to identify potential predictors of changes in MBF at rest and during stress.

Time -- Philosophy.

Dementia -- Treatment.

Stuttgart : Enke, 1899.

Stuttgart : F. Enke, 1883.

Breslau : Preuss & Junger, 1897.

Berlin : A. Hirschwald, 1870.

Berlin : J. Springer, 1897.

Berlin : J. Springer, 1894.

Berlin : A. Hirschwald, 1900.

Leipzig : C.F. Winter, 1861.

Leipzig : W. Engelmann, 1862.

Berlin : Hirschwald, 1876.

Halle : M. Niemeyer, 1895.

Tubingen : H. Laupp, 1867.

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François Bachoc, José Betancourt, Reinhard Furrer, Thierry Klein.

Source: Electronic Journal of Statistics, Volume 14, Number 1, 1962--2008.

Abstract:
The asymptotic analysis of covariance parameter estimation of Gaussian processes has been subject to intensive investigation. However, this asymptotic analysis is very scarce for non-Gaussian processes. In this paper, we study a class of non-Gaussian processes obtained by regular non-linear transformations of Gaussian processes. We provide the increasing-domain asymptotic properties of the (Gaussian) maximum likelihood and cross validation estimators of the covariance parameters of a non-Gaussian process of this class. We show that these estimators are consistent and asymptotically normal, although they are defined as if the process was Gaussian. They do not need to model or estimate the non-linear transformation. Our results can thus be interpreted as a robustness of (Gaussian) maximum likelihood and cross validation towards non-Gaussianity. Our proofs rely on two technical results that are of independent interest for the increasing-domain asymptotic literature of spatial processes. First, we show that, under mild assumptions, coefficients of inverses of large covariance matrices decay at an inverse polynomial rate as a function of the corresponding observation location distances. Second, we provide a general central limit theorem for quadratic forms obtained from transformed Gaussian processes. Finally, our asymptotic results are illustrated by numerical simulations.