mon

Removable surface-wave networks for in-situ material health monitoring

A system for measuring properties of a surface under test with surface waves includes a surface wave network including a dielectric substrate, a reactive grid of a plurality of metallic patches on a first surface of the dielectric substrate, a plurality of electronic nodes on the first surface of the dielectric substrate, and a ground plane on a second surface of the dielectric substrate permeable to RF fields of the surface waves, and a controller configured for causing a respective one of the electronic nodes to transmit at least one surface wave and configured for collecting data for signals received by at least one other of the plurality of electronic nodes.




mon

Monolithic optical coupling module based on total internal reflection surfaces

In one aspect, an optical device comprises a monolithic optical module which includes a first total internal reflection (TIR) surface, a second TIR surface adjacent the first TIR surface, and a first optical port aligned with the first internal optical beam dividing interface. An interface between the first TIR surface and the second TIR surface forms a first internal optical beam dividing interface. An exterior surface of the first TIR surface and an exterior surface of the second TIR surface form a generally V-shaped notch on the monolithic optical module. A first optical beam entering the monolithic optical module through the first optical port and incident on the first internal optical beam dividing interface is partially reflected by the first TIR surface to travel in a first direction as a second optical beam and partially reflected by the second TIR surface to travel in a second direction as a third optical beam. The second direction is generally opposite to the first direction.




mon

Suppressed carrier harmonic amplitude modulator

A circuit includes a switched modulator stage combining an information signal with a square wave carrier to produce a first modulated signal; and a second modulation stage forming additional steps in the first modulated signal to produce a second modulated signal.




mon

Circuit interrupter employing a linear transducer to monitor contact erosion

A circuit interrupter includes, a first contact and a second contact, the second contact being moveable relative to the first contact, a drive assembly structured to move the second contact relative to the first contact, and an erosion monitoring device including a linear transducer coupled to a portion of the drive assembly. The liner transducer is structured to generate an output signal representative of an amount of linear displacement of the portion of the drive assembly, wherein the erosion monitoring device is structured to monitor a degree of erosion of at least one of the first contact and the second contact based on the output signal.




mon

Method and apparatus for forming fine gauge and monofilament single and double-armed sutures

An apparatus for forming armed sutures has a swaging station for receiving, holding and swaging needles that are deposited therein. A linear motor drives a suture insertion gripper, which pulls suture from a supply reel and inserts a cut end thereof into a needle held in the swaging station. A ganged needle transfer assembly with a plurality of spaced needle gripper units carries needles along a line substantially at right angles to the suture line and transfers them to and from the swaging station and other needle processing stations. A precisor orients needles prior to placement in the swaging station and a pull test assembly tests armed sutures in both destructive and non-destructive modes. Both ends of the production line may be automated, e.g., by robots which load and offload needles prior to and after swaging, respectively. The apparatus is capable of forming double armed sutures by using a rotatable mount for the suture insertion gripper and a secondary, loop gripper. A suture transfer gripper extending up to the suture from a multi-tiered stack of slide tables. The suture transfer gripper cooperates with the suture insertion and loop grippers to hold the suture during cutting, insertion and transfer to the pull test apparatus and thereby protects the suture during processing.




mon

Ceremonial luminary and associated process

A ceremonial illuminary including a voltage supply mechanism, a switching mechanism that is electrically connected to the voltage supply mechanism, a first lamp electrically connected to the switching mechanism, a second lamp electrically connected to the switching mechanism wherein the switching mechanism provides voltage to the first lamp to illuminate the first lamp and then switches to provide voltage to the second lamp instead of the first lamp when the first lamp burns-out and no longer illuminates. The first lamp and the second lamp are secured with an enclosure.




mon

Lighting fixture that self-estimates its power usage and monitors its health

Apparatuses, methods and systems for lighting fixture determining its power usage and monitoring its operational health are disclosed. One embodiment includes a method of a lighting fixture determining its power usage. The method includes sensing, by an ambient light sensor, an intensity of light emitted from the lighting fixture, and estimating power usage of the lighting fixture based on the sensed intensity of light.




mon

Electric de-icing device and related monitoring system

The invention relates to a de-icing device for an element of a nacelle of a turbojet engine, including at least one heating resistant mat connected to at least one electrical power source (3) and thus defining an assembly (1) of resistant mats, characterized in that the assembly of resistant mats includes one or more subassemblies of resistant mats, each subassembly in turn including one or more resistant mats of the assembly, and each subassembly of resistive mats having a different ohmic value.




mon

Hoist health and usage monitoring system and components thereof

Health and usage monitoring systems for aircraft hoist systems are described herein. In some embodiments, a health and usage monitoring system comprises a capacitive load cell and a processing unit for communication with the capacitive load cell, the capacitive load cell comprising a load receiving surface and a capacitive assembly coupled to the load receiving surface, the capacitive assembly comprising parallel electrically conductive plates separated by a reversibly deformable spacer construction wherein the parallel plates comprise aligned apertures providing a passageway through the capacitive assembly for the hoist system cable.




mon

Antimony compounds useful for deposition of antimony-containing materials

Precursors for use in depositing antimony-containing films on substrates such as wafers or other microelectronic device substrates, as well as associated processes of making and using such precursors, and source packages of such precursors. The precursors are useful for deposition of Ge2Sb2Te5 chalcogenide thin films in the manufacture of nonvolatile Phase Change Memory (PCM) or for the manufacturing of thermoelectric devices, by deposition techniques such as chemical vapor deposition (CVD) and atomic layer deposition (ALD).




mon

Dispersion medium comprising monocarboxylic esters for preparations of solids

The invention concerns a composition comprising as component (A): 10% to 97% by weight, based on the total weight of the composition, of one or more monocarboxylic esters of the general formula R1—CO—OR2, in which R1 is a saturated or unsaturated, branched or straight-chain, aliphatic group having 11 to 23 carbon atoms and R2 is a branched or straight-chain aliphatic group, a cycloaliphatic group or aromatic group having 1 to 13 carbon atoms, and the sum of the carbon atoms of the groups R1 and R2 is not more than 30, the monocarboxylic ester or esters possessing a boiling point of more than 250° C. under a standard pressure of 101.3 kPa, and as component (B): 3% to 90% by weight, based on the total weight of the composition, of one or more dispersants, the composition possessing a viscosity at 25° C. of less than 5000 mPas. The invention further concerns the use of the composition as a dispersion medium, millbases obtained from the composition, and the use of the millbases.




mon

Monitoring and alarm device for construction machinery

The invention relates to a monitoring and alarm device for construction machinery having long and heavy booms, such as cranes, in particular mobile cranes, is characterized in that a monitor system is provided, which monitors parameters that may change in case of an undesired lowering of the boom or of boom sections in a non-operating condition, and triggers an optical and/acoustic and/or wireless alarm system if the parameters change.




mon

Method and apparatus for condition monitoring of valve

In the method and apparatus of the invention, the process point is taken into account when the condition and performance of a control valve are monitored. In the condition monitoring of the valve, process measurements are used in addition to measurements inside the valve in such a manner that the process measurements identify the operating point at which the valve operates, and the measurements inside the valve are observed at these operating points to detect changes and to determine the condition of the valve. According to an aspect of the invention, the variables representing the operating point of an industrial process are considered when changes in the friction load of the valve and/or the load factor of the actuator are observed.




mon

Railway system using acoustic monitoring

A method of monitoring and/or controlling components of a railway system which includes a track and at least one train that is operable to run on said track, comprises the steps of: a) providing an acoustic transducer proximate the railway for picking up acoustic signals; b) receiving acoustic signals from the transducer; and c) analyzing the received signals.




mon

Method and sequential monitoring overlay system for track circuits

A sequential monitoring system is for an interlocking logic system and a track circuit system including a plurality of track circuits. The sequential monitoring system includes an interface between the interlocking logic system and the track circuit system; and a processor structured to monitor a state of each of the track circuits, validate a sequence of state changes of the track circuits, and interrupt and correct invalid track circuit state indications between the track circuit system and the interlocking logic system. The interface normally passes inputs from the track circuit system to outputs to the interlocking logic system. When an out of sequence event occurs, the processor applies a quarantine to a minimum of three of the track circuits in a quarantined area, thereby inhibiting use of an unoccupied track circuit in the quarantined area.




mon

Replication of patterned thin-film structures for use in plasmonics and metamaterials

The present invention provides templating methods for replicating patterned metal films from a template substrate such as for use in plasmonic devices and metamaterials. Advantageously, the template substrate is reusable and can provide plural copies of the structure of the template substrate. Because high-quality substrates that are inherently smooth and flat are available, patterned metal films in accordance with the present invention can advantageously provide surfaces that replicate the surface characteristics of the template substrate both in the patterned regions and in the unpatterned regions.




mon

Devices, systems, and methods for adherence monitoring and devices, systems, and methods for monitoring use of consumable dispensers

Devices, systems, and methods are provided for adherence monitoring, and devices, systems, and methods are provided for monitoring use of consumable dispensers. In general, the devices, systems, and methods can facilitate an individual's adherence to a schedule for consuming consumables and can facilitate monitoring and tracking of the individual's adherence to the schedule. The devices, systems, and methods can allow data regarding the individual's historical adherence to the schedule to be accessible via a computer system. In one embodiment, an accessory is provided that can be configured to attach to consumable dispensers. The accessory can be configured to be removably and replaceably coupled to the dispenser. The accessory can be configured to provide a notification to a user indicating that a certain event occurred and/or that a certain action needs to be taken. The accessory can be configured to sense attachment thereof to and removal thereof from the dispenser.




mon

Monorail vehicle apparatus with gravity-augmented contact load

Apparatus and method for gravity-augmented preload of drive wheels in a monorail vehicle travelling along a guide rail bearing and contact surfaces that are non-parallel with the gravity vector. The vehicle has a structure defining a pivot location against the bearing surface, as well as first and second assemblies for engaging the rail on the bearing and contact surfaces, respectively. The vehicle is mounted so its center of gravity is at a rear longitudinal offset rrl from the pivot location and a vertical offset rvert from the guide rail. A force and moment balance thus created in a normal load on a drive wheel engaged with the bearing surface at the pivot location, where the load value exceeds a standard normal load generated by the mass of the monorail vehicle alone.




mon

On-train rail track monitoring system

An automatic inspection system is provided for monitoring rail track for detecting and generating alerts for certain hazards to the operation of trains that may cause various safety concerns and even derailment. The monitoring is during normal railway service runs without interrupting the normal railway services. In one implementation, an imaging module is used on a passenger or freight train to capture video images of the rail track under the train in motion. In one implementation, the captured video images are automatically processed in a computer using a software module which is based on digital image processing techniques and algorithms to determine whether an irregularity is present on the rail track. In one implementation, video images containing detected irregularities on the rail track are transmitted to a control center for further analysis and possible alert.




mon

Monorail vehicle apparatus with gravity-controlled roll attitude and loading

Monorail vehicle that travels on a non-featured rail with substantial profile variation and controls roll attitude, lateral location, and loading through judicious placement of the vehicle's center of gravity without using springs or suspensions. The vehicle has a bogie for engaging the non-featured rail so the center of gravity has a lateral offset r1 from the rail centerline to produce a roll moment Nr determined by vehicle's mass and value of r1. The center of gravity also has a vertical offset r2. The bogie uses first and second assemblies for engaging the rail to produce a pair of surface normal reaction forces to thus control roll attitude and loading by the placement of the center of gravity, thereby enabling accurate alignment of the monorail vehicle.




mon

Money handling apparatus

In a money handling apparatus 10, an inlet 21 receives money of a plurality of different currencies. A control unit 40 controls a transport unit 31 such that the money is sorted and delivered from the transport unit 31 to the outlets 23, 24 and 25 based on a money recognition result by a recognition unit 32. The control unit 40 judges whether the currency having been recognized by the recognition unit 32 is assigned to any of the outlet 23, 24 and 25. When this happens, the control unit 40 transports the money to the assigned outlet. When the currency of the money having been recognized by the recognition unit 32 is not assigned to any of the outlet 23, 24 and 25, if there is an outlet to which no currency is assigned, the control unit 40 assigns and transports the money to that outlet.




mon

Low-friction seal ring with inexpensive diamond coating

The present invention refers to a seal ring for a mechanical seal, comprising: a base body (2) with a diamond layer (3) which is applied to the base body (2) and configured as a sliding surface, wherein the diamond layer (3) has a thickness (D) which is less than or equal to 4 μm, particularly less than or equal to 3 μm, particularly less than or equal to 2 μm, particularly preferably about 1 μm, and wherein the base body (2) is without fissures or only comprises fissures that have a maximum longitudinal extension (L) on a surface of the base body (2) or in the base body (2) that is less than or equal to 5 μm.




mon

Coaxial passive radiation monomer

A coaxial passive radiation monomer apparatus is disclosed. In accordance with an aspect of the present disclosure, there is disclosed a dynamic speaker monomer combined with a passive radiator in a single unitary structure located in spatial proximity with respect to one another to thereby and further comprising an elastic material at the base of the speaker assembly for enhanced and optimized resonance frequencies for the active and passive components of the overall device.




mon

Removal of hydrogen sulfide as ammonium sulfate from hydropyrolysis product vapors

A system and method for processing biomass into hydrocarbon fuels that includes processing a biomass in a hydropyrolysis reactor resulting in hydrocarbon fuels and a process vapor stream and cooling the process vapor stream to a condensation temperature resulting in an aqueous stream. The aqueous stream is sent to a catalytic reactor where it is oxidized to obtain a product stream containing ammonia and ammonium sulfate. A resulting cooled product vapor stream includes non-condensable process vapors comprising H2, CH4, CO, CO2, ammonia and hydrogen sulfide.




mon

Lithographic printing plate precursor, lithographic printing plate platemaking method, and polymerizable monomer

There is provided a lithographic printing plate precursor that enables image recording using a laser and that provides an excellent scumming resistance and an excellent developability while maintaining a satisfactory printing durability. Also provided are a platemaking method, and a novel polymerizable monomer. A lithographic printing plate precursor has a support, and an image recording layer disposed thereon and containing a radical polymerization initiator and a polymerizable monomer that has a sulfonamide group and at least two ethylenically unsaturated groups; a lithographic printing plate platemaking method uses this lithographic printing plate precursor; and a polymerizable monomer has a sulfonamide group and at least two ethylenically unsaturated groups.




mon

Split ply tires and bead area monocomponents

An intermediate article of manufacture formed as a first stage bead area subassembly for a split ply pneumatic tire carcass is disclosed. The bead area subassembly has an annular bead core; a bead apex; a ply strip; and preferably a sidewall affixed to the ply strip. The subassembly is formed into a disk-shaped bead area monocomponent. The ply strip is wrapped about the bead core and the apex to form a ply turnup and both the ply strip and the ply turnup extend radially outwardly from the bead core. The bead area subassembly when formed into the disk-shaped bead area monocomponent is placed on an annular holder device. The combination of the bead area monocomponent on the holder device can be stacked for storage and latter assembly into a split ply carcass. Preferably, the ply turnup can be oriented extending inside or axially inward of the bead core on final assembly to form a split ply tire having axially inside turnups. In the preferred embodiment the ply strip is reinforced by radially extending ply cords.




mon

MONITORING APPLICATION STATES FOR DEPLOYMENT DURING RUNTIME OPERATIONS

Interaction between development environments and runtime environments to ensure that underlying process components are in an acceptable state before deploying application updates. A deploy state monitor in a development environment interacts with runtime values in executing applications to manage deployment requests and states of executing applications.




mon

OBJECT MONITORING IN CODE DEBUGGING

According to example embodiments of the present invention, an object to be monitored is determined, the object being associated with a variable in a code snippet including a plurality of statements. The object is monitored in execution of the plurality of statements. If a plurality of updates of the object are detected in the execution of the plurality of statements, a snapshot associated with each of the updates of the object is created. The snapshot includes a current value of the object and a memory address for the current value of the object.




mon

Mnemonic Support of Users in Guided Activity Floorplans

Methods and systems that facilitate the generation, presentation, and adaptation of an anchored information bar, associated with a guided activity floorplan or wizard, in support of assisting users as they complete the different steps of a complex task as the user employs software applications (and associated user interfaces) on their devices to go about their different activities.




mon

Monofilament line cutting tool

A monofilament line cutting tool is formed by sandwiching a cutting blade between first and second plastic sheets which are thermally bonded to one another. A monofilament line receiving slot in the plastic sheets extends to the blade whereby monofilament line bent into a U-shape may be placed in contact with the blade cutting edge. The plastic sheets are part of spool forming plastic sheet portions which are thermally bonded to one another and shaped into a spool. The plastic sheets forming the tool are selectively pivotable about a live hinge relative to the spool. The plastic sheets can be separated from one another for forming: a sphere generally around the cutting edge; a pair of elongate barrels extending parallel along each side of the monofilament line receiving slot and adjacent the cutting edge; or, a monofilament line receiving cavity extending to the blade cutting edge.




mon

Systems and methods for localization of tire pressure monitoring system wheel modules

Embodiments relate to unidirectional TPMS utilizing information from a corresponding vehicle system in order to correlate with vehicle speed information to be used in a tire localization methodology. In an embodiment, the vehicle system is an anti-lock brake system (ABS), and the vehicle speed can be used in a localization scheme that reconstructs a +/−1 g ripple with waveform, amplitude, frequency and phase parameters. Because the waveform is known to be sinusoidal (due to the wheel rotation), the amplitude is known to be 2 g peak-to-peak (due to the gravitational +/−1 g), the frequency depends on vehicle speed (which can be estimated from centrifugal force measurements), and an algorithm is discussed herein for determining the phase by correlation, the +/−1 g ripple can be reconstructed and the wheels localized therefrom.




mon

Oxygen monolayer on a semiconductor

A Si or Ge semi-conductor substrate includes an oxygen monolayer on a surface thereof. The oxygen monolayer can be fractional or complete. A Si4+ or Ge4+ oxidation state of the surface of the Si or Ge substrate, respectively, resulting from the presence of the oxygen monolayer represents less than 50%, preferably less than 40% and more preferably less than 30% of the sum of Si1+, Si2+, Si3+ and Si4+ oxidation states or the sum of Ge1+, Ge2+, Ge3+ and Ge4+ oxidation states, respectively, as measured by XPS.




mon

Interchangeable cases for biometric monitoring devices

A biometric monitoring device and multiple carrying cases for same are provided. In some implementations, the case may be made from a flexible viscoelastic material and the biometric monitoring device may be slipped into a receptacle in the case through an opening in the case; the opening may become distended during the insertion of the biometric monitoring device. In some implementations, the case may feature a display window that, in combination with materials of the biometric monitoring device, may mask a display of the biometric monitoring device from view when the display is off and may allow the display to be seen when the display is displaying content.




mon

Towel tags to permit minimizing the use of water and detergent during washing and minimizing wear and tear of towels, the spread of germs and diseases between towel users, and minimizing the use of energy, and saving money

Towel tags to permit minimizing the use of water and detergent during washing and minimizing wear and tear of towels, the spread of germs and diseases between towel users, and minimizing the use of energy, and saving money. The abstract of the disclosure is submitted herewith as required by 37 C.F.R. §1.72(b). As stated in 37 C.F.R. §1.72(b): A brief abstract of the technical disclosure in the specification must commence on a separate sheet, preferably following the claims, under the heading “Abstract of the Disclosure.” The purpose of the abstract is to enable the Patent and Trademark Office and the public generally to determine quickly from a cursory inspection the nature and gist of the technical disclosure. Any statements made relating to the abstract are not intended to limit the claims in any manner and should not be interpreted as limiting the claims in any manner.




mon

Brazed diamond dressing tool

A dressing blade for finishing and reconditioning new and used abrasive grinding and cutting tools has a slab-shaped shank with an extension protruding longitudinally from the shank. Superabrasive grains are disposed on the surface of the extension and held in place by a brazed metal composition. This composition is formed by brazing a powdered mixture of brazing metal components and active metal components. Specific extension configurations are provided which allow aligning the superabrasive grains in single layer arrangement for precise dressing and simple fabrication of the tool. The novel dressing tool exhibits excellent wear characteristics.




mon

Apparatus, system and method for using a diamond-impregnated wire to cut an object

An apparatus, a system and a method may use a diamond-impregnated wire loop to cut an underwater pipeline. The apparatus may have a frame, a carriage attached to the frame and/or pulleys connected to the carriage. The diamond-impregnated wire loop may be connected to the pulleys. The carriage may move relative to the frame to direct the diamond-impregnated wire loop in a forward direction relative to the frame and/or through the pipeline.




mon

Cutting tool with blade made of fine-crystalline diamond

The present invention relates to a cutting tool, in particular in the form of a razor blade, a scalpel, a knife, a machine knife, scissors etc., which has a synthetic diamond layer with a cutting edge. The diamond layer thereby consists of fine-crystalline diamond.




mon

Method of dressing an abrasive wheel using a polycrystalline CVD synthetic diamond dresser and method of fabricating the same

A method of dressing a wheel using a polycrystalline CVD synthetic diamond dresser, the method comprising: rotating the wheel; and contacting a working surface of the wheel with a working surface of the polycrystalline CVD synthetic diamond dresser, wherein the polycrystalline CVD synthetic diamond dresser is oriented such that a leading edge of the working surface of the polycrystalline CVD synthetic diamond dresser is formed of larger grains than a trailing edge of the working surface of the polycrystalline CVD synthetic diamond dresser.




mon

Apparatus, system and method for using a diamond-impregnated wire to cut an object

An apparatus, a system and a method may use a diamond-impregnated wire loop to cut an underwater pipeline. The apparatus may have a frame, a carriage attached to the frame and/or pulleys connected to the carriage. The diamond-impregnated wire loop may be connected to the pulleys. The carriage may move relative to the frame to direct the diamond-impregnated wire loop in a forward direction relative to the frame and/or through the pipeline.




mon

Aluminum-diamond composite and manufacturing method

Disclosed is an aluminum-diamond composite having both high thermal conductivity and thermal expansion coefficient close to those of semiconductor elements, which is improved in platability in the surface and surface roughness so that the composite becomes suitable for use as a heat sink of a semiconductor element of the like. Specifically disclosed is a plate-like aluminum-diamond composite containing diamond particles and a metal mainly composed of aluminum. The aluminum-diamond composite is composed of a composite part and surface layers formed on both sides of the composite part, and the surface layers are composed of a material containing a metal mainly composed of aluminum. The diamond particle content is 40-70% by volume of the entire aluminum-diamond composite.




mon

Two-stage hydroprocessing apparatus with common fractionation

Two-stage hydroprocessing uses a common dividing wall fractionator. Hydroprocessed effluents from both stages of hydroprocessing are fed to opposite sides of the dividing wall.




mon

Knitted component for an article of footwear including a full monofilament upper

An article of footwear including a full monofilament upper is described. The full monofilament upper incorporates a knitted component including a monofilament knit element. The monofilament knit element is formed by knitting with a monofilament strand. The monofilament knit element is formed of unitary knit construction with the remaining portions of the knitted component, including peripheral portions that are knit using a natural or synthetic twisted fiber yarn. An inlaid tensile element can extend through the knitted component, including portions of the monofilament knit element. The monofilament knit element may be knitted with a monofilament strand according to a variety of knit structures.




mon

Article of footwear including a monofilament knit element with peripheral knit portions

An article of footwear including a knitted component having a monofilament knit element with peripheral knit portions is described. The knitted component includes a monofilament knit element formed by knitting with a monofilament strand. The monofilament knit element is formed of unitary knit construction with the remaining portions of the knitted component, including peripheral portions that are knit using a natural or synthetic twisted fiber yarn. An inlaid tensile element can extend through the knitted component, including portions of the monofilament knit element. The monofilament knit element may be knitted with a monofilament strand according to a variety of knit structures.




mon

Article of footwear including a monofilament knit element with a fusible strand

An article of footwear including a full monofilament upper is described. The full monofilament upper incorporates a knitted component including a monofilament knit element. The monofilament knit element is formed by knitting with a monofilament strand. The monofilament knit element is formed of unitary knit construction with the remaining portions of the knitted component, including peripheral portions that are knit using a natural or synthetic twisted fiber yarn. An inlaid tensile element can extend through the knitted component, including portions of the monofilament knit element. The monofilament knit element may be knitted with a monofilament strand according to a variety of knit structures. A fusible strand may be knit with the monofilament knit element. Upon heating, the fusible strand can combine and surround the monofilament strand within the monofilament knit element.




mon

Article of footwear including a monofilament knit element with peripheral knit portions

An article of footwear including a knitted component having a monofilament knit element with peripheral knit portions is described. The knitted component includes a monofilament knit element formed by knitting with a monofilament strand. The monofilament knit element is formed of unitary knit construction with the remaining portions of the knitted component, including peripheral portions that are knit using a natural or synthetic twisted fiber yarn. An inlaid tensile element can extend through the knitted component, including portions of the monofilament knit element. The monofilament knit element may be knitted with a monofilament strand according to a variety of knit structures.




mon

EBOLA MONOCLONAL ANTIBODIES

The present disclosure provides antibodies, and antigen-binding fragments thereof that bind to EBOV glycoprotein. The present disclosure further provides hybridoma cell lines and methods for making and using the compositions provided herein.




mon

MULTI-SPECIFIC ANTI-PSEUDOMONAS PSL AND PCRV BINDING MOLECULES AND USES THEREOF

This disclosure relates to combination therapies comprising anti-Pseudomonas Psl and PcrV bispecific binding molecules and related compositions, for use in prevention and treatment of Pseudomonas infection.




mon

IMMUNE-STIMULATING MONOCLONAL ANTIBODIES AGAINST HUMAN INTERLEUKIN-2

The invention relates to a human Interleukin-2 (hIL-2) specific monoclonal antibody (mAb), or antigen binding fragment thereof, the binding of which to hIL-2 inhibits binding of hIL-2 to CD25 and the antibody is characterized by any of the parameters: the variable chain of the mAb comprises the amino acid sequence of SEQ ID NO 005 or SEQ ID NO 006; the binding to hIL-2 is characterized by a dissociation constant (KD)≦7.5 nmol/L; the binding to hIL-2 is characterized by an off-rate (Koff)≦1×10−4 s−1 and/or the antibody displays no measurable cross-reactivity to murine IL-2.




mon

METHODS AND COMPOSITIONS FOR RISK PREDICTION, DIAGNOSIS, PROGNOSIS, AND TREATMENT OF PULMONARY DISORDERS

The invention provides diagnostic and therapeutic targets for pulmonary disease, in particular, fibrotic lung disease. The inventors have found that a genetic variant MUC5B gene is associated with increased expression of the gene, increased risk of developing a pulmonary disease, and an improved prognosis and survival among those developing the pulmonary disease.




mon

Monoclonal Antibodies That Specifically Block Biological Activity Of A Tumor Antigen

This invention relates to novel monoclonal antibodies that specifically bind to the alpha-folate receptor. In some embodiments, the antibodies inhibit a biological activity of folate receptor-α (FR-α). The antibodies are useful in the treatment of certain cancers, particularly cancers that have increased cell surface expression of the alpha-folate receptor (“FR-α”), such as ovarian, breast, renal, colorectal, lung, endometrial, or brain cancer. The invention also relates to cells expressing the monoclonal antibodies, antibody derivatives, such as chimeric and humanized monoclonal antibodies, antibody fragments, and methods of detecting and treating cancer using the antibodies, derivatives, and fragments.