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Use of ionic liquids in amidation reactions for proteolysis targeting chimera synthesis

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00304G, Paper
Michela Eleuteri, Jenny Desantis, Gabriele Cruciani, Raimondo Germani, Laura Goracci
Selective degradation of disease-causing proteins using proteolysis targeting chimeras (PROTACs) has gained great attention, thanks to its several advantages over traditional therapeutic modalities.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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New Generation of Highly Reactive Allylborating Agents For Cu(I)-Catalyzed Allylation of Chiral Sulfinylimines

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00291A, Paper
Michael S. Alexeev, Tatyana V. Strelkova, Michail M. Ilyin, Jr., Yulia V. Nelyubina, Ivan A. Bespalov, Michael Medvedev, Victor N Khrustalev, Nikolai Kuznetsov
The implementation of selective catalytic processes with highly active reagents is an attractive strategy that meets modern principles of sustainable development of chemistry. In the current study, we for the...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Those magnificent flying machines

The aviation industry’s roller-coaster ride




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Chicken gun test: Saving jets from bird strikes

According to ICAO, at least 34 bird strikes happen every day, causing around $1 billion worth damages every year




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Google’s moneymaking machine still pumping out massive profits despite multiple threats

Google is still thriving while the company navigates through a pivotal shift to artificial intelligence and battles regulators trying to topple its internet empire




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OpenAI builds first chip with Broadcom and TSMC, scales back foundry ambition

OpenAI is working with Broadcom and TSMC to build its first in-house chip designed to support its artificial intelligence systems, per sources




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Chinese researchers develop AI model for military use on back of Meta's Llama

ChatBIT was fine-tuned and "optimised for dialogue and question-answering tasks in the military field", the paper said




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WHO to evacuate 1,000 Gazan women, children for urgent medical care

Last week, U.N. investigators said Israel was deliberately targeting health facilities in Gaza, and killing and torturing medical personnel there, accusing the country of "crimes against humanity".




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Over 77 per cent of India’s children lack WHO-suggested diversity in diet, study finds

The states of Uttar Pradesh, Rajasthan, Gujarat, Maharashtra and Madhya Pradesh reported the highest levels of inadequate diversity in children's diets -- all above 80 per cent -- while Sikkim and Meghalaya were the only two to report an under-50 per cent prevalence




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Air passenger with suspected mpox symptoms isolated at Tiruchi govt. hospital

When contacted, a senior hospital official told The Hindu that the patient’s blood sample has been sent for further testing




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Tiruchi man with mpox symptoms: Sample has returned negative, says Tamil Nadu Health Minister

The man, who had returned from Sharjah on October 31, was found to have fever during screening on arriving at the Tiruchi airport.




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WHO says strike on Gaza polio vaccination centre wounds four children

The World Health Organization’s chief Tedros Adhanom Ghebreyesus said the health centre was “in an area where a humanitarian pause was agreed to allow vaccination to proceed” and that the attack could put off parents of children needing a second vaccine




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How can AI, ML skills help sharpen problem-solving abilities in children?

As the world is rapidly moving towards the evolving digital space, skills like problem-solving have become more important than ever. The entire market size of AI is projected to grow from USD 214.6 billion in 2024 to 1,339.1 billion in 2030 with a CAGR of 35.7%. In Today's scenario, skills like problem-solving are not just limited to professionals, it becomes crucial to teach kids how to think critically and creatively to steer through the complexities of modern life. This not only sharpens their abilities but also boosts innovation and helps develop young minds to use tools needed to solve real-world problems.




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Anusha’s impressive Kuchipudi

A rich Kuchipudi repertoire was put together by Anusha and her troupe.




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Life skill coaching, moving from experiential avoidance to psychological flexibility




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From CEO to Chief Purpose Officer

If companies are to think beyond profits, chief executives must lead from the front




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From soaps to lip balms: How demand for donkey milk has kicked off a farming revolution in Tiruchi district

Once a ubiquitous beast of burden, the donkey is slowly making its way out of oblivion in Tiruchi as the global beauty industry discovers the benefits of its milk




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Chickpea imports unlikely to ease prices, yellow peas seen as substitute

Limited availability of chickpeas in the world market could force India to import of yellow peas, which are available in abundance, say officials




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Homegrown chic

Lakme Fashion Week Summer/Resort 2018 featured menswear that focussed on sustainable homegrown fabrics and indigenous silhouettes




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The new machine in town

A new power-packed version of the Audi R5 changes a good thing for the better




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Embracing relational teaching [electronic resource] : how strong relationships promote student self-regulation and efficacy / Anthony R. Reibel.

Bloomington, IN : Solution Tree Press, [2023]




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Equity and inclusion in higher education [electronic resource] : strategies for teaching / edited by Rita Kumar and Brenda Refaei.

Cincinnati : University of Cincinnati Press, 2021.




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Everyday artfulness [electronic resource] : a posthuman perspective on young children's play with materials / Lucy Hill.

Oxford ; New York : Peter Lang, [2024]




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How successful schools are more than effective [electronic resource] : principals who build and sustain teacher and student wellbeing and achievement / Christopher Day, David Gurr, editors

Cham : Springer, [2024]




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Neurodevelopment in the post-pandemic world [electronic resource] : the altered trajectory of children's education, mental health, and brain development / Molly Colvin, Jennifer Linton Reesman, Tannahill Glen.

New York, NY : Oxford University Press, [2024]




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How Kalki penned Ponniyin Selvan dipping into archival books in an old steel trunk

For the historical book, the author travelled widely across Tamil Nadu and Sri Lanka




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Malayalam scenarist and theatre practitioner Gopan Chidambaram on writing ‘Thuramukham’ and ‘Iyobinte Pusthakam’

TheWriter of two of the best period dramas in the recent history of Malayalam cinema, Gopan Chidambaram talks speaks about how Thuramukham, a play written by his father in 1968, was adapted to the screen and why he often gravitates towards historical tales




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Protests against the screening of ‘The Kerala Story’ in Kochi

The screenings at two other multiplexes in Kochi were cancelled




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Alice Birch’s adaptation of David Cronenberg’s ‘Dead Ringers’ converts the anarchic physicality of childbirth into something laboratory-like

The Mantle twins want to “change the way women give birth” — the body horror subgenre has always been nimble and alert to the red-button political issues of the day




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Nandini Reddy on ‘Anni Manchi Sakunamule’: I remembered the warmth of my grandmother’s palm

B V Nandini Reddy, director of the Telugu film ‘Anni Manchi sakunamule’, talks about understanding relationships across age groups and what she learnt from Sooraj Barjatya films




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Apple rolls out new AirPods, Mac chips, MacBook pros

Apple introduced two chips -the M1 Pro and the M1 Max in the new MacBook Pro 14 and 16-inch models



  • Computers & Laptops

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The invention of chic : Thérèse Bonney and Paris Moderne / Lisa Schlansker Kolosek ; with 188 illustrations.

New York : Thames & Hudson in association with Cooper-Hewitt, National Design Museum, Smithsonian Institution, 2002.




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Suzy Embo : foto's = photos, 1953-1980 / textes, Ivan Alechine, Tamara Berghmans, Ann Deckers, Pieter De Reuse.

Bruxelles : CFC-Editions, [2017]




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Hong Kong poems in English and Chinese / by Andrew Parkin and Laurence Wong ; with translations by Evangeline Almberg [and three others].

Vancouver : Ronsdale Press, 1997.




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Daughter of Shanghai / Tsai Chin.

London : Chatto & Windus, 1988.




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The PHD movie (2011) / directed by Vahe Gabuchian [DVD].

[U.S.A.] : Piled Higher and Deeper Publishing, LLC, [2012]




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The strange cases of Magistrate Pao/ translated from the Chinese and retold by Leon Comber, illustrations by Lo Koon-Chiu.

Tokyo : Charles E. Tuttle Company, [1964]




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Pien Chih-lin : a study in modern Chinese poetry / Lloyd Haft.

Dordrecht, Holland ; Cinnaminson, N.J. : Foris Publications, 1983.




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Popular songs and ballads of Han China / [edited and compiled by] Anne Birrell.

London : Unwin Hyman, 1988.




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Trees on the mountain : an anthology of new Chinese writing / edited by Stephen C. Soong and John Minford.

Hong Kong : Chinese University Press, [1984]




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A silver treasury of Chinese lyrics / edited by Alice W. Cheang.

Hong Kong : Research Centre for Translation, Chinese University of Hong Kong, [2003]




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The I ching ; or, Book of changes. Volume II / the Richard Wilhelm translation rendered into English by Cary F. Baynes ; foreword by C.G. Jung.

[London] : Routledge & Kegan Paul Ltd, 1951.




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A brief history of Chinese fiction / Lu Hsun ; translated by Yang Hsien-yi and Gladys Yang.

Peking : Foreign Languages Press, 1982.




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Song without music : Chinese tzʻu poetry / edited by Stephen C. Soong.

Hong Kong : Chinese University Press, [1980]




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The interlingual critic : interpreting Chinese poetry / James J.Y. Liu.

Bloomington : Indiana University Press, c1982.




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A new literary history of modern China / edited by David Der-Wei Wang.

Cambridge, Massachusetts : The Belknap Press of Harvard University Press, 2017.




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A Chinese-English dictionary : Hakka-dialect as spoken in Kwang-tung province / prepared by D. MacIver ; revised and rearranged with many additional terms and phrases by M.C. Mackenzie, E.P. Mission, Wu-king-fu.

Taiwan : SMC Publishing Inc., 1991.




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Oxford English-Chinese reader's dictionary / A.S. Hornby, E.C. Parnwell = Niujin Ying Han shuang jie ci dian / bian zhu Hao'enbei, Ba'enwei'er ; fan yi Li Beida, Zhao Shuxian, Zheng Zanchen.

Singapore : Oxford University Press, 1982.




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Les écritures cunéiformes et leur déchiffrement / sous la direction de Brigitte Lion et Cécile Michel ; collection dirigée par Anne Yvonne Guillou.

Paris : Khéops, 2021.




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Sochineni︠i︡a / ︠I︡Uriĭ Tyn︠i︡anov.

Moskva : Gosudarstvennoe izdatelʹstvo khudozhestvennoĭ literatury, 1959.