Anal. Methods, 2024, 16,2077-2084
DOI: 10.1039/D4AY00041B, Paper

Wenjuan Wang, Danrong Chen, Yujiao Cai, Zijing Liu, Hongfen Yang, Hongbin Xie, Jinquan Liu, Shengyuan Yang
Here, we show a paper-based POCT sensor based on lactate dehydrogenase-mediated alginate gelation combined with visual distance reading and smartphone-assisted colorimetric dual-signal analysis to determine the concentration of L-lactate in yogurt samples.
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Anal. Methods, 2024, 16,2002-2008
DOI: 10.1039/D4AY00276H, Communication

Yajie Huang, Yajun Zheng, Qianqian Zuo, Zhiming Zhang, Lixuan Zhu, Yun Li, Zhiping Zhang
A novel surface charge induced electrospray ionization is proposed due to its features of no contact between sample solution and metal electrode, fast analytical process (less than 40 s), and high analytical sensitivity.
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Anal. Methods, 2024, 16,2147-2151
DOI: 10.1039/D3AY01378B, Technical Note

Shao-Chun Hsueh, Ling-Hsuan Wang, Yung-Chen Liao, Hui-Yu Chiang, Cheng-Huang Lin
A method for the extraction and accumulation of Ag nanoparticles utilizing capillary action through a piece of triangular-shaped cotton paper is reported.
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Anal. Methods, 2024, 16,2085-2092
DOI: 10.1039/D4AY00018H, Paper

Yue Liu, Guanwen Su, Wei Wang, Hongyuan Wei, Leping Dang
Design and working principle of bacterial capture and identification using a ZnO/Ag microfluidic SERS sensor array.
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00079J, Paper

Yunyin Yang, Sian Chen, Changqiu Zhang, Yanqing Li, Xinrong Zong, Yitao Lv, Min Zhang
Upon experiencing a negligible change of 0.5 V which only takes 5 more seconds, the signal value of an e-GCE was efficiently enhanced from 2-fold to 30-fold compared with a bare GCE.
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00170B, Paper

Zhengming Qian, Qinggui Lei, Dan Tang, Guoying Tan, Qi Huang, Fucai Zhou, Wenhao Wang
Sweet tea is a functional herbal tea with anti-inflammatory, anti-diabetic, and other effects, in which phloridzin and trilobatin are two functional compounds.
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00303A, Paper

O. Kare Siva Prakasam, Akashlina Basu, Koel Chaudhury, Soumen Das
A paper chip employs an impedance method to determine the characteristics of the droplet. We compare the traditional evaporation method with the electrical method to study the evaporation of various liquids.
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Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00460D, Paper

Anqi Liu, Meng Jiang, Yuyin Wu, Han Guo, Ling Kong, Zhiwei Chen, Zhaofeng Luo
β-Lactoglobulin, a naturally occurring milk protein and a major cause of milk allergy in infants, was the focus of this study. A highly selective, sensitive, and cost-effective BLI biosensor was...
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D3AY02172F, Paper

Fatemeh Barzegar, Samaneh Nabizadeh, Marzieh Kamankesh, Jahan B. Ghasemi, Abdorreza Mohammadi
Excessive dietary polyamines (PAs), including putrescine (PUT), spermine (SPM), and spermidine (SPD), have become a worldwide concern due to their carcinogenicity and reduced shelf life.
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00331D, Paper

Jintao Yi, Xianqin Han, Jiahao Jian, Yayan Lai, Jun Lu, Lei Peng, Zhongkai Liu, Jun Xue, Hui Zhou, Xun Li
The dual-mode fluorescence and colorimetric detection of 2,6-pyridinedicarboxylic acid (DPA) based on the enhanced peroxidase-like activity and fluorescence property of a novel MOF.
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Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00214H, Paper

Open Access

  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Lixy Olinda León-Morán, Marta Pastor-Belda, Pilar Viñas, Natalia Arroyo-Manzanares, María Dolores García, María Isabel Arnaldos, Natalia Campillo
The nature and proportions of hydrocarbons in the cuticle of insects is characteristic of the species and age. Chemical analysis of cuticular hydrocarbons allows species discrimination, which is of great...
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Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00526K, Paper

Bin Liu, Yu Yin, qianwen Li, wanwan Li, Fubing Xiao, Jinquan Liu, Yan Tan, Shengyuan Yang
Herein, a novel sort of phosphorus and iron-doped carbon dots (P,Fe-CDs) with outstanding peroxidase activity and excellent fluorescence performance was hydrothermally synthesized to colorimetrically and fluorimetrically detect tannic acid (TA)....
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Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00187G, Minireview

Aleksandra Owczarzy, Karolina Kulig, Katarzyna Piordas, Patrycja Piśla, Patrycja Sarkowicz, Wojciech Rogóż, Małgorzata Maciążek-Jurczyk
Traditional sample preparation techniques based on liquid-liquid extraction (LLE) or solid phase extraction (SPE) often suffer from a major error due to the matrix effects caused by significant co-extraction of...
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Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00342J, Paper

Cristian Henrique Krause, Alexandre Batista Schneider, Leandro Kolling, Lauren Thauani Teixeira Oliveira, Márcia M. Silva
An alternative approach to assay iron (Fe) in biodiesel by differential pulse adsorptive cathodic stripping voltammetry (DPAdCSV) is presented herein. The sample treatment involved a simple, rapid, but effective extraction...
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00333K, Paper

David Ulisses Tega, Luan Felipe Campos Oliveira, Patrick Cesar Ferreira, Bruna Beatriz Soldera, Heliara Dalva Lopes Nascimento, Marcos Nogueira Eberlin, Alessandra Sussulini
Optimization of a LC-V-EASI-MS system. Employment of LC-V-EASI-MS and online SPE to enhance analytical performance for caffeine determination reaching 90 s per sample.
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D3AY02075D, Paper

Natpapas Wiriyachaiporn, Jetnapang Kongrueng, Kannika Sukkuea, Rattana Tanrattanawong, Jarunee Vanichtanankul, Thanaya Saeyang, Tararat Jantra, Deanpen Japrung, Weerakanya Maneeprakorn, Suwussa Bamrungsap, Pareena Janchompoo, Ekawat Pasomsub
Analytical and pre-clinical evaluation of a visual screening lateral flow device for SARS-CoV-2 virus protein detection and its system characterization.
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00146J, Paper

Dumei Ma, Yiting Luo, Xiaoya Zhang, Zehu Xie, Yinghua Yan, Chuan-Fan Ding
A fluorescence method based on Cu-triggered click reaction of azide modified CD63 aptamer and alkyne capped Pdots was developed for breast cancer derived exosome detection.
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00301B, Paper

Jayasudha Palanisamy, Mansour K. Gatasheh, Ashraf Atef Hatamleh
Carbazole–indolium based colorimetric probe was designed for detecting cyanide ions in various water samples. An outstanding response was shown by paper test strips prepared using the probe for the easy detection of cyanide in real time.
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00278D, Minireview

Open Access

  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Robert D. Crapnell, Craig E. Banks
Additive manufacturing (3D-printing), in particular fused filament fabrication, presents a paradigm shift in the way electrochemical based biosensing platforms are produced, giving rise to a new generation of personalized and on-demand biosensors.
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00246F, Paper

Bingchen Wang, Yifan Wang, Xiuyuan Zhang, Kuo He
In order to improve the detection efficiency of ochratoxin, a superparamagnetic nano-material was synthesized for solid phase extraction of ochratoxin.
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Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D3AY02200E, Paper

Qiong Liu, Mei Yang, He Zhang, Wenjie Ma, Xin Fu, Huiqing Li, Sainan Gao
Tuberculosis caused by Mycobacterium bovis poses a global infectious threat to humans and animals. Therefore, there is an urgent need to develop a sensitive, precise, and easy-to-readout strategy. Here, a...
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RSC Med. Chem., 2024, 15,3395-3417
DOI: 10.1039/D4MD00334A, Research Article

Vu Ngoc Toan, Do Son Hai, Hoang Thi Kim Van, Nguyen Minh Tri, Duong Ngoc Toan, Nguyen Thi Thanh Mai, Nguyen Dinh Thanh
D-Glucose-conjugated thioureas from 2-aminopyrimidines had inhibitory activity against α-amylase, α-glucosidase, DPP-4, PTP1B. The cytotoxicity, inhibitory kinetics, and molecular simulations of the most potent inhibitors 8k, 8j, 8f, and 8h were studied.
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RSC Med. Chem., 2024, 15,3576-3596
DOI: 10.1039/D4MD00438H, Research Article

Ruolin Cao, Fangyu Du, Zhiqiang Liu, Pengcheng Cai, Minggang Qi, Wei Xiao, Xuefei Bao, Guoliang Chen
Rho-associated coiled-coil containing kinase (ROCK) plays an important role in inflammation.
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RSC Med. Chem., 2024, 15,3418-3432
DOI: 10.1039/D4MD00170B, Research Article

Open Access

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Chien Van Tran, Thao Thi Phuong Tran, Anh The Nguyen, Loc Van Tran, Ninh Thi Pham, Luu Thi Nguyen, Dung Thi Nguyen, Michelle D. Garrett, Nga Thi Nguyen, Thao Thi Do, Christopher J. Serpell, Sung Van Tran
Madecassic acid and silybin have been conjoined to produce hybrid compounds with improved and different activity against liver cancer cells.
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RSC Med. Chem., 2024, 15,3529-3557
DOI: 10.1039/D4MD00481G, Research Article

Mohamed K. S. El-Nagar, Mai I. Shahin, Mohammed F. El-Behairy, Ehab S. Taher, Mohamed F. El-Badawy, Marwa Sharaky, Dalal A. Abou El Ella, Khaled A. M. Abouzid, Mai Adel
Discovery of novel pyridazinone derivatives with dual antimicrobial and anticancer activities.
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RSC Med. Chem., 2024, 15,3609-3615
DOI: 10.1039/D4MD00501E, Research Article

Open Access

  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Gciniwe S. Mathenjwa, Abir Chakraborty, Abantika Chakraborty, Ronel Muller, Mathew P. Akerman, Moira L. Bode, Adrienne L. Edkins, Clinton G. L. Veale
Rationally modified Hsp90 inhibitors which retained of on-target activity but showed no engagement of intracellular Hsp90, or stimulation of the heat shock response, were found to significantly alter the extracellular fibronectin network.
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RSC Med. Chem., 2024, 15,3616-3624
DOI: 10.1039/D4MD00306C, Research Article

Open Access

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Adam Throup, Manar Saleh Zraikat, Andrew Gordon, Shohreh Jafarinejad Soumehsaraei, Kathrin D. Haase, Laurence H. Patterson, Patricia A. Cooper, Katherine Hanlon, Paul M. Loadman, Mark Sutherland, Steven D. Shnyder, Helen M. Sheldrake
Cyclobutanes provide a versatile scaffold for the synthesis of small molecule integrin antagonists with good metabolic stability and in vivo tolerability.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00257A, Research Article

Shahabuddin, Uzma, Mohammad Azam, Mehtab Parveen, Nurul Huda Abd Kadir, Kim Min, Mahboob Alam
In light of the ongoing pandemic caused by SARS-CoV-2, effective and clinically translatable treatments are desperately needed for COVID-19 and its emerging variants.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00517A, Research Article

Open Access

  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Arianna Amenta, Susanna Comi, Marcelo Kravicz, Silvia Sesana, Antonia Antoniou, Daniele Passarella, Pierfausto Seneci, Sara Pellegrino, Francesca Re
A novel, glutathione-activated prodrug of pimasertib (PROPIMA) has been developed. PROPIMA showed ability to inhibit tumour cell migration and proliferation controlled over time, while also achieving a high incorporation rate into liposomes.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00537F, Research Article

Open Access

  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Abdelfattah Faouzi, Alexandre Arnaud, François Hallé, Jean Roussel, Mandy Aymard, Vincent Denavit, Cong Viet Do, Angélique Mularoni, Mohamed Salah, Ahmed ElHady, Thanh-Nhat Pham, Alexandre Bancet, Marc Le Borgne, Raphaël Terreux, Roland Barret, Matthias Engel, Thierry Lomberget
A series of sulfur-containing tetracycles was designed and evaluated for their ability to inhibit protein kinase DYRK1A, a target known to have several potential therapeutic applications including cancers, Down syndrome or Alzheimer's disease.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00471J, Research Article

Poorvi Saraf, Bhagwati Bhardwaj, Akash Verma, Mohammad Aquib Siddiqui, Himanshu Verma, Pradeep Kumar, Samridhi Srivastava, Sairam Krishnamurthy, Saripella Srikrishna, Sushant Kumar Shrivastava
Screening piperazine derivatives via ChEMBL database led to the design and synthesis of novel dual COX-2/5-LOX inhibitors with strong anti-inflammatory, analgesic, and anti-cancer activity.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00673A, Review Article

Juhyung Song, Cheoljun Park, Francis E. B. Cabanting, Yong Woong Jun
Potential therapeutic target proteins for upregulating DNA repair system are reviewed, along with reported small-molecule activators.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00662C, Research Article

Rajat Arora, Ayan Mukherjee, Gilbert Arthur, Mark W. Nachtigal, Frank Schweizer
We describe the multi-step synthesis of different dibasic and tribasic galactosamine-based glycosylated antitumor ether lipids (GAELs) and their cytotoxic response in comparison to doxorubicin and cisplatin.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD90044H, Correction

Open Access

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Kennosuke Itoh, Hiroki Nakahara, Atsushi Takashino, Aya Hara, Akiho Katsuno, Yuriko Abe, Takaaki Mizuguchi, Fumika Karaki, Shigeto Hirayama, Kenichiro Nagai, Reiko Seki, Noriko Sato, Kazuki Okuyama, Masashi Hashimoto, Ken Tokunaga, Hitoshi Ishida, Fusako Mikami, Kofi Dadzie Kwofie, Hayato Kawada, Bangzhong Lin, Kazuto Nunomura, Toshio Kanai, Takeshi Hatta, Naotoshi Tsuji, Junichi Haruta, Hideaki Fujii
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00383G, Research Article

Open Access

  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Walaa K. Mousa, Ashif Y. Shaikh, Rose Ghemrawi, Mohammed Aldulaimi, Aya Al Ali, Nour Sammani, Mostafa Khair, Mohamed I. Helal, Farah Al-Marzooq, Emilia Oueis
An AMP-derived short 15-mer peptide and its cyclic derivatives have low micromolar broad spectrum antibacterial activity, with rapid onset of bactericidal effect and a membrane-targeting mode of action.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00617H, Research Article

Aida Buza, Cüneyt Türkeş, Mustafa Arslan, Yeliz Demir, Busra Dincer, Arleta Rifati Nixha, Şükrü Beydemir
In this research, a series of sulfonamides incorporating a 1,2,3-triazolyloxime substituted 1,2,3-triazolyl moiety was conceptualized, synthesized, and investigated as carbonic anhydrase inhibitors.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00511B, Research Article

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Francesco Melfi, Marialuigia Fantacuzzi, Simone Carradori, Ilaria D'Agostino, Alessandra Ammazzalorso, Noemi Mencarelli, Marialucia Gallorini, Mattia Spano, Paolo Guglielmi, Mariangela Agamennone, Sazan Haji Ali, Ali Al-Samydai, Francesca Sisto
Monoterpene-derived azo benzenes showed selective antibacterial activity against Helicobacter pylori with a safe profile. An in silico investigation highlighted the inosine 5'-monophosphate dehydrogenase enzyme as the putative target.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00621F, Research Article

Chunfei Zhang, Yixin Liu, Xiao Zhang, Chunping Wan, Zewei Mao
A series of novel benzofuran-based chalcone derivatives could be considered as potent VEGFR-2 inhibitors.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00508B, Review Article

Carlos Roberto Tavolari Jortieke, Angélica Rocha Joaquim, Fernando Fumagalli
This review presents the recent findings on antibacterial agents against Mycobacterium fortuitum and reveals the most promising and effective chemical frameworks to inspire the development of new drugs.
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00623B, Research Article

Ojaswitha Ommi, Priyanka Sudhir Dhopat, Shashikanta Sau, Madhu Rekha Estharla, Srinivas Nanduri, Nitin Pal Kalia, Venkata Madhavi Yaddanapudi
A series of pyrazole–ciprofloxacin hybrids were designed, synthesized, and tested for antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Mycobacterium tuberculosis, aiming to combat antibiotic resistance.
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