Smithsonian Secretary Wayne Clough, left, talks with Carlos Jaramillo, scientist at the Smithsonian Tropical Research Institute in Panama, at a research site near the Panama […]

The post Wayne Clough & Carlos Jaramillo, at a research site near the Panama Canal. appeared first on Smithsonian Insider.

The discovery of two new extinct camel species by scientists from the University of Florida and the Smithsonian is casting new light on the history of the tropics, a region containing more than half the world's biodiversity and some of its most important ecosystems.

The post Two new species of extinct camels discovered in Panama Canal excavations appeared first on Smithsonian Insider.

Researchers from the Smithsonian Tropical Research Institute are recommending that Panama adopt revised traffic patterns and slower speeds for vessels crossing the Gulf of Panama to reduce the risk of collisions between ships and whales.

The post Ships need to slow down for whales in Gulf of Panama, scientists advise appeared first on Smithsonian Insider.

This past summer, Laura Walker became the first scientist to collect slime molds from soils at the Barro Colorado Nature Monument in Panama, a reserve administered by the Smithsonain since 1946.

The post Panama’s slime molds get attention from Arkansas University grad student appeared first on Smithsonian Insider.

Archaeologists working at the Smithsonian Tropical Research Institute in Panama have discovered a cluster of 12 unusual stones in the back of a small, prehistoric rock-shelter near the town of Boquete.

The post 4,000-year-old shaman’s stones discovered near Boquete, Panama appeared first on Smithsonian Insider.

Douglas Owsley, the division head for physical anthropology at the Smithsonian’s National Museum of Natural History, presented today a forensic analysis of 17th-century human remains […]

The post Forensic analysis of 17th-century human remains at Jamestown, Va., reveals evidence of survival cannibalism appeared first on Smithsonian Insider.

Fond of a range of marine and freshwater vegetation such as turtle grass and eelgrass, the Florida manatee spends most of its waking hours grazing […]

The post Algae bloom toxins may make Florida’s manatees and sea turtles susceptible to deadly accidents appeared first on Smithsonian Insider.

A team of researchers has for the first time mapped the above ground carbon density of an entire country in high fidelity. They integrated field […]

The post Research team creates first carbon map of an entire country: Panama appeared first on Smithsonian Insider.

The Panama Amphibian Rescue and Conservation project recently announced that the golden frog, a national icon on the brink of extinction, has been successfully raised […]

The post Success: Panama’s golden frog bred in captivity appeared first on Smithsonian Insider.

Scientists from the Smithsonian’s National Museum of Natural History have just named and described the Spectacular Guyane False-form beetle, or Guyanemorpha spectabilis, from Guyane (French Guiana). […]

The post Remarkably large and colorful new beetle discovered in French Guiana appeared first on Smithsonian Insider.

Out in Montana’s Big Sky Country Dale Greenwalt spends his summers seeking the incredibly tiny and fragile. Armed with a putty knife honed razor-sharp on […]

The post Quality of insect fossils from Montana’s Flathead River astounds scientists appeared first on Smithsonian Insider.

The Republic of Panama’s proposal to implement four Traffic Separation Schemes for commercial vessels entering and exiting the Panama Canal and ports was approved unanimously […]

The post Commercial shipping lanes changed in Panama to save humpback whales appeared first on Smithsonian Insider.

A research team from the Smithsonian and Arizona State University have developed a new, non-destructive method using spectroscopic analysis to help unravel the complex chemistry […]

The post Feathers yield mysteries of pigment chemistry to spectroscopic analysis appeared first on Smithsonian Insider.

The name Panama is said to mean “abundance of fish.” Now a new study estimates that between 1950 and 2010, the amount of fish taken […]

The post Panamanian fish catch is vastly under-reported, study reveals appeared first on Smithsonian Insider.

Human skin and gut microbes influence processes from digestion to disease resistance. Despite the fact that tropical forests are the most biodiverse terrestrial ecosystems on […]

The post Smithsonian scientists discover tropical tree microbiome in Panama appeared first on Smithsonian Insider.

A bright orange poison dart frog with a unique call was discovered in Donoso, Panama, and described by researchers from the Smithsonian Tropical Research Instituteand […]

The post New Poison Dart Frog from Panama appeared first on Smithsonian Insider.

More than two million migrating raptors passed over Panama City on Sunday, Nov. 2, doubling the previous record of almost 900,000 tallied in a single […]

The post Panama shatters raptor migration record appeared first on Smithsonian Insider.

Studies show that on average, the weight of cremated remains for men is about 7.13 pounds (plus or minus 1.2 pounds) and for women, 4.9 […]

The post Hi-Tech Analysis Cracks Curious Case of Contaminated Cremains appeared first on Smithsonian Insider.

She was a stunning brown queen; drowned some 46 million years ago in a shallow lake in Montana. Her remains, recently recovered along the Flathead […]

The post New Montana ant species emerge from 46-million-year-old rock appeared first on Smithsonian Insider.

The bush dog is one of the most enigmatic of the world’s canid species, seldom seen throughout its range in Central and South America. New […]

The post Elusive bush dog widespread in Panama appeared first on Smithsonian Insider.

Cobia, a promising fish for aquaculture, lives throughout the world’s oceans except in the Central and Eastern Pacific. In August 2015, a large number of […]

The post Invasive Cobia Spreads in Panama appeared first on Smithsonian Insider.

Seven fossil teeth exposed by the Panama Canal expansion project are the first evidence of a monkey on the North American continent before the Isthmus […]

The post First North American Monkey Fossils Found in Panama Canal Excavation appeared first on Smithsonian Insider.

Ricardo Moreno, research associate at the Smithsonian Tropical Research Institute (STRI) in Panama and director of the Yaguará Panamá Foundation, reported at the 20th Congress […]

The post 26 jaguars killed in Panama so far this year appeared first on Smithsonian Insider.

In 1969, 60 to 100 peacock bass imported from Buga, Colombia, were introduced into a pond in Panama for sport fishing. Several individuals escaped. By […]

The post Peacock bass invasion Had devastating, long-term impact on Panama’s Fish appeared first on Smithsonian Insider.

Food is scarce in the deep, dark regions of the ocean where barbeled dragonfishes and their relatives dwell. Known as the Stomiidae, some of these […]

The post Odd anatomy: flexible joint between skull and spine allow dragonfish to open wide appeared first on Smithsonian Insider.

In the early 20th century, Canada geese were considered endangered in the U.S. So in the 1950s and 1960s, birds from the Midwest were released […]

The post Study of bacteria inside guts of wild Canada geese shows greater danger than earlier studies exposed appeared first on Smithsonian Insider.

Ninety Limosa harlequin frogs (Atelopus limosus) bred in human care are braving the elements of the wild after Smithsonian scientists sent them out into the […]

The post Panama: First release of endangered frogs appeared first on Smithsonian Insider.

Pullulanase (EC 3.2.1.41) is a well known starch-debranching enzyme that catalyzes the cleavage of α-1,6-glycosidic linkages in α-glucans such as starch and pullulan. Crystal structures of a type I pullulanase from Paenibacillus barengoltzii (PbPulA) and of PbPulA in complex with maltopentaose (G5), maltohexaose (G6)/α-cyclodextrin (α-CD) and β-cyclodextrin (β-CD) were determined in order to better understand substrate binding to this enzyme. PbPulA belongs to glycoside hydrolase (GH) family 13 subfamily 14 and is composed of three domains (CBM48, A and C). Three carbohydrate-binding sites identified in PbPulA were located in CBM48, near the active site and in domain C, respectively. The binding site in CBM48 was specific for β-CD, while that in domain C has not been reported for other pullulanases. The domain C binding site had higher affinity for α-CD than for G6; a small motif (FGGEH) seemed to be one of the major determinants for carbohydrate binding in this domain. Structure-based mutations of several surface-exposed aromatic residues in CBM48 and domain C had a debilitating effect on the activity of the enzyme. These results suggest that both CBM48 and domain C play a role in binding substrates. The crystal forms described contribute to the understanding of pullulanase domain–carbohydrate interactions.

Death-associated protein kinase 1 (DAPK1) is a serine/threonine protein kinase that regulates apoptosis and autophagy. DAPK1 is considered to be a therapeutic target for amyloid-β deposition, endometrial adenocarcinomas and acute ischemic stroke. Here, the potent inhibitory activity of the natural anthraquinone purpurin against DAPK1 phosphorylation is shown. Thermodynamic analysis revealed that while the binding affinity of purpurin is similar to that of CPR005231, which is a DAPK1 inhibitor with an imidazopyridazine moiety, the binding of purpurin was more enthalpically favorable. In addition, the inhibition potencies were correlated with the enthalpic changes but not with the binding affinities. Crystallographic analysis of the DAPK1–purpurin complex revealed that the formation of a hydrogen-bond network is likely to contribute to the favorable enthalpic changes and that stabilization of the glycine-rich loop may cause less favorable entropic changes. The present findings indicate that purpurin may be a good lead compound for the discovery of inhibitors of DAPK1, and the observation of enthalpic changes could provide important clues for drug development.

The bond-valence method has been used for valence calculations of FeMo/V cofactors in FeMo/V proteins using 51 crystallographic data sets of FeMo/V proteins from the Protein Data Bank. The calculations show molybdenum(III) to be present in MoFe7S9C(Cys)(HHis)[R-(H)homocit] (where H4homocit is homocitric acid, HCys is cysteine and HHis is histidine) in FeMo cofactors, while vanadium(III) with a more reduced iron complement is obtained for FeV cofactors. Using an error analysis of the calculated valences, it was found that in FeMo cofactors Fe1, Fe6 and Fe7 can be unambiguously assigned as iron(III), while Fe2, Fe3, Fe4 and Fe5 show different degrees of mixed valences for the individual Fe atoms. For the FeV cofactors in PDB entry 5n6y, Fe4, Fe5 and Fe6 correspond to iron(II), iron(II) and iron(III), respectively, while Fe1, Fe2, Fe3 and Fe7 exhibit strongly mixed valences. Special situations such as CO-bound and selenium-substituted FeMo cofactors and O(N)H-bridged FeV cofactors are also discussed and suggest rearrangement of the electron configuration on the substitution of the bridging S atoms.

This user-friendly, portable, and extensive identification guide features large color illustrations of more than 900 species; the first range maps published to show the distribution of Panama's birds and concise text that describes field marks for identification, as well as habitat, behavior, and vocalizations.

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Benjamin Ziman, Peter Karabinis, Paul Barghouth, and Nestor J. Oviedo

Nutrient availability upon feeding leads to an increase in body size in the planarian Schmidtea mediterranea. However, it remains unclear how food consumption integrates with cell division at the organismal level. Here we show that Sirtuins is evolutionarily conserved in planarians and specifically demonstrate that Sirtuin-1 (Smed-Sirt-1) regulates organismal growth by impairing both feeding behavior and intestinal morphology. Disruption of Smed-Sirt-1 with either RNAi or pharmacological treatment leads to reduced animal growth. Conversely, enhancement of Smed-Sirt-1 with resveratrol accelerates growth. Differences in growth rates were associated with changes in the amount of time to locate food and overall consumption. Furthermore, Smed-Sirt-1(RNAi) animals displayed reduced cell death and increased stem cell proliferation accompanied by impaired expression of intestinal lineage progenitors and reduced branching of the gut. Altogether, our findings indicate Sirtuin-1 is a crucial metabolic hub capable of controlling animal behavior, tissue renewal and morphogenesis of the adult intestine.

To understand the long-term effects of a prolonged tropical storm in the Panama Canal watershed, Robert Stallard, staff scientist at the Smithsonian Tropical Research Institute and research hydrologist at the U.S. Geological Survey, and Armando Ubeda, the LightHawk Mesoamerica program manager, organized four flights over the watershed to create a digital map of landslide scars.

The post Smithsonian hydrologist discovers that rainfall has dried up Panama’s drinking water appeared first on Smithsonian Insider.

Miniature camels and horses, a rhinoceros and a giant bear-dog are among fossils unearthed in the recent excavations of the Panama Canal expansion project. These […]

The post First five years of Panama Canal excavations reveal fossil finds appeared first on Smithsonian Insider.

"I'm getting paid to do what I like doing," says entomologist David Roubik. He loved nature and being outdoors when he was a kid, and now he does fieldwork in the tropical forests of Panama. He loves to travel, and his research takes him around the world. Can his work, then, be called a job?

The post Tropical Research Institute entomologist David Roubik talks about his life as a scientist based in Panama appeared first on Smithsonian Insider.

Mark Torchin, a marine ecologist at the Smithsonian Tropical Research Institute (STRI) in Panama, talks about how he studies the parasites of invasive marine animals such as snails. Much of his research focuses on biological invasions and the dynamics between the host, the parasites and the surrounding ecosystem.

The post Meet our Scientist–Mark Torchin tracks invasive marine species and their parasites in Panama appeared first on Smithsonian Insider.

Digging up early human and animal remains from the field in Africa, performing examination and publishing research about her findings, then enticing and educating the public about the implications are all in a week's work for Briana Pobiner.

The post Meet Our Scientist–Briana Pobiner, human origins researcher at the National Museum of Natural History appeared first on Smithsonian Insider.

Meet Rachel Collin, a staff scientist and director of the Bocas Research Station at the Smithsonian Tropical Research Institute in Panama. Rachel studies the evolution of marine gastropods (snails) and oversees multiple disciplines of marine biology at the Collin Lab in Bocas del Toro.

The post Meet Our Scientist: Rachel Collin, an expert in the evolution and development of snails who is working in Panama appeared first on Smithsonian Insider.

Meet Smithsonian scientist Justin Touchon, a National Science Foundation (NSF) postdoctoral researcher at the Smithsonian Tropical Research Institute in Panama.

Justin's work focuses on developmental ecology and reproductive plasticity of the hourglass treefrog (Dendropsophus ebraccatus) and red-eyed treefrog (Agalychnis callidryas). Justin and his advisor, Karen Warkentin, were the first to have witnessed the frogs laying eggs in water, in addition to doing so on land -- something with major implications for the evolutionary biology of similar creatures.

The post Meet Our Scientist: Justin Touchon, Frog Follower at the Smithsonian Tropical Research Institute in Panama appeared first on Smithsonian Insider.

The post Museum Conservation Institute research scientist Ed Vicenzi discusses his work analyzing daguerreotypes appeared first on Smithsonian Insider.

Meet Rachel Page, a Smithsonian scientist in Panama who studies frog-eating bats (fringe-lipped bats), among other topics. Her current research focuses on learning and memory in neotropical bats, combining field studies with laboratory experiments to learn about predator cognition and its effects on the evolution of their prey.

The post Meet our Scientist Rachel Page. She studies frog-eating bats, and other animals, in Panama appeared first on Smithsonian Insider.

The post Barro Colorado Island: The Smithsonian’s research outpost in the Panama Canal appeared first on Smithsonian Insider.

Bocas Research Station’s research assistant Arcadio Castillo ran into these curious looking fish babies while working close to the dock. After some investigation, we found […]

The post Toadfish (Batrachoididae) babies in Bocas del Toro, Panama appeared first on Smithsonian Insider.

Meg studies intergroup competition in white‐faced capuchin monkeys by tracking them through radio telemetry collars and observing their behaviors.

The post Meet our scientist Meg Crofoot, primate researcher in Panama appeared first on Smithsonian Insider.

The Smithsonian Conservation Biology Institute and the Smithsonian Tropical Research Institute are working together as part of the Panama Amphibian Rescue and Conservation Project have […]

The post New Amphibian Rescue Lab in Panama appeared first on Smithsonian Insider.

A team of some 30 taxonomists, many from the Smithsonian Tropical Research Institute, accompanied by renowned photographer Christian Ziegler, conduct a week-long bioblitz on Cobia […]

The post Bioblitz!! Cobia Island, Panama appeared first on Smithsonian Insider.

No divers were in danger when two large squid (species Taningia danae) began acting aggressively toward a robot submersible operated deep in the Pacific from NOAA’s […]

The post Rare squid “T. danae” captured in new video appeared first on Smithsonian Insider.

Known around the world for personal and culturally inspired choreography, Dana Tai Soon Burgess has been named the Smithsonian’s first choreographer-in-residence at the National Portrait […]

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Known around the world for personal and culturally inspired choreography, Dana Tai Soon Burgess has been named the Smithsonian’s first choreographer-in-residence at the National Portrait […]

The post Dana Tai Soon Burgess Dance Company @ Portrait Gallery appeared first on Smithsonian Insider.

When Smithsonian Tropical Research Institute paleobotanist Carlos Jaramillo learned that Panama was expanding its canal in 2006 and blasting 100 million tons of rock to […]

The post Using Fossils in Panama to Model Future Climate Change appeared first on Smithsonian Insider.