The present invention relates to VEGF-binding agents, DLL4-binding agents, VEGF/DLL4 bispecific binding agents, and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human VEGF, antibodies that specifically bind human DLL4, and bispecific antibodies that specifically bind human VEGF and/or human DLL4. The present invention further provides methods of using the agents to inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.

A recombinant vector comprises simian adenovirus 36, simian adenovirus 42.1, simian adenovirus 42.2 and/or simian adenovirus 44 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses one or more simian adenovirus-36, -42.1, -42.2 or -44 gene(s) is also described. Methods of using the vectors and cell lines are provided.

The present invention relates to the use of the miRNA expression profile, particularly of miR-199a-5p, and the target genes regulated thereby for the diagnosis, prognosis and use of miR-199a-5p inhibitors for treating fibroproliferative disorders.

The invention relates to polynucleotide agents targeting the complement component C5 gene, and methods of using such polynucleotide agents to inhibit expression of C5 and to treat subjects having a complement component C5-associated disease, e.g., paroxysmal nocturnal hemoglobinuria.

Described herein are methods and compositions for treatment of immune-related diseases or disorders by modulating DD1α activity, alone or in combination with modulation of PD-1 activity. In some embodiments, the methods and compositions described herein are directed to treatment of cancer and/or infections (e.g., bacterial infection, and/or fungal infection). In some embodiments, the methods and compositions described herein are directed to treatment of autoimmune diseases and/or inflammation. In some embodiments, the methods and compositions described herein are directed to treatment of asthma, and allergy. Methods for identifying patients who are more likely to be responsive to and benefit from an immunotherapy that targets DD1α and/or PD-1 activity or expression are also described herein.

The present invention provides methods for assessing whether a subject is at risk of developing a neurological disorder, diagnosing or confirming whether a subject is afflicted with a neurological disorder, assessing whether PD has progressed in a subject afflicted with PD, assessing whether a neurological disorder is developing in a subject who has been identified as being at risk of developing the neurological disorder, assessing whether a subject afflicted with a neurological disorder is likely to benefit from a therapy, assessing whether a subject afflicted with a neurological disorder has benefited from a therapy, treating a subject afflicted with a neurological disorder, and prophylactically treating a subject who has been identified as being at risk of developing a neurological disorder. The present invention also provides epitopes, compounds and compositions relating to these methods.

The present invention relates to a plant-based wrapping paper for wrapping food. The plants (raw materials) may be fruits, herbs, medicinal plants, tea, vegetables and/or spices. The invention further relates to a method for producing said wrapping paper, its use for wrapping food or its use as packaging material.

The present invention is directed to novel organoleptic compounds, a process of augmenting, enhancing or imparting taste to a material selected from the group consisting of a foodstuff, a chewing gum, a dental product, an oral hygiene product and a medicinal product comprising the step of incorporating an olfactory acceptable amount of such novel organoleptic compounds, and a process of improving, enhancing or modifying a fragrance composition through the addition of an olfactory acceptable amount of such novel organoleptic compounds.

The present invention is directed to recombinant thraustochytrids that grow on sucrose and cell cultures comprising the recombinant thraustochytrids as well as methods of producing cell cultures, biomasses, microbial oils, compositions, and biofuels using the recombinant thraustochytrids.

Tools (100) are provided for use in uncapping one or more of a plurality of linearly-oriented, spaced-apart tubes; each cap having a cap upper surface with a depression. The tools comprise a body (30) having first portion (40) for engagement by a user and a second portion (50) for engaging a plurality of caps. The second portion comprises a plurality of spaced-apart projections (60). Each projection is configured for releasably engaging a cap. The projection may comprise two or more spaced-apart projection elements (62,64). Optionally, the first portion is configured in a non-coplanar relationship with respect to the second portion. Methods of use are also provided.

A fuselage panel made of composite material having a skin with an opening, at least part of the contour of which is reinforced by an integrated reinforcement made of composite material. The fuselage panel includes at least one liner made of composite material which is attached to and superposed on the reinforced skin portion and participates at least partially in defining the contour of the opening, the panel additionally including consolidating members, each passing at least partially through the liner and at least partially through the reinforced skin portion.

A method for making a water-degradable paper sheet involves the following: providing at least one strip of a water-soluble binding material in the form of a dry film; providing at least two strips each made of at least one ply of cellulose wadding; placing the strip of water-soluble binding material between the two strips of cellulose wadding; humidifying, assembling and pressing the three strips; and drying the complex strip thus obtained. The sheet thus obtained can be used for making a roll carrier mandrel by helically winding one or more strips from the sheet about a cylinder. Articles produced from the sheet can particularly be used in the field of products for sanitary or domestic use.

Positioning system of sectors of a device for producing an airplane fuselage in which a lamination mandrel comprises a plurality of sectors borne by a supporting structure and mobile along guides between: an expanded lamination position and a contracted disassembling position. Each guide comprises a fixed part borne by the supporting structure and a mobile part sliding along/with respect to the fixed part in a rectilinear direction H. Between a portion of each mobile part facing towards the respective sector and a stiffening structure of the sector a positioning device is provided which allows adjustment of the position of the sector with respect to the guide in two directions which lie in a plane RP perpendicular to the axis H of the guide.

A constraint system of sectors of a device for producing an airplane fuselage in which a lamination mandrel is adapted to receive and support a band of impregnated synthetic material. The lamination mandrel comprises a plurality of sectors angularly spaced about the axis and mobile between: an expanded lamination position and a contracted disassembling position. A constraint system is provided between each sector and the sectors adjacent thereto which guarantees a predetermined arrangement of the first sector with respect to the second sector adjacent thereto, preventing any translation along two directions which lie in an adjustment plane perpendicular to an axis RD which extends radially from the symmetry axis to the external surface.

The present disclosure relates to methods and apparatuses for assembling diapers, each including a chassis connected with front and back elastic belts. As discussed in more detail below, opposing end regions of the chassis are connected with regions of the elastic belts where the elasticity of the elastic belts has been removed or deactivated. An elastic laminate may be formed by continuously bonding elastic strands between a first continuous substrate layer and a second continuous substrate layer such that the elastic strands are bonded to both the first substrate layer and the second substrate layer in heavy-bond regions. And the elastic strands are bonded to the first substrate layer and/or the second substrate layer with in light-bond regions. The elastic strands are then intermittently deactivated by cutting the strands into one or more discrete pieces in the light-bond regions. The discrete pieces retract and remain in the light-bond regions.

The invention relates to a potassium sulphate powder wherein about 80 wt % or more of the powder has a particle size of about 0.2 mm or lower, preferably about 0.13 mm or less. The particle size preferably is such, that about 80 wt % or more is about 0.02 mm or higher, more preferably about 0.04 mm or higher. This potassium sulphate powder dissolves easily in water, more in particular, 50 gram of said potassium sulphate powder dissolves in 1 liter of water without stirring within 1 minute, preferably within 30 sec. This potassium sulphate powder is very suitable as foliar fertilizer, in particular for broad acre crops. Further, the invention relates to the use of foliar potassium fertilizer, to enhance the uptake of potassium from the soil.

An esteramide compound of the following formula (I): R1OOC-A-CONR2R3 (I) is described, wherein: A is a covalent bond or a methylene group —CH2—;R1 is an optionally substituted, saturated or unsaturated aliphatic or cycloaliphatic hydrocarbon group including from 5 to 36 carbon atoms,R2 and R3, either identical or different, are groups selected from a hydrogen atom, and optionally substituted hydrocarbon groups, preferably including from 1 to 36 carbon atoms, andR2 and R3 not being simultaneously hydrogen atoms. Also described, are applications for using the esteramide compound, notably as a solvent.

A composition of matter comprising: a combination of a phytate and a plurality of microorganisms comprising a Trichoderma virens fungus, a Bacillus amyloliquefaciens bacterium, and one or a plurality of mycorrhizae fungi that is placed in the vicinity of a plant root in a manner that allows the microorganisms in the composition of matter to colonize said plant root; and a method for increasing plant yield comprising: placing a combination of a phytate and a plurality of microorganisms comprising a Trichoderma virens fungus, a Bacillus amyloliquefaciens bacterium, and one or a plurality of mycorrhizae fungi in the vicinity of a plant root in a manner that allows the microorganisms in the composition of matter to colonize said plant root.

An engineered topsoil for use in soil reclamation and a method of producing the same are disclosed that seek to replicate undisturbed native reference topsoil from near the site in need of land reclamation. The engineered topsoil is formed from a base amount of subsoil and amendment comprised of an effective amount of surrogate humin material sufficient to replicate the estimated humin organic carbon content of the native reference topsoil, and an effective amount of plant residue material sufficient to replicate the estimated non-humin organic carbon content of the native reference topsoil.

Water heaters are described that are user-powered, such that external sources of power are unnecessary. The water heaters include a heating device and a generator coupled to a crank such that power is generated as the crank is rotated, which can be used to power the heating device.

A protective cover for handbags and like objects is provided, which comprises a portable and self-contained storage pouch. The protective cover can be attached to the exterior of a handbag by various mechanisms and can comprise one or more carrying straps. The protective cover can be made from a durable, water resistant and germ resistant material capable of preventing dirt, moisture and harsh chemicals from reaching the handbag. This protective cover can also prevent germ contamination of the handbag or other surfaces by removing it from the handbag and washing it after use.

A control system according to the principles of the present disclosure includes a fuel system diagnostic module and a pump control module. The fuel system diagnostic module performs a diagnostic test on a fuel system when a vacuum pump is switched off to prevent flow through the vacuum pump and thereby seal a portion of the fuel system from an atmosphere. The vacuum pump includes a cam ring, a rotor that rotates within the cam ring, and vanes that slide into and out of slots in the rotor as the rotor rotates. The pump control module switches on the vacuum pump for a predetermined period to force the vanes out of the slots and into contact with the cam ring to seal the vacuum pump before switching off the vacuum pump for the fuel system diagnostic test.

Downhole tool fluid flow control apparatus including a first fluid valve between a first portion of a first flowline and a second portion of a second flowline. The first and second flowlines are adjacent each other. A second fluid valve is between a second portion of the first flowline and a first portion of the second flowline. The first and second fluid valves are controllable to cause fluid flow between the first portion of the first flowline and the second portion of the second flowline or between the first portion of the second flowline and the second portion of the first flowline.

A catamaran type vessel for use in a wastewater facility for servicing submerged air diffusers is disclosed. The vessel has spaced apart pontoon having an A-frame spanning between the upper decks of the pontoon and connecting the pontoons. A hook connected to a winch is secured to a cross header above the space between the pontoons. The hook is lowered into water and lifts an air header, to which the air diffusers are connected. An air diffuser is then pulled on the pontoons and serviced. The vessel is then propelled to a position to service other air diffusers in the pontoon.

A flotation system for a recreational board such as a stand up paddleboard includes an elongated substrate that is sized and shaped to releaseably wrap around the perimeter of a recreational board. The elongated substrate is constructed of a buoyant material such as foam, and defines a plurality of apertures that can be used to store items such as beverages and personal belongings. The elongated substrate is releaseably attached to the board by a variety of fastening means, and serves to increase stability and buoyancy of the board, and to protect the board.

Cutting device, method and use are for cutting of a line extending from a floating vessel. The cutting device is structured for placement on the vessel. The cutting device comprises: at least one guide structured for directional steering of the line past a cutting area for the line; and at least one of the following cutting-promoting devices: at least one induction coil device directed inwards toward the cutting area and structured for heating, hence weakening, of the line within the cutting area; and at least one moveable cutting knife with an opposite contact surface directed inwards toward the cutting area and also structured for cutting of the line within the cutting area.

Methods and apparatuses for drying electronic devices are disclosed. Embodiments include methods and apparatuses that heat and decrease pressure within the electronic device. Some embodiments increase and decrease pressure while adding heat. Other embodiments include a desiccator for removing moisture from the air being evacuated from the electronic device prior to the air reaching an evacuation pump. Further embodiments detect humidity within the low-pressure chamber and determine when to increase and/or decrease pressure based on the humidity. Still further embodiments determine that the device is sufficiently dry to restore proper function based on the detected humidity, and in some embodiments based on the changes in humidity while pressure is being increased and/or decreased. Still further alternate embodiments automatically control some or all aspects of the drying of the electronic device. Additional embodiment disinfect the electronic device.

A skate squaring device includes a main frame having a slot to receive a skate blade. The main frame is designed to attach to a portion of a skate sharpening fixture such that calibration lines on the main frame are perpendicular to a centerline axis of a body of the skate blade when mounted in the holder. A magnetic angle is attached to the end of the skate blade and positioned adjacent a face of the main frame having the calibration lines to determine if the skate blade edge is square.

A stationary strength training equipment includes a frame assembly, a lockable bilateral user interface installed on the frame assembly, a balancing structure connected to the lockable bilateral user interface, a plurality of user selectable weights supported by the frame assembly and connected to the balancing structure, a load detecting strain gauge disposed on the user selectable weights to detect a weight of the user selectable weights being lifted, and an informing device connected to the lockable bilateral user interface to detect and show a warning signal to a user. The lockable bilateral user interface further includes a locking mechanism assembly and a central pivot assembly; the balancing structure is able to rotate along the central pivot assembly, and the locking mechanism assembly selectively restricts a rotation of the balancing structure.

Exercise equipment, particularly a linear movable structure and associated selectable elastic resistance bands with or without guide track members are designed to allow low-impact exercises for one or two persons at the same time while permitting either or both participants to remain stationary when utilizing the equipment.

A push-up device and method of use has been disclosed that employs the use of a spherical member that makes contact with the ground surface and supports the weight of a user when the user grasps the handle members of the push-up device and/or rests thereon. The user may balance his or her body on the push-up device while exercising. The push-up device is operable to permit the push-up device to move or translate in various directions or angles when the user is resting thereon by rotating the spherical member omni-directionally. As such, not only may a user stimulate chest and/or other upper-body muscles, but the user may also stimulate abdominals or other lower-body muscles, permitting the user to stimulate a more variety of his or her muscles through balancing himself or herself on the push-up device through the curved surface of the spherical member.

Technologies for generating user-specific workout plans and tracking a user's progress are disclosed. The user-specific workout plan may be based on a user's goal and the particular workout facility to be used by the user. During performance of the user-specific workout by the user, the user is provided with workout data regarding the user's performance Such workout data may be based on sensor data generated by sensors of the exercise machine used by the user and/or other sensors carried or worn by the user.

An exercise machine with a two directional pivoting user support assembly has a user support or platform which supports the user and pivots about a first pivot axis during an exercise movement, and is also pivotable about at least one second pivot axis to involve the user's core muscles in balancing and maintaining the user support in a stable position. A manually operable locking device with a simple flip switch lever is provided for selectively locking the user support against rotation about the second pivot axis, so that the user can easily chose whether to perform the exercise with a stable support or to add a level of difficulty by using the unstable seat mode and exercising core muscles during the exercise.

The present invention discloses a drive device for a rotor of s carousel door, In addition to a main drive motor (10), which has a main-drive-motor shaft (12), the drive device according to the invention comprises a secondary drive motor (12) with a secondary-drive-motor shaft (22). The main-drive-motor shaft (12) is coupled at least indirectly to the secondary-drive-motor shaft (22, 62) in terms of rotation, and therefore the secondary-drive-motor shaft (22, 62) is coupled to the rotor in terms of movement.

The invention provides for a receptor, capable of binding to a target molecule, linked to a hygroscopic polymer or hydrogel; and the use of this receptor in a device for detecting the target molecule in a gaseous and/or liquid phase. The invention also provides for a method for detecting the presence of a target molecule in the gas phase using the device. In particular, the receptor can be a peptide capable of binding a 2,4,6-trinitrotoluene (TNT) or 2,4,-dinitrotoluene (DNT).

A household appliance (100) comprises a cabinet (105) accommodating a drum for loading items to be dried and a drying air circuit for circulating drying air through the drum for drying the items therein. The drying air circuit comprises air heating elements (415) for heating the drying air fed to the drum, and the cabinet is provided with a worktop (110) defining a surface (130) having a plurality of apertures (135) in fluid communication with an air conveying system (205,225,230) adapted to deliver a flow of air through said apertures. The air conveying system comprises an air duct (230) thermally coupled to the air heating elements in such a way as to cause heat generated by the air heating elements to heat the air to be delivered through the apertures in the drying surface.

The small clothes iron for use with children's clothes is a small iron when compared to a traditional clothes iron. The small clothes iron resembles a toy train wherein a front surface resembles a face of a toy character while a top surface includes a handle, control buttons, and a chimney/smokestack for refilling a water reservoir. The small clothes iron has a smaller iron surface on a bottom surface, which is useful in ironing small clothes for children and infants.

A rebuildable conveyor roller includes a hollow, cylindrical roller tube having a first end opposite a second end. The roller tube has a rebuildable conveyor roller bearing assembly provided at the first end and the second end. The rebuildable conveyor roller bearing assembly is affixed to the roller tube such that at least a part of the rebuildable conveyor roller bearing assembly is removable from the roller tube. A hub of the rebuildable conveyor roller bearing assembly has a generally circular shape that is dimensioned to fit inside the internal diameter of the roller tube. The hub has a centrally located hole through which a stub shaft may be inserted. A bearing holder is inserted in an internal cavity provided within the hub for securing the rebuildable conveyor roller bearing assembly to the roller tube.

A vertical conveying channel is made of elastic fabric. The elastic fabric's latitude elastic deformation rate is 100˜450%, latitude resilience is 300˜2500N, and latitude elastic recovery rate is 70˜100%; preferably, the latitude elastic deformation rate is 120˜400%, the latitude resilience is 350˜2300N, and the latitude elastic recovery rate is 75˜98%; more preferably, the latitude elastic deformation rate is 140˜350%, the latitude resilience is 550˜2200N, and the latitude elastic recovery rate is 80˜96%; most preferably, the latitude elastic deformation rate is 170˜300%, the latitude resilience is 750˜2000N, and the latitude elastic recovery rate is 85˜94%. The vertical conveying channel can be used for vertical conveying of cargo or personnel, preferably used in the field of lifesaving, engineering or military.

A method for forming a piece of a sheet metal is performed by positioning a consumable body, made of metal, proximate to the piece of the sheet metal. The consumable body is rapidly vaporized, and the gas pressure generated thereby is directed into the piece of the sheet metal. This results in acceleration of the piece of sheet metal, and it is collided into a stationary body at a velocity, generally in excess of 200 m/s. Depending upon the type of stationary body, the piece of sheet metal is deformed into a predetermined shape or is welded onto the stationary body. The vaporization is accomplished by passing a high current of electricity into the consumable body. The effect of the vaporized metal may be augmented by additional components in the consumable body.

An apparatus for producing a textile product generally includes a feeding section for providing a starting material to facilitate producing a textile product derived from the starting material; a drafting section operably coupled to the feeding section for gripping, pulling, stretching and breaking at least one strand of the starting material into at least one continuous and cohesive network of an intermediate product; and a spinning section operably coupled to the drafting section for winding and twisting the at least one continuous and cohesive network of an intermediate product onto a removable receiving member to form the textile product; the feeding section, the drafting section, and the spinning section are configured to form the textile product in a continuous operation.

Rope (4) having an eye (2). The rope (4) comprises a first rope portion (8) and a second rope portion (10). The first rope portion (8) and the second rope portion (10) are spliced into each other for forming a spliced connection for obtaining the eye (2). The first rope portion (8) and the second rope portion (10) are formed from an end portion of the rope (4).

A rope assembly that is adapted to extend between first and second attachment points comprises a line arranged to define a plurality of loops and at least one pair of organizers. The at least one pair of organizers is configured to engage the line such that line segments of the line between the at least one pair of organizers are maintained in a desired relationship with each other and such that the desired relationship facilitates transfer of loads through the rope assembly between the first and second attachment points.

An excavation system employing a high-pressure pulsed air jet that may optionally be used in combination with a low-pressure high velocity blower for excavating improvised explosive devices or other buried objects. The excavation system may also be employed to operate a pneumatic tool such as a cut-off tool or a chisel. The high velocity blower may incorporate a bifurcated fan duct having two air outlets. The system may include a pressure control module for regulating the from a high-pressure air source to an evacuation valve. The evacuation valve employs first and second valves where the second valve controls the operation of the first valve.

A rolled latch for excavator buckets that increases duration and facilitates maintenance work since it is changed instead of requiring weld fill, and includes three primary parts: a core, a top wear plate and a bottom wear plate. The parts are manufactured of rolled steel. The core remains between the top and bottom wear plates, and the top and bottom wear plates are welded to the core.

Devices, cartridges, and method are described herein for emulating smoking wherein a device generates an aerosol for inhalation by a subject by heating a viscous material that can have a tactile response in the mouth or respiratory tract, while reducing Hoffman analytes and mutagenic compounds delivered to the user as compared to a common tobacco cigarette.

The invention relates to a biodegradable plastic having increased biodegradation speed. Said plastic comprises a) finely distributed particle of a biodegradable, water-soluble, organic component, and b) finely distributed particles of a water-soluble, inorganic component promoting the growth of microorganisms and comprising N, P, and/or S. Said plastic is particularly based on cellulose esters such as cellulose acetate. Preferable components A are water-soluble saccharides and/or water-soluble organic acids. Said particularly advantageous biodegradable plastic is particularly available in the form of fibers, films, injection molded items, granulate beads, and containers. Controlled-release biocides and/or fertilizers can also be included in the molded part, wherein the molded part is degraded faster in the environment as said ingredients are released. The accelerated biodegradation is based on a synergistic interaction of the components indicated.

A system for producing porous masses may include a mold cavity disposed along the material path, at least one hopper before at least a portion of the mold cavity for feeding a matrix material to the material path, a heat source in thermal communication with at least a first portion of the material path, and a cutter disposed along the material path after the first portion of the material path.

Method of applying phase transition substance to impart reduced ignition propensity to a smoking article comprising a tobacco column and a wrapper surrounding the tobacco column and having a porous structure with a base permeability. The method comprising forming a pattern of phase transition material on the wrapper such that, when subjected to the heat of the tobacco column burning firecone, the phase transition material at least partially fills the wrapper porous structure in the vicinity of the burning firecone to form an area on the wrapper having reduced permeability lower than that of the wrapper base permeability. The reduced permeability of the wrapper in the vicinity of the burning firecone imparts reduced ignition propensity such that there is insufficient air flow to sustain combustion of the firecone or insufficient air flow to sustain an intensity of the burning firecone necessary to ignite the substrate.

This disclosure describes embodiments of novel line dispensing devices and methods for dispensing and retracting a line of a line dispensing device.