A double ring network system configured with two or more transmission stations each including a pair of bi-directionally communicative communication ports, including any adjacent two transmission stations as terminal stations, and any transmission station as a base, as mutually connected in a ring form by communication ports through a transmission line, for intercommunications between transmission stations, in which the transmission stations are each adapted to determine whether or not frame signals are received from adjacent transmission stations, transmit route identifying frame signals for identification of routes to adjacent transmission stations, when having failed in reception, and set own station as a terminal station substituting for a current terminal station, when having received no responses to the route identifying frames from adjacent transmission stations, so they are kept from arriving at ring-like connected subsequent transmission stations.

Various topologies of a quality of service application controller and related techniques to optimize the communications performance an application executing on a device participating in a communications environment are disclosed. The communications environment may include a cellular network, an unlicensed spectrum network, or a combination of the two. The quality of service application controller observes one or more key performance indicators of the communications network, and retrieves a policy from a policy store specific to the application. The quality of service application controller then modifies the execution of the application and/or the configurable aspects of the communications environment to optimize the communications performance of the application. For example, the application's data throughput may be increased, the power draw of the application may be minimized, data requested by the application may be minimized, or the apparent response time of the application's response to a web service may be minimized.

Methods and apparatus for intercepting communications in an Internet Protocol (IP) network involve maintaining dialing profiles for respective subscribers to the IP network, each dialing profile including a username associated with the corresponding subscriber, and associating intercept information with the dialing profile of a subscriber whose communications are to be monitored. Intercept information will include determination information for determining whether to intercept a communication involving the subscriber, and destination information identifying a device to which intercepted communications involving the subscriber are to be sent. When the determination information meets intercept criteria communications are established with a media relay through which communications involving the subscriber will be conducted or are being conducted to cause the media relay to send a copy of the communications involving the subscriber to a mediation device specified by the destination information.

A wireless communication system and, more specifically, a measurement method and apparatus for inter-cell interference coordination in a wireless communication system are disclosed. Herein, a method for supporting measurement of a User Equipment (UE) by a first base station in a wireless communication system includes the steps of acquiring information of downlink subframe configuration of a second base station, determining measurement objects of downlink resource of the first base station based on the downlink subframe configuration of the second base station; transmitting information of the measurement objects to the UE, and receiving measurement result for the measurement objects from the UE.

A reception apparatus is configured to receive data including a plurality of packets each of which has information on a time point when the packet is generated; to extract a terminal packet which is a packet included in the data received and which has information on a time point which is nearest to a current time point; and to control an operation clock by comparing the information on the time point included in the terminal packet with information on an elapsed time obtained by adding information on a time point, which is included in a terminal packet of preceding data, to an elapsed time from when the preceding data is received to the current time point.

A network system has: a communication device configured to perform frame transmission and reception; a network configured to transfer the frame; a gateway connected between the communication device and the network; and a controller configured to perform management of the communication device and the network. The frame is classified into a control frame for communicating control information necessary for communication and a data frame for communicating data between communication devices. The gateway determines whether a frame received from a source communication device is the control frame or the data frame, forwards the control frame to the controller, and forwards the data frame to the network. The controller performs the management based on the control frame received from the gateway. The network transfers the data frame received from the gateway to a destination communication device without through the controller.

A mobile user terminal, which communicates with a base station in an intermittent fashion, the mobile user terminal includes a radio transmitter which transmits downlink channel quality information indicating downlink channel quality and an uplink pilot signal to a base station in an intermittent fashion; and a transmit time controller which synchronizes transmit time of the downlink quality information and transmit time of the uplink pilot signal relative to each other, such that the downlink quality information and the uplink pilot signal are sent in adjacent different timings in a period corresponding to a state of intermittent communicate.

There are provided a power transmission chain which can reduce a noise level further by eliminating unfavorable combinations from a random arrangement of combinations of pitch lengths and pin shapes and a power transmission system using the same power transmission chain. With respect to pitch length, links include two types of a link L1 which has a small pitch length and a link L2 which has a large pitch length. With respect to pin shape, pins include two types a pin P1 of which a curvature of a rolling contact surface is large and a pin P2 of which the curvature of the rolling contact surface is small. The links are arranged so that a possibility is avoided that a combination of (L2, P2) and a combination of (L2, P1) come immediately after a combination of (L1, P2) in a chain traveling direction, and that a possibility is adopted that a combination of (L1, P2) or a combination of (L1, P1) comes immediately after the combination of (L1, P2).

In the present invention, one or both of an active wheel or a passive wheel is composed of an eccentric transmission wheel and is combined with a synchronous transmission belt for forming an eccentric wheel transmission wheel series, so that when the feet input forces at different angles from the treadle shafts of the treadles to an active wheel shaft combined on the active wheel through cranks, the active wheel forms different transmission speed ratios relative to the passive wheel according to the treadle angle, and random inward packing is performed to the transmission belt (100) of the engage end of the eccentric passive wheel (413) during the transmission for stabling the operation.

A vehicle powertrain has an engine, a driving shaft having a passage defined therein, a driven shaft, a pump, a hydraulic fluid reservoir, and a CVT. A driving pulley of the CVT includes a fixed sheave and a movable sheave disposed on the driving shaft for rotation therewith, a spring biasing a movable sheave away from the fixed sheave, and a CVT chamber fluidly communicating with the passage of the driving shaft. The pump supplies hydraulic fluid from the reservoir to the passage in the driving shaft. The hydraulic fluid flows from the passage to the CVT chamber to create a hydraulic pressure in the CVT chamber. The hydraulic pressure in the CVT chamber biases the movable sheave toward the fixed sheave.

A bicycle transmission control apparatus comprises a control unit that provides a first signal to operate a first derailleur a gear shift distance from a first origin sprocket to a first destination sprocket. The control unit receives a condition signal that indicates a condition resulting from at least one of the first derailleur and a second derailleur; and an adjustment controller moves the first derailleur an adjustment distance less than the gear shift distance in response to the condition signal.

A belt-type stepless transmission is provided with: an input shaft; an input pulley having a stationary sheave and a movable sheave; a transmission shaft disposed parallel to the input shaft; an output pulley having a stationary sheave and a movable sheave; a belt wound around the input pulley and the pulley; an output shaft disposed coaxially with the transmission shaft; and a cam mechanism having a sheave-side cam which is provided and affixed to the movable sheave and a shaft-side cam which is provided and affixed to the output shaft and causing the sheave-side cam and the shaft-side cam to make contact with each other to thereby enable the transmission of torque between the movable sheave and the output shaft and apply an axial pressing force corresponding to the torque to the movable sheave.

A clamping device (1) of a traction mechanism drive, comprising a fixedly positioned base part (2), with which a pivot arm (3) is associated. The pivot arm (3) can be pivoted via a rotary bearing, consisting of a hub (9), a pin (5) of the base part (2) and a sliding bearing (10). A spring means (12) inserted between the base part (2) and the pivot arm (3) exerts an expansion force and effects a non-positive support of a tensioning roller (11) that is connected to the pivot arm (3) on a traction mechanism. In order to damp adjusting movements of the pivot arm (3), a damping device (13) is provided, which comprises two separate spring-loaded friction elements. For this purpose, a friction disk (14) is supported with form fit on the supporting disk (8) connected to the pin (5) of the base part (2) and with friction fit on the pivot arm (3). The damping device (13) further comprises a friction ring (17), which is fixed to the pivot arm (3) and is supported with friction fit on an inner wall (19) of the crucible-shaped base part (2) and which directly cooperates with the spring means (12).

A continuously variable transmission for a vehicle comprises a primary pulley, a secondary pulley, and a belt entrained around both pulleys in an opposite manner between the fixed and movable sheaves thereof. One pulley carries a selectively deployable stop that may be placed into position to mechanically limit the range of motion between the fixed and movable sheaves. This establishes an actual maximum transmission ratio that is larger than the nominal minimum transmission ratio but smaller than the nominal maximum transmission ratio achievable by the transmission during normal operation thereof. When such a transmission is used on a utility vehicle attached to a substance dispensing applicator operatively driven by the vehicle's engine, the application rate stays substantially constant despite changes in engine speed when the user keeps the transmission upshifted to the actual maximum transmission ratio set by the position of the deployed stop.

A friction drive belt has a pulley contact portion of a belt body, and at least the pulley contact portion is made of a rubber composition. Numerous pores are formed in a surface of the pulley contact portion of the belt body, and numerous small protrusions having an average height of 4-40 μm are formed to protrude from the surface.

A belt-type continuously variable transmission for a vehicle includes: a primary pulley including a first fixed sheave fixed to an input shaft, and a first movable sheave relatively non-rotatable and relatively movable in axial direction to the input shaft due to spline-fitting of a female spline formed on an inner circumferential portion thereof to a male spline formed on the input shaft; a secondary pulley including a second fixed sheave fixed to an output shaft in parallel with the input shaft, and a second movable sheave relatively non-rotatable and relatively movable in the axial direction to the output shaft due to spline-fitting of a female spline formed on an inner circumferential portion thereof to a male spline formed on the output shaft; and a transmission belt, the belt-type continuously variable transmission for a vehicle disposed with at least one of a first groove width defining portion disposed on the primary pulley for defining a maximum groove width of the first pulley groove and a second groove width defining portion disposed on the secondary pulley for defining a maximum groove width of the second pulley groove, the first groove width defining portion and the second groove width defining portion being disposed on one shaft of the input shaft and the output shaft, and the other shaft having a uniform shaft diameter in an range of sliding of the first movable sheave or the second movable sheave in the axial direction except a site with the male spline formed, the other shaft being disposed on the opposite side to the one shaft.

An arrangement for supplying oil to a chain drive which drives a transmission oil pump that is axially offset relative to a torque converter and embedded in an intermediate plate in a vehicle having a torque converter. The driven sprocket of the chain drive is supported by a converter neck mounted in a centering plate. A seal is provided between the converter neck and the sprocket and is arranged adjacent the sliding fit between the converter neck and the sprocket. To compensate for the suppression of lubrication of the seal, the neck bearing and the chain drive, a valve is integrated in the intermediate plate, and a duct is provided in the plane, in which the centering plate is screwed to the intermediate plate, such that excess oil flowing from the valve is selectively directed to the seal, the neck bearing and the chain drive.

A hydraulic damper for providing fluid damping to a tensioner in a drive system that includes a damper cup, which is mounted to the tensioner and configured to rotate about a central axle in tandem with the tensioner, an end plate having an outer face and an inner face, which is attached to the damper cup forming a fluid chamber, a peg attached to the end plate and extending away from the inner face and toward the damping cup, a damping fluid, which is contained within the fluid chamber, a plurality of shear plates housed within the fluid chamber comprising alternating fixed plates engaged with a fixed component of the tensioner and rotatable plates engaged with a rotatable component of the tensioner where the peg extends through openings in each of the shear plates allowing for rotation of the rotatable plate with the rotation of the peg.

In a silent chain transmission, noise performance is improved by preventing guide plates of a silent chain from contacting sprocket teeth before the link plates of the chain contact the sprocket teeth. The silent chain transmission comprises a silent chain in engagement with a sprocket. The silent chain comprises guide rows, each having a pair of guide plates and a plurality of middle link plates, and non-guide rows, each having a plurality of inner link plates. An engagement starting point of the middle link plate with a sprocket tooth and an engagement starting point of the inner link plate with the sprocket tooth are set at positions such that the guide plate is prevented from contacting the sprocket tooth before the respective link plates start to engage the sprocket tooth when runout of the chain in the direction of its width occurs.

A clip-type mechanism for tensioning slack in a chain. A spring-biased piston is positioned in a bore in a housing. A ratchet rack is positioned on the piston, along with a clip member. A recess in the housing bore has an annular member with a hardened surface to reduce wear.

A chain belt-type continuously variable transmission in which ratchet-type chain belts are wound on driving and driven pulley devices, each of which has a variable diameter, in order to control the shift ratio. Driving belt supports are disposed in a driving pulley device so as to radially contract and expand. Driven belt supports are disposed in a driven pulley device so as to radially contract and expand. Teeth in the front portions of the driving belt supports and the driven belt supports and teeth in the rear portions of the driving belt supports and the driven belt supports are oriented in opposite directions. Front and rear ratchet gears formed on the driving belt supports and the front and rear ratchet gears formed on the driven belt supports are oriented in opposite directions and are arranged in alternating positions without being formed at corresponding positions in a line.

A belt-driven continuously variable transmission having a downsized torque cam assembly for creating forward thrust to push a movable sheave toward a fixed sheave. The belt-driven continuously variable transmission is adapted to output a torque while changing a speed ratio continuously by altering an effective diameter position of a driving belt. The belt-driven continuously variable transmission is comprised of: an output gear, which is fitted onto the rotary shaft of the driven pulley to output the torque while being allowed to rotate relatively; a piston, which is fitted onto the rotary shaft of the driven pulley between the movable sheave and the output gear while being allowed to rotate integrally with the movable sheave and to reciprocate in an axial direction of the rotary shaft, and which increases an internal pressure of the hydraulic chamber by moving toward the movable sheave; and a torque cam assembly, which is interposed between the piston and the output gear, and which pushes the piston toward the movable sheave when the torque transmitted through the driven pulley is increased.

A transmission system for vehicles, including bicycles, is disclosed. The system aligns a chain or other drive means to a center of each of a plurality of provided sprockets, allows for a smaller, lighter and more durable shifter/controller, and reduces various complications associated with cable slack and shifting. A derailleur is provided with linear actuated features to directly translate drive means from one position to another along a desired path.

A secondary assembly drive of an internal combustion engine and a method for operating same are provided. The secondary assembly drive includes: a first drive wheel (1) which can be rotatably connected to a crank shaft (CR) of the internal combustion engine, an electric machine which can be operated either as a generator (AL) of as a motor (M) and a second drive wheel (2) which can be rotatably connected to the electric machine (AL, M), an air-conditioning compressor (A/C) and a third drive wheel (3) which can be rotatably connected to the air-conditioning compressor, a traction element (4) which rotates infinitely and which wraps around the drive wheels, and an actuable clutch (7) for disconnecting the drive of the electric machine and of the air-conditioning compressor from the crankshaft when necessary. In addition, the air-conditioning compressor is designed for operation in both rotational directions, and a reversal of the rotational direction between the generator operating mode and the motor operating mode of the electric machine is provided.

A secondary assembly drive of an internal combustion engine and a method for operating same are provided. The secondary assembly drive includes, in two drive planes, an assembly drive (2) and a starter drive (12) and permits, in addition to a normal operating mode, the following operating modes: —starting of the internal combustion engine, —boosting of the internal combustion engine, —air-conditioning, and —deactivation of the assembly drive (2).

The present invention is structured by using one or both of an active wheel and a passive wheel being composed of an eccentric transmission wheel and being combined with a synchronous transmission belt for forming an eccentric wheel transmission wheel series, so that in the reciprocal treadle performed by the human's feet, when the feet input forces at different angles from the treadle shafts of the treadles to an active wheel shaft combined on the active wheel through cranks, the active wheel forms different transmission speed ratios relative to the passive wheel according to the treadle angle.

A power transmission belt comprising cord, elastomeric undercord, at least one pair of opposing v-shaped pulley contact surfaces, and having discontinuous fiber embedded in the undercord, some of which protrude from a contact surface. The fiber comprises deformable polymer, such as nylon, and the fiber protrusions are substantially erect with respect to the surface and substantially straight or slightly bowed, especially near the free end, and the fiber protrusions are deformed from an original cross-sectional shape, which may be substantially round or oval or the like, to an elongated, oval, oblong, kidney, or flattened circle shape. The protruding fiber length is at least two fiber diameters.

The present invention relates to methodology and constructs for modifying plant architecture and enhancing plant biomass and/or sucrose yield.

A method and apparatus for mixing fluids, such as beverage syrup and water, uses countercurrent injection to improve blending of the fluids. A mixing chamber has a first inlet through which a first fluid is fed to the mixing chamber, and a second inlet through which a countercurrent injection nozzle extends and is operative to inject a second fluid into a stream of the first fluid. The countercurrent injection nozzle is equipped with a check valve to control the flow of fluid into the mixing chamber. The mixing chamber may include additional inlets that may be fitted with countercurrent injection nozzles to permit the countercurrent injection of other fluid, such as flavorings, into the stream of the first fluid.

A device for depositing a mixture of powders to form an object with composition gradients, including: a plurality of tanks respectively configured to contain different powders; a powder mixer placed under the tanks and including a rotatably mounted mixing member; a plurality of powder dispensing mechanisms respectively cooperating with the tanks, and each configured to regulate mass flow rate of the powder escaping from a respective of the tanks towards the mixer; a powder mixture collector placed under the mixer; and a powder mixture dispenser placed under the collector.

A method of mixing together liquids or liquid/solid combinations, and mixing apparatus/universal combine utilizing a vertical spinning container or vessel having a rib, or a cross rib in its bottom wall. The container is spun about a vertical axis with no wobbling component to the motion. Meshed elements are used for high shear mixing. Start/stop routines, and variable acceleration/speed values are used, to facilitate complete mixing. Use of ‘impeller’ blade stirrers is completely eliminated.

An apparatus, system and method for mixing and dispensing dental impression materials is described. A dental impression material mixing machine comprises a water dispenser fluidly coupled to a hollow mixing axle, the mixing axle extending through a pulley, wherein an inner circumference of the hollow mixing axle forms a water conduit and an outer circumference of the hollow mixing axle forms a hub connector, a closeable valve inserted at a water entrance to the water conduit and electronically coupled to a water pump, an electronically commutated motor rotatably coupled to the pulley, wherein the hub connector receives a tubular rotatable hub of a disposable mixing vessel comprising dry dental impression powder, and wherein water is dispensed from the water dispenser into the disposable mixing vessel through the water conduit and hub orifice.

A flow mixer and conditioner for use within a conduit conditions flowing media within the conduit to provide a swirl-free, symmetric, and reproducible velocity profile regardless of upstream flow distortions, disturbances, or anomalies. Tabs are cut from a single plate and bent or affixed to provide mixing and conditioning of the flowing media. Single tabs or tab pairs emanating from common vertices can be formed so that they diverge in, or against, the direction of flowing media. The flow conditioner requires as little as three pipe diameters downstream and upstream to mix and condition the flow stream allowing close placement to elbows, valves, tees, and other disturbances typically seen in industrial plants.

An eddy-current-minimizing flow plug has an outer radial wall with open flow channels formed between the plug's inlet and outlet. The plug has a central region coupled to the inner surface of the outer radial wall. Each open flow channel includes (i) a first portion originating at the inlet and converging to a location in the plug where convergence is contributed to by changes in thickness of the outer radial wall and divergence of the central region, and (ii) a second portion originating in the plug and diverging to the outlet where divergence is contributed to by changes in thickness of the outer radial wall and convergence of the central region. For at least a portion of the open flow channels, a central axis passing through the first and second portions is non-parallel with respect to the given direction of the flow.

An apparatus for containing and mixing a load of liquids and solids is disclosed. The apparatus includes an elongated tank, which includes a lower portion and an upper portion. The apparatus further includes an elongated rotatable shaft within the tank. At least one blade is connected to the shaft and is configured to mix the liquids and solids when the shaft is rotated. The apparatus also includes a shaft support configured for maintaining the shaft in a rotatable manner within the tank. The shaft support is selectively moveable in a manner permitting the shaft to move in an upward direction from the lower portion toward the upper portion, and in a downward direction from the upper portion toward the lower portion. An is contained with the tank for moving the shaft support in the upward direction and in the downward direction.

Provided are a fluid agitation apparatus using a structure which is simple in shape and short in a fluid passage direction without a movable part so as to produce a sufficient effect from the viewpoint of reducing temperature fluctuation, and a thermostatic apparatus using the fluid agitation apparatus. The fluid agitation apparatus is installed in a fluid passage and includes, in an order from an upstream side thereof: a dividing part for dividing a flow of a fluid into a plurality of flows; a circumvolving part for circumvolving the fluid about an axis in a flow direction of the fluid; and an accelerating part for increasing a flow rate of the fluid.

A dissolution generator includes: an upright housing; a screen assembly extending across an interior of the housing, and configured to support a column of powder thereabove; a spray nozzle disposed below the screen assembly and directed towards the screen assembly; and a pressure mechanism disposed above the screen assembly, and configured to apply a substantially constant downward pressure.

An improved dual-shaft preconditioner (10) of simplified design is provided giving increased moisturization and partial cooking of food or feed ingredients. The preconditioner (10) includes an elongated, tapered housing (12) presenting a pair of side-by-side, communicating housing sections (58, 60), with a corresponding pair of converging shafts (20, 22) within the sections (58, 60) and having a series of elongated, outwardly extending mixing elements (24, 26) secured to the shafts (20, 22). The preconditioner (10) is designed for use in a system including a downstream processing device, such as an extruder (146).

The present invention generally relates to multiple emulsions, and to methods and apparatuses for making multiple emulsions. A multiple emulsion generally describes larger droplets that contain one or more smaller droplets therein. The larger droplets may be suspended in a third fluid in some cases. These can be useful for encapsulating species such as pharmaceutical agents, cells, chemicals, or the like. In some cases, one or more of the droplets can change form, for instance, to become solidified to form a microcapsule, a liposome, a polymerosome, or a colloidosome. Multiple emulsions can be formed in one step in certain embodiments, with generally precise repeatability, and can be tailored to include one, two, three, or more inner droplets within a single outer droplet (which droplets may all be nested in some cases).

The present invention relates to the field of organic chemistry and in particular to organic free radicals used as polarizing agents in the technique of Dynamic Nuclear Polarization (DNP), which involves transferring the polarization of electron spins to the nuclei of a compound whose Nuclear Magnetic Resonance (NMR) is being observed. It concerns Dinitroxide-type Biradical polarizing agents characterized by a rigid linkage between the aminoxyl groups of said nitroxide units. This particular structure enables, at low temperatures and high fields, optimal transfer of polarization and optimal enhancement of NMR/MAS signals of the polarized nuclei of the compound studied.

This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and/or secretion and/or abdominal disorders or diseases and/or treatment related to diseases related to RET dysfunction or where modulation of RET activity may have therapeutic benefit including but not limited to all classifications of irritable bowel syndrome (IBS) including diarrhea-predominant, constipation-predominant or alternating stool pattern, functional bloating, functional constipation, functional diarrhea, unspecified functional bowel disorder, functional abdominal pain syndrome, chronic idiopathic constipation, functional esophageal disorders, functional gastroduodenal disorders, functional anorectal pain, inflammatory bowel disease, proliferative diseases such as non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, medullary thyroid cancer, follicular thyroid cancer, anaplastic thyroid cancer, papillary thyroid cancer, brain tumors, peritoneal cavity cancer, solid tumors, other lung cancer, head and neck cancer, gliomas, neuroblastomas, Von Hippel-Lindau Syndrome and kidney tumors, breast cancer, fallopian tube cancer, ovarian cancer, transitional cell cancer, prostate cancer, cancer of the esophagus and gastroesophageal junction, biliary cancer, adenocarcinoma, and any malignancy with increased RET kinase activity.

The present invention relates to novel synthetic substituted heterocyclic compounds and pharmaceutical compositions containing the same that are capable of inhibiting or antagonizing a family of receptor tyrosine kinases, Tropomysosin Related Kinases (Trk), in particular the nerve growth factor (NGF) receptor, TrkA. The invention further concerns the use of such compounds in the treatment and/or prevention of pain, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, or a disease, disorder or injury relating to dysmyelination or demyelination or the disease or disorder associated with abnormal activities of NGF receptor TrkA.

A method of manufacturing an anhydrous copper complex of formula C12H10CICuN2O4 and methods of treating neuromuscular and other diseases, including but not limited to fibromyalgia, multiple sclerosis, muscular dystrophy, rheumatoid arthritis, pain, fatigue, sleeplessness, loss of fine motor control, speech loss, inflexibility, Alzheimer's, dementia, amyotrophic lateral sclerosis, depression, lyme disease, lyme disease co-infection, gastroparesis (GP), myopathy, chronic inflammation and/or incontinence. The anhydrous copper complex preferably is administered in a pharmaceutical and/or dietary supplement composition of the invention.

The present invention relates to compounds of Formula I or II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which relates to mophinan compounds useful as μ, δ and/or κ receptor opioid compounds and pharmaceuticals containing same that may be useful for mediating analgesia, combating drug addiction, alcohol addiction, drug overdose, mental illness, bladder dysfunctions, neurogenic bladder, interstitial cystitis, urinary incontinence, premature ejaculation, inflammatory pain, peripherally mediated and neuropathic pain, cough, lung edema, diarrhea, cardiac disorders, cardioprotection, depression, and cognitive, respiratory, diarrhea, irritable bowel syndrome and gastro-intestinal disorders, immunomodulation, and anti-tumor agents.

The present invention relates to the use of selective adenosine A1 agonists, in particular the dicyanopyridines of formula (I), for the treatment and/or prophylaxis of glaucoma and ocular hypertension as well as the their use for the production of a medicament for the treatment and/or prophylaxis of glaucoma and ocular hypertension.

The disclosure relates to BAX activators and therapeutic uses relates thereto. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer, comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a compound disclosed herein or pharmaceutically acceptable salt to a subject in need thereof.

Compounds according to Formula I and Formula II are potent inhibitors of Arginase I and II activity: where R1, R2, R3, R4, R5, R6, R7, R8, R9, D, M, X, and Y are defined as set forth in the specification. The invention also provides pharmaceutical compositions of the compounds and methods of their use for treating or preventing a disease or a condition associated with arginase activity.

The present invention provides processes for the preparation of saturated ketone morphinan compounds. In particular, the invention provides processes for the conversion of a morphinan comprising an allyl alcohol ring moiety into a morphinan comprising a saturated ketone ring moiety by an isomerization reaction catalyzed by an inorganic salt of a late transition metal.

A magnetized nut for fastening a compressor wheel of an exhaust turbocharger to a turbo shaft. The nut has a base body made of a non-magnetic material forming a hollow space for accommodating a magnetic material, and a method for the production of the magnetized nut. In order to provide a magnetized nut that is produced in a simple and cost-effective manner and ensures as equal a distribution of mass as possible with regard to the rotational axis of the nut, the magnetic material is introduced into the hollow space using injection molding.

A polishing pad, having a polishing layer comprising a thermoset polyurethane foam, wherein the polishing layer has an in-plane variation of 12 or less in microrubber A hardness, the variation being obtained by measuring the polishing layer from a polishing surface side of the layer, the thermoset polyurethane foam contains, as raw material components, an isocyanate component and active-hydrogen-containing compounds, and the active-hydrogen-containing compounds comprise a trifunctional polyol having at least one terminated hydroxyl group that is a secondary hydroxyl group, and having a hydroxyl group value of 150 to 1,000 mg KOH/g in an amount of 10 to 50 parts by weight for 100 parts by weight of the active-hydrogen-containing compounds.