Mobilized teams trained to help during  crisis & trauma By Heather Sherrill Editor-in-Chief Over winter...

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1. After death, special trains take 16 migrant workers to home districts  The Tribune India
2. Unable to Overcome Impact Of Tragedy: Aurangabad Train Accident Survivor  NDTV
3. NHRC issues notice to Maharashtra govt over deaths of migrant workers in Aurangabad train mishap, seeks det...  Zee News
4. Tragedy on tracks  The Indian Express
5. Coronavirus Essential podcast | Aurangabad train mows down 17 migrant workers; COVID-19 spreads in 8 Maharashtra jails  Moneycontrol.com
6. View Full coverage on Google News

Could you perform under this kind of pressure if it meant saving your loved ones? I ask myself this question all the time and it is precisely why I train consistently at Front Sight and encourage you to do the same. In both of the following videos, the good guys execute exactly the skills we […]

Rey, Leia and C-3PO get emotional.

The author of the new book “Making Comics” has a plan for her grant windfall: the study of the “split” in the human brain between writing and drawing.

Scarlett Johansson is back for a solo movie, coming out May 1, 2020.

Fanny packs and Kristen Wiig's Cheetah fill the frame in the teaser to the franchise's first sequel.

As fires tear across California, a Silicon Valley technology company believes artificial intelligence could be the key to preventing them in the future.

A sputtering offense and a bad defense is causing the Raiders to be outscored by nearly eight points per game after adjusting for strength of schedule.

The Members team ultimately fell 10-4 to the press team, despite valiant efforts from players such as 2020 presidential hopeful and team pitcher Kirsten Gillibrand.

Low-key no longer: The presidential candidate and his actress girlfriend appeared together at public events over the holiday weekend.

The small town mayor is raking in some cash from A-list donors.

The "Charmed" actress defended her decision to help raise money for the controversial Democratic candidate, saying Williamson is addressing the "soulful ache of the nation."

Like the Kennedy Center Honors, the gallery’s gala has turned into a red-carpet affair.

Anthony Fauci praised Brad Pitt's performance, saying "Everything he said on SNL is what’s going on.”

They prey on panic — and spurn attempts to quench it.

The administration is celebrating the brain drain and helping the real swamp.

Digital vs paper: ink on paper may still have the advantage In a recent edition of Scientific American, Ferris Jabr took a look at how technology is affecting the way we read and the differences between reading on screens and …

Portrait Lighting is a powerful photography tool available on newer iPhone models cameras. Apple aimed to bring studio-quality effects to the camera app by analyzing light on a subject in real-time while in portrait mode, and the result is the portrait lighting mode feature. There are five different studio-like effects to choose from, in the ... Read More

oscon: Community Management Training - strategic planning, creating buzz, handling conflict + more http://t.co/eHz9h6VfnU @jonobacon #oscon

oscon: RT @jonobacon: working on my material for my community management training class - be sure to join me in Portland -...

I’m excited to speak with Pavel Cherkashin in today’s episode of the How To CEO podcast!. Pavel is a co-founder and managing partner at Mindrock Capital. Pavel is also a managing partner at GVA Capital. I spoke with him about what founders and CEOs need to know about raising early checks. When Should Founders Try […]

The post How Founders and CEOs Can Raise Early Checks (With Pavel Cherkashin) appeared first on ReadWrite.

I am requesting that you publish this letter as a response to the article so that my side of the story can be heard in order to provide a balanced view.

Through Hiking the Pacific Crest Trail at 10

The Amateur Traveler talks to Jessica from Williamsburg Virgina who traveled last Summer to the Ukraine with an ethnomusicologist from Villiage Harmony to learn how to sing Ukrainian folk music. Jessica travelled both to larger cities like the capital Kiev and Ivano-Frankivsk and small country villages. She also journeyed into the Carpathian mountains on the Romanian border. Jessica relates some of the stories about the people she met, the food they ate and scary public bathrooms. Learn why you should not whistle indoors or give someone a dozen roses in the Ukraine.

Hear about hiking the Kings Trail (Kungsleden) in Swedish Lapland as the Amateur Traveler talks to Agata from nullnfull.com about this northern and rugged portion of Sweden. Agata says, “Lapland is all about nature and wilderness”.

Hear about hiking Japan's Nakasendo Trail as the Amateur Traveler talks to Dave Grenewetzki about his experiences on this trip into the Japanese countryside between Kyoto and Tokyo.

Hear about travel to Kiev in the Ukraine as the Amateur Traveler talks to Amy Butler from thewayfarersbook.com about her adopted city.

Hear about travel to Minas Gerais, Brazil as the Amateur Traveler talks to Juergen Keller from southamerica.travel about the colonial heart of Brazil.

Hear about hiking the Kumano Koto trek in Japan as the Amateur Traveler talks to Sherry Ott about her experience on this trail that was used by medieval emperors on the Kii Peninsula. 

As ISIS expands its reach into Afghanistan, it is training children and teenagers to become the next generation of jihadis.

Jennifer Usellis-Mackay, aka the Klingon Pop Warrior, sings "Somewhere Over the Rainbow" in her native tongue. The performance took place in 2015 at Chicago's iO Theater. From the video description:

Opening for Improvised Star Trek, I sang a new (old) song. Got some newly translated words the day of the performance... enjoy this little slice of nerdiness... or don't.

Vocals - The Klingon Pop Warrior (Jennifer Usellis-Mackay) Guitar - The Red Shirt (Joe Mizzi) Translation - Admiral qurgh (Christopher Lipscombe) Video - Eric Scull

(via r/ObscureMedia) Read the rest

One positive upside of the past two months is how sheltering at home has all but emptied area animal shelters. It’s tough to get solid numbers nationally, but shelters in cities and regions all across America are reporting massive surges in animal adoptions. 

Even the steep increase in Google searches for “adopt a pet,” up a whopping 335 percent in April, proves what we probably all knew anyway — that in times of stress, having a furry friend is a huge comfort for millions.

Unfortunately, one of the downsides of the past two months is there are no trainers available to help whip some of these new family pets, particularly puppies, into shape. From barking and jumping to house training and scratching, The Complete Guide to Puppy and Dog Training Bundle is a full plan for getting the newest member of your family integrated into the house safely and sanely all by yourself.

The collection includes eight courses all geared toward getting a new dog or puppy behaving the right way. And if you’ve ever had any thoughts about starting a dog training business of your own, this coursework is a perfect starting spot.

Puppies: A-Z Guide to Puppy & Dog Training kicks off the learning, explaining the best way to train, teach and socialize your puppy so they grow into a joyful, well balanced, and well-behaved dog. 

Of course, most puppies each have their particular issues, so a handful of courses look more closely at some of the tactics for helping your puppy overcome certain challenging behaviors. Read the rest

RCMP say a 50-year-old man died and a 60-year-old man is in hospital following a crash involving a CP Rail train Friday morning.

France defender Samuel Umtiti has picked up a calf injury in just the second session since Barcelona returned to training from the cornonavirus quarantine.

One of the most popular hikes in South America, the Inca Trail is definitely the experience of a lifetime. A centuries-old trail, it begins in the ancient Incan capital of Cusco and winds some 88 kilometers to some of the world’s most iconic ruins: Machu Picchu. Of course, the entirety of Inca Trail is absolutely stunning, from stunning snowcapped Andean peaks to centuries-old ruins situated in bucolic river valleys. However, these 5 highlights are truly bound to make your jaw drop.

Wayllabamba. The endpoint of the first day’s trek along the Inca Trail, Wayllabamba, which means “grassy plain” in Quechua, is the perfect spot to watch the sunset behind the dramatic Andean peaks. This grassy plain overlooks a stunning spot of Andean scenery, with centuries-old Incan terraces winding through the surrounding mountainsides. There is even a village nearby where travelers can mingle with local villagers.

The Valley of Llulluchapampa. Trekkers will start off the first portion of day two of the journey hiking through the picturesque Valley of Llulluchapampa. As you gradually ascend in altitude, you will even be afforded perfect views of stunning snowcapped cliffs.

Runkuracay: This unique oval structure, sometimes colloquially know as the “Egg Hut,” is believed to have been a kind of rest stop for Incan travelers, called a tambo, providing them with a place to spend the night and rest their animals. It is the perfect place to enjoy a mid-hike break and marvel at the beauty of Incan architecture.

Sayacmarca: First discovered by the famous Hiram Bingham when he wandered along a road extending from Machu Picchu, the dramatic Sayacmarca is situated at a fork in an old Incan road in a dense subtropical forest full of butterflies and hummingbirds. Quechua for “Dominant Town,” these unique ruins have an almost mystical air about them and are arguably the most impressive along the Inca Trail (except for Machu Picchu itself, of course!). It is believed that Sayacmarca was actually built by the Colla, a major enemy of the Incas, and that the Incas took over the site following their conquest of the group.

Phuyupatamarca: Dubbed “La Ciudad entre la Niebla” (“The City above the Clouds”), this major archeological site is situated a staggering 3,200 meters above sea level. Apropos to the nickname, Phuyupatamarca is very often surrounded by dense, white clouds. The ruins, dramatically constructed into a steep cliffside, contain five stone baths that fill up with freshwater during the rainy season. It is believed that these baths were used for religious ceremonies. Visitors can also check out the site’s elaborate hydraulic system, a true testament to impressive capabilities of Incan engineering. Of all of the Incan ruins in the region, Phuyupatamarca is arguably the most intact and therefore a truly spectacular site for trekkers passing through.

Huiñay Huayna (Wiñay Wayna): Huiñay Huayna (traditionally spelled Wiñay Wayna in Quechua, the language of the Incas) was constructed into a steep hillside overlooking the Urubamba River. In addition to the site’s ancient houses and temples, it also boasts an incredibly complex system of Incan terraces, formerly used for agriculture. The name of the site roughly translates to “Forever Young,” and many trekkers report that these ruins are the most beautiful found along the trail.

These are just some of what you will see along the Inca Trail: Learn more about popular Inca Trail itineraries here

My flight was booked! My dream of hiking the Inca Trail, and walking through the sun gate to Machu Picchu was finally becoming a reality. But then, the reality hit me. I have never done an overnight hike before! What do I pack? How do I get into shape? Is it safe? Do I go alone or with a group? As excited as I was, I realized I had a lot of planning ahead of me, but every moment of preparation (and sometimes extreme anxiety) was all worth it. Here are a few tips and tricks that helped me not only survive the Inca Trail, but have the trip of a lifetime!

1. Find an Incredible Tour Group

Before booking my trip, I was not sure how I felt about going with a tour group. I was worried that traveling with a group of strangers would take away from the trip. However, after plenty of research, I decided to go with Active Adventures on the Ultimate Peru Adventure.

Our trip leader was not only full of helpful and interesting information, but became a friend who gave local tips, and made me feel comfortable and safe. I became close friends with my small tour group of 10 people, and still keep in touch with them. Picking a quality tour group like Active Adventures not only helped take the stress out of travelling logistics, but is truly what made my trip an enjoyable experience. (And for all the foodies out there, our Inca Trail chefs were incredible).

2. Get Fit

On the Inca Trail we had people of all ages, sizes, and fitness levels. However, I highly recommend preparing your body a little, and familiarizing yourself with how your body reacts to high altitude. But, don’t worry, you don’t need to an extreme amount of training. To prepare, I went on one to two hikes a week, and did plenty of dog walking. My hikes on average ranged from 3 to 7 miles.

However, as fit as you are, everybody reacts differently to altitude. Try finding a hike in your area that has somewhat of a higher altitude. I only had the opportunity to do one higher altitude hike. It was not as high as the Inca Trail, but it still gave me an idea of how my body feels in high altitude. But don’t stress out too much! Your tour leader has helped many people hike the Inca Trail, and will be there to help you if you start to feel sick, or simply need a little extra motivation.

3. Technology Tools

I am a firm believer in digital detoxing when traveling, but when hiking in the wilderness, it is comforting to know that I have helpful resources at my fingertips if I ever need it. When hiking or traveling, there are always a few resources and apps I like to have on my phone or iTouch to stay safe.

As a traveler, we are more vulnerable to security threats or identity theft on public computers and Wi-Fi. I choose to use a VPN when traveling for Wi-Fi security in hotels, to avoid computer viruses, and to gain access to content that is geo-blocked. For my Inca Trail trek I downloaded the MotionX GPS app. The app supports GPS navigation without the need for cell service. Thankfully our guides kept us on track, but it was comforting knowing that if anything happened, I could use my phone as a backup for navigation help.

4. Make a Visit to Your Doctor

When traveling anywhere, it is important to check in with your doctor. Different regions of the world may require various vaccinations, or medication. Before visiting your doctor, it is also helpful to do a little bit of your own research as to what medications or vaccinations are needed for travel. Your doctor may be familiar with vaccinations needed for Peru, but you are the only person who knows what your trip will consist of. Be sure to mention to your doctor if you are going to the Peruvian Amazon, or high altitude.

For the Inca Trail I recommend packing the following medications:

-Altitude sickness medication (Acetazolamide)

                       -Imodium

                       -Antibiotics (Ciprofloxacin)

                       -Bug spray (not technically a medication, but important to bring as well)

                       -Ibuprofen (always good to have)

This list is most likely what your doctor will recommend as well, but be sure to do your own research as well. You may need malaria pills or certain vaccinations depending on where else your trip is going, or personal previous medical history.

5. Pack Light

The hardest part of my trip (aside from trekking up the stairs of the Inca Trail) was packing! There are several limitations on how much you pack on the Inca Trail in order to maintain that porters are being treated fairly and respectfully. Each porter is limited to carrying 20kg. This includes all blankets, clothes, and the porter’s personal belongings. Talk to your Active Adventure tour guide before leaving on your trip to find out up to date information on how much you are able to pack, and information on sleeping bags and pads.

Aside from packing light, there are of course certain items you will want to pack, depending on the time of year your trek is. I used Her Packing List, along with the information provided by Active Adventures to help me in packing everything I need.

6. Have the Time of Your Life

Last, but not least, be ready to have incredible experiences and memories that will last a life time. When I first booked my trip to Peru and the Inca Trail I had certain expectations and ideas of what the trip would be like. I was looking forward to seeing Machu Picchu, but what I found was that the most memorable and exciting parts of my trip were not necessarily seeing the big tourist spots like Machu Picchu, but the journey getting there, and the unexpected surprises that came along the way. Peru and its people exceeded all expectations, and opened my mind in ways I did not know were possible.

Hi, my name is Jess Signet. My parents were travelers since before I was born. Even in the womb, I was able to travel all over the place! Boy, did things NOT change as I grew older!
Knowing there’s more to the world than the bubble I live in made me want to travel even further. Traveling is my drug and I’m addicted. (Please, no intervention!)

Part of the Sport Relief promo for the BBC UK Homepage

The following article, Video Scrubbed of Obama-Biden Ambassador To China Praising Their Response to Coronavirus: “I take my hat off to China”, was first published on 100PercentFedUp.com.

During a recent interview on CNN, Obama-Biden ambassador to China (2014-2017) Max Baucus compared standing up to China on the coronavirus to “Hitler in the ’30s.” Baucus has proven himself to be sympathetic to China in recent interviews, where he puts down America and praises the Chinese. The MSNBC video via The Washington Free Beacon […]

Continue reading: Video Scrubbed of Obama-Biden Ambassador To China Praising Their Response to Coronavirus: “I take my hat off to China” ...

The peroxisome is a subcellular organelle that functions in essential metabolic pathways, including biosynthesis of plasmalogens, fatty acid β-oxidation of very-long-chain fatty acids, and degradation of hydrogen peroxide. Peroxisome biogenesis disorders (PBDs) manifest as severe dysfunction in multiple organs, including the central nervous system (CNS), but the pathogenic mechanisms in PBDs are largely unknown. Because CNS integrity is coordinately established and maintained by neural cell interactions, we here investigated whether cell-cell communication is impaired and responsible for the neurological defects associated with PBDs. Results from a noncontact co-culture system consisting of primary hippocampal neurons with glial cells revealed that a peroxisome-deficient astrocytic cell line secretes increased levels of brain-derived neurotrophic factor (BDNF), resulting in axonal branching of the neurons. Of note, the BDNF expression in astrocytes was not affected by defects in plasmalogen biosynthesis and peroxisomal fatty acid β-oxidation in the astrocytes. Instead, we found that cytosolic reductive states caused by a mislocalized catalase in the peroxisome-deficient cells induce the elevation in BDNF secretion. Our results suggest that peroxisome deficiency dysregulates neuronal axogenesis by causing a cytosolic reductive state in astrocytes. We conclude that astrocytic peroxisomes regulate BDNF expression and thereby support neuronal integrity and function.

Assembled α-synuclein in nerve cells and glial cells is the defining pathological feature of neurodegenerative diseases called synucleinopathies. Seeds of α-synuclein can induce the assembly of monomeric protein. Here, we used sucrose gradient centrifugation and transiently transfected HEK 293T cells to identify the species of α-synuclein from the brains of homozygous, symptomatic mice transgenic for human mutant A53T α-synuclein (line M83) that seed aggregation. The most potent fractions contained Sarkosyl-insoluble assemblies enriched in filaments. We also analyzed six cases of idiopathic Parkinson's disease (PD), one case of familial PD, and six cases of multiple system atrophy (MSA) for their ability to induce α-synuclein aggregation. The MSA samples were more potent than those of idiopathic PD in seeding aggregation. We found that following sucrose gradient centrifugation, the most seed-competent fractions from PD and MSA brains are those that contain Sarkosyl-insoluble α-synuclein. The fractions differed between PD and MSA, consistent with the presence of distinct conformers of assembled α-synuclein in these different samples. We conclude that α-synuclein filaments are the main driving force for amplification and propagation of pathology in synucleinopathies.

Manganese (Mn) is an essential micronutrient required for the normal development of many organs, including the brain. Although its roles as a cofactor in several enzymes and in maintaining optimal physiology are well-known, the overall biological functions of Mn are rather poorly understood. Alterations in body Mn status are associated with altered neuronal physiology and cognition in humans, and either overexposure or (more rarely) insufficiency can cause neurological dysfunction. The resultant balancing act can be viewed as a hormetic U-shaped relationship for biological Mn status and optimal brain health, with changes in the brain leading to physiological effects throughout the body and vice versa. This review discusses Mn homeostasis, biomarkers, molecular mechanisms of cellular transport, and neuropathological changes associated with disruptions of Mn homeostasis, especially in its excess, and identifies gaps in our understanding of the molecular and biochemical mechanisms underlying Mn homeostasis and neurotoxicity.

12 March 2015 , Volume 91, Number 2

16 December 2019

Invitation Only Research Event

Invitation Only Research Event

6 February 2014 , Volume 70, Number 1

Beautiful Kyiv has been brutalized