Flurries of snow descended in abject defiance of the calendar on Saturday, from Pennsylvania to Maine, with white globs of frozen water falling even in Manhattan.

Flurries of snow descended in abject defiance of the calendar on Saturday, from Pennsylvania to Maine, with white globs of frozen water falling even in Manhattan.

With regulations urging residents statewide to wear masks when in public, here is how Southern Utahsn have fared following the recommended guidelines

Top 10 scorers in Purdue men's basketball history

Indianapolis police arrested a man on Saturday near the location of the fatal police shooting of Dreasjon "Sean" Reed days earlier.

Dennis Barrett, an east Indianapolis native, died of the coronavirus in March. His wife remembers him as a devoted father and ambitious entrepreneur.

Demonstrators describe an arrest and pepper ball use by IMPD during a protest over the death of Dreasjon Reed near 62nd Street and Michigan Road.

Indianapolis police arrested a man on Saturday near the location of the fatal police shooting of Dreasjon "Sean" Reed days earlier.

Police used a taser several times during the arrest of a man on Friday.

Volunteers from six Santa Clarita Valley high schools step forward to help those shut in by the COVID-19 pandemic.

Comparing “Likes” with “Tweets” of the Most Shared Stories

How coping with OCD prepared one man for the challenges of the coronavirus pandemic.

Prince Charles praises their "dedication, resilience and hard work" in a letter left outside his home.

A polar vortex has blasted into the northeastern US this weekend bringing rare May snowfall and record low temperatures to some areas.

Filed under: North America, United States

Continue reading Sorry Indianapolis, You're No Longer the Sole Location Offering TSA PreCheck Enrollment Background Checks

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• NASA engineers are continuing to drive the Mars Curiosity Rover while working from home.
• The job is highly technical and delicate, but the team has already managed to complete a successful operation under lockdown.
• Business Insider asked two of the rover team how they manage their work-life balance now the rover has colonised their living space.
• Visit Business Insider's homepage for more stories.

Life during lockdown has meant millions of people having to adapt to their home and work lives colliding. But what's that like when your work involves driving a nuclear-powered robot on the surface of Mars?

Business Insider spoke to two of the NASA technicians currently piloting the Mars Curiosity rover from home. It's a delicate operation that takes careful planning between a team of roughly 75 NASA engineers and scientists. Even while working remotely, the team was able to rig up their home workstations well enough that the rover has already completed a successful drilling operation while its human operators are in lockdown.

Despite doing the most otherworldly job imaginable, the Curiosity rovers are having to contend with familiar stresses of lockdown working life. They told Business Insider their personal tips and tricks for staying focused and healthy as they work from home.

Get comfy

Matt Gildner is the planning team lead for the rover, which means he directs a team of about 20 people who build the commands to send the rover to tell it where to go and what to do. Gildner's day involves staying permanently teleconferenced in to conversations using two headsets, one in each ear. A few times a day he also uses red-blue 3D glasses to examine images sent back by the rover.

His first change to his work-from-home set-up: Get a better chair. "The first week I got here I had an old wooden bank chair that while it looked really nice next to my desk, [was] not very comfortable," said Gildner. He quickly swapped this out for a more comfortable ergonomic chair. He and his wife are also making cold-brew coffee every night, ready to go in the morning.

Make sure you're seeing some kind of change

Gildner's also trying to make sure he doesn't stay glued to his ergonomic chair, making it a point to get up and moving around. "It's really about just getting up and stepping away from the desk for a while," Gildner said. This could be to just go to the kitchen to get a snack or, in Gildner's case, tend to some home baking projects.

"I was already baking some bread before this all happened, but I did kind of up my game in that area," he said. Specifically Gildner (a fan of the YouTube cooking channel "Bon Appetit") has started experimenting with overnight dough fermentation.

"It's nice to go and have something new to see every morning that changed overnight, or you get to see something progress," he said. "That's an important part of mental health and this point in time — to make sure you are having something in your life that is life-changing and dynamic despite your being in the same place."

He draws a parallel between this and his work on the rover. "That is one of the big draws of working a spacecraft operation, especially on Mars, is that every day we're driving to a new place and I get to look at images that no human has ever seen before. And Mars is always throwing us something new."

Keep a firm line between work time and downtime

"I also tend to really shut my computer down and put my phone away for work at the end of the day, just because I want to still try to keep some good separation between work life and home life, even though they're happening in the same place right now," Gildner said.

Project lead Alicia Allbaugh, who oversees the entire team of 75, also likes to draw a clear line between home and work life. She also recommends "not blending home tasks during your work time."

"I try not to deviate too much from what I would've done at work. Because then it can get you distracted and you start pulling away," she said.

Allbaugh also had to divvy up parts of the house with her husband, who also works at NASA. The two didn't want to work in adjacent rooms because they might hear each other's teleconferences through the walls, so Allbaugh works upstairs while her husband gets the kitchen, along with the couple's two rescue bunnies Oreo and Grayce.

In her free time Allbaugh has been tinkering with home improvements, and finished a long-standing project of painting and varnishing some linen-closet doors.

Respect other people's rhythms

As manager of a large team, Allbaugh also has to be sensitive to the fact that everyone has different daily rhythms working from home, especially those with children. Sudden mutes in meetings for children talking and clocks chiming have become the norm.

"We're all very empathetic for each other. I mean we find this adorable. We're not frustrated, whereas if someone came in and interrupted your meeting when you were in the conference room, you may have been like, 'What was that about?'" said Allbaugh.

Keep up the social side of the office

Allbaugh's team has also tried to keep social elements of their office going through virtual happy hours, and she has set up open-office tea break meetings so her team can just come in for a chat, which she thinks is important to keep up even as the lockdown drags on. "Because at first it's novel, and then it's okay — now it's a marathon," she said.  

SEE ALSO: NASA engineers explain what it's like to drive a nuclear-powered Mars rover from home during the pandemic

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Hairdressers have been forced to go underground as lockdown regulations stifle their livelihood and job security. For some, bootlegging has been 'life-saving'.

Four minutes and 28 seconds. That is how long it took a News24 reporter to find cigarettes – meant to be banned under Level 4 lockdown regulations – which were available for purchase at one of many places in South Africa.

We reassessed our hierarchy of needs, and survival always outweighs the rest. To be blunt, we would rather have load shedding than risk dying, writes Adriaan Basson.

The Stormers look set to receive a boost with centre Rikus Pretorius signing a contract extension.

Former captain Paul O'Connell says it will be vital for the British & Irish Lions to pick a leader capable of beating the Springboks at their own game.

After six weeks of negotiating, the UN Security Council was close to agreeing on a resolution for a global ceasefire during the Covid-19 pandemic. Seems fair, right? Let's agree to stop killing each other for a while, so we can focus on the virus that's killing us instead?

China proposed that the text explicitly mention a commitment by member nations to support the efforts of the World Health Organization — who Donald Trump has blamed (without evidence) for withholding information on the coronavirus outbreak.

So the US looked at the resolution and said "LOL no," despite last minute efforts to reach a compromise. As The Guardian reports:

On Thursday night, French diplomats thought they had engineered a compromise in which the resolution would mention UN “specialized health agencies” (an indirect, if clear, reference to the WHO).

The Russian mission signaled that it wanted a clause calling for the lifting of sanctions that affected the delivery of medical supplies, a reference to US punitive measures imposed on Iran and Venezuela. However, most security council diplomats believed Moscow would withdraw the objection or abstain in a vote rather than risk isolation as the sole veto on the ceasefire resolution.

While everyone else seemed game to go along with these compromises, the US insisted it was one big Chinese trick. As one diplomat told CNN:  "This discussion has been taken hostage by issues that do not have to do with the real issues at stake. Instead it has been transformed into a fight between the US and China. Read the rest

The following article, Professor Who Mocked Barron Trump During Senate Hearings Gets Censorship Position at Facebook, was first published on 100PercentFedUp.com.

Facebook just announced a 20 person board of oversight that will assist with content moderation. One of the people selected for the board, a professor at Stanford Law School, was announced as a member of the board and is raising eyebrows because of her snarky comment about Barron Trump during Senate Impeachment Hearings. Pamela Karlan, […]

Continue reading: Professor Who Mocked Barron Trump During Senate Hearings Gets Censorship Position at Facebook ...

The following article, Witness Tampering? Asst. HHS Secretary Releases Threatening Text Messages From Dem Rep. Eric Swalwell: “In clear violation of House Ethics rules “, was first published on 100PercentFedUp.com.

Now that Michael Caputo, who was previously a target of the Mueller investigation, has been cleared, he has released some pretty damning text messages from the virulently anti-Trump lawmaker from California, Rep. Eric Swalwell (D). The text messages appear to prove that Swalwell, who has spent the last 3 1/2 years calling for Trump’s impeachment, […]

Continue reading: Witness Tampering? Asst. HHS Secretary Releases Threatening Text Messages From Dem Rep. Eric Swalwell: “In clear violation of House Ethics rules “ ...

Invitation Only Research Event

Event participants

Ambassador Linda Thomas-Greenfield, Assistant Secretary of State for African Affairs, US Department of State
Chair: Dame Rosalind Marsden, Associate Fellow, Africa Programme, Chatham House

12 March 2015 , Volume 91, Number 2

Reiterlied posted a photo:

A tribute to Pirates I made last year when winter was coming to an end.

(You can find the blog post I wrote last year at Stuck in Plastic: www.stuckinplastic.com/2019/04/week-17-ching-shih/)

Travel blogger and photographer Andy Luten drove 4,200 miles across six states to see the grounded jets, detailing the shocking state of aviation.

Protease-activated receptor 2 (PAR-2) is activated by secreted proteases from immune cells or fungi. PAR-2 is normally expressed basolaterally in differentiated nasal ciliated cells. We hypothesized that epithelial remodeling during diseases characterized by cilial loss and squamous metaplasia may alter PAR-2 polarization. Here, using a fluorescent arrestin assay, we confirmed that the common fungal airway pathogen Aspergillus fumigatus activates heterologously-expressed PAR-2. Endogenous PAR-2 activation in submerged airway RPMI 2650 or NCI–H520 squamous cells increased intracellular calcium levels and granulocyte macrophage–colony-stimulating factor, tumor necrosis factor α, and interleukin (IL)-6 secretion. RPMI 2650 cells cultured at an air–liquid interface (ALI) responded to apically or basolaterally applied PAR-2 agonists. However, well-differentiated primary nasal epithelial ALIs responded only to basolateral PAR-2 stimulation, indicated by calcium elevation, increased cilia beat frequency, and increased fluid and cytokine secretion. We exposed primary cells to disease-related modifiers that alter epithelial morphology, including IL-13, cigarette smoke condensate, and retinoic acid deficiency, at concentrations and times that altered epithelial morphology without causing breakdown of the epithelial barrier to model early disease states. These altered primary cultures responded to both apical and basolateral PAR-2 stimulation. Imaging nasal polyps and control middle turbinate explants, we found that nasal polyps, but not turbinates, exhibit apical calcium responses to PAR-2 stimulation. However, isolated ciliated cells from both polyps and turbinates maintained basolateral PAR-2 polarization, suggesting that the calcium responses originated from nonciliated cells. Altered PAR-2 polarization in disease-remodeled epithelia may enhance apical responses and increase sensitivity to inhaled proteases.

Inter-α-inhibitor is a proteoglycan essential for mammalian reproduction and also plays a less well-characterized role in inflammation. It comprises two homologous “heavy chains” (HC1 and HC2) covalently attached to chondroitin sulfate on the bikunin core protein. Before ovulation, HCs are transferred onto the polysaccharide hyaluronan (HA) to form covalent HC·HA complexes, thereby stabilizing an extracellular matrix around the oocyte required for fertilization. Additionally, such complexes form during inflammatory processes and mediate leukocyte adhesion in the synovial fluids of arthritis patients and protect against sepsis. Here using X-ray crystallography, we show that human HC1 has a structure similar to integrin β-chains, with a von Willebrand factor A domain containing a functional metal ion-dependent adhesion site (MIDAS) and an associated hybrid domain. A comparison of the WT protein and a variant with an impaired MIDAS (but otherwise structurally identical) by small-angle X-ray scattering and analytical ultracentrifugation revealed that HC1 self-associates in a cation-dependent manner, providing a mechanism for HC·HA cross-linking and matrix stabilization. Surprisingly, unlike integrins, HC1 interacted with RGD-containing ligands, such as fibronectin, vitronectin, and the latency-associated peptides of transforming growth factor β, in a MIDAS/cation-independent manner. However, HC1 utilizes its MIDAS motif to bind to and inhibit the cleavage of complement C3, and small-angle X-ray scattering–based modeling indicates that this occurs through the inhibition of the alternative pathway C3 convertase. These findings provide detailed structural and functional insights into HC1 as a regulator of innate immunity and further elucidate the role of HC·HA complexes in inflammation and ovulation.

The U.S. refugee protection system, while generous in many respects, has become less robust over the last two decades. The unique and often diverse needs of emerging refugee populations have exposed severe limitations in the standard resettlement approach.This report examines U.S. legal and policy responses to those seeking protection and addresses the barriers, gaps, and opportunities that exist.

While aspects of the U.S. immigration system facilitate newcomers’ contributions to economic growth and competitiveness, others undermine them. Reforms are needed to enhance the job-creating power of U.S. employers and strengthen the system’s ability to select effectively from the large pool of foreign workers.

This report analyzes prenatal behaviors and birth outcomes of Black immigrant mothers, and finds that Black immigrant mothers are less likely to give birth to preterm or low-birth-weight infants than U.S.-born Black women, but more likely to experience these birth outcomes than other immigrant and U.S.-born women.

This report focuses on the development of children of Black immigrants in the United States, comparing against the outcomes for their peers in native-born and other immigrant families. It also compares these U.S. children to those in the United Kingdom, where there is a large Black immigrant population but a notably different policy context of reception.

Colm Delves had the two most important qualities of a successful CEO – ability and affability. Joining Digicel in 2003 from Hibernia Foods and initially working on a mobile licence in Lebanon, he was soon appointed CFO, quickly making his mark....

The National Water Commission (NWC) says a loss in power supply forced the shutdown of the Dinthill facility today, leaving some northern St Catherine communities without water.  The affected communities are: Linstead,...

The words humble and affectionate were among the many adjectives that reverberated during the virtual thanksgiving service for 62-year-old Roger Chang, as family friends paid tribute to the late businessman.  Chang, who went missing on...

This volume, by a former senior counsel to the 9/11 Commission, argues that the U.S. approach to immigration and border security is off-kilter and not keeping pace with the scope and complexity of people’s movement around the world, nor with expectations regarding freedom of movement.

So once I went on a night out and I kissed a drunk girl and she was hinting she wanted to come home with me but I didn't let it happen. If this happens again will it be weird if I bring a girl home at like 3 in the morning and I live with my parents. Do I have to hide her? What if we have sex? In the morning my mum just come in and opens the door to get my washing. What if she does this and there is a girl in the bed? Will I get in trouble? I don't know anything about this stuff. I'm 21 do people this age even do this or is it only people in there 30s? It will be nice to spend the night with a girl. Is it a bad idea. I have no brothers or friends so I don't know what people do. I want to know for the next time?

Ahead of National Citizenship Day, this commentary examines how regulations for the implementation of the federal Workforce Innovation and Opportunity Act (WIOA) at state and local levels could jeopardize citizenship preparation services for millions of immigrants across the United States.

Testimony of Doris Meissner, Director of MPI's U.S. Immigration Policy Program, before the Senate Homeland Security and Governmental Affairs Committee.

Testimony of Doris Meissner, Senior Fellow and Director, U.S. Immigration Policy Program, before the Committee on Homeland Security and Governmental Affairs, U.S. Senate.

(May 1, 2020) On April 24, 2020, Singapore’s chief justice announced an extension to June 1, 2020, of the period during which the courts of Singapore would hear only essential and urgent matters in order to slow local transmission of COVID-19. On the same day, the Supreme Court, state courts, and family justice courts each […]

1. India's research body partners with vaccine manufacturing company to develop indigenous vaccine for COVID-19  China.org.cn
2. India to develop ‘fully indigenous’ Covid vaccine as ICMR partners with Bharat Biotech  ThePrint
3. ICMR teams up with Bharat Biotech to develop Covid-19 vaccine  Times of India
4. ICMR partners with Bharat Biotech to develop an indigenous coronavirus vaccine  Times Now
5. ICMR joins with Hyderabad firm to develop COVID-19 vaccine  Northeast Now
6. View Full coverage on Google News

During a three week outreach in November, OM Italy speaks to the heart of a young man called Antonio.

A new church in Pisa puts the gospel at the centre of everything and has committed to reaching its neighbours, especially young people and students.

God opens doors for an international team to minister in Urfa, Turkey, an ancient city with no Christian church and only a handful of believers.