ic

Fluid purification level control apparatuses and methods

Apparatuses and methods for level control in a fluid purification apparatus. The apparatuses and methods include a fluid purification apparatus and a level sensor that regulates operation of the fluid purification apparatus. The level sensor may further operate a bypass valve or a heater.




ic

Optimizing feed mixer performance in a paraffinic froth treatment process

The invention relates to improved bitumen recovery processes and systems. One process provides for operation of a bitumen froth treatment plant at optimum shear rates in the feed pipe carrying the bitumen froth to the froth settling unit. Another process provides for optimizing the design of a bitumen froth treatment plant by optimizing the diameter of the feed pipe to impart an optimum shear rate to the bitumen froth mixture and further optimizing the volume of the feed pipe to impart an optimum residence time for the bitumen froth stream in the feed pipe. An optimal plant design is also disclosed, the plant including optimal diameter and volume of the feed pipe.




ic

Hydrocarbon resource processing device including spirally wound electrical conductors and related methods

A device for processing a hydrocarbon resource may include a hydrocarbon processing container configured to receive the hydrocarbon resource therein and having a pair of opposing ends with an enlarged width medial portion therebetween. The device may also include a radio frequency (RF) source, and a first spirally wound electrical conductor surrounding the hydrocarbon processing container and coupled to the RF source. The device may further include a second spirally wound electrical conductor carried within the hydrocarbon processing container. The first spirally wound electrical conductor may be configured to generate magnetic fields with the hydrocarbon processing container that are parallel with an axis thereof.




ic

Apparatus for removing heavy polynuclear aromatic compounds from a hydroprocessed stream

An improved apparatus strips HPNA's from hydroprocessed streams in a fractionation column having a split shell configuration. Only one vapor stripping feed is required to the split shell of the fractionation column. The resulting reduction in steam requirement provides a superior fractionation in the column.




ic

Hydrocarbon resource processing device including spirally wound electrical conductor and related methods

A device for processing a hydrocarbon resource may include a hydrocarbon processing container configured to receive the hydrocarbon resource therein and having a pair of opposing ends with an enlarged width medial portion therebetween. The device may also include a radio frequency (RF) source, and a spirally wound electrical conductor surrounding the hydrocarbon processing container and coupled to the RF source. The spirally wound electrical conductor may be configured to generate magnetic fields within the hydrocarbon processing container that are parallel with an axis thereof.




ic

Split-shell fractionation columns and associated processes for separating aromatic hydrocarbons

Split-shell fractionation columns and associated processes for separating aromatic hydrocarbons. A split-shell fractionation column includes a housing shell having a first height and a partition having a second height and disposed within the housing shell. The partition includes first and second vertically oriented baffles separated by a gap region, a seal plate connecting top ends of the baffles, a first input port formed to extend through the partition for the introduction of a gas into the gap region, and a first output port formed to extend outwardly from a bottom of the gap region and through the housing shell. The partition defines a first distillation zone and a second distillation zone within the housing shell.




ic

System and process for producing high quality gasoline by catalytic hydrocarbon recombination

A system and process for the preparation of high quality gasoline through recombination of catalytic hydrocarbon includes fractionator and extractor. The upper part of the fractionator is equipped with light petrol pipeline, the lower part of the fractionator is equipped with heavy petrol pipeline, the middle part of the fractionator is equipped with medium petrol pipeline. The medium petrol pipeline is connected with a medium petrol extractor, the upper part of the medium petrol extractor is connected with the medium petrol raffinate oil hydrogenation unit through the pipeline, the lower part of the medium petrol extractor is connected with the medium petrol aromatic hydrocarbon hydrogenation unit through the pipeline. The medium petrol aromatic hydrocarbon hydrogenation unit is then connected with the light petrol pipeline in the upper part of the fractionator through the pipeline, the lower part of the heavy petrol extractor is connected with the medium petrol aromatic hydrocarbon hydrogenation unit through the pipeline, the upper part of the heavy petrol extractor is connected with the medium petrol raffinate oil hydrogenation unit through the pipeline.




ic

Filter device, method for its operation and use thereof

A filter device for filtering a suspension includes at least one filter for continuous creation of a filter cake including particles from the suspension, at least one dispensing device configured to apply at least one first wash liquid to the filter cakes, at least one steaming unit configured to steam the filter cake using steam; at least one removal device configured to remove a surface layer of the filter cake facing away from the at least one filter, wherein the filter device is configured to convey the filter cake to the at least one removal device, the at least one dispensing device and the at least one steaming device, and at least one transport device configured to transport the removed surface layer of the filter cake away from the filter device.




ic

Method for fabricating divided wall columns

The invention relates to a method producing a portioned column by forming a first segment and a third segment into arcuate segments, and attaching these arcuate segments to a second z-shaped segment to from two contiguous volumes with approximately semi-circular cross-sections that combine to form a partitioned, approximately cylindrical segment.




ic

Method and apparatus for processing of spent lubricating oil

The present invention provides a method and an apparatus for recovery of spent lubricating oil. The evaporation of hydrocarbon fractions from spent lubricating oil is carried out in three steps. The first step is at approximately 150-1030 mbar and between 70-240° C. in which is greater than 99% water, greater than 99% of ethylene glycol and greater than 50% of hydrocarbon molecules with normal boiling point up to 310° C. are evaporated from spent oil. The second step is operated at 6-30 mbar and 200-2900 C in which predominantly gasoil and light vacuum gasoil fractions are evaporated. The third step is operated at 250-320° C. and 0.5-15 mbar in which mainly heavy vacuum gasoil (boiling range of 425 to 570° C. on ASTM D-1160 test) is evaporated from spent oil.




ic

Dial of circular hosiery knitting machine of the type with cylinder and dial with yarn cutting device

A dial of a circular hosiery knitting machine of the type with a cylinder and dial with yarn cutting device. The dial comprises a dial body which is substantially disk-shaped. The dial is provided with a cutting device, which comprises a plurality of cutting sectors which are distributed around the axis of the dial body and have cutting edges. The cutting sectors are arranged at sectors of the dial body which are intended to be free from needles. The cutting device comprises a cutter which is adapted to abut against the cutting edges of the cutting sectors to cut at least one yarn engaged by one of the cutting sectors in its rotary motion about the axis of the dial body with respect to the cutter.




ic

Auxetic fabric structures and related fabrication methods

Auxetic fabric structures, of the sort which can be useful in conjunction with composite materials, and related methods of fabrication.




ic

Orthopedic padding

An orthopedic padding including an elongate spacer fabric having spaced faces interconnected and separated by an intermediate spacer area, the spaced faces having a knitted construction different from a knitted construction of the intermediate spacer area, and the elongate fabric constructed at least in part of hydrophobic monofilament yarn knitted in an open construction for breathability.




ic

Double-cylinder circular machine, particularly for knitting hosiery items or the like, with simplified actuation mechanism

A double-cylinder circular machine, particularly for knitting hosiery items, with simplified actuation mechanism, comprising a supporting structure which comprises a footing, which supports a lower needle cylinder, and a column which extends substantially vertically, protrudes upwardly from the footing and supports an upper needle cylinder, which is arranged above and coaxially with respect to the lower needle cylinder, and further comprising elements for the actuation of the lower needle cylinder and of the upper needle cylinder with a rotary motion about a common axis, the actuation elements comprising an electric motor which is connected kinematically to the lower needle cylinder and to the upper needle cylinder and is accommodated inside the column.




ic

System and method for voice control of medical devices

A light-based medical diagnostic system includes a plurality of semiconductor diodes with pump beams and a multiplexer capable of combining the pump beams and generating at least a multiplexed pump beam comprising one or more wavelengths. A first waveguide structure is configured to receive at least a portion of the one or more wavelengths and outputs a first optical beam. A second waveguide structure is configured to receive at least a portion of the first optical beam and to communicate at least the portion of the first optical beam to an output end of the second waveguide structure to form an output beam. A lens system is configured to receive at least a portion of the output beam and to communicate at least the portion of the output beam onto a part of a patient's body, such as a patient's blood.




ic

Knitting machine, particularly with a high gauge

A knitting machine comprising a needle holder, which supports a plurality of needles which can be actuated with an alternating motion along their axis and means for guiding the needles on the needle holder which comprise channels for forming knitting which are defined proximate to the end of the needle holder and sliding channels which are defined on the needle holder in a region that is spaced from the end of the needle holder, each one of the channels for forming knitting being engageable by a needle and defining with its inlet, which is directed toward the outside of the needle holder, resting contact regions for the knitting during the retracting motion of the needles, the number of the sliding channels being smaller than the number of the channels for forming knitting.




ic

Knitted fabric bed skirt

A knitted fabric is designed and adapted to fit box springs of varying size. The knitted fabric includes four panels that each includes three layers—a middle layer, a top layer and bottom layer. The knitted fabric is elastic and stretches to fit over the box spring. The four panel construction provides a large opening on the top of the box spring, which allows the knitted fabric to be removed from the box spring without removal of the mattress.




ic

Headband for use with medical sensor

Headbands configured to provide pressure against a medical sensor secured to a patient's forehead are provided. The headbands may include one or more low friction materials to enable an elastic band of a tensioning mechanism to evenly stretch. Additionally or alternatively, the headbands may include two or more bands adapted to secure the headband to various portions of a patient's head. Still further, the headbands may be configured to independently vary the pressure created between two or more sensors and the patient's head.




ic

Knitted fabric

A knitted fabric is disclosed, comprising a first fabric layer, a second fabric layer and a plurality of pliable threads having a predetermined length, the respective ends of the pliable threads being stitched to the first and second layers thereby connecting the first and second layers. Preferably the fabric also contains sacrificial yarn to tie in the pliable threads. Also disclosed is a method for knitting a fabric according to the invention. The fabric has uses in inflatable devices, including airbags, or lifting devices.




ic

Warp knitted fabric manufacturing method

The invention addresses the problem of providing a warp knitted fabric manufacturing method capable of stably producing a warp knitted fabric wherein the longitudinal stretchability is 200%. To solve the problem, the invention is a warp knitted fabric manufacturing method that forms bands of a warp knitted structure with increased longitudinal stretchability by forming stitches with an elastic warp (2) while knitting in an elastic inserted yarn (3) in the warp direction and knitting in the weft (4) in the course direction, wherein: active feed means (30), which are obtained by placing a single follower roller (323) above two drive rollers (321, 322), are disposed on the respective paths of the warp (2) and the inserted yarn (3) to feed the warp (2) and the inserted yarn (3) to the warp knitting machine while increasing the respective elongation percentage. The active feed means (30) keep the respective feed rates of the warp (2) and the inserted yarn (3) constant while feeding same to the crochet warp knitting machine (40).




ic

Support surface cover having different frictional zones

An apparatus is disclosed for placement on a support surface between the support surface and a living being, wherein the living being has a bony prominence. The apparatus includes a first zone having a first coefficient of friction, the first zone being configured for positioning proximate the bony prominence. A second zone is adjacent the first zone, the second zone having a second coefficient of friction higher than the first coefficient of friction. The second zone is configured for positioning remote from the bony prominence. A method of preventing or healing decubitus ulcers includes positioning the bony prominence over the first zone and positioning an area remote from the bony prominence over the second zone.




ic

Knitted component for an article of footwear including a full monofilament upper

An article of footwear including a full monofilament upper is described. The full monofilament upper incorporates a knitted component including a monofilament knit element. The monofilament knit element is formed by knitting with a monofilament strand. The monofilament knit element is formed of unitary knit construction with the remaining portions of the knitted component, including peripheral portions that are knit using a natural or synthetic twisted fiber yarn. An inlaid tensile element can extend through the knitted component, including portions of the monofilament knit element. The monofilament knit element may be knitted with a monofilament strand according to a variety of knit structures.




ic

Linear electronic transducer

An electronic transducer comprises a knitted structure extendible in two dimensions defined by its courses and wales. An electro-conductive yarn (4) defines at least one single course in the structure adjacent non-conductive yarns (2), and is to be part of a circuit providing an indication of an electrical characteristic of the yarn. When unextended in either direction, successive loops of the stitches including the electro-conductive yarn are in engagement. Extension of the structure in the course direction separate loops forming the stitches, and extension in the wale direction urges the loops together. The structure can be used in methods of registering extension of the structure in either or both of the course and wale directions.




ic

Article of footwear including a monofilament knit element with peripheral knit portions

An article of footwear including a knitted component having a monofilament knit element with peripheral knit portions is described. The knitted component includes a monofilament knit element formed by knitting with a monofilament strand. The monofilament knit element is formed of unitary knit construction with the remaining portions of the knitted component, including peripheral portions that are knit using a natural or synthetic twisted fiber yarn. An inlaid tensile element can extend through the knitted component, including portions of the monofilament knit element. The monofilament knit element may be knitted with a monofilament strand according to a variety of knit structures.




ic

Article of footwear including a monofilament knit element with a fusible strand

An article of footwear including a full monofilament upper is described. The full monofilament upper incorporates a knitted component including a monofilament knit element. The monofilament knit element is formed by knitting with a monofilament strand. The monofilament knit element is formed of unitary knit construction with the remaining portions of the knitted component, including peripheral portions that are knit using a natural or synthetic twisted fiber yarn. An inlaid tensile element can extend through the knitted component, including portions of the monofilament knit element. The monofilament knit element may be knitted with a monofilament strand according to a variety of knit structures. A fusible strand may be knit with the monofilament knit element. Upon heating, the fusible strand can combine and surround the monofilament strand within the monofilament knit element.




ic

Article of footwear including a monofilament knit element with peripheral knit portions

An article of footwear including a knitted component having a monofilament knit element with peripheral knit portions is described. The knitted component includes a monofilament knit element formed by knitting with a monofilament strand. The monofilament knit element is formed of unitary knit construction with the remaining portions of the knitted component, including peripheral portions that are knit using a natural or synthetic twisted fiber yarn. An inlaid tensile element can extend through the knitted component, including portions of the monofilament knit element. The monofilament knit element may be knitted with a monofilament strand according to a variety of knit structures.




ic

System and method for forming a design from a flexible filament having indicators

The present disclosure is directed to a flexible filament that includes a length of material configured to be used in forming at least a portion of a textile product to have at least a portion of a visual pattern that is visible on at least one of a first side or a second side of the textile product. The material includes a plurality of stitch indicators formed on the material to separate the material into a plurality of segmented regions, at least one of the stitch indicators or the segmented regions forming at least the portion of the visual pattern visible on the at least one of the first side or the second side of the textile product.




ic

Logistic transport system for nutritional substances

A preservation system for storage and logistic transport of nutritional substances. The preservation system obtains information about the nutritional substance to be preserved, senses and measures the external environment to the preservation system, senses and measures the internal environment to the preservation system, senses and measures the state of the nutritional substance, and stores such information throughout the period of preservation. Using this accumulated information, the preservation system can measure, or estimate, changes in nutritional content (usually degradation) during the period of preservation. Additionally, the preservation system can use this information to dynamically modify the preservation system to minimize detrimental changes to the nutritional content of the nutritional substance, and in some cases actually improve the nutritional substance attributes.




ic

Sandwich cookie dipper

A sandwich cookie dipper for dipping sandwich cookies in milk includes a handle, a cookie cradle and a transition element that interconnects to and sets off the cookie cradle from the handle. The cookie cradle comprises a thin, resilient rod-like member configured to substantially conform to a part of an outer circumference of a crème layer sandwiched between two disk-like cookie members of a sandwich cookie. The sandwich cookie secured thereby is less likely to dislodge as it is dipped and brought to the cookie eater's mouth.




ic

Compact juicer

A fruit and vegetable juicer has a motor above which is a filter basket that is surrounded by a collection chamber. A feed tube is supported above the filter basket and is integral with a lid to the collection chamber. In preferred embodiments, the separation chamber comprises a central liquid collection portion and a pulp collection portion that surrounds it. In particularly preferred embodiments, the inside diameter of the interior sidewall that separates the pulp collection chamber from the juice collection chamber is tapered toward a central axis of rotation. The smaller diameter end of the sidewall is adjacent to an upper rim of the filter basket.




ic

Multi-functional electric cooker

A multi-functional electric cooker includes a heating boiler body (1) and a cover (2). The cooker also includes a rice soup collecting container (3) which is mounted between the heating boiler body (1) and the cover (2), a sealing ring (7) which is set between the rice soup collecting container (3) and the heating boiler body (1), and a rice soup sucker (6). An opening of one end of the sucker is located at the bottom of the rice soup collecting container (3) and the height of the opening is adjusted along with the amount of the rice in the heating boiler body. An opening of the other end of the sucker is located in the rice soup collecting container (3).




ic

Vacuum frying device and method for using the same

A method of converting a conventional atmospheric frying device to a vacuum frying device is provided. The method includes positioning a hood on top of a conventional frying device to provide an enclosure for drawing a vacuum within the modified devices. In addition, the method can include strengthening the existing vat so that it is capable of withstanding the forces associated with vacuum frying.




ic

Device and method to simulate cooking stuffing in a bird

The present invention provides a device and method for simulating cooking stuffing in a bird, such as a turkey. Stuffing prepared with the device and method of the invention has both the appearance and taste of cooked-in-the-bird stuffing. In addition, the device and method of the invention allows the user to prepare simulated cooked-in-the-bird stuffing at any time, in any quantity and in less time compared to the several hours usually needed to cook stuffing in a bird. The invention, therefore, provides all the benefits of cooked-in-the-bird stuffing without the safety concerns of bacterial contamination when cooked in a bird.




ic

Treatment device for treating food products with conditioned air

A treatment device for treating food products with conditioned air comprises a housing which delimits a treatment space and is provided with an entry and an exit, at least one conveying device for conveying the products from the entry throughout the treatment space to the exit, the conveying device between the entry and the exit following a conveying path with several windings which are situated one above the other, air-circulation device for circulating conditioned air throughout the treatment space via a hollow drum. According to a first aspect, air-conditioning device are provided upstream of the air-circulation device for conditioning the air. According to a second aspect, at least one winding of the conveying path near the entry has a pitch which is different to the pitch of the downstream windings.




ic

Shell cracking and retaining device

A shell cracking and retaining device for cracking shelled food products, wherein the device entirely or substantially retains food, shell portions and other debris during the cracking process, and therefore prevents said food, shell portions and other debris from being sent airborne from the device.




ic

Two-piece electric coffee maker

The two-piece electric coffee maker includes a Dallah (a traditional Arabian coffee pot for making Arabian coffee) and an electric stove. The coffee pot has a temperature sensor that extends from the base of the coffee pot handle into the pot. The base of the handle also has an electrical connector extending downward from the handle. The electric stove has a housing, a ceramic heating element or plate, a display console, and a mating electrical connector facing upward so that the connectors engage each other when the pot is placed on the heating element. An electronic control unit in the stove housing regulates boiling water for the coffee, reducing the heat after the water has started to boil, annunciating an alarm signal when the temperature of the water is suitable to add coffee grounds to the pot, and monitors brewing time for the coffee.




ic

Capsule for the preparation of a beverage embedding an identification element

The invention relates to a capsule for the preparation of a beverage. The capsule includes first and second covering walls connected for forming a cavity containing a beverage ingredient and a contactless identifying element for identifying the capsule by detecting the identifying element using the detector of a beverage producing device. The identifying element is preferably disposed in the cavity.




ic

Food condition maintaining device

The inventive food holding apparatus comprises a holding area that accommodates food and warms the food with heat radiated by a bottom surface and with warm convection air. Part of the convection air forms an air curtain having a Bernoulli effect that removes excess moisture from the external surface of the food and maintains the food in a warm, crisp condition. The apparatus conditions food to attain a biologically safe noncooking temperature and to retain its freshly cooked texture and internal moisture for more than two hours. This lets restaurants serve the food longer to its customers, allowing efficient batch cooking and significantly decreasing food waste.




ic

Machine having an improved blade structure, for extracting puree or juice

Machine (1) for extracting puree, or fruit juice starting from vegetable or animal food, such as a rough extractor or a fine extractor. The machine (1) comprises essentially a cylindrical body (2) having an inlet (3) for the product to treat, an outlet (4) for a part of the product that can be used and an outlet (5) for another part of product to dispose of. The rotor (6) is wheeled to a motor (80) by a shaft (15). The product that is put in the cylindrical body (2) of the machine (1) is pushed by centrifugal force by a plurality of blades (20) of the rotor (6) to pass through a sieve (7) having holes (8) and a cylindrical or conical shape. The blades (20) of the rotor (6) comprise, in particular a first portion (21) having a first concavity and a second portion (22) having a second concavity opposite to the first.




ic

Device for regulating the level of a liquid in a boiler of a coffee machine

The present invention relates to a device to regulate the level of a liquid inside a boiler of a coffee machine, having a transparent duct connected to the boiler and designed to visibly display the level of the liquid inside the boiler, a capacitive sensor that can be positioned outside the transparent duct in determined positions and designed to generate electric signals representing the presence or absence of liquid in correspondence to the position of the sensor along the transparent duct. The sensor of the device has first measuring elements and second measuring elements, both of capacitive type; the second measuring elements are positioned at a predetermined distance from the first measuring elements, and a measuring device designed to measure the impedance between the first and second measuring elements and to generate signals indicating the presence or absence of liquid in correspondence to the position of the sensor. The invention also relates to the machine that includes this device.




ic

System for the application of ozone in grains

System for application of ozone on grains made up essentially by one or more ozone mixers with particulates separator (1) for injecting air in the grains mass, one or more ozone mixers (2) for injecting air in the grains mass, a base of the device for grains treatment with ozone (3), a transport and discharge device (4), and an air cooling filter (5) that can be used individually or jointly to apply ozone on the grains mass.




ic

Microwave cookware

A cookware system includes a microwaveable metal collecting pan, configured in a bowl shape with a plurality of elongated slots disposed thereon. The collector pan is positioned in a supporting bowl to catch dripping fluids and to provide a basin to hold water during steam cooking. A food item can be placed inside the pan, which is in turn placed inside the bowl and covered with a lid.




ic

Coffee machine comprising a frothing device and means for cleaning the frothing device and a milk suction line and process for rinsing the milk suction line

A coffee machine comprises a frothing device, wherein an internal milk channel leading to a frothing chamber is provided into which opens a bypass air inlet for operable air supply to the frothing device. A flexible milk suction line connects the frothing device with a milk supply container. Means are provided for cleaning the frothing device and the milk suction line with rinsing water from a continuous-flow water heater of the coffee machine. A controlled valve arrangement is provided which feeds rinsing water from the continuous-flow water heater to the bypass air inlet of the frothing device. A milk suction end of the milk suction line is directly or indirectly, fluid-conductively connectable with a residual water pan of the coffee machine prior to feeding rinsing water to the bypass air inlet.




ic

Device and method for decaffeinating a liquid

The invention proposes a device for decaffeinating a liquid. The device includes at least one cathode electrode and at least one anode electrode which are spaced apart and which are immersed in the liquid; a power supply coupled to the at least one cathode electrode and the at least one anode electrode and configured to apply power thereto, wherein the at least one cathode electrode and the at least one anode electrode are configured to generate an electric field in the liquid upon application of the power to attract caffeine molecules in the liquid to the at least one cathode electrode; wherein the at least one cathode electrode is made of or coated with an absorbing material configured to absorb at least part of the caffeine molecules that are attracted to the at least one cathode electrode.




ic

Novel method for preparing pH dependent Ultra Small Polymeric Nanoparticles for topical and/or Transdermal delivery

The invention provides a new method for preparing ultra-small polymeric-lipidic delivery nanoparticles (USDNs) that were synthesized by a nanoprecipitation method followed by a layer-by-layer nanodeposition. The USDNs particle size can be controlled between 5-25 mn and provides loading capacities of 22.12% to 72.08%. Moreover, the USDNs platform provides pH controlled drug release, within a terminal release ratio of 68% at pH 5.0 and almost no release to pH of 7.5. Furthermore, based on their small sizes (5-25 nm) and unique composition, the USDNs penetrates the skin strata efficiently, release the payload at the target site as topical or transdermal treatment of a variety of skin disorders. Additionally the USDNs system can be used to treat and diagnoses other crucial diseases (Cancer, Alzheimer, etc) can be combined with various micro-needles or needles free array technologies for special application.




ic

BICYCLIC PYRAZOLONE COMPOUNDS AND METHODS OF USE

The present invention provides substituted bicyclic pyrazolone compounds, which are used to inhibit or modulate the activity of receptor tyrosine kinases, especially Axl, Mer, c-Met and Ron. The invention also provides pharmaceutical compositions comprising the compound disclosed herein, and a method of preventing, treating or lessening the severity of a proliferative disorder in a patient with the compounds or the pharmaceutical compositions disclosed herein.




ic

CANCER TARGETING BY ANTI-EGFR PEPTIDES AND APPLICATIONS THEREOF

A molecule comprising a lipid, a peptide and a linker to bind the lipid to the peptide which have specific amino acid sequence to bind to Epidermal Growth Factor Receptor (EGFR) of tumor cells, and a liposomal composition which is targeted by the molecule, and method for preparing thereof is disclosed.




ic

MULTI-SPECIFIC ANTI-PSEUDOMONAS PSL AND PCRV BINDING MOLECULES AND USES THEREOF

This disclosure relates to combination therapies comprising anti-Pseudomonas Psl and PcrV bispecific binding molecules and related compositions, for use in prevention and treatment of Pseudomonas infection.




ic

ANTIGENS ASSOCIATED WITH ENDOMETRIOSIS, PSORIATIC ARTHRITIS AND PSORIASIS

Specific binding members that bind the ED-A isoform of fibronectin for use in methods of diagnosis, detection, imaging and/or treatment of endometriosis, and/or for use in delivery to the neovasculature of endometriotic tissue of a molecule conjugated to the specific binding member. Specific binding members that bind tenascin-C, especially the A1, A2, A3, A4 and/or D domain tenascin-C large isoform, for use in methods of diagnosis, detection, imaging and/or treatment of endometriosis, psoriatic arthritis or psoriasis, and/or for use in delivery to the neovasculature of endometriotic, psoriatic arthritic or psoriatic tissue of a molecule conjugated to the specific binding member.




ic

Immunological Targeting of Pathological Tau Proteins

The present invention relates to methods and compositions for treating, preventing, and diagnosing Alzheimer's Disease or other tauopathies in a subject by administering an immunogenic tau peptide or an antibody recognizing the immunogenic tau epitope under conditions effective to treat, prevent, or diagnose Alzheimer's Disease or other tauopathies. Also disclosed are methods of promoting clearance of aggregates from the brain of the subject and of slowing progression of tau-pathology related behavioral phenotype in a subject.