A new strategy for probabilistic graphical modeling is developed that draws parallels to community detection analysis. The method jointly estimates an undirected graph and homogeneous communities of nodes. The structure of the communities is taken into account when estimating the graph and at the same time, the structure of the graph is accounted for when estimating communities of nodes. The procedure uses a joint group graphical lasso approach with community detection-based grouping, such that some groups of edges co-occur in the estimated graph. The grouping structure is unknown and is estimated based on community detection algorithms. Theoretical derivations regarding graph convergence and sparsistency, as well as accuracy of community recovery are included, while the method's empirical performance is illustrated in an fMRI context, as well as with simulated examples.

We consider the problem of estimating the latent structure of a social network based on the observed information diffusion events, or cascades, where the observations for a given cascade consist of only the timestamps of infection for infected nodes but not the source of the infection. Most of the existing work on this problem has focused on estimating a diffusion matrix without any structural assumptions on it. In this paper, we propose a novel model based on the intuition that an information is more likely to propagate among two nodes if they are interested in similar topics which are also prominent in the information content. In particular, our model endows each node with an influence vector (which measures how authoritative the node is on each topic) and a receptivity vector (which measures how susceptible the node is for each topic). We show how this node-topic structure can be estimated from the observed cascades, and prove the consistency of the estimator. Experiments on synthetic and real data demonstrate the improved performance and better interpretability of our model compared to existing state-of-the-art methods.

Anomaly detection is not an easy problem since distribution of anomalous samples is unknown a priori. We explore a novel method that gives a trade-off possibility between one-class and two-class approaches, and leads to a better performance on anomaly detection problems with small or non-representative anomalous samples. The method is evaluated using several data sets and compared to a set of conventional one-class and two-class approaches.

The horseshoe prior is frequently employed in Bayesian analysis of high-dimensional models, and has been shown to achieve minimax optimal risk properties when the truth is sparse. While optimization-based algorithms for the extremely popular Lasso and elastic net procedures can scale to dimension in the hundreds of thousands, algorithms for the horseshoe that use Markov chain Monte Carlo (MCMC) for computation are limited to problems an order of magnitude smaller. This is due to high computational cost per step and growth of the variance of time-averaging estimators as a function of dimension. We propose two new MCMC algorithms for computation in these models that have significantly improved performance compared to existing alternatives. One of the algorithms also approximates an expensive matrix product to give orders of magnitude speedup in high-dimensional applications. We prove guarantees for the accuracy of the approximate algorithm, and show that gradually decreasing the approximation error as the chain extends results in an exact algorithm. The scalability of the algorithm is illustrated in simulations with problem size as large as $N=5,000$ observations and $p=50,000$ predictors, and an application to a genome-wide association study with $N=2,267$ and $p=98,385$. The empirical results also show that the new algorithm yields estimates with lower mean squared error, intervals with better coverage, and elucidates features of the posterior that were often missed by previous algorithms in high dimensions, including bimodality of posterior marginals indicating uncertainty about which covariates belong in the model.

Graphical models are commonly used to represent conditional dependence relationships between variables. There are multiple methods available for exploring them from high-dimensional data, but almost all of them rely on the assumption that the observations are independent and identically distributed. At the same time, observations connected by a network are becoming increasingly common, and tend to violate these assumptions. Here we develop a Gaussian graphical model for observations connected by a network with potentially different mean vectors, varying smoothly over the network. We propose an efficient estimation algorithm and demonstrate its effectiveness on both simulated and real data, obtaining meaningful and interpretable results on a statistics coauthorship network. We also prove that our method estimates both the inverse covariance matrix and the corresponding graph structure correctly under the assumption of network “cohesion”, which refers to the empirically observed phenomenon of network neighbors sharing similar traits.

When the data is distributed across multiple servers, lowering the communication cost between the servers (or workers) while solving the distributed learning problem is an important problem and is the focus of this paper. In particular, we propose a fast, and communication-efficient decentralized framework to solve the distributed machine learning (DML) problem. The proposed algorithm, Group Alternating Direction Method of Multipliers (GADMM) is based on the Alternating Direction Method of Multipliers (ADMM) framework. The key novelty in GADMM is that it solves the problem in a decentralized topology where at most half of the workers are competing for the limited communication resources at any given time. Moreover, each worker exchanges the locally trained model only with two neighboring workers, thereby training a global model with a lower amount of communication overhead in each exchange. We prove that GADMM converges to the optimal solution for convex loss functions, and numerically show that it converges faster and more communication-efficient than the state-of-the-art communication-efficient algorithms such as the Lazily Aggregated Gradient (LAG) and dual averaging, in linear and logistic regression tasks on synthetic and real datasets. Furthermore, we propose Dynamic GADMM (D-GADMM), a variant of GADMM, and prove its convergence under the time-varying network topology of the workers.

We consider a setting where multiple players sequentially choose among a common set of actions (arms). Motivated by an application to cognitive radio networks, we assume that players incur a loss upon colliding, and that communication between players is not possible. Existing approaches assume that the system is stationary. Yet this assumption is often violated in practice, e.g., due to signal strength fluctuations. In this work, we design the first multi-player Bandit algorithm that provably works in arbitrarily changing environments, where the losses of the arms may even be chosen by an adversary. This resolves an open problem posed by Rosenski et al. (2016).

Jun Zhang, Yujie Gai, Xia Cui, Gaorong Li.

Source: Brazilian Journal of Probability and Statistics, Volume 34, Number 2, 370--393.

Abstract:
This paper studies the measure of symmetry or asymmetry of a continuous variable under the multiplicative distortion measurement errors setting. The unobservable variable is distorted in a multiplicative fashion by an observed confounding variable. First, two direct plug-in estimation procedures are proposed, and the empirical likelihood based confidence intervals are constructed to measure the symmetry or asymmetry of the unobserved variable. Next, we propose four test statistics for testing whether the unobserved variable is symmetric or not. The asymptotic properties of the proposed estimators and test statistics are examined. We conduct Monte Carlo simulation experiments to examine the performance of the proposed estimators and test statistics. These methods are applied to analyze a real dataset for an illustration.

Danilo Covaes Nogarotto, Caio Lucidius Naberezny Azevedo, Jorge Luis Bazán.

Source: Brazilian Journal of Probability and Statistics, Volume 34, Number 2, 304--322.

Abstract:
The interest on the analysis of the zero–one augmented beta regression (ZOABR) model has been increasing over the last few years. In this work, we developed a Bayesian inference for the ZOABR model, providing some contributions, namely: we explored the use of Jeffreys-rule and independence Jeffreys prior for some of the parameters, performing a sensitivity study of prior choice, comparing the Bayesian estimates with the maximum likelihood ones and measuring the accuracy of the estimates under several scenarios of interest. The results indicate, in a general way, that: the Bayesian approach, under the Jeffreys-rule prior, was as accurate as the ML one. Also, different from other approaches, we use the predictive distribution of the response to implement Bayesian residuals. To further illustrate the advantages of our approach, we conduct an analysis of a real psychometric data set including a Bayesian residual analysis, where it is shown that misleading inference can be obtained when the data is transformed. That is, when the zeros and ones are transformed to suitable values and the usual beta regression model is considered, instead of the ZOABR model. Finally, future developments are discussed.

Mohsen Maleki, Arezo Hajrajabi, Reinaldo B. Arellano-Valle.

Source: Brazilian Journal of Probability and Statistics, Volume 34, Number 2, 273--290.

Abstract:
In this paper, we study the finite mixtures of autoregressive processes assuming that the distribution of innovations (errors) belongs to the class of scale mixture of skew-normal (SMSN) distributions. The SMSN distributions allow a simultaneous modeling of the existence of outliers, heavy tails and asymmetries in the distribution of innovations. Therefore, a statistical methodology based on the SMSN family allows us to use a robust modeling on some non-linear time series with great flexibility, to accommodate skewness, heavy tails and heterogeneity simultaneously. The existence of convenient hierarchical representations of the SMSN distributions facilitates also the implementation of an ECME-type of algorithm to perform the likelihood inference in the considered model. Simulation studies and the application to a real data set are finally presented to illustrate the usefulness of the proposed model.

Victor Coscrato, Rafael Izbicki, Rafael B. Stern.

Source: Brazilian Journal of Probability and Statistics, Volume 34, Number 2, 230--250.

Abstract:
Despite its common practice, statistical hypothesis testing presents challenges in interpretation. For instance, in the standard frequentist framework there is no control of the type II error. As a result, the non-rejection of the null hypothesis $(H_{0})$ cannot reasonably be interpreted as its acceptance. We propose that this dilemma can be overcome by using agnostic hypothesis tests, since they can control the type I and II errors simultaneously. In order to make this idea operational, we show how to obtain agnostic hypothesis in typical models. For instance, we show how to build (unbiased) uniformly most powerful agnostic tests and how to obtain agnostic tests from standard p-values. Also, we present conditions such that the above tests can be made logically coherent. Finally, we present examples of consistent agnostic hypothesis tests.

Saralees Nadarajah, Yuancheng Si.

Source: Brazilian Journal of Probability and Statistics, Volume 34, Number 1, 183--187.

Abstract:
Da Paz, Balakrishnan and Bazan [Braz. J. Probab. Stat. 33 (2019), 455–479] introduced the L-logistic distribution, studied its properties including estimation issues and illustrated a data application. This note derives a closed form expression for moment properties of the distribution. Some computational issues are discussed.

Mohd Arshad, Omer Abdalghani.

Source: Brazilian Journal of Probability and Statistics, Volume 34, Number 1, 167--182.

Abstract:
Suppose that $pi_{1},pi_{2},ldots ,pi_{k}$ be $k(geq2)$ independent exponential populations having unknown location parameters $mu_{1},mu_{2},ldots,mu_{k}$ and known scale parameters $sigma_{1},ldots,sigma_{k}$. Let $mu_{[k]}=max {mu_{1},ldots,mu_{k}}$. For selecting the population associated with $mu_{[k]}$, a class of selection rules (proposed by Arshad and Misra [ Statistical Papers 57 (2016) 605–621]) is considered. We consider the problem of estimating the location parameter $mu_{S}$ of the selected population under the criterion of the LINEX loss function. We consider three natural estimators $delta_{N,1},delta_{N,2}$ and $delta_{N,3}$ of $mu_{S}$, based on the maximum likelihood estimators, uniformly minimum variance unbiased estimator (UMVUE) and minimum risk equivariant estimator (MREE) of $mu_{i}$’s, respectively. The uniformly minimum risk unbiased estimator (UMRUE) and the generalized Bayes estimator of $mu_{S}$ are derived. Under the LINEX loss function, a general result for improving a location-equivariant estimator of $mu_{S}$ is derived. Using this result, estimator better than the natural estimator $delta_{N,1}$ is obtained. We also shown that the estimator $delta_{N,1}$ is dominated by the natural estimator $delta_{N,3}$. Finally, we perform a simulation study to evaluate and compare risk functions among various competing estimators of $mu_{S}$.

Abedin Haidari, Amir T. Payandeh Najafabadi, Narayanaswamy Balakrishnan.

Source: Brazilian Journal of Probability and Statistics, Volume 34, Number 1, 150--166.

Abstract:
Consider two parallel systems, say $A$ and $B$, with respective lifetimes $T_{1}$ and $T_{2}$ wherein independent component lifetimes of each system follow exponentiated generalized gamma distribution with possibly different exponential shape and scale parameters. We show here that $T_{2}$ is smaller than $T_{1}$ with respect to the usual stochastic order (reversed hazard rate order) if the vector of logarithm (the main vector) of scale parameters of System $B$ is weakly weighted majorized by that of System $A$, and if the vector of exponential shape parameters of System $A$ is unordered mojorized by that of System $B$. By means of some examples, we show that the above results can not be extended to the hazard rate and likelihood ratio orders. However, when the scale parameters of each system divide into two homogeneous groups, we verify that the usual stochastic and reversed hazard rate orders can be extended, respectively, to the hazard rate and likelihood ratio orders. The established results complete and strengthen some of the known results in the literature.

Durba Bhattacharya, Sourabh Bhattacharya.

Source: Brazilian Journal of Probability and Statistics, Volume 34, Number 1, 71--89.

Abstract:
Present day bio-medical research is pointing towards the fact that cognizance of gene–environment interactions along with genetic interactions may help prevent or detain the onset of many complex diseases like cardiovascular disease, cancer, type2 diabetes, autism or asthma by adjustments to lifestyle. In this regard, we propose a Bayesian semiparametric model to detect not only the roles of genes and their interactions, but also the possible influence of environmental variables on the genes in case-control studies. Our model also accounts for the unknown number of genetic sub-populations via finite mixtures composed of Dirichlet processes. An effective parallel computing methodology, developed by us harnesses the power of parallel processing technology to increase the efficiencies of our conditionally independent Gibbs sampling and Transformation based MCMC (TMCMC) methods. Applications of our model and methods to simulation studies with biologically realistic genotype datasets and a real, case-control based genotype dataset on early onset of myocardial infarction (MI) have yielded quite interesting results beside providing some insights into the differential effect of gender on MI.

Dan J. Spitzner.

Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 4, 861--893.

Abstract:
This article proposes a calibration scheme for Bayesian testing that coordinates analytically-derived statistical performance considerations with expert opinion. In other words, the scheme is effective and meaningful for incorporating objective elements into subjective Bayesian inference. It explores a novel role for default priors as anchors for calibration rather than substitutes for prior knowledge. Ideas are developed for use with multiplicity adjustments in multiple-model contexts, and to address the issue of prior sensitivity of Bayes factors. Along the way, the performance properties of an existing multiplicity adjustment related to the Poisson distribution are clarified theoretically. Connections of the overall calibration scheme to the Schwarz criterion are also explored. The proposed framework is examined and illustrated on a number of existing data sets related to problems in clinical trials, forensic pattern matching, and log-linear models methodology.

Glaura C. Franco, Helio S. Migon, Marcos O. Prates.

Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 4, 756--781.

Abstract:
Observation and parameter driven models are commonly used in the literature to analyse time series of counts. In this paper, we study the characteristics of a variety of models and point out the main differences and similarities among these procedures, concerning parameter estimation, model fitting and forecasting. Alternatively to the literature, all inference was performed under the Bayesian paradigm. The models are fitted with a latent AR($p$) process in the mean, which accounts for autocorrelation in the data. An extensive simulation study shows that the estimates for the covariate parameters are remarkably similar across the different models. However, estimates for autoregressive coefficients and forecasts of future values depend heavily on the underlying process which generates the data. A real data set of bankruptcy in the United States is also analysed.

Dani Gamerman.

Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 4, 686--705.

Abstract:
Point processes are one of the most commonly encountered observation processes in Spatial Statistics. Model-based inference for them depends on the likelihood function. In the most standard setting of Poisson processes, the likelihood depends on the intensity function, and can not be computed analytically. A number of approximating techniques have been proposed to handle this difficulty. In this paper, we review recent work on exact solutions that solve this problem without resorting to approximations. The presentation concentrates more heavily on discrete time but also considers continuous time. The solutions are based on model specifications that impose smoothness constraints on the intensity function. We also review approaches to include a regression component and different ways to accommodate it while accounting for additional heterogeneity. Applications are provided to illustrate the results. Finally, we discuss possible extensions to account for discontinuities and/or jumps in the intensity function.

Salem M. Al-Gezeri, Robert G. Aykroyd.

Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 3, 498--519.

Abstract:
The use of Markov random field (MRF) models has proven to be a fruitful approach in a wide range of image processing applications. It allows local texture information to be incorporated in a systematic and unified way and allows statistical inference theory to be applied giving rise to novel output summaries and enhanced image interpretation. A great advantage of such low-level approaches is that they lead to flexible models, which can be applied to a wide range of imaging problems without the need for significant modification. This paper proposes and explores the use of conditional MRF models for situations where multiple images are to be processed simultaneously, or where only a single image is to be reconstructed and a sequential approach is taken. Although the coupling of image intensity values is a special case of our approach, the main extension over previous proposals is to allow the direct coupling of other properties, such as smoothness or texture. This is achieved using a local modulating function which adjusts the influence of global smoothing without the need for a fully inhomogeneous prior model. Several modulating functions are considered and a detailed simulation study, motivated by remote sensing applications in archaeological geophysics, of conditional reconstruction is presented. The results demonstrate that a substantial improvement in the quality of the image reconstruction, in terms of errors and residuals, can be achieved using this approach, especially at locations with rapid changes in the underlying intensity.

Rosineide F. da Paz, Narayanaswamy Balakrishnan, Jorge Luis Bazán.

Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 3, 455--479.

Abstract:
Tadikamalla and Johnson [ Biometrika 69 (1982) 461–465] developed the $L_{B}$ distribution to variables with bounded support by considering a transformation of the standard Logistic distribution. In this manuscript, a convenient parametrization of this distribution is proposed in order to develop regression models. This distribution, referred to here as L-Logistic distribution, provides great flexibility and includes the uniform distribution as a particular case. Several properties of this distribution are studied, and a Bayesian approach is adopted for the parameter estimation. Simulation studies, considering prior sensitivity analysis, recovery of parameters and comparison of algorithms, and robustness to outliers are all discussed showing that the results are insensitive to the choice of priors, efficiency of the algorithm MCMC adopted, and robustness of the model when compared with the beta distribution. Applications to estimate the vulnerability to poverty and to explain the anxiety are performed. The results to applications show that the L-Logistic regression models provide a better fit than the corresponding beta regression models.

Rodrigo Citton P. dos Reis, Enrico A. Colosimo, Gustavo L. Gilardoni.

Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 2, 374--396.

Abstract:
In the data analysis from multiple repairable systems, it is usual to observe both different truncation times and heterogeneity among the systems. Among other reasons, the latter is caused by different manufacturing lines and maintenance teams of the systems. In this paper, a hierarchical model is proposed for the statistical analysis of multiple repairable systems under different truncation times. A reparameterization of the power law process is proposed in order to obtain a quasi-conjugate bayesian analysis. An empirical Bayes approach is used to estimate model hyperparameters. The uncertainty in the estimate of these quantities are corrected by using a parametric bootstrap approach. The results are illustrated in a real data set of failure times of power transformers from an electric company in Brazil.

Francisco Cribari-Neto, Rodney V. Fonseca.

Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 2, 329--355.

Abstract:
The log-linear Birnbaum–Saunders model has been widely used in empirical applications. We introduce an extension of this model based on a recently proposed version of the Birnbaum–Saunders distribution which is more flexible than the standard Birnbaum–Saunders law since its density may assume both unimodal and bimodal shapes. We show how to perform point estimation, interval estimation and hypothesis testing inferences on the parameters that index the regression model we propose. We also present a number of diagnostic tools, such as residual analysis, local influence, generalized leverage, generalized Cook’s distance and model misspecification tests. We investigate the usefulness of model selection criteria and the accuracy of prediction intervals for the proposed model. Results of Monte Carlo simulations are presented. Finally, we also present and discuss an empirical application.

Kushal K. Dey, Sourabh Bhattacharya.

Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 2, 222--266.

Abstract:
Transformation based Markov Chain Monte Carlo (TMCMC) was proposed by Dutta and Bhattacharya ( Statistical Methodology 16 (2014) 100–116) as an efficient alternative to the Metropolis–Hastings algorithm, especially in high dimensions. The main advantage of this algorithm is that it simultaneously updates all components of a high dimensional parameter using appropriate move types defined by deterministic transformation of a single random variable. This results in reduction in time complexity at each step of the chain and enhances the acceptance rate. In this paper, we first provide a brief review of the optimal scaling theory for various existing MCMC approaches, comparing and contrasting them with the corresponding TMCMC approaches.The optimal scaling of the simplest form of TMCMC, namely additive TMCMC , has been studied extensively for the Gaussian proposal density in Dey and Bhattacharya (2017a). Here, we discuss diffusion-based optimal scaling behavior of additive TMCMC for non-Gaussian proposal densities—in particular, uniform, Student’s $t$ and Cauchy proposals. Although we could not formally prove our diffusion result for the Cauchy proposal, simulation based results lead us to conjecture that at least the recipe for obtaining general optimal scaling and optimal acceptance rate holds for the Cauchy case as well. We also consider diffusion based optimal scaling of TMCMC when the target density is discontinuous. Such non-regular situations have been studied in the case of Random Walk Metropolis Hastings (RWMH) algorithm by Neal and Roberts ( Methodology and Computing in Applied Probability 13 (2011) 583–601) using expected squared jumping distance (ESJD), but the diffusion theory based scaling has not been considered. We compare our diffusion based optimally scaled TMCMC approach with the ESJD based optimally scaled RWM with simulation studies involving several target distributions and proposal distributions including the challenging Cauchy proposal case, showing that additive TMCMC outperforms RWMH in almost all cases considered.

Yong-Chao Zhang, Na Zhang.

Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 1, 184--191.

Abstract:
We investigate the equivalence of dynamic and static asset allocations in the case where the price process of a risky asset is driven by a Poisson process. Under some mild conditions, we obtain a necessary and sufficient condition for the equivalence of dynamic and static asset allocations. In addition, we provide a simple sufficient condition for the equivalence.

Norbert Hirschauer, Sven Grüner, Oliver Mußhoff, Claudia Becker, Antje Jantsch.

Source: Statistics Surveys, Volume 14, 71--91.

Abstract:
Besides the inferential errors that abound in the interpretation of $p$-values, the probabilistic pre-conditions (i.e. random sampling or equivalent) for using them at all are not often met by observational studies in the social sciences. This paper systematizes different sampling designs and discusses the restrictive requirements of data collection that are the indispensable prerequisite for using $p$-values.

John J. Dziak, Donna L. Coffman, Matthew Reimherr, Justin Petrovich, Runze Li, Saul Shiffman, Mariya P. Shiyko.

Source: Statistics Surveys, Volume 13, 150--180.

Abstract:
Researchers are sometimes interested in predicting a distal or external outcome (such as smoking cessation at follow-up) from the trajectory of an intensively recorded longitudinal variable (such as urge to smoke). This can be done in a semiparametric way via scalar-on-function regression. However, the resulting fitted coefficient regression function requires special care for correct interpretation, as it represents the joint relationship of time points to the outcome, rather than a marginal or cross-sectional relationship. We provide practical guidelines, based on experience with scientific applications, for helping practitioners interpret their results and illustrate these ideas using data from a smoking cessation study.

Norbert Hirschauer, Sven Grüner, Oliver Mußhoff, Claudia Becker.

Source: Statistics Surveys, Volume 12, 136--172.

Abstract:
Data on how many scientific findings are reproducible are generally bleak and a wealth of papers have warned against misuses of the $p$-value and resulting false findings in recent years. This paper discusses the question of what we can(not) learn from the $p$-value, which is still widely considered as the gold standard of statistical validity. We aim to provide a non-technical and easily accessible resource for statistical practitioners who wish to spot and avoid misinterpretations and misuses of statistical significance tests. For this purpose, we first classify and describe the most widely discussed (“classical”) pitfalls of significance testing, and review published work on these misuses with a focus on regression-based “confirmatory” study. This includes a description of the single-study bias and a simulation-based illustration of how proper meta-analysis compares to misleading significance counts (“vote counting”). Going beyond the classical pitfalls, we also use simulation to provide intuition that relying on the statistical estimate “$p$-value” as a measure of evidence without considering its sample-to-sample variability falls short of the mark even within an otherwise appropriate interpretation. We conclude with a discussion of the exigencies of informed approaches to statistical inference and corresponding institutional reforms.

Miklós Z. Rácz, Sébastien Bubeck.

Source: Statistics Surveys, Volume 11, 1--47.

Abstract:
Extracting information from large graphs has become an important statistical problem since network data is now common in various fields. In this minicourse we will investigate the most natural statistical questions for three canonical probabilistic models of networks: (i) community detection in the stochastic block model, (ii) finding the embedding of a random geometric graph, and (iii) finding the original vertex in a preferential attachment tree. Along the way we will cover many interesting topics in probability theory such as Pólya urns, large deviation theory, concentration of measure in high dimension, entropic central limit theorems, and more.

Kevin McGoff, Sayan Mukherjee, Natesh Pillai.

Source: Statistics Surveys, Volume 9, 209--252.

Abstract:
The topic of statistical inference for dynamical systems has been studied widely across several fields. In this survey we focus on methods related to parameter estimation for nonlinear dynamical systems. Our objective is to place results across distinct disciplines in a common setting and highlight opportunities for further research.

Lutz Dümbgen, Markus Pauly, Thomas Schweizer.

Source: Statistics Surveys, Volume 9, 32--105.

Abstract:
This survey provides a self-contained account of $M$-estimation of multivariate scatter. In particular, we present new proofs for existence of the underlying $M$-functionals and discuss their weak continuity and differentiability. This is done in a rather general framework with matrix-valued random variables. By doing so we reveal a connection between Tyler’s (1987a) $M$-functional of scatter and the estimation of proportional covariance matrices. Moreover, this general framework allows us to treat a new class of scatter estimators, based on symmetrizations of arbitrary order. Finally these results are applied to $M$-estimation of multivariate location and scatter via multivariate $t$-distributions.

Adrien Saumard, Jon A. Wellner.

Source: Statistics Surveys, Volume 8, 45--114.

Abstract:
We review and formulate results concerning log-concavity and strong-log-concavity in both discrete and continuous settings. We show how preservation of log-concavity and strong log-concavity on $mathbb{R}$ under convolution follows from a fundamental monotonicity result of Efron (1965). We provide a new proof of Efron’s theorem using the recent asymmetric Brascamp-Lieb inequality due to Otto and Menz (2013). Along the way we review connections between log-concavity and other areas of mathematics and statistics, including concentration of measure, log-Sobolev inequalities, convex geometry, MCMC algorithms, Laplace approximations, and machine learning.

Oleksandr Sverdlov, Weng Kee Wong, Yevgen Ryeznik.

Source: Statistics Surveys, Volume 8, 2--44.

Abstract:
Adaptive clinical trials are becoming increasingly popular research designs for clinical investigation. Adaptive designs are particularly useful in phase I cancer studies where clinical data are scant and the goals are to assess the drug dose-toxicity profile and to determine the maximum tolerated dose while minimizing the number of study patients treated at suboptimal dose levels. In the current work we give an overview of adaptive design methods for phase I cancer trials. We find that modern statistical literature is replete with novel adaptive designs that have clearly defined objectives and established statistical properties, and are shown to outperform conventional dose finding methods such as the 3+3 design, both in terms of statistical efficiency and in terms of minimizing the number of patients treated at highly toxic or nonefficacious doses. We discuss statistical, logistical, and regulatory aspects of these designs and present some links to non-commercial statistical software for implementing these methods in practice.

Nancy Heckman

Source: Statist. Surv., Volume 6, 113--141.

Abstract:
The popular cubic smoothing spline estimate of a regression function arises as the minimizer of the penalized sum of squares $sum_{j}(Y_{j}-mu(t_{j}))^{2}+lambda int_{a}^{b}[mu''(t)]^{2},dt$, where the data are $t_{j},Y_{j}$, $j=1,ldots,n$. The minimization is taken over an infinite-dimensional function space, the space of all functions with square integrable second derivatives. But the calculations can be carried out in a finite-dimensional space. The reduction from minimizing over an infinite dimensional space to minimizing over a finite dimensional space occurs for more general objective functions: the data may be related to the function $mu$ in another way, the sum of squares may be replaced by a more suitable expression, or the penalty, $int_{a}^{b}[mu''(t)]^{2},dt$, might take a different form. This paper reviews the Reproducing Kernel Hilbert Space structure that provides a finite-dimensional solution for a general minimization problem. Particular attention is paid to the construction and study of the Reproducing Kernel Hilbert Space corresponding to a penalty based on a linear differential operator. In this case, one can often calculate the minimizer explicitly, using Green’s functions.

Jeffrey Picka

Source: Statist. Surv., Volume 6, 74--112.

Abstract:
This paper gives an overview of statistical inference for disordered sphere packing processes. These processes are used extensively in physics and engineering in order to represent the internal structure of composite materials, packed bed reactors, and powders at rest, and are used as initial arrangements of grains in the study of avalanches and other problems involving powders in motion. Packing processes are spatial processes which are neither stationary nor ergodic. Classical spatial statistical models and procedures cannot be applied to these processes, but alternative models and procedures can be developed based on ideas from statistical physics. Most of the development of models and statistics for sphere packings has been undertaken by scientists and engineers. This review summarizes their results from an inferential perspective.

Gregory J. Matthews, Ofer Harel

Source: Statist. Surv., Volume 5, 1--29.

Abstract:
There is an ever increasing demand from researchers for access to useful microdata files. However, there are also growing concerns regarding the privacy of the individuals contained in the microdata. Ideally, microdata could be released in such a way that a balance between usefulness of the data and privacy is struck. This paper presents a review of proposed methods of statistical disclosure control and techniques for assessing the privacy of such methods under different definitions of disclosure.

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Arctic sea ice extent (SIE) in September 2019 ranked second-to-lowest in history and is trending downward. The understanding of how internal variability amplifies the effects of external $ ext{CO}_2$ forcing is still limited. We propose the VARCTIC, which is a Vector Autoregression (VAR) designed to capture and extrapolate Arctic feedback loops. VARs are dynamic simultaneous systems of equations, routinely estimated to predict and understand the interactions of multiple macroeconomic time series. Hence, the VARCTIC is a parsimonious compromise between fullblown climate models and purely statistical approaches that usually offer little explanation of the underlying mechanism. Our "business as usual" completely unconditional forecast has SIE hitting 0 in September by the 2060s. Impulse response functions reveal that anthropogenic $ ext{CO}_2$ emission shocks have a permanent effect on SIE - a property shared by no other shock. Further, we find Albedo- and Thickness-based feedbacks to be the main amplification channels through which $ ext{CO}_2$ anomalies impact SIE in the short/medium run. Conditional forecast analyses reveal that the future path of SIE crucially depends on the evolution of $ ext{CO}_2$ emissions, with outcomes ranging from recovering SIE to it reaching 0 in the 2050s. Finally, Albedo and Thickness feedbacks are shown to play an important role in accelerating the speed at which predicted SIE is heading towards 0.

Application and use of deep learning algorithms for different healthcare applications is gaining interest at a steady pace. However, use of such algorithms can prove to be challenging as they require large amounts of training data that capture different possible variations. This makes it difficult to use them in a clinical setting since in most health applications researchers often have to work with limited data. Less data can cause the deep learning model to over-fit. In this paper, we ask how can we use data from a different environment, different use-case, with widely differing data distributions. We exemplify this use case by using single-sensor accelerometer data from healthy subjects performing activities of daily living - ADLs (source dataset), to extract features relevant to multi-sensor accelerometer gait data (target dataset) for Parkinson's disease classification. We train the pre-trained model using the source dataset and use it as a feature extractor. We show that the features extracted for the target dataset can be used to train an effective classification model. Our pre-trained source model consists of a convolutional autoencoder, and the target classification model is a simple multi-layer perceptron model. We explore two different pre-trained source models, trained using different activity groups, and analyze the influence the choice of pre-trained model has over the task of Parkinson's disease classification.

Monte Carlo simulation is useful to compute or estimate expected functionals of random elements if those random samples are possible to be generated from the true distribution. However, when the distribution has some unknown parameters, the samples must be generated from an estimated distribution with the parameters replaced by some estimators, which causes a statistical error in Monte Carlo estimation. This paper considers such a statistical error and investigates the asymptotic distributions of Monte Carlo-based estimators when the random elements are not only the real valued, but also functional valued random variables. We also investigate expected functionals for semimartingales in details. The consideration indicates that the Monte Carlo estimation can get worse when a semimartingale has a jump part with unremovable unknown parameters.

We show, by an explicit construction, that a mixture of univariate Gaussians with variance 1 and means in $[-A,A]$ can have $Omega(A^2)$ modes. This disproves a recent conjecture of Dytso, Yagli, Poor and Shamai [IEEE Trans. Inform. Theory, Apr. 2020], who showed that such a mixture can have at most $O(A^2)$ modes and surmised that the upper bound could be improved to $O(A)$. Our result holds even if an additional variance constraint is imposed on the mixing distribution. Extending the result to higher dimensions, we exhibit a mixture of Gaussians in $mathbb{R}^d$, with identity covariances and means inside $[-A,A]^d$, that has $Omega(A^{2d})$ modes.

The transfer learning technique is widely used to learning in one context and applying it to another, i.e. the capacity to apply acquired knowledge and skills to new situations. But is it possible to transfer the learning from a deep neural network to a weaker neural network? Is it possible to improve the performance of a weak neural network using the knowledge acquired by a more powerful neural network? In this work, during the training process of a weak network, we add a loss function that minimizes the distance between the features previously learned from a strong neural network with the features that the weak network must try to learn. To demonstrate the effectiveness and robustness of our approach, we conducted a large number of experiments using three known datasets and demonstrated that a weak neural network can increase its performance if its learning process is driven by a more powerful neural network.

The very first case of corona-virus illness was recorded on 30 January 2020, in India and the number of infected cases, including the death toll, continues to rise. In this paper, we present short-term forecasts of COVID-19 for 28 Indian states and five union territories using real-time data from 30 January to 21 April 2020. Applying Holt's second-order exponential smoothing method and autoregressive integrated moving average (ARIMA) model, we generate 10-day ahead forecasts of the likely number of infected cases and deaths in India for 22 April to 1 May 2020. Our results show that the number of cumulative cases in India will rise to 36335.63 [PI 95% (30884.56, 42918.87)], concurrently the number of deaths may increase to 1099.38 [PI 95% (959.77, 1553.76)] by 1 May 2020. Further, we have divided the country into severity zones based on the cumulative cases. According to this analysis, Maharashtra is likely to be the most affected states with around 9787.24 [PI 95% (6949.81, 13757.06)] cumulative cases by 1 May 2020. However, Kerala and Karnataka are likely to shift from the red zone (i.e. highly affected) to the lesser affected region. On the other hand, Gujarat and Madhya Pradesh will move to the red zone. These results mark the states where lockdown by 3 May 2020, can be loosened.

In this paper we propose a bimodal gamma distribution using a quadratic transformation based on the alpha-skew-normal model. We discuss several properties of this distribution such as mean, variance, moments, hazard rate and entropy measures. Further, we propose a new regression model with censored data based on the bimodal gamma distribution. This regression model can be very useful to the analysis of real data and could give more realistic fits than other special regression models. Monte Carlo simulations were performed to check the bias in the maximum likelihood estimation. The proposed models are applied to two real data sets found in literature.

Segmentation of cardiac images, particularly late gadolinium-enhanced magnetic resonance imaging (LGE-MRI) widely used for visualizing diseased cardiac structures, is a crucial first step for clinical diagnosis and treatment. However, direct segmentation of LGE-MRIs is challenging due to its attenuated contrast. Since most clinical studies have relied on manual and labor-intensive approaches, automatic methods are of high interest, particularly optimized machine learning approaches. To address this, we organized the "2018 Left Atrium Segmentation Challenge" using 154 3D LGE-MRIs, currently the world's largest cardiac LGE-MRI dataset, and associated labels of the left atrium segmented by three medical experts, ultimately attracting the participation of 27 international teams. In this paper, extensive analysis of the submitted algorithms using technical and biological metrics was performed by undergoing subgroup analysis and conducting hyper-parameter analysis, offering an overall picture of the major design choices of convolutional neural networks (CNNs) and practical considerations for achieving state-of-the-art left atrium segmentation. Results show the top method achieved a dice score of 93.2% and a mean surface to a surface distance of 0.7 mm, significantly outperforming prior state-of-the-art. Particularly, our analysis demonstrated that double, sequentially used CNNs, in which a first CNN is used for automatic region-of-interest localization and a subsequent CNN is used for refined regional segmentation, achieved far superior results than traditional methods and pipelines containing single CNNs. This large-scale benchmarking study makes a significant step towards much-improved segmentation methods for cardiac LGE-MRIs, and will serve as an important benchmark for evaluating and comparing the future works in the field.

Cooperation between different data owners may lead to an improvement in forecast quality - for instance by benefiting from spatial-temporal dependencies in geographically distributed time series. Due to business competitive factors and personal data protection questions, said data owners might be unwilling to share their data, which increases the interest in collaborative privacy-preserving forecasting. This paper analyses the state-of-the-art and unveils several shortcomings of existing methods in guaranteeing data privacy when employing Vector Autoregressive (VAR) models. The paper also provides mathematical proofs and numerical analysis to evaluate existing privacy-preserving methods, dividing them into three groups: data transformation, secure multi-party computations, and decomposition methods. The analysis shows that state-of-the-art techniques have limitations in preserving data privacy, such as a trade-off between privacy and forecasting accuracy, while the original data in iterative model fitting processes, in which intermediate results are shared, can be inferred after some iterations.

Spatial trajectories are ubiquitous and complex signals. Their analysis is crucial in many research fields, from urban planning to neuroscience. Several approaches have been proposed to cluster trajectories. They rely on hand-crafted features, which struggle to capture the spatio-temporal complexity of the signal, or on Artificial Neural Networks (ANNs) which can be more efficient but less interpretable. In this paper we present a novel ANN architecture designed to capture the spatio-temporal patterns characteristic of a set of trajectories, while taking into account the demographics of the navigators. Hence, our model extracts markers linked to both behaviour and demographics. We propose a composite signal analyser (CompSNN) combining three simple ANN modules. Each of these modules uses different signal representations of the trajectory while remaining interpretable. Our CompSNN performs significantly better than its modules taken in isolation and allows to visualise which parts of the signal were most useful to discriminate the trajectories.

We study the information content of nuclear masses from the perspective of global models of nuclear binding energies. To this end, we employ a number of statistical methods and diagnostic tools, including Bayesian calibration, Bayesian model averaging, chi-square correlation analysis, principal component analysis, and empirical coverage probability. Using a Bayesian framework, we investigate the structure of the 4-parameter Liquid Drop Model by considering discrepant mass domains for calibration. We then use the chi-square correlation framework to analyze the 14-parameter Skyrme energy density functional calibrated using homogeneous and heterogeneous datasets. We show that a quite dramatic parameter reduction can be achieved in both cases. The advantage of Bayesian model averaging for improving uncertainty quantification is demonstrated. The statistical approaches used are pedagogically described; in this context this work can serve as a guide for future applications.

Beginning from a basic neural-network architecture, we test the potential benefits offered by a range of advanced techniques for machine learning, in particular deep learning, in the context of a typical classification problem encountered in the domain of high-energy physics, using a well-studied dataset: the 2014 Higgs ML Kaggle dataset. The advantages are evaluated in terms of both performance metrics and the time required to train and apply the resulting models. Techniques examined include domain-specific data-augmentation, learning rate and momentum scheduling, (advanced) ensembling in both model-space and weight-space, and alternative architectures and connection methods.

Following the investigation, we arrive at a model which achieves equal performance to the winning solution of the original Kaggle challenge, whilst being significantly quicker to train and apply, and being suitable for use with both GPU and CPU hardware setups. These reductions in timing and hardware requirements potentially allow the use of more powerful algorithms in HEP analyses, where models must be retrained frequently, sometimes at short notice, by small groups of researchers with limited hardware resources. Additionally, a new wrapper library for PyTorch called LUMINis presented, which incorporates all of the techniques studied.