This invention publicizes a chronic renal disease diagnostic kit, comprised of FGF23 monoclonal antibody, biotin labeling reagent Sulfo-NHS-LC-Biotin, PBS buffer solution (pH7.0, 0.1M), casein saline solution, streptomycin avidin and substrate TMB. The labeling condition is the weight ratio of FGF23 antibody and Sulfo-NHS-LC-Biotin, which is 1:5-1:12. The dilution ratio of streptomycin avidin is 1:3000. The lowest testing threshold limit value of FGF23 kit is 10 pg/ml, whose sensitivity is 10 times higher than that of common monoclonal antibody, which is very significant for early diagnose of chronic renal disease.

In sporadic Alzheimer's disease, neurofibrillary lesion formation is preceded by extensive post-translational modification of the microtubule associated protein tau. Immunoassays have been developed recently that detect tau in biological specimens, thus providing a means for pre-mortem diagnosis of Alzheimer's disease, which has remained elusive. These assays have been improved by the analysis of relevant post-translational modifications, such as phosphorylation, however opportunity for improvement remains. The present invention addresses this issue by disclosing synthetic methylated peptides derived from the tau protein of paired helical filaments and non-diseased control brain. Alzheimer's disease specificity is provided by the presence or absence of methyl moieties on lysine residues and differences between mono-, di-, and tri-methylation. The methylated peptide is useful as an antigen and a binding partner for identifying compounds that interact with the peptide and the methylated tau protein, including antibodies that can distinguish non-diseased brain from that affected by Alzheimer's disease. The resulting antibodies are useful diagnostically and therapeutically. The compounds that specifically bind to methylated tau proteins are useful for eliminating abnormally methylated tau.

If you happen to run into any medical residents anytime soon, they may look a little fatigued and broke, especially if they happen to be residents or pediatricians of UCSF Benioff Children’s Hospital of Oakland. Today, the CIR/SEIU Healthcare union that represents resident physicians and pediatricians said it plans to rally in front of the hospital on Friday at 12:15 p.m. along with nurses and community leaders to demand better wagers and working conditions.…

News you don't want to miss for Easter Weekend:

Oakland will temporarily close 74 miles of city streets to automobile traffic in an effort to give ample space for pedestrians, bike riders, and runners during the covid-19 shelter in place, The Guardian reports.…

This is a warning to every UK worker aged 22 or over. You’re about to get a pay rise, but it may cost you, and you may not even be told.

IT’S the “life-saving” organisation that is slowly emerging from the shadows.

IT IS an ambitious fundraising target but one that dedicated fundraisers are confident of reaching in a bid to make a state-of-the art children’s emergency department in Hampshire a reality.

WINCHESTER Sings! a local community choir, held a fundraising evening in May to raise money for Winchester & District Young Carers (WYC).

NEARLY a decade since the last sell-out tour, Les Misérables is touring again and is back at Southampton’s Mayflower Theatre.

A FURTHER four people who have tested positive for coronavirus have died in Hampshire in the last 24 hours.

THE future of a much-loved Southampton band considered one of the rising stars of British indie pop is in doubt after music equipment worth thousands was stolen.

A FURTHER four people who have tested positive for coronavirus have died in Hampshire in the last 24 hours.

ONLY a small number of mass cycling events would be affected by the proposed cap on cyclists in New Forest events.

A CRISIS appeal to save a Fareham based charity has raised almost £50,000 in less than a

SOUTHAMPTON’S iconic Go! Rhinos sculptures bowed out in style tonight.

SHE was one of the most eye-catching of the iconic beasts that captured the imagination of animallovers and tourists alike in Southampton this summer.

WICKHAM Festival chiefs have promised to top their best ever event next year.

A FURTHER five people across Hampshire have died after testing positive for coronavirus.

A FURTHER two people across Hampshire have died after testing positive for coronavirus.

SOUTHAMPTON GP surgeries have seen a significant drop in appointments due to the effects of the coronavirus pandemic.

NINE more people who have tested positive for coronavirus in Hampshire have died in the last 24 hours.

They have been allowed to wander free for centuries and as such have attracted thousands upon thousands of visitors.

"Yesterday Was Everything" Misery Signals Documentary released. Jon did audio post production for the film.

Ohio is ramping up its ability to test for COVID-19, which means a big increase in testing by the end of May. Statehouse correspondent Andy Chow reports Gov. Mike DeWine is now announcing new protocols to follow since testing won't be as limited as it once was.

Connecticut’s finance committee has approved a tax package that increases revenue by more than $2 billion over the next two years. Democrats say the increase is needed to fund the state’s $43.3 billion two-year budget proposal.

Some of the bills passed by Connecticut lawmakers in committee this week challenge Governor Ned Lamont’s control of state finances, which could lead to testy budget negotiations with the governor in coming days.

Release date : June 12, 2020
Synopsis : Scott (Pete Davidson) has been a case of arrested development ever since his firefighter father died when he was seven. ...

Cardiologists in Columbus are the first in the nation to test new technology for patients suffering from atrial fibrillation. Doctors say it's a safer and more effective alternative.

Denise's eyebrow-raising action seems to have something to do with hookup rumors, which started to spark in late November 2019, involving her and former 'RHOBH' star Brandi Glanville.

NASA's administrator confirms the 'Mission: Impossible' actor is having discussions about shooting a film at the International Space Station with Musk's SpaceX.

Denise's eyebrow-raising action seems to have something to do with hookup rumors, which started to spark in late November 2019, involving her and former 'RHOBH' star Brandi Glanville.

The 'In Da Club' rapper also reveals whether he still loves his 22-year-old son, whom he shares with Shaniqua Tompkins, and the possibility to patch things up with him.

The 'Super Bass' hitmaker says in a question and answer session on Twitter that she will debut 'a baby bump' in a couple months and reveals her cravings during the coronavirus lockdown.

The 'I Believe I Can Fly' singer vows to be on his best behavior if he is released on bond and placed on house arrest while awaiting trial for sex charges.

Sharon is touched as daughter Kelly Osbourne surprises her with a special Mother's Day gift and the host shows it off to her co-hosts and fans on her TV show 'The Talk'.

The 'I Believe I Can Fly' singer vows to be on his best behavior if he is released on bond and placed on house arrest while awaiting trial for sex charges.

Sharon is touched as daughter Kelly Osbourne surprises her with a special Mother's Day gift and the host shows it off to her co-hosts and fans on her TV show 'The Talk'.

Mylan CEO Heather Bresch repeatedly told the panel last month that Mylan made just $50 in profit for EpiPens sold for more than $300 apiece.

Greater visible presence of officers on the streets to reassure the public.

Should private companies be undertaking police work? Dave Woodhall argues not.

Paradise Gray began his career in hip-hop under the tutelage of masters like Pete DJ Jones and Disco King Mario. However, he really hit his stride when he began booking hip-hop acts and hosting in 1986 at a nightclub in the heart of Times Square called the Latin Quarter. While at the club, he would have a front row seat to the introduction of a new generation of hip-hop artists—the key acts in what would come to be called the genre’s Golden Age.

After the club closed in 1988, Paradise would form the group X-Clan with some friends, and deliver some of the most powerful, conscious rap records of all time.

Paradise has a new book about his time at the LQ called No Half Steppin’: An Oral and Pictorial History of New York City Club the Latin Quarter and the Birth of Hip-Hop’s Golden Era.

See http://theciphershow.com/episode/190/ for full show notes and comments.

A charity concert has raised £700 for the Edgbaston-based charity Ammalife.

Jake Ellenberger, a retired UFC fighter and Marine, joins Joey Diaz and Lee Syatt live in studio. We also have a special visit from Kate Quigley.

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Rockers ranging from Jimi Hendrix to Elton John speak of the pioneer's impact. Continue reading…

Alan Clawley is really struggling to garner a useful reaction from Birmingham City Council.

Mayor helps collection as £85,000 raised.

Birmingham St Mary’s Hospice has unveiled its latest venture aimed at supporting the services on which so many rely.

City enterprises combine for celebration of brewing.

Birmingham's Children's Hospital benefits from entrepreneur's efforts.

King's Heath Walk of Fame latest.