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Medidata Accelerates Launch of myMedidata Platform, Responding to COVID-19

Several countries have announced ambitious goals to be powered completely by renewable energy, while other nations set smaller, incremental goals. These high aspirations have sparked quite a debate amongst industry experts, and we here at Renewable Energy World are curious to hear what you, our readers, have to say.

John Mitchell, IPC president and CEO, provides information on how IPC and the electronics manufacturing industry are responding to the coronavirus pandemic.

As people around the world gather online to address the global challenges posed by COVID-19, we want to share some of the steps we have taken so far to support the communities we serve, while keeping our critical internet infrastructure running smoothly. Protecting Our People In late January, Verisign established a task force to monitor […]

The post How We’re Responding to the COVID-19 Crisis appeared first on Verisign Blog.

You may recall the recent case of Golden Ocean Group Ltd v Salgaocar Mining Industries PVT Ltd [2011] EWHC 56 (Comm) in which it was argued that a valid guarantee had been given as a result of a chain of emails exchanged between two parties. At...

A conversation is beginning around the future of the UK’s regulatory regime post-Brexit, with the Financial Conduct Authority (FCA) talking about adopting a broader outcomes-based approach and is even questioning disclosure levels. Jonathan Master b...

The global impact of Coronavirus is now undeniable, as one might expect from a highly contagious disease originating from the world’s second largest economy and most populous nation.  Insurance claims are bound to follow and whilst market...

By Marcus Noland HONOLULU (August 23, 2019)—For three generations, the United States championed a rules-based multilateral trading system. That stance was overturned by the election of an avowed protectionist, Donald Trump, as president. It would be understandable for Asians to wonder if this shift amounts to a permanent change in U.S. trade policy, and if so, how to proceed. Trump’s presidential campaign was notable in that it emphasized two issues—immigration and trade—that had seldom been in the forefront of U.S. presidential campaigns. But public opinion polls revealed that these issues were of growing importance to a sizeable number of voters whose preferences mirrored Trump’s protectionist positions.

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Moon Jae-in South Korean President and Vladimir Putin Russian President met on September 6 in Far Eastern Federal University in Russia's Vladivostok to discuss issues including the current North Korea nuclear crisis and economic cooperation between Russia and South Korea for 2 hours and 40 minutes. The two leaders agreed that the North's nuclear tests are "unacceptable" but differed in how it must be handled including cutting crude oil supplies to North Korea. President Moon said, "When ...

Companies are facing difficult times with reporting, audits and meetings in view of the COVID-19  outbreak. In this update we take a look at the measures that have been announced this week to assist companies. Whilst we are seeing some creative...

On 17 May 2019, the European Council established a framework and implemented a new sanctions regime which now allows the EU to impose targeted sanctions to “deter and respond to cyber-attacks which constitute an external threat to the EU and i...

What you need to know UK regulatory guidance has been updated to the effect that the timescale for responding to individuals’ requests (including subject access requests) is one calendar month from the day of receipt of the ...

What you need to know UK regulatory guidance has been updated to explain what ‘manifestly unfounded’ and ‘excessive’ means in relation to the individual rights of data subjects under GDPR. This includes but is not limited to ...

Women in the South Pacific island nation of Vanuatu are dealing with six crises currently – COVID 19, drought, scarcity of potable water, and volcanic ash, acid rain and sulphur gas as there are several active volcanoes on the island. But global women’s rights organisations are collaborating with regional alliances in supporting local women.

The post How Some Pacific Women are Responding to Climate Change and Natural Disasters appeared first on Inter Press Service.

Disqualified lawmaker Lau Siu-lai was denied the opportunity to respond to allegations of not genuinely upholding Hong Kong’s mini-constitution before she was barred from trying to win back her seat in the Legislative Council, a judge has observed.Mr Justice Anderson Chow Ka-ming made the remark on Thursday while hearing an election petition from Lau, who has asked the High Court to determine whether pro-establishment lawmaker Chan Hoi-yan had been duly elected to the office of Kowloon West…

Like much of the West, Argentina did not take many early precautionary actions after the Covid-19 epidemic was confirmed in January, but became the first Latin American country to act decisively with a 12 March public health emergency declaration. The presidential decree came a day after the World Health Organization (WHO) declared a global pandemic, […]

The post Argentina Responds Boldly to Coronavirus Crisis appeared first on Inter Press Service.

SUKKUR: As many as 10 children drowned in water ponds and canals on Friday. Reports said a 12-year-old boy Sajid, s/o Abdul Majeed Soomro, residing at a village Allah Dino Soomro in Badin district,...

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If you're a fitness junkie with a cool $14 million to spend on a home in Denver, it's hard to beat 460 Saint Paul Street.

To better understand how ADB’s developing members are weathering the COVID-19 crisis, the Economic Research and Regional Cooperation Department launched the ADB COVID-19 Policy Database.

ADB and AIM today launched the #DigitalAgainstCOVID-19 virtual challenge to crowdsource digital solutions and ideas to help countries in Asia and the Pacific deal with the medium- and long-term...

The 2019 novel Coronavirus (COVID-19), first reported from Wuhan, People’s Republic of China (PRC), on 31 December 2019, is the latest emerging infectious disease to be declared a public health emergency of international concern. The situation is rapidly evolving, with more than 43,000 confirmed cases reported from at least 25 countries, and more than 1,000 deaths as of 11 February 2020, with PRC accounting for nearly all (99%) cases and deaths.

ADB is formulating an aggressive set of actions to protect the poor, the vulnerable, and wider populations across Asia and the Pacific. And to ensure economies will rebound as swiftly as possible.

To better understand how ADB’s developing members are weathering the COVID-19 crisis, the Economic Research and Regional Cooperation Department launched the ADB COVID-19 Policy Database.

Our best mathematical theory of consciousness is sparking a rethink of one of science’s hardest problems – how simple matter gives rise to a complex mind

Our best mathematical theory of consciousness is sparking a rethink of one of science’s hardest problems – how simple matter gives rise to a complex mind

ABSTRACT

Bacillus anthracis is a spore-forming bacterium that causes devastating infections and has been used as a bioterror agent. This pathogen can survive hostile environments through the signaling activity of two-component systems, which couple environmental sensing with transcriptional activation to initiate a coordinated response to stress. In this work, we describe the identification of a two-component system, EdsRS, which mediates the B. anthracis response to the antimicrobial compound targocil. Targocil is a cell envelope-targeting compound that is toxic to B. anthracis at high concentrations. Exposure to targocil causes damage to the cellular barrier and activates EdsRS to induce expression of a previously uncharacterized cardiolipin synthase, which we have named ClsT. Both EdsRS and ClsT are required for protection against targocil-dependent damage. Induction of clsT by EdsRS during targocil treatment results in an increase in cardiolipin levels, which protects B. anthracis from envelope damage. Together, these results reveal that a two-component system signaling response to an envelope-targeting antimicrobial induces production of a phospholipid associated with stabilization of the membrane. Cardiolipin is then used to repair envelope damage and promote B. anthracis viability.

IMPORTANCE Compromising the integrity of the bacterial cell barrier is a common action of antimicrobials. Targocil is an antimicrobial that is active against the bacterial envelope. We hypothesized that Bacillus anthracis, a potential weapon of bioterror, senses and responds to targocil to alleviate targocil-dependent cell damage. Here, we show that targocil treatment increases the permeability of the cellular envelope and is particularly toxic to B. anthracis spores during outgrowth. In vegetative cells, two-component system signaling through EdsRS is activated by targocil. This results in an increase in the production of cardiolipin via a cardiolipin synthase, ClsT, which restores the loss of barrier function, thereby reducing the effectiveness of targocil. By elucidating the B. anthracis response to targocil, we have uncovered an intrinsic mechanism that this pathogen employs to resist toxicity and have revealed therapeutic targets that are important for bacterial defense against structural damage.

The extracellular matrix (ECM) initiates mechanical cues that activate intracellular signaling through matrix–cell interactions. In blood vessels, additional mechanical cues derived from the pulsatile blood flow and pressure play a pivotal role in homeostasis and disease development. Currently, the nature of the cues from the ECM and their interaction with...

Cervical spondylotic myelopathy (CSM) is a neurologic condition that develops insidiously over time as degenerative changes of the spine result in compression of the cord and nearby structures. It is the most common form of spinal cord injury in adults; yet, its diagnosis is often delayed. The purpose of this article is to review the pathophysiology, natural history, diagnosis, and management of CSM with a focus on the recommended timeline for physicians suspecting CSM to refer patients to a spine surgeon. Various processes underlie spondylotic changes of the canal and are separated into static and dynamic factors. Not all patients with evidence of cord compression will present with symptoms, and the progression of disease varies by patient. The hallmark symptoms of CSM include decreased hand dexterity and gait instability as well as sensory and motor dysfunction. magnetic resonance imaging is the imaging modality of choice in patients with suspected CSM, but computed tomography myelography may be used in patients with contraindications. Patients with mild CSM may be treated surgically or nonoperatively, whereas those with moderate-severe disease are treated operatively. Due to the long-term disability that may result from a delay in diagnosis and management, prompt referral to a spine surgeon is recommended for any patient suspected of having CSM. This review provides information and guidelines for practitioners to develop an actionable awareness of CSM.

William Joyce and Tobias Wang

Rafael Dalmau

Most freshwater bacterial communities are characterized by a few dominant taxa that are often ubiquitous across freshwater biomes worldwide. Our understanding of the genomic diversity within these taxonomic groups is limited to a subset of taxa. Here, we investigated the genomic diversity that enables Limnohabitans, a freshwater genus key in funneling carbon from primary producers to higher trophic levels, to achieve abundance and ubiquity. We reconstructed eight putative Limnohabitans metagenome-assembled genomes (MAGs) from stations located along broad environmental gradients existing in Lake Michigan, part of Earth’s largest surface freshwater system. De novo strain inference analysis resolved a total of 23 strains from these MAGs, which strongly partitioned into two habitat-specific clusters with cooccurring strains from different lineages. The largest number of strains belonged to the abundant LimB lineage, for which robust in situ strain delineation had not previously been achieved. Our data show that temperature and nutrient levels may be important environmental parameters associated with microdiversification within the Limnohabitans genus. In addition, strains predominant in low- and high-phosphorus conditions had larger genomic divergence than strains abundant under different temperatures. Comparative genomics and gene expression analysis yielded evidence for the ability of LimB populations to exhibit cellular motility and chemotaxis, a phenotype not yet associated with available Limnohabitans isolates. Our findings broaden historical marker gene-based surveys of Limnohabitans microdiversification and provide in situ evidence of genome diversity and its functional implications across freshwater gradients.

IMPORTANCE Limnohabitans is an important bacterial taxonomic group for cycling carbon in freshwater ecosystems worldwide. Here, we examined the genomic diversity of different Limnohabitans lineages. We focused on the LimB lineage of this genus, which is globally distributed and often abundant, and its abundance has shown to be largely invariant to environmental change. Our data show that the LimB lineage is actually comprised of multiple cooccurring populations for which the composition and genomic characteristics are associated with variations in temperature and nutrient levels. The gene expression profiles of this lineage suggest the importance of chemotaxis and motility, traits that had not yet been associated with the Limnohabitans genus, in adapting to environmental conditions.

Rafael Nadal revealed this week he was doubtful there will be further tennis in 2020.

As Anna prepares her statement, Alice introduces us to a new form of missile delivery. Chris plays really old games instead of the other old...

Jameela Jamil also came to Teigen and Kondo's defense, calling Roman "distasteful" and "cliche" for criticizing women of color for being successful in business.

Some of this year's Oscar nominees, including Andrew Garfield and Michael Shannon, react to news of their nomination.

The Real Madrid midfielder got creative as he denied a report claiming that he would be included in a swap deal that would see him join Sevilla

President Trump Thursday said he thinks former Vice President Joe Biden should respond to a claim from a former staffer that he assaulted her in 1993 even as he cast doubt on the veracity of the allegation.

Dominic Raab has said that criminal gangs are "actively targeting" both national and international organisations responding to the Covid-19 pandemic.

A small flock of shorebirds contaminated with oil after touching down on a northern Alberta tailings pond is expected to be released back into the wild within a week.

Ofcom received over 400 complaints about the presenter's remarks on the conspiracy theory

'Mistakes happen, and we all make them. What's important, though, is that you own them'

Comedian said he got 'such s***' for suggesting tiger trader deserves his prison sentence

The singer said their post had been badly timed

RB Leipzig chief executive Oliver Mintzlaff insists he is calm over the future of Timo Werner amid speculation linking the forward with Liverpool and Chelsea.