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Blast from the past

What kind of gadgets did we use before the advent of information technology? Let’s take a look…




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Drawings from India




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Drawings from India




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25YT_DRAWINGS FROM INDIA part I




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25YT_DRAWINGS FROM INDIA part II




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Drawings from India




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Drawings from India




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Drawings from India




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Drawings from India




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Drawings from India I




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Drawings from India II




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Drawings from India III




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Drawings from India IV




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History from the streets

Taran learns about the Portuguese influence in Goa during a visit to Chandor village.




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On the mechanism of carboxylate elimination from carbohydrate monoester-derived radicals

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00241E, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Julia A. Turner, Hendrik Zipse, Mark S. Taylor
Computational analysis of the HAT-induced expulsion of carboxylic acids from monoacylated pyranosides implicates concerted elimination through a hydrogen-bonded transition state.
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Selective recognition between aromatics and aliphatics by cage-shaped borates supported by a machine learning approach

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00408F, Paper
Open Access
Yuya Tsutsui, Issei Yanaka, Kazuhiro Takeda, Masaru Kondo, Shinobu Takizawa, Ryosuke Kojima, Akihito Konishi, Makoto Yasuda
Exploration of a Lewis acid with high selectivity for hydrocarbon moieties is assisted by a machine learning approach. Molecular polarizability is an essential factor, leading to design guidelines for Lewis acid catalysts with dispersion forces.
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Correction: Recent progress of core-substituted naphthalenediimides: highlights from 2010

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB90045F, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Sheshanath V. Bhosale, Sidhanath V. Bhosale, Suresh K. Bhargava
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Copper-catalyzed ortho-thiocyanation of aromatic amines

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00137K, Communication
Monak Patel, Nitish Kumar, Hussain Bhukya, Bharatkumar Z. Dholakiya, Togati Naveen
Here, we described an efficient ortho- C(sp2)-H thiocyanation of anilines for the synthesis of aryl thiocyanates. This protocol tolerates a variety of aromatic amines to provide the desired products in good to excellent yields.
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Synthesis of fluorescent 5-heteroarylpyrimidine-containing oligonucleotides via post-synthetic trifluoromethyl conversion

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00402G, Paper
Yuta Ito, Hisato Tanaka, Ayana Murakami, Yasufumi Fuchi, Yoshiyuki Hari
5-(Benzimidazol-2-yl)- and 5-(benzothiazol-2-yl)-pyrimidine bases-modified oligonucleotides were prepared by post-synthetic trifluoromethyl conversion and their fluorescence properties were measured.
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DMSO promoted catalyst-free oxidative C–N/C–O couplings towards synthesis of imidazoles and oxazoles

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00383G, Paper
Debasish Bera, Rajib Sarkar, Tiyasa Dhar, Pinaki Saha, Prasanta Ghosh, Chhanda Mukhopadhyay
Dimethyl sulfoxide (DMSO)-promoted catalyst-free oxidative C–N coupling and C–O coupling under oxidant-free conditions are outlined.
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Synthesis of alkenylphosphine oxides via Tf2O promoted addition–elimination of ketones and secondary phosphine oxides

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00318G, Communication
Jiangkai Ma, Lianjie Wang, Anjiang Qiao, Zhongxian Li, Fengqian Zhao, Junliang Wu
An efficient method for the synthesis of alkenylphosphine oxides via the addition-elimination of SPOs to ketones has been developed. The reaction exhibits good yields and compatibility. Several conversions have also proven the value of this method.
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Vinylogous and stereoselective domino synthesis of pyrano[2,3-c]pyrroles from alkylidene meldrum's acids

Org. Biomol. Chem., 2024, 22,2948-2952
DOI: 10.1039/D4OB00233D, Communication
Mariia Savchuk, Giang Vo-Thanh, Sylvain Oudeyer, Hélène Beucher, Jean-François Brière
An expeditious diatereoselective synthesis of pyrano[2,3-c]pyrroles thanks to a domino Vinylogous aza-Michael-Aldol-Cyclocondensation (aza-VMAC) reaction to alkylidene Meldrum's acid derivatives.
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Unusual immunosuppressive pyridine-containing bisnor- (c23), tetranor- (c21) and pentanor- (c20) sesterterpenoids from Tibetan Leucosceptrum canum

Org. Biomol. Chem., 2024, 22,3019-3024
DOI: 10.1039/D4OB00334A, Paper
Man Li, Ling Feng, Han Zhang, Yan-Chun Liu, Ting-Ting Zhou, Yu Zheng, Kai Guo, Yan Liu, Sheng-Hong Li
Six unusual pyridine-containing bisnor- (C23), tetranor- (C21) and pentanor- (C20) sesterterpenoids were obtained from the medicinal plant Leucosceptrum canum of Tibetan origin. The immunosuppressive activities of these sesterterpenoids were observed.
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Synthesis of alkynyl sulfides via base-promoted nucleophilic ring-opening of α-bromostyrene sulfonium salt

Org. Biomol. Chem., 2024, 22,2953-2957
DOI: 10.1039/D4OB00203B, Communication
Junqi Zhou, Ziyu Wang, Hanmiao Xu, Mengke Su, Jian Wen
An effective method for synthesizing various alkynyl sulfides has been developed using tetramethylene sulfoxide as a sulfur source through base-promoted nucleophilic ring-opening reactions.
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Identification and quantification of local antiaromaticity in polycyclic aromatic hydrocarbons (PAHs) based on the magnetic criterion

Org. Biomol. Chem., 2024, 22,3035-3044
DOI: 10.1039/D4OB00114A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Erich Kleinpeter, Andreas Koch
The ring current effect of entirely and partly (anti)aromatic PCHs are calculated and employed to visualize, qualify and quantify existing (anti)aromaticity, especially to decide unequivocally between PAHs and PAAHs.
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Photochromism of phenazine-2,3-diol derivatives through excited state intermolecular proton transfer based on keto–enol tautomerization

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00387J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Kazuki Ohira, Kumpei Kozuka, Naoki Kaneda, Masahiro Yamamoto, Keiichi Imato, Yousuke Ooyama
It was found that phenazine-2,3-diol derivatives exhibit photochromism through excited state intermolecular proton transfer (ESInterPT) processes based on keto–enol tautomerization.
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BBr3-mediated dearomative spirocyclization of biaryl ynones: facile access to spiro[5.5]dienones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00274A, Communication
Gaurav Jaiswal, Subhas Chandra Pan
BBr3 mediated dearomative spirocyclization of biaryl ynones has been reported for the direct synthesis of spiro[5.5]dienones with a tri-substituted double bond.
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Synthesis of Deuteriodifluoromethylthiolated Isocoumarins-1- imines and Isocoumarins Enabled by Multi-Component Reagents System (MCRS)

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00328D, Communication
Xuemin Li, Haofeng Shi, Jiaxin He, Jialiang Wu, Fengxia Sun, Yunfei Du
The combining use of BnSCF2D, mCPBA and Tf2O serves as an efficient multi-component reagents system (MCRS) for the synthesis of deuteriodifluoromethylthiolated isocoumarins-1-imines/isocoumarins via intramolecular cyclization/ deuteriodifluoromethylthiolation of 2-alkynylbenzamide/2-alkynylbenzoates. The approach...
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Natural products from human microbiome: an emergent frontier in organic synthesis and drug discovery

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00236A, Review Article
Goverdhan Mehta, Saumitra Sengupta, Srihari Pabbaraja
Often referred to as “second genome”, human microbiome is at the epicenter of a complex inter-habitat biochemical network, such as the “gut-brain axis”, which have emerged as significant determinant of...
The content of this RSS Feed (c) The Royal Society of Chemistry




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TEMPO/PhI(OAc)2 promotes the α-aminophosphinoylation of alcohols with amines and H-phosphine oxides in aqueous medium

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00302K, Communication
Qiang Huang, Xin Jin, Lvjia Wu, Jiangdong Li, Qianlu Xing, Xianheng Wang, Changkuo Zhao
The aminophosphinoylation of alcohols with amines and H-phosphine oxides provides an efficient and mild approach to access various α-aminoalkylphosphine oxides in good yields with good tolerance of functional groups using H2O as a clean solvent.
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Measuring local pH at interfaces from molecular tumbling: A concept for designing EPR-active pH-sensitive labels and probes

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00167B, Paper
Open Access
Maxim A. Voinov, Nicholas Nunn, Roshan Rana, Atli Davidsson, Alex I. Smirnov, Tatyana I. Smirnova
EPR-based local pH measurements based on changes in rotational dynamics of spin-bearing molecules upon protonation.
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Base- and sulfur-promoted oxidative lactonization of chalcone-acetate Michael adducts: access to pyran-2-ones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00479E, Communication
Cao Nguyen Nguyen, Duc Toan Nguyen, Ha An Tran, Dinh Hung Mac, Thi Thu Tram Nguyen, Pascal Retailleau, Thanh Binh Nguyen
A cost-effective, practical, straightforward and scalable synthesis of α-pyrones via base- and sulfur-promoted annulation of phenylacetates and chalcones is reported.
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DevTools Digest - Chrome 35: Updates to the Developer Tools in Chrome 35

Updates to the Chrome Developer Tools: CSS property quick search, memory stats for heap snapshots, CodeMirror upgrade and more.




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Tab Discarding in Chrome: a Memory-Saving Experiment




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2022 holds promise for the airline sector

Omicron might dent growth, but the long-term outlook seems promising




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From geopolitics strife to a war of words between two aviation giants

Qatar Airways and Airbus lock horns over safety concerns




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Chicken gun test: Saving jets from bird strikes

According to ICAO, at least 34 bird strikes happen every day, causing around $1 billion worth damages every year




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Reviving businesses will benefit from air cargo’s growth

India’s air cargo industry is well positioned to scale up further, thanks to a strong airport cargo infrastructure




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Rajasthan-based firm barred from making ‘Insulin’ homeopathic tablets

A licence for the manufacture of this product was cancelled; this follows a complaint from Kerala-based RTI activist K.V. Babu with the Prime Minister’s public grievance cell




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ICMR invites expression of interest from firms for making anaemia detection device

The council wants to expand the effective screening network of anaemia among different age populations across India




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The Girl From Laapataa Ladies, Heeramandi

'I joined Heeramandi's shoot right after completing Laapataa Ladies.''When I landed on the Heeramandi sets, I was like "Oh my God!" because this was for the first time I was seeing such a huge set in my life.'




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'Can't Say Bigg Boss Promoting Polygamy'

'Ranvir will run out of steam pretty soon.''The way he is reacting or rather, overreacting to things, I am sure he will be exhausted soon.''You need to chill at times to play a game like Bigg Boss.'




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A Film From Manipur That You Must See

'This story has been always there since my childhood because of missing people.''I remember a family member who disappeared and I kept wondering what happened to him.'





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Rajesh Munirathnam's Journey: From Senior Developer to Leading AI-Powered Data Initiatives in Data, Analytics, and AI

Rajesh Munirathnam's journey includes his pursuit of advanced education, such as enrolling in MIT Professional Education's Applied Data Science Program, which emphasizes leveraging AI for effective decision-making




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Lessons for talent managers from Abdul Kalam

It is time managers revisit their stereotypical notions of who is talented and what talent is




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Life skill coaching, moving from experiential avoidance to psychological flexibility




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From CEO to Chief Purpose Officer

If companies are to think beyond profits, chief executives must lead from the front




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Farmers from flood-ravaged northern States to gather in Chandigarh to press for special package, compensation from Centre 

Farmers associated with as many as 16 farmer outfits from the States Punjab, Haryana, Himachal Pradesh, Rajasthan, Uttar Pradesh, and Uttarakhand would be participating




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From soaps to lip balms: How demand for donkey milk has kicked off a farming revolution in Tiruchi district

Once a ubiquitous beast of burden, the donkey is slowly making its way out of oblivion in Tiruchi as the global beauty industry discovers the benefits of its milk