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Correction: Rational design, synthesis, and evaluation of uncharged, “smart” bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase. [Additions and Corrections]

VOLUME 295 (2020) PAGES 4079–4092There was an error in the abstract. “The pyridinium cation hampers uptake of OPs into the central nervous system (CNS)” should read as “The pyridinium cation hampers uptake into the central nervous system (CNS).”




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Correction: Histone demethylase KDM6B promotes epithelial-mesenchymal transition. [Additions and Corrections]

VOLUME 287 (2012) PAGES 44508–44517In Fig. 1A, the wrong image for the control group was presented. The authors inadvertently cropped the control images in Fig. 1, A and E, from the same raw image. Fig. 1A has now been corrected and does not affect the results or conclusions of the work. The authors sincerely apologize for their mistake during figure preparation and for any inconvenience this may have caused readers.jbc;295/19/6781/F1F1F1Figure 1A.




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Inbox: Are Giants waiting to make big splash?

Do you think the Giants are just waiting around and could go after Bryce Harper for a big splash? Beat reporter Maria Guardado answers this question and more from fans.




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Uniform patch to mark 150 years of pro baseball

All 30 Major League teams will wear special "MLB 150" patches on their uniforms for the entire 2019 season in honor of the 150th anniversary of the 1869 Cincinnati Red Stockings, the first openly all-salaried professional baseball team.




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Giants open spring camp as work in progress

One year after making a pair of high-profile acquisitions in Andrew McCutchen and Evan Longoria, the Giants have experienced a far slower and quieter winter, leaving the club with quite a few question marks as pitchers and catchers reported to Scottsdale, Ariz., for the start of Spring Training on Tuesday.




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Reasons for optimism for each MLB club

On this opening week of Spring Training, all 30 Major League teams have one thing in common: optimism. Here's an optimism cheat sheet for each of them.




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Giants see Bochy as lock for Hall of Fame

Bruce Bochy isn't sure what his next step will be after he retires from managing the Giants at the end of the season, but it's safe to assume that a trip to Cooperstown is in his near future.




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'It's time': Giants' Bochy to retire after this season

Bruce Bochy, who guided the Giants to three World Series championships in 2010, '12 and '14, announced Monday that he will retire at the end of the 2019 season, capping a celebrated 25-year managerial career in the Majors.




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Posey inspired for final season with Bochy

Buster Posey has known only one manager since making his debut with the Giants a decade ago. While it's hard for him to envision playing for someone other than Bruce Bochy, he wasn't surprised to hear about his longtime manager's plans to retire after the 2019 season.




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Widening the drug trial net has the potential to reduce respiratory failure




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Benefits of face masks and social distancing in Tuberculosis - a lesson learnt the hard way during the COVID-19 pandemic.




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The war on drugs has failed: doctors should lead calls for drug policy reform




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US must address addiction as an illness, not as a moral failing, Surgeon General says




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NHS spent 8% more on medicines last year




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First case of Zika virus spread through sexual contact is detected in UK




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Chemoprevention of colorectal cancer in individuals with previous colorectal neoplasia: systematic review and network meta-analysis




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Role of phospholipid synthesis in the development and differentiation of malaria parasites in the blood [Microbiology]

The life cycle of malaria parasites in both their mammalian host and mosquito vector consists of multiple developmental stages that ensure proper replication and progeny survival. The transition between these stages is fueled by nutrients scavenged from the host and fed into specialized metabolic pathways of the parasite. One such pathway is used by Plasmodium falciparum, which causes the most severe form of human malaria, to synthesize its major phospholipids, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine. Much is known about the enzymes involved in the synthesis of these phospholipids, and recent advances in genetic engineering, single-cell RNA-Seq analyses, and drug screening have provided new perspectives on the importance of some of these enzymes in parasite development and sexual differentiation and have identified targets for the development of new antimalarial drugs. This Minireview focuses on two phospholipid biosynthesis enzymes of P. falciparum that catalyze phosphoethanolamine transmethylation (PfPMT) and phosphatidylserine decarboxylation (PfPSD) during the blood stages of the parasite. We also discuss our current understanding of the biochemical, structural, and biological functions of these enzymes and highlight efforts to use them as antimalarial drug targets.




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Melding the best of two worlds: Cecil Pickett's work on cellular oxidative stress and in drug discovery and development [Molecular Bases of Disease]

Many chemicals and cellular processes cause oxidative stress that can damage lipids, proteins, or DNA (1). To quickly sense and respond to this ubiquitous threat, organisms have evolved enzymes that neutralize harmful oxidants such as reactive oxygen species and electrophilic compounds (including xenobiotics and their breakdown products) in cells.These antioxidant enzymes include GSH S-transferase (GST),2 NADPH:quinone oxidoreductase 1, thioredoxin, hemeoxygenase-1, and others (2, 3). Many of these proteins are commonly expressed in cells exposed to oxidative stress.The antioxidant response element (ARE) is a major regulatory component of this cellular stress response. The ARE is a conserved, 11-nucleotide-long DNA motif present in the 5'-flanking regions of many genes encoding antioxidant proteins. The laboratory of Cecil Pickett (Fig. 1) at the Merck Frosst Centre for Therapeutic Research in Quebec discovered ARE, a finding reported in the early 1990s in two JBC papers recognized as Classics here (4, 5).jbc;295/12/3929/F1F1F1Figure 1.Cecil Pickett (pictured) and colleagues first described the ARE motif, present in the 5' regions of many genes whose expression is up-regulated by oxidative stress and xenobiotics. Photo courtesy of Cecil Pickett.ARE's discovery was spurred in large part by Pickett's career choice. After completing a PhD in biology and a 2-year postdoc at UCLA in the mid-1970s, he began to work in the pharmaceutical industry.Recruited to Merck in 1978 by its then head of research and development (and later CEO), Roy Vagelos, “I became interested in how drug-metabolizing enzymes were induced by various xenobiotics,” Pickett says.According to Pickett, Vagelos encouraged researchers at the company...




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Yasmin Afina

Research Assistant, International Security Programme

Biography

Yasmin Afina joined Chatham House as research assistant for the International Security programme in April 2019. She formerly worked for the United Nations Institute for Disarmament Research (UNIDIR)’s Security and Technology Programme, and the United Nations Office for Disarmament Affairs (UNODA).

Yasmin’s research at Chatham House covers projects related to nuclear weapons systems, strategic weapons systems, emerging technologies including cyber and artificial intelligence, and international law.

In her previous capacities, Yasmin’s research included international, regional and national cybersecurity policies, the international security implications of quantum computing, and algorithmic bias in autonomous technologies and law enforcement operations.

Yasmin holds an LL.M. from the Geneva Academy of International Humanitarian Law and Human Rights, an LL.B. from the University of Essex, and a French Bachelor of Laws and Postgraduate degree (Maîtrise) in International Law from the Université Toulouse I Capitole.

Areas of expertise

  • Cybersecurity of weapons systems, command control and communication systems
  • Cybersecurity policies and governance
  • Autonomous technologies (incl. artificial intelligence, machine learning)
  • International law (incl. international humanitarian law, international human rights law, jus ad bellum)
  • Nuclear weapons policy

Past experience

2018-19Programme assistant, security and technology, United Nations Institute for Disarmament Research (UNIDIR)
2017-18Project assistant, emerging security issues, United Nations Institute for Disarmament Research (UNIDIR)
2017Weapons of Mass Destruction Programme, United Nations Institute for Disarmament Research (UNIDIR)
2017-18LL.M., Geneva Academy of International Humanitarian Law and Human Rights (CH)
2016-17Maîtrise, Université Toulouse I Capitole (FR)
2016Convention on Certain Conventional Weapons Implementation Support Unit, United Nations Office for Disarmament Affairs (UNODA) Geneva Branch
2013-17LL.B., University of Essex (UK)
2013-16Licence (Bachelor of Laws), Université Toulouse I Capitole (FR)
2014Volunteer, World YWCA




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Security and Prosperity in Asia: The Role of International Law

1 November 2019

The 'Security and Prosperity in Asia' conference looked at the impact of international law in the Asia-Pacific with a focus on regional economic and security issues such as the South China Sea disputes.

Security and Prosperity in Asia Cover Image.jpg

Singapore skyline at sunset, 2016. Photo: Getty Images.

About the Conference

At a time of geopolitical uncertainty and with multilateralism under pressure, this conference brought together diverse actors to explore the evolving role of international law on critical security and economic issues in the Asia-Pacific. From trade agreements to deep-sea mining, cyberwarfare to territorial disputes, the breadth of the discussion illustrated the growing reach of international law in the region.

Hosted by the International Law Programme and the Asia-Pacific Programme at Chatham House on 27 March 2019, the conference focused on three themes: trade and investment, maritime security and governance, and emerging security challenges. What trends are emerging in terms of engagement with international law in the region, and how can international standards play a greater role in encouraging collaboration and reducing tensions? And, with the eastward shift in geopolitical power, how will Asia-Pacific states shape the future of international law?




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Michelle Bachelet: ‘Politics Is Getting Nastier’

12 December 2019

Gitika Bhardwaj

Editor, Communications & Publishing, Chatham House

Michelle Bachelet

United Nations High Commissioner for Human Rights; President of Chile (2006-10) and (2014-18)
In a series exploring women in international affairs, Michelle Bachelet speaks to Gitika Bhardwaj about her experiences of sexism in politics, her concerns about the pace of change for women’s rights and how to address the social inequalities driving people to protest around the world.

Bachelet-11.jpg

UN High Commissioner for Human Rights, Michelle Bachelet, the first woman to become president of Chile in 2006, talks about her experiences as a woman in politics and her work realising human rights around the world. Photo: Chatham House.

Michelle Bachelet, as a young woman you became involved with political issues, supporting Chile’s transition to democracy following the Augusto Pinochet regime. What first sparked your interest in politics and what was it like for you as a young woman in Chile at this time?

I guess it’s related to the environment that I lived in as a child because none of my parents were involved in politics but they were people who were interested in what happened to other people. We would have interesting discussions about what was going on in Chile and around the world and I had grown up being a person who wanted to be part of finding solutions to different challenges.

When I was a student, there were lots of things happening in Chile that I became interested in even though I was in medical school at the time. Then came an important political moment in the 1970s for Chile and I thought that I needed to help make Chile a better place for everyone – that my voice alone would not be enough – so I wanted to meet other people who might have answers to the questions I had. That’s when I became politically active.

I always say that, in my milk bottle, the word responsibility was included because I always have felt responsible for things. My parents also always used to tell me that we’re all human beings and, although we might have differences, we should all have dignity and be respected and have the same rights and opportunities because it is the right thing to do. So that’s how I became what I became.

You became the first woman in Latin America to hold the post of minister of national defence in 2002 and pushed to include more women in conflict resolution. Given that the inclusion of women in peace processes increases the likelihood of agreements being reached, yet women are largely excluded from the negotiating tables, why should more women in peace and security be prioritized? 

I used to push hard to have more women as negotiators and mediators at different levels when I was minister of national defence but I was told ‘We don’t have enough women with the capacity’. Of course that was not true. So one of the tasks I set myself was to build a roster of capable women so that tomorrow nobody could use this excuse. 

We built a roster, but still, as you say, there was a tendency not to have women included at all levels. I think this is because there’s still machoism and sexism that exists at some levels. Some men feel that women are weaker, that they’re not capable enough, and that’s not true. Women are important because women have the right skills to be negotiators and mediators.

I have to say that UN Secretary-General António Guterres has done a great job by appointing women in half of all the posts for special envoys and special representatives in conflict places. But we still need to do more. 

Why do I believe women make a difference? Conflicts matter to both women and men because they impact both, but usually, the experiences of women are invisible in the eyes of many who work in negotiating and mediating peace. That’s why you need people that can bring this perspective to the table. 

The other thing is that women can often get close to other women in conflict places, and in that case, they can get a lot of useful information from women on the ground because they don’t feel threatened by other women. This is particularly true of women who have been victims of sexual violence who are more willing to tell another woman what they have experienced. 

But, at the end of the day, women are half of the population of the world and I think we need them to be represented adequately.

In 2006, you became the first female president of Chile, what was this like for you and did you feel pressure taking up this mantle?

Yes of course. I mean, there were a lot of people who would say ‘I want to vote for you but I don’t think it’s a woman’s place’. Journalists would also ask you ‘You are divorced and don’t have a man by your side. How are you going to cope?’ and I would respond by saying ‘I have always done it myself.’

Sometimes if I took some time to make a decision, because I thought it needed a bit more time to reflect on what to do, they would say ‘She doesn’t take decisions’ but if you made a quick decision then they would say ‘She improvises’. I’m not complaining, I’m just describing the kinds of things that go on, and these are the things I have spoken about with other female leaders from around the world. For example, I once talked to Helle Thorning-Schmidt, the former prime minister of Denmark, and she would tell me that during the election campaign they would discuss the size of her purse and if she had a boyfriend. I mean, really, people tend to diminish women by talking about unsubstantial issues – there will be a lot of attempts to try to bring a woman’s self-esteem down. 

What I would say is, if you know exactly why you are there and what you want to do as a president, parliamentarian or whatever and you’re sure that what you want to do is the right thing – and the smart thing – then do it. Pick a team that is honest, that works with the same passion as you and that is loyal to you but is not afraid to tell you when things aren’t working. But it’s hard and difficult and politics is getting nastier every day.

You said politics is getting nastier. Julia Gillard recently spoke to me about the dark side of social media for women. In what ways do you think politics is changing for women in particular?

I remember seeing that, in the European Parliament, about 85 per cent of women have experienced psychological violence whether they have received death threats or threats of rape and all kinds of things just because they’re female.

There is also a bias against women during election campaigns where people say she cannot be elected because she’s not capable just because she’s a woman. 

Then there are those that, as I mentioned before, try to talk about personal things or spread fake news. Politics has always been about debate between people with different positions, and that’s fine, but I think sometimes you see it goes past the limit in terms of respect for the other person.

Then there is the language. Failing to understand that the other person is a competitor, not an enemy, and using language to, sort of, symbolically destroy the other one is not right. I see it everywhere and I think that’s not what politics is for – we came to serve the people and words matter. 

I think all of these things are making a lot of people not want to get involved in politics anymore because it’s not the kind of environment that we want to be in. But I hope, on the other hand, that if we have more women in politics, maybe we can turn that trend to a more positive and constructive one, where there can still be intense debate but in a way where everybody feels that we’re all part of the same country and we can all build the country together.

How did you find your male counterparts responding to you as leader? Was there a time, for example, your gender became an issue for you while you were in office?

When I was a student of medicine, what mattered was whether you were a good student or a good doctor, not if you were a man or a woman, but in politics, I found that when I appointed ministers, some of them struggled with me being a woman. For example, sometimes I would conclude a meeting by saying ‘We’re going to do this’ but there would be a male minister who would have to have the last word. Or some of them, particularly the more senior ones who had been in senior positions before, found it challenging to accept a secondary role to a woman.

On the other hand, with the military, I had no problem. Neither as minister of defence and neither as president because they understood the chain of command.

It’s interesting to look at women in other leadership positions too. For example, I remember a friend who worked in a place many years ago and she would tell me that she needed to swear and almost to spit on the ground so that men would respect her because the majority of the leaders there were men. I said to her ‘You don’t need to look like a man to be a leader.’

Perhaps sometimes it’s more difficult because strength is understood in different ways but my message would be that you can be a leader in your own way. 

Michelle Bachelet takes part in a ceremonial parade following her inauguration on 11 March 2006 outside the Congress in Valparaiso, Chile. Michelle Bachelet was sworn in as Chile's first woman president in the history of the socially conservative country. Photo: Getty Images.

While president of Chile, you introduced a number of policies aimed at addressing women’s rights issues notably on the gender pay gap and on sexual and reproductive rights for women.

How do you view your legacy on these issues? Were there other policies you wanted to implement but were unable to? And how would you like these initiatives to be furthered today in light of, for example, the rolling back of reproductive rights for women in some parts of the world?

We went from trying to improve the legal framework that applies to women to creating the Ministry of Women and Gender Equity. We also tried to push for changing the electoral roll with quotas for women which we got to an extent but not as much as I wanted. There was no appetite for having a quota for 40 per cent of all those elected to be women so we settled for 40 per cent of all candidates to be women. We still improved a little bit in terms of the number of women being elected from 14 per cent to 24 per cent through this but I didn’t get everything I wanted. Nevertheless, during my time in office, we were able to increase the representation of women in the Senate and the House which was positive. 

On sexual and reproductive rights, in Chile, abortion was criminalized so we were able to decriminalize abortion and we also advanced LGTBI rights and so on. We also developed a better legal framework for dealing with sexual violence but of course sexual violence is a complicated issue that cannot be solved in a short period of time and we need to continue working strongly on that.

The other thing I’m a believer of is the importance of early child development which is good for both boys and girls. So we set up a network of kindergartens free of charge, particularly for poorer people, because there are so many women who cannot afford to put their children in kindergartens while they study or work. So we tried to do lots of things to expand women’s opportunities and women’s rights during my time in office.

Women are increasingly making it to the top level of politics around the world, yet in Latin America, the number of female heads of states has dropped to 0 following a generation of female political leaders across the continent.

Why do you think this is the case and could we see this change again in the future? Do you think Chile is likely to see another female president soon, and if so, who do you think could take up the mantle?

The truth is that there was a moment that I think the region had four or so female heads of states, and although there are currently some female vice presidents, the number of presidents is 0 but I wouldn't be able to say that this is necessarily a bad thing. There doesn’t need to be a female president every time. We need to have female leaders where their citizens believe that they’re the best people to lead their countries.

But we do need to do more to support women making it to the top so they can have all the skills needed to be a president or a prime minister and work more with young women too so that they can think of themselves as being able to take up such positions of leadership in the future. 

In Chile, I hope, of course, there will be another woman president one day but I have no idea when. I will not run again, I can tell you that, but I hope when the time comes, the people of Chile will believe in them.

In your current role, you have said that ‘The climate crisis is the greatest threat to human rights’ and that climate change and gender equality are inextricably linked. How do you see this link and what does that mean for how these issues should be addressed?

Climate change is the biggest threat to human rights because it affects the right to life, to food, to health and to live without violence, and if we are not able to tackle it, it will lead to water scarcity, food insecurity, forced migration and conflict – all of which we are seeing already.

Why is it linked to gender equality? There are many reasons. One of them is that women, who make up half the global population, are usually among the most vulnerable people in the world. Today there are billions of people who don’t have access to water, sanitation or housing with women having less access to all of these tools that would permit them to adapt [to a changing climate].

For example, women will be more affected by food insecurity because imagine a woman who is pregnant without food. She will likely end up being underweight, and then afterwards, this will impact her child who will be at risk of malnourishment. We see it everywhere where women avoid eating so that their children can eat.

Furthermore, if we have water scarcity, that will also affect women because today, in many parts of the world, women and girls fetch the water for their families. If water becomes increasingly scarce, they will have to walk longer to fetch it, and today we already see women and girls who are subject to sexual gender-based violence as they carry out their day-to-day tasks. 

That’s why we need to provide women with the tools to empower them and to devise gender-responsive policies to climate change. 

Throughout your career, have you seen the scale and pace of change for human rights, particularly women’s rights, around the world that you would have wanted?

It depends on how you look at things. It has been over 70 years since the Universal Declaration of Human Rights was written when maternal mortality was incredibly high in many parts of the world and women did not have the vote everywhere.

If you look from that time to now, of course, women’s rights have seen a lot of progress. Maternal mortality has reduced and women can vote I think [in almost every democracy].

But over the last few years, we have seen a pushback on women’s rights, particularly in some areas like sexual and reproductive health rights, and that it something that concerns me a lot.

So I would say we’re not there yet. I hope we will be able to push back the pushback and move forward. Because if we go on along the same trajectory as we are now, we will have economic equality for women in 120 years, which is too long. I mean, nobody wants your great, great, great grandchildren to have to wait so long for equality. We need to stand up for women’s rights – and for all human rights – now and accelerate the progress we’ve been making.

In the past couple of months, there have been ongoing protests in Chile and around the world. What in your estimation is driving the protests and in what ways should governments, civil society and others respond to help address their demands?

I think it’s a phenomenon we are seeing in Chile and many places around the world. It’s a new process where young people are voicing their grievances but with no particular leaders. It’s what some people are calling a ‘new power’ and I think the situation in Chile is very similar to what’s happening in Lebanon, Hong Kong and elsewhere but with different triggers. 

In some places, people are challenging the outcome of an election; in other places, they are protesting because leaders want to change the constitution to be re-elected again; in other places, it can be, like in the case of Chile, a result of economic issues following the increase of the price of what you would call the Underground here. These inequalities lead to a mistrust in our institutions and in traditional leaders and I think this is a universal experience at the moment.

The current political and economic system is not delivering and it’s failing to meet people’s needs. So these young people protesting don’t see, in the current political and economic system, the solutions to the concerns they have.

The other thing that is interesting is the role social media has played in many of these recent protests. Social media has become a different way to allow people to learn from each other. When the students in Chile decided to protest against the increasing price of public transport, they went to the Metro and jumped over the barriers and then, two weeks’ later, I saw it in New York. Hundreds of students, for different reasons – against police brutality – doing exactly the same thing. So they learn from each other and they see what works in one place. 

So I think there is something in the world that is making people go to the streets. If it’s peacefully done then that’s fine. The problem is that sometimes it has triggered a harsh response from governments and that leads to more violence. 

I believe what needs to be done is to try to set up a national dialogue that includes all sectors of all societies where governments listen to the grievances that people have. You cannot change things in a day but I think people are reasonable enough to understand if you are committed to change. 

That’s why the UN has developed the Agenda 2030 on Sustainable Development to leave no one behind. It probably won’t solve everything, but it will, I guess, if we are able to achieve the goals, help us have a planet that’s for everyone. 




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ICC’s Influence Can Be Strengthened by Ukraine’s Case

22 April 2020

Kateryna Busol

Robert Bosch Stiftung Academy Fellow, Russia and Eurasia Programme
Second in a two-part series analysing why Ukraine’s attempts at international justice are worth taking - and outlining how the impact goes far beyond just the Russia-Ukraine conflict. Part two examines Ukraine’s appeal to the International Criminal Court (ICC) to seek individual criminal responsibility of the alleged perpetrators of the gravest crimes in occupied Crimea and eastern Ukraine.

2020-04-23-Ukraine-Anniversary-Conflict

Marking the Day of The National Flag of Ukraine, a day before celebrations of the anniversary of state independence. Photo by ANATOLII STEPANOV/AFP via Getty Images.

The recognition by Ukraine of the jurisdiction of the International Criminal Court (ICC) to consider grave crimes allegedly perpetrated in its territory has led to the ICC Prosecutor’s preliminary examination identifying a wave of alleged war crimes and crimes against humanity.

There are claims of persecution, forced conscription, deportation, sham trials, enforced disappearances, and property seizure - in Crimea. As well as killings, torture, inhuman treatment, sexual violence, and indiscriminate shelling - in Donbas. The court now needs to decide whether to open a full investigation which could lead to charges against specific individuals, as in the trial currently taking place in the Netherlands over MH-17.

However, the ICC does remain a court of last resort as Ukraine retains the principal power to prosecute grave violations perpetrated in its eastern regions and Crimea, with the court only stepping in if Ukraine (or another court with jurisdiction) is either unwilling or unable to do so.

As the evidence mounts up, Ukrainian investigators, prosecutors and judges are becoming more open to cooperation with foreign experts, law firms, human rights NGOs and younger domestic professionals - a significant proportion of whom are women.

Transformation shows determination

This is an unusual shift, given the rigid hierarchical nature of post-Soviet institutions, with elderly males in most of the top positions. The transformation shows the determination to see perpetrators of crimes in Crimea and Donbas tried by the ICC, with joint professional development trainings and joint communications about the alleged crimes.

Ukraine has also been strengthening its institutions. The Prosecutor’s Office of the Autonomous Republic of Crimea has been improving quality control of its war crime proceedings, and has taken a strong pro-ICC stance. The Office of the Prosecutor General established a special department to monitor the armed conflict proceedings, and two specialised war crime units have been formed in Donbas.

Although too early to assess progress - given recent prosecution reform and that much-needed legislation on international crimes is still pending – these are promising signs of Ukraine’s intent to take a specialised approach to armed conflict violations. And Ukrainian civil society organisations are also playing a more important role, documenting alleged crimes and sending evidence to the ICC.

Any intervention by the ICC in Ukraine also has a considerable impact on the wider dynamics of addressing international crimes, further extending the court’s reach beyond a focus on Africa which has attracted widespread criticism since it began in 2002.

The ICC has already opened investigations in Georgia, Bangladesh/Myanmar, and Afghanistan, with preliminary examinations in Colombia, Venezuela, Iraq/UK, Palestine, and The Philippines. But the Ukrainian case would further develop the European subtleties of the court’s jurisprudence.

Although the ICC is currently investigating the 2008 Russia-Georgia war, the active phase of that armed conflict lasted for just five days whereas Russia’s military involvement in Ukraine has been ongoing for the six years. The temporal difference in no way diminishes the suffering of victims and the necessity for the proper investigation, prosecution and compensation in the Georgian context.

And yet, going by even the preliminary findings of the ICC prosecutor, the spectrum of war crimes and crimes against humanity allegedly perpetrated in Ukraine is much wider. Some incidents, such as the illegal construction of the Crimean Bridge, is an amalgam of the violations against property, cultural heritage and the environment. Cumulatively, the Ukrainian and Georgian cases would substantially contribute to the development of the court’s emerging European lenses.

The Russia-Ukraine armed conflict is also the first instance of armed hostilities of such magnitude and duration in Europe since World War II and the Yugoslav Wars. The ICC’s readiness to take on such geopolitically challenging cases which leave itself open to attack will be tested.

But by examining new contexts - including Ukraine - the ICC would develop a more layered reading of the nature and scope of the crimes it works on. For example, alleged indoctrination and use of children by armed groups in eastern Ukraine is likely to differ from the known practices of abducting and recruiting child soldiers in Africa.

Investigating evidence of Russia’s persecution of pro-Ukrainian activists - forcing them out of Crimea - coupled with the creation of favourable conditions for Russian citizens to relocate to Crimea could lead to proving the existence of a policy of mass colonisation of the peninsula - adding new layers to the court’s jurisprudence on population displacement. And previously under-prosecuted crimes may come to the fore, such as attacks on cultural property or causing the destruction of the environment.

Although the ICC proceedings on Ukraine – along with those being held by the International Court of Justice (ICJ) - are unlikely to bring immediate results, Ukraine has developed an international adjudication strategy based on the available viable options and what can be practically delivered.

The simple act of a reputed international court outlining Russia’s alleged violations in Crimea and Donbas and naming those individually responsible would be an impactful achievement in itself, regardless of whether Russia pays any attention or compensation.

And any international judgments or those of domestic courts such as the Dutch MH-17 proceedings and Russia’s response - predicted to be non-compliance - is an important argument for continuing sanctions against Russia over its conduct in Ukraine.

The mutually reinforcing effect of both the Crimea and Donbas proceedings within Ukraine and at international courts should not be underestimated. These investigations into war crimes, terrorism and human rights issues are deeply relevant - not only for the conflict itself, but also for the development of international law.

Part One of this series assesses Ukraine’s efforts to hold Russia accountable as a state at the International Court of Justice (ICJ).




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The Morass of Central American Migration: Dynamics, Dilemmas and Policy Alternatives

Invitation Only Research Event

22 November 2019 - 8:15am to 9:30am

Chatham House | 10 St James's Square | London | SW1Y 4LE

Event participants

Anita Isaacs, Professor of Political Science, Haverford College; Co-Director, Migration Encounters Project
Juan Ricardo Ortega, Principal Advisor for Central America, Inter-American Development Bank
Chair: Amy Pope, Associate Fellow, Chatham House; US Deputy Homeland Security Adviser for the Obama Administration (2015-17)

2019 has seen a record number of people migrating from Central America’s Northern Triangle – an area that covers El Salvador, Guatemala and Honduras. Estimates from June 2019 have placed the number of migrants at nearly double of what they were in 2018 with the increase in numbers stemming from a lack of economic opportunity combined with a rise in crime and insecurity in the region. The impacts of migration can already be felt within the affected states as the exodus has played a significant role in weakening labour markets and contributing to a ‘brain drain’ in the region. It has also played an increasingly active role in the upcoming US presidential election with some calling for more security on the border to curb immigration while others argue that a more effective strategy is needed to address the sources of migration. 

What are the core causes of Central American migration and how have the US, Central American and now also Mexican governments facilitated and deterred migration from the region? Can institutions be strengthened to alleviate the causes of migration? And what possible policy alternatives and solutions are there that could alleviate the pressures individuals and communities feel to migrate?   

Anita Isaacs, professor of Political Science at Haverford College and co-director of the Migration Encounters Project, and Juan Ricard Ortega, principal advisor for Central America at the Inter-American Development Bank, will join us for a discussion on the core drivers of migration within and across Central America.

Attendance at this event is by invitation only. 

Event attributes

Chatham House Rule

Department/project

US and Americas Programme




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US 2020: America’s National Security Strategy and Middle East Policy

Invitation Only Research Event

10 February 2020 - 10:30am to 11:30am

Chatham House | 10 St James's Square | London | SW1Y 4LE

Event participants

Dr Kori Schake, Resident Scholar and Director of Foreign and Defense Policy Studies, American Enterprise Institute 
Chair: Dr Leslie Vinjamuri, Director, US and Americas Programme

In the run-up to the 2016 US presidential election, then-candidate Donald Trump made a series of campaign promises concerning US foreign policy towards the Middle East. Since assuming office, President Trump has withdrawn the US from the Joint Comprehensive Plan of Action, withdrawn troops from Syria, relocated the US embassy in Israel to Jerusalem and orchestrated the strike against ISIS leader Abu Bakr al-Baghdadi.

Against a backdrop of Trump's inclination towards withdrawing from the region, countries across the Middle East are being rocked by protests, Turkey’s purchase of Russia’s S-400 missile has threatened to undermine cohesion within NATO and the much hoped for ceasefire in Libya between UN-backed government leader, Fayez al-Sarraj, and opposition leader, Khalifa Haftar, failed to materialize.

In light of the upcoming US elections in November 2020, the future of US national security policy promises to be a prominent issue for the next administration. In this vein, the US and Americas Programme at Chatham House plans a yearlong focus on the pivotal US 2020 elections.

At this event, Dr Kori Schake, director of foreign and defense policy studies at the American Enterprise Institute will discuss the future of US foreign policy towards the Middle East. How have domestic and party politics in the US – and the unfolding presidential campaign – shaped recent policy decisions by the Trump administration? Should we expect policy objectives in the Middle East to remain consistent or shift under a second Trump term? And what direction could US foreign policy towards the region take under a Democratic administration?

Attendance at this event is by invitation only. 

Event attributes

Chatham House Rule

Department/project

US and Americas Programme




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Virtual Roundtable: The End of Globalism? Remaining Interconnected While Under Increased Pressure to Isolate

Invitation Only Research Event

30 March 2020 - 1:00pm to 2:00pm

Zoom Audio Call

Event participants

Fred Hochberg, Chairman and President, Export-Import Bank of the United States, 2009 -17
Chair: Dr Leslie Vinjamuri, Director, US and the Americas Programme, Chatham House

This event is part of the Chatham House Global Trade Policy Forum. We would like to take this opportunity to to thank founding partner AIG and supporting partners Clifford Chance LLP, Diageo plc and EY for their generous support of the forum. 

US and Americas Programme




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Virtual Roundtable: As COVID-19 Hits the Developing World, Where is the American-led Global Response?

Research Event

9 June 2020 - 2:00pm to 3:00pm
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Lord Mark Malloch-Brown, Chairman, SGO; Former Deputy Secretary-General and Chief of Staff, United Nations
Dr Elizabeth Cousens, President and CEO, United Nations Foundation
Ambassador Nicholas Burns, Roy and Barbara Goodman Family Professor of the Practice of Diplomacy and International Relations at the Harvard Kennedy School; US Under Secretary of State for Political Affairs, 2005 – 2008
Chair: Dr Leslie Vinjamuri, Director, US and the Americas Programme, Chatham House

This event is part of the US and Americas Programme Inaugural Virtual Roundtable Series on the US and the State of the World and will take place virtually only.

This event will take place from 14:00 – 15:00 BST.

US and Americas Programme

Department/project




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Diabetes Core Update: COVID-19 – Cardiovascular Concerns, April 2019

This special issue focuses on Cardiovascular Concerns with Diabetes an COVID-19. 

Recorded April 19, 2020.

This is a part of the American Diabetes Associations ongoing project providing resources for practicing clinicians on the care of Diabetes during the Covid-19 pandemic.  Todays discussion is an audio version of a webinar recorded on April 19, 2020.

Presented by:

Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health

John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Director, Family Medicine Residency Program, Chair-Department of Family Medicine, Abington Jefferson Health




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Covid-19: NHS bosses told to assess risk to ethnic minority staff who may be at greater risk




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Covid-19: Doctors face shortages of vital drugs, gases, and therapeutics, survey finds




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Trust boss gave misleading information to GMC about consultant who was unfairly dismissed




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Covid-19: South Korea relaxes social distancing after the number of new cases drops below 10 a day




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Covid-19: Projections of mortality in the US rise as states open up




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Covid-19: Woman with terminal cancer should be released from care home to die with family, says judge




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Cow’s milk allergy guidelines are not evidence based and are beset by conflicts of interest, researchers warn




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