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PUMP SYSTEM, USE OF A PNEUMATIC RESISTANCE AND MEDICAL DEVICE OR GAS-MEASURING DEVICE

A pump system (120) has a central pump unit (110), with which at least one hook-up unit (130). The least one hook-up unit (130) is from a group of a plurality of hook-up units (130) that can be combined in modular form for setting an operating point of a pump (10) that forms the pump unit (110). A method uses such a hook-up unit (130) in a pump system (120) for setting an operating point of the pump unit (110) thereof. A medical device is provided with such a pump unit (110) or with such a pump unit (110) and at least one hook-up unit (130) combined with the pump unit (110).




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Methods of filtering multiple contaminants, mitigating contaminant formation, and recycling greenhouse gases using a humic and fulvic reagent

A highly alkalized humic and fulvic filter reagent for the removal of multiple contaminants from a gas is provided. The contaminants removed from the gas stream may include, but are not limited to, Carbon Dioxide, Sulfur Oxide, Nitrogen Oxides, Hydrogen Sulfides, radionuclides, mercaptans, ammonia, toxic metals, particulates, volatile vapors, and organics. The present invention further includes the disposal of the filter reagent by way of using the highly alkalized humic and fulvic filter for soil fertility, releasing the carbon dioxide from the filter reagent, converting the liquid filter reagent into a solid for disposal or for use as a contaminant removal filter for waters, wastes, and chemicals.




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Fines capture and recycle system and uses thereof

A cyclone system for a gasifier having two or more cyclones arranged in series sharing a combined loop seal and dipleg is disclosed. Also disclosed is a method for capturing and recycling fines with the cyclone system.




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Process for the preparation of surface-treated calcium carbonate material and use of same in the control of organic material in an aqueous medium

The present invention relates to a process for the production of a surface-treated calcium carbonate, the use of this surface-treated calcium carbonate in a process for the control of organic material in an aqueous medium, as well as to a composite of surface-treated calcium carbonate and organic material, such as a composite of surface-treated calcium carbonate and to the use of such a composite.




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Textile belt, method for making it, and its use

An industrial textile belt, a method for making it, and its use. The belt includes a seam with joining ends that can be joined together so that the belt becomes an endless loop. The joining ends have seam areas with cross-machine direction wear yarns on their machine surface. The wear yarns receive wear stress when the belt slides against the support surface of a processing device.




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Composition and use of hydrogenated alkyl ketene dimers

Latent dispersants were made by the hydrogenation of an alkyl ketene dimer, alkenyl ketene dimer, or ketene multimer. Adding the latent dispersant to paper or paperboard increased its resistance to water and water vapor while maintaining recyclability and repulpability. Additionally, provided is a method for increasing the repulpability of a wax coated paper or paperboard. Dispersants made by the hydrolysis of the alkyl ketene dimer, alkenyl ketene dimer, and ketene multimer are also described.




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Process for the preparation of surface-treated calcium carbonate material and use of same in the control of organic material in an aqueous medium

The present invention relates to a process for the production of a surface-treated calcium carbonate, the use of this surface-treated calcium carbonate in a process for the control of organic material in an aqueous medium, as well as to a composite of surface-treated calcium carbonate and organic material, such as a composite of surface-treated calcium carbonate and to the use of such a composite.




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Process for the preparation of surface-treated calcium carbonate material and use of same in the control of organic material in an aqueous medium

The present invention relates to a process for the production of a surface-treated calcium carbonate, the use of this surface-treated calcium carbonate in a process for the control of organic material in an aqueous medium, as well as to a composite of surface-treated calcium carbonate and organic material, such as a composite of surface-treated calcium carbonate and to the use of such a composite.




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Use of nanocrystaline cellulose and polymer grafted nanocrystaline cellulose for increasing retention, wet strength, and dry strength in papermaking process

The invention provides methods and compositions for improving the characteristics of paper substrates. The method involves adding to a paper substrate an NCC-polymer. NCC-polymers have unique chemical properties which result in improvements in wet strength, dry strength and drainage retention properties of the paper substrates.




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Copolymer blend compositions for use to increase paper filler content

Disclosed are methods for increasing the filler content of paper or paperboard, comprising (a) combining a heterogeneous polymer blend with a ground calcium carbonate filler; (b) combining the resulting mixture with a pulp slurry; and (c) processing the resulting slurry mixture to form a sheet of paper or paperboard. Also disclosed are methods of increasing the filler content of paper or paperboard comprising (1) combining either a heterogeneous polymer blend or a ground calcium carbonate filler with a pulp slurry, (2) combining the remaining component with the pulp slurry; and (c) processing the resulting pulp slurry mixture to form a sheet of paper or paperboard.




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IDENTIFYING USER MANAGED SOFTWARE MODULES

A method for identifying user managed software modules includes: receiving a query that includes an input module name or an input address range. The method further includes, responsive to determining that the input module name or input address range of the received query is not stored in one or more data structures identifying one or more software modules that have been loaded into memory without a directed load, searching a data structure identifying software modules that have been loaded into memory via directed loads for the respective input module name or input address range.




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IDENTIFYING USER MANAGED SOFTWARE MODULES

A computer system for identifying user managed software modules includes program instructions for: receiving a request for a directed load of a software module into memory, wherein the request includes an address; storing the software module at the address in the received request; adding a name and an address range of the stored software module to a data structure identifying software modules that have been loaded into memory via directed loads; receiving a query that includes an input module name or an input address range; and responsive to determining that the input module name or input address range of the received query is not stored in one or more data structures identifying one or more software modules that have been loaded into memory without directed loads, searching the data structure identifying software modules that have been loaded into memory via directed loads for the respective query.




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AUTOMATIC GENERATION OF VALIDATORS TO VALIDATE DEPLOYMENT CODE USED FOR CONFIGURING SERVERS

A validation system is configured to automatically generate validators for one or more target systems. The validation system includes: a memory storing a computer process, a network interface configured to interface with the one or more target systems over a computer network, and a processor executing the computer process. The computer process is configured to parse the deployment code to identify components in deployment code, generate validator code for each identified component, and use the network interface to transmit the validator codes to the one or more target systems.




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ANALYZING DEPLOYMENT PIPELINES USED TO UPDATE PRODUCTION COMPUTING SERVICES USING A LIVE PIPELINE TEMPLATE PROCESS

Techniques are presented for managing a deployment pipeline using an inheritable and extensible source code template—generally referred to as a live pipeline template (LPT). As described, live pipeline templates may be used to manage deployment pipelines which, in turn, are used to launch, maintain, and update the services and systems used to host and provide computing services.




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USER TERMINAL DEVICE, AND MODE CONVERSION METHOD AND SOUND SYSTEM FOR CONTROLLING VOLUME OF SPEAKER THEREOF

A user terminal apparatus is disclosed. The user terminal apparatus includes a touch screen which senses a multi gesture that is performed by using at least two fingers or other input tools, and a controller which provides an individual volume control mode by which a volume of one speaker apparatus is independently controllable with respect to a volume of the remainder of a plurality of speaker apparatuses, and which is convertible into a group volume control mode in order to combine a plurality of speaker apparatuses into a group such that volumes of the plurality of speaker apparatuses can be jointly controlled in response to the multi gesture sensed via the touch screen while the individual volume control mode is provided.




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USER INTERFACES IN A COMPUTER SYSTEM

The disclosure relates to generation of at least one second instance of a user interface presented by a first device. The first device stores data objects comprising event information associated with user interfaces presented by the first device based on data from a source of data. The first device can generate a user interface based on data from the source of data and at least one of the stored data objects. The at least one data object is communicated from the first device for use by at least one second device in generation of a second instance of the generated user interface by the at least one second device.




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METHOD AND SYSTEM FOR GENERATING AND CONTROLLING COMPOSITE USER INTERFACE CONTROL

Embodiments of the present disclosure relate to the field of multimedia technologies and disclose methods for generating and controlling a composite user interface control and an electronic device. The method for generating a composite user interface control includes the following steps: creating at least one composite control, where the composite control includes at least two subcontrols; adding each subcontrol to the composite control; respectively setting a general attribute and a unique attribute of each subcontrol; acquiring a resource of each subcontrol and transmitting the resource to a corresponding subcontrol; and adding an event response mechanism to the composite control. In some embodiments of the present disclosure, the method for generating a composite user interface control may enable a manner for generating a user interface control to be relatively simple, which facilitates control over and modification on all user interface controls or a single user interface control on a user interface.




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Mnemonic Support of Users in Guided Activity Floorplans

Methods and systems that facilitate the generation, presentation, and adaptation of an anchored information bar, associated with a guided activity floorplan or wizard, in support of assisting users as they complete the different steps of a complex task as the user employs software applications (and associated user interfaces) on their devices to go about their different activities.




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REUSE SUPPORT SYSTEM AND METHOD

A reuse support system of an embodiment includes a display controller which displays, on a display, an image including an image of a boundary sample which serves as a reference for reuse of a facility in response to operation of a worker, an acceptor which accepts selection of a reuse mode of the facility, and a manager which manages a delivery destination of the facility based at least in part on the reuse mode of the facility selected by the acceptor.




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REUSE SUPPORT SYSTEM AND METHOD

A reuse support system is provided. The system includes an acquisitor which acquires skill data of workers, a grantor which grants a work license to the workers based on the acquired skill data of the workers and stores the granted work license for each of the workers in a storage, and a provider which reads the work license from the storage in response to authentication operation of the workers and provides an image according to the read work license.




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USER INTERFACE CONTROL LAYOUT METHOD AND ELECTRONIC DEVICE

Embodiments of this disclosure relate to the field of multimedia technologies, and disclose a user interface control layout method and an electronic devices. The user interface control layout method includes the following steps: creating a relative layout container, where the relative layout container is used to contain child controls, and the child controls are a relative layout container or a normal control; specifying an attribute of a child control for the relative layout container; generating the child control; and if the child control is a relative layout container, repeating the foregoing steps, until all the child controls in the relative layout container are normal controls. In some embodiments of this disclosure, multiple UI controls of different sizes or types may be generated one by one through layout and arrangement, and the UI controls of different sizes or types may be nested with each other, and thereby UI interfaces based on different rules can be quickly implemented to meet different requirements of various products for UI control arrangement.




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GENERATING LABELS FOR IMAGES ASSOCIATED WITH A USER

A method includes identifying an image associated with a user, where the image is identified as at least one of captured by a user device associated with the user, stored on the user device associated with the user, and stored in cloud storage associated with the user. The method also includes determining one or more labels for the image, where the one or more labels are based on at least one of metadata, a primary annotation, and a secondary annotation and the secondary annotation is generated by performing label expansion on at least one of the metadata and the primary annotation. The method also includes generating a mapping of the one or more labels to one or more confidence scores, wherein the one or more confidence scores indicate an extent to which the one or more labels apply to the image.




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RECOMMENDING PAGES OF CONTENT TO AN ONLINE SYSTEM USER BY IDENTIFYING CONTENT FROM RECOMMENDED PAGES TO THE USER

An online system, such as a social networking system, recommends pages of content to users. The recommendation is presented in a recommendation unit presenting one or more representations of pages to a user. Additionally, the user may interact with the recommendation unit to change representations of pages presented by the recommendation unit. A representation of a page presented by the recommendation unit includes content from one or more content items on the page selected based on interaction with the content items on the page and types of content included in content items on the page (e.g., image data, video data, destination address). Representations of different pages may differ based on the types of content included in content items selected from the different pages.




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SYSTEMS AND METHODS FOR PROCESSING REAL-TIME AND HISTORICAL DATA AND GENERATING PREDICTIVE GRAPHICAL USER INTERFACES

Computer implemented systems and methods are provided for generating a predictive graphical user interface. In some embodiments, a system for generating a predictive graphical user interface may comprise at least one processor configured to receive real-time and historical data associated with utilization of a facility. The at least one processor may be configured to generate, based on the real-time and historical data, instructions to display a user interface depicting a first representation of utilization of the facility at a first time. The at least one processor may be configured to receive a request to display a second representation of utilization of the facility, the request including a selection of a second time, and generate, based on the real-time and historical data, instructions to display, within the interface, a second representation of utilization of the facility, the second representation reflecting utilization at the second time, wherein the second time is a future time relative to the first time.




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Methods and Systems for Managing Multiple Communication Sessions from a Single On-Screen User Interface

An exemplary communication session management system concurrently presents a plurality of session icons within a single on-screen user interface, each session icon representative of a respective communication session and configured to visually indicate a session status of the respective communication session. The communication session management system further detects a user action performed by a user with respect to one of the plurality of session icons, modifies a communication session in response to the user action, and graphically indicates the modification of the session status of the communication session. Corresponding systems and methods are also described.




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Multiple user lockbox

A lockbox includes a body and a lid connected to body and pivotable between a closed position and an open position. The body defines an enclosure and includes a body aperture and the lid includes a first lid aperture positioned adjacent to the body aperture when the lid is in the closed position, such that insertion of a padlock shackle through the body aperture and the lid aperture prevents pivoting movement of the lid from the closed position to the open position. The lockbox includes a slot intersecting one of the body aperture and the lid aperture for insertion of an item into the enclosure when the lid is in the closed position. A padlock shackle inserted through the body aperture and the lid aperture prevents passage of an item through the slot.




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Foot manifolds, apparatuses, systems, and methods for applying reduced pressure to a tissue site on a foot

Apparatuses, systems, and methods for applying reduced pressure to a tissue site on a foot are provided. An apparatus may include an insole and a tissue contacting surface covering at least a portion of the insole. At least one portion of the tissue contacting surface is removable to form a void. The apparatus may also include a reduced-pressure interface for receiving reduced pressure from a reduced-pressure source, and at least one flow channel fluidly coupled to the reduced-pressure interface and the void.




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Apparatuses and methods for thermodynamic energy transfer, storage and retrieval

Systems and methods for transferring and optionally storing and/or retrieving thermal energy are disclosed. The systems and methods generally include a heat engine and a heat pump, the heat engine including first isothermal and gradient heat exchange mechanisms, and the heat pump including second isothermal and gradient heat exchange mechanisms. The heat engine and the heat pump exchange heat with each other countercurrent across the first and second gradient heat exchange mechanisms, the first isothermal heat exchange mechanism transfers heat to an external heat sink, and the second isothermal heat exchange mechanism receives heat from an external heat source.




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Articles containing copper nanoparticles and methods for production and use thereof

Articles containing a matrix material and plurality of copper nanoparticles in the matrix material that have been at least partially fused together are described. The copper nanoparticles are less than about 20 nm in size. Copper nanoparticles of this size become fused together at temperatures and pressures that are much lower than that of bulk copper. In general, the fusion temperatures decrease with increasing applied pressure and lowering of the size of the copper nanoparticles. The size of the copper nanoparticles can be varied by adjusting reaction conditions including, for example, surfactant systems, addition rates, and temperatures. Copper nanoparticles that have been at least partially fused together can form a thermally conductive percolation pathway in the matrix material.




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Process for recycling of steel industry iron bearing by-products, pellet obtained in that process and use thereof

The present invention relates to a process for the recycling of steel industry iron bearing by-products into a shape suitable for feeding into a direct reduction furnace, comprising the steps of mixing and grinding 50 to 99 wt % of ore and pellet fines and 1 to 50 wt % of slurry, mill scale and/or bag house dust, pelletizing the mixture and indurating the pellets so obtained by heating for 5-60 minutes at a temperature in the range of 1100-1350° C.; and a pellet produced from Iron bearing waste material and having compression strength of at least 2.8 kN and/or a drop number of at least 3.




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Hands free air chuck and method of use

A tool for filling a tire with a gas is provided. The tool includes: an air chuck; a shaft connected to the air chuck; a rim hook connected to the shaft; and a spring located between the shaft and the rim hook. A method of filling a tire is also provided. The method may include: connecting an air chuck to a valve stem; attaching a hook and spring assembly attached to the air chuck to a rim associated with the tire to be filled; and flowing a fluid through, the air chuck and into the valve stem.




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Processes for preparing valve metal powders, powders prepared thereby and uses therefor

Processes comprising: melting a mixture comprising a valve metal precursor and a diluting agent in at least one first vessel under a first set of temperature and residence time conditions; transferring the mixture to at least one second vessel; and initiating, in the at least one second vessel, a reaction of the valve metal precursor to form a valve metal under a second set of temperature and residence time conditions; valve metal powder prepared thereby and uses therefor.




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Towel tags to permit minimizing the use of water and detergent during washing and minimizing wear and tear of towels, the spread of germs and diseases between towel users, and minimizing the use of energy, and saving money

Towel tags to permit minimizing the use of water and detergent during washing and minimizing wear and tear of towels, the spread of germs and diseases between towel users, and minimizing the use of energy, and saving money. The abstract of the disclosure is submitted herewith as required by 37 C.F.R. §1.72(b). As stated in 37 C.F.R. §1.72(b): A brief abstract of the technical disclosure in the specification must commence on a separate sheet, preferably following the claims, under the heading “Abstract of the Disclosure.” The purpose of the abstract is to enable the Patent and Trademark Office and the public generally to determine quickly from a cursory inspection the nature and gist of the technical disclosure. Any statements made relating to the abstract are not intended to limit the claims in any manner and should not be interpreted as limiting the claims in any manner.




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Cleaning compositions for use in closed loop cleaning machines

Embodiments of the present disclosure include cleaning processes, closed loop cleaning machines, and methods of cleaning an article. The cleaning process includes contacting a surface of an article with a cleaning composition in a cleaning chamber, where the cleaning composition includes at least about 85 percent by weight organic solvents, based on total weight of the cleaning composition, and where at least about 5 percent by weight of the organic solvents is propylene glycol, based on total weight of the organic solvents, to clean the surface of the article, collecting the cleaning composition including contaminants, and recovering the cleaning composition via distillation, where a distillation apparatus removes the contaminants from the cleaning composition and is connected to the cleaning chamber by a process stream.




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Ductile mode machining methods for hard and brittle components of plasma processing apparatuses

A method of ductile mode machining a component of a plasma processing apparatus wherein the component is made of nonmetallic hard and brittle material wherein the method comprises single point turning the component with a diamond cutting tool causing a portion of the nonmetallic hard and brittle material to undergo a high pressure phase transformation to form a ductile phase portion of the hard and brittle material during chip formation wherein a turned surface is formed from a phase changed material and the turned surface is a grooved textured surface of phase changed material.




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Dressing device for a grinding wheel and its use in a centreless nuclear fuel pellet grinder

The invention relates to a device for dressing a grinding wheel, comprising a sleeve to hold a corundum rod laterally and to guide it along its longitudinal axis, a ram to apply constant thrust force onto the corundum rod held in place and guided in the sleeve, to bring it into contact with the grinding wheel, means of rigidly connecting the ram shaft to the end of the corundum rod, and linear guide means for the sleeve for translating the corundum rod parallel to the axis of the grinding wheel while keeping the rod pressed against the grinding wheel with a constant force. Application to a centerless grinder in which the grinding wheel is used to grind nuclear fuel pellets.




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Titanium based ceramic reinforced alloy for use in medical implants

A titanium based, ceramic reinforced alloy ingot for use in producing medical implants. An ingot is formed from an alloy having comprising from about 5 to about 35 wt. % niobium, from about 0.5 to about 3.5 wt. % silicon, and from about 61.5 to about 94.5 wt. % of titanium. The alloy has a hexagonal crystal lattice α phase of from about 20 vol % to about 70 vol %, and a cubic body centered β crystal lattice phase of from about 30 vol. % to about 80 vol. %. The ingot has an ultimate tensile strength of about 940 MPa or more, and a Young's modulus of about 150 GPa or less. A molten substantially uniform admixture of a niobium, silicon, and titanium alloy is formed, cast into a shape, and cooled into an ingot. The ingot may then be formed into a medical implant and optionally annealed.




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Fluid purification level control apparatuses and methods

Apparatuses and methods for level control in a fluid purification apparatus. The apparatuses and methods include a fluid purification apparatus and a level sensor that regulates operation of the fluid purification apparatus. The level sensor may further operate a bypass valve or a heater.




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Method of produced water treatment, method of water reuse, and systems for these methods

A method of produced water treatment in an in-situ recovery method of producing bitumen from oil sand, the method has the steps of: separating bitumen from bitumen-mixed fluid so as to leave produced water, the bitumen-mixed fluid having been recovered from the oil sand wells; and filtering the produced water via a microfiltration membrane made of polytetrafluoroethylene.




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Filter device, method for its operation and use thereof

A filter device for filtering a suspension includes at least one filter for continuous creation of a filter cake including particles from the suspension, at least one dispensing device configured to apply at least one first wash liquid to the filter cakes, at least one steaming unit configured to steam the filter cake using steam; at least one removal device configured to remove a surface layer of the filter cake facing away from the at least one filter, wherein the filter device is configured to convey the filter cake to the at least one removal device, the at least one dispensing device and the at least one steaming device, and at least one transport device configured to transport the removed surface layer of the filter cake away from the filter device.




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Headband for use with medical sensor

Headbands configured to provide pressure against a medical sensor secured to a patient's forehead are provided. The headbands may include one or more low friction materials to enable an elastic band of a tensioning mechanism to evenly stretch. Additionally or alternatively, the headbands may include two or more bands adapted to secure the headband to various portions of a patient's head. Still further, the headbands may be configured to independently vary the pressure created between two or more sensors and the patient's head.




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Handgrip sleeve for use with a crochet hook

An apparatus for removably securing resilient cushioning and gripping support to a crochet hook to facilitate its manipulation. Handgrip sleeve for use with a crochet hook is a lightweight, resilient gripping sleeve having an interior cavity for the accommodation of a crochet hook. Complete with gripping members and an elastomeric composition, handgrip sleeve for use with a crochet hook provides increased comfort and decreased fatigue for a user during the completion of a handicraft project.




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Packed bed scrubber using a fusel oil solvent

A two stage scrubber process for ethanol fermentation has a first stage using fusel oil to remove the hazardous air pollutants and recover the majority of the ethanol. A second stage uses water as the scrubbing solvent to recover any residual ethanol that is stripped from the first stage.




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System and method for preparing a beverage suitable for consumption, and a use of such a system, a receiving chamber and a holder

A system for preparing a beverage suitable for consumption, for instance coffee and/or tea, is disclosed. The system comprises an apparatus for dispensing beverage under pressure to a nozzle of the system, and at least one receiving chamber which is placeable or is placed downstream of this nozzle. During use, the nozzle spouts a jet of the beverage with relatively high velocity to and/or into the receiving chamber. The receiving chamber is provided with at least one outflow opening for dispensing beverage received in this chamber. The system is at least configured to substantially counteract or prevent formation of foam of this beverage, in particular when the beverage is spouted to and/or into the receiving chamber. Further disclosed is an assembly at least provided with a holder, to a holder, a receiving body, the use of a said system and to a method for preparing a beverage suitable for consumption.




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BICYCLIC PYRAZOLONE COMPOUNDS AND METHODS OF USE

The present invention provides substituted bicyclic pyrazolone compounds, which are used to inhibit or modulate the activity of receptor tyrosine kinases, especially Axl, Mer, c-Met and Ron. The invention also provides pharmaceutical compositions comprising the compound disclosed herein, and a method of preventing, treating or lessening the severity of a proliferative disorder in a patient with the compounds or the pharmaceutical compositions disclosed herein.




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FACTOR H BINDING PROTEIN VARIANTS AND METHODS OF USE THEREOF

Variant factor H binding proteins that can elicit antibodies that are bactericidal for at least one strain of Neisseria meningitidis, compositions comprising such proteins, and methods of use of such proteins, are provided.




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METHODS AND COMPOSITIONS FOR SUPPRESSING RETROVIRUSES

The disclosure provides methods and compositions for suppressing retroviruses, including novel methods for treating a retroviral infection in a human in need of such treatment, comprising delivering a functional meiosis arrest female protein 1 (MARF1) to cells containing a retroviral provirus, together with novel expression constructs comprising a coding sequence encoding a functional MARF1 operatively linked to a promoter, vectors comprising such constructs, and packaging cell lines for use in making such vectors.




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MULTI-SPECIFIC ANTI-PSEUDOMONAS PSL AND PCRV BINDING MOLECULES AND USES THEREOF

This disclosure relates to combination therapies comprising anti-Pseudomonas Psl and PcrV bispecific binding molecules and related compositions, for use in prevention and treatment of Pseudomonas infection.




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OPOID RECEPTOR BINDING AGENTS AND USES THEREOF

Agents that specifically bind to an opioid receptor in a conformationally specific way can be used to induce a conformational change in the receptor. Such agents have therapeutic applications and can be used in X-ray crystallography studies of the receptor. Such agents can also be used to improve drug discovery via compound screening and/or structure-based drug design.




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NOTCH1 RECEPTOR BINDING AGENTS AND METHODS OF USE THEREOF

The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor and inhibits tumor growth. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.