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Donor-derived DNA variability in fingernails of acute myeloid leukemia patients after allogeneic hematopoietic stem cell transplantation detected by direct PCR




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Differentiation of transplanted haematopoietic stem cells tracked by single-cell transcriptomic analysis




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A more accurate incidence of acute spinal cord injury in South Korea can be estimated by the national health insurance system




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Efficient generation of mouse models with the prime editing system




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Impact of corticosteroid therapy on outcomes of persons with SARS-CoV-2, SARS-CoV, or MERS-CoV infection: a systematic review and meta-analysis




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Parkinson disease and the immune system — associations, mechanisms and therapeutics




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Evaluation of an AI system for the detection of diabetic retinopathy from images captured with a handheld portable fundus camera: the MAILOR AI study




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Relationship between markers of malnutrition and clinical outcomes in older adults with cancer: systematic review, narrative synthesis and meta-analysis




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Author Correction: <i>Cdkn1a</i> deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation




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ZBP1 (DAI/DLM-1) promotes osteogenic differentiation while inhibiting adipogenic differentiation in mesenchymal stem cells through a positive feedback loop of Wnt/β-catenin signaling




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Ionomycin ameliorates hypophosphatasia via rescuing alkaline phosphatase deficiency-mediated L-type Ca<sup>2+</sup> channel internalization in mesenchymal stem cells




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La medición de la satisfacción de usuarios como indicador de calidad en los sistemas bibliotecarios: el caso de las universidades públicas de noroeste de México

Verdugo-Sánchez, José-Alfredo La medición de la satisfacción de usuarios como indicador de calidad en los sistemas bibliotecarios: el caso de las universidades públicas de noroeste de México., 2015 PhD Thesis thesis, Universidad Complutense de Madrid. [Thesis]




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Impact of Covid-19 on the media system. Communicative and democratic consequences of news consumption during the outbreak // Impacto del Covid-19 en el sistema de medios. Consecuencias comunicativas y democráticas del consumo de noticias durante el

Casero-Ripollés, Andreu Impact of Covid-19 on the media system. Communicative and democratic consequences of news consumption during the outbreak // Impacto del Covid-19 en el sistema de medios. Consecuencias comunicativas y democráticas del consumo de noticias durante el brote. El profesional de la información, 2020, vol. 29, n. 2. [Journal article (Unpaginated)]




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Fluoride varnish and dental caries in preschoolers: a systematic review and meta-analysis




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Dental caries experience, care index and restorative index in children with learning disabilities and children without learning disabilities: a systematic review and meta-analysis




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Coronavirus Crisis Shows Cracks in the U.S. Governing System, Analysts Say

China’s autocratic system has performed better in some aspects than America’s democracy so far in responding to the coronavirus pandemic, but it is too early to write off the United States despite its many early missteps, analysts at a China Institute event said.




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Autoimmunity and organ damage in systemic lupus erythematosus




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Coronavirus Crisis Shows Cracks in the U.S. Governing System, Analysts Say

China’s autocratic system has performed better in some aspects than America’s democracy so far in responding to the coronavirus pandemic, but it is too early to write off the United States despite its many early missteps, analysts at a China Institute event said.




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Coronavirus Crisis Shows Cracks in the U.S. Governing System, Analysts Say

China’s autocratic system has performed better in some aspects than America’s democracy so far in responding to the coronavirus pandemic, but it is too early to write off the United States despite its many early missteps, analysts at a China Institute event said.




stem

Coronavirus Crisis Shows Cracks in the U.S. Governing System, Analysts Say

China’s autocratic system has performed better in some aspects than America’s democracy so far in responding to the coronavirus pandemic, but it is too early to write off the United States despite its many early missteps, analysts at a China Institute event said.




stem

Coronavirus Crisis Shows Cracks in the U.S. Governing System, Analysts Say

China’s autocratic system has performed better in some aspects than America’s democracy so far in responding to the coronavirus pandemic, but it is too early to write off the United States despite its many early missteps, analysts at a China Institute event said.




stem

Coronavirus Crisis Shows Cracks in the U.S. Governing System, Analysts Say

China’s autocratic system has performed better in some aspects than America’s democracy so far in responding to the coronavirus pandemic, but it is too early to write off the United States despite its many early missteps, analysts at a China Institute event said.




stem

Coronavirus Crisis Shows Cracks in the U.S. Governing System, Analysts Say

China’s autocratic system has performed better in some aspects than America’s democracy so far in responding to the coronavirus pandemic, but it is too early to write off the United States despite its many early missteps, analysts at a China Institute event said.




stem

Coronavirus Crisis Shows Cracks in the U.S. Governing System, Analysts Say

China’s autocratic system has performed better in some aspects than America’s democracy so far in responding to the coronavirus pandemic, but it is too early to write off the United States despite its many early missteps, analysts at a China Institute event said.




stem

Coronavirus Crisis Shows Cracks in the U.S. Governing System, Analysts Say

China’s autocratic system has performed better in some aspects than America’s democracy so far in responding to the coronavirus pandemic, but it is too early to write off the United States despite its many early missteps, analysts at a China Institute event said.




stem

Coronavirus Crisis Shows Cracks in the U.S. Governing System, Analysts Say

China’s autocratic system has performed better in some aspects than America’s democracy so far in responding to the coronavirus pandemic, but it is too early to write off the United States despite its many early missteps, analysts at a China Institute event said.




stem

Coronavirus Crisis Shows Cracks in the U.S. Governing System, Analysts Say

China’s autocratic system has performed better in some aspects than America’s democracy so far in responding to the coronavirus pandemic, but it is too early to write off the United States despite its many early missteps, analysts at a China Institute event said.




stem

Coronavirus Crisis Shows Cracks in the U.S. Governing System, Analysts Say

China’s autocratic system has performed better in some aspects than America’s democracy so far in responding to the coronavirus pandemic, but it is too early to write off the United States despite its many early missteps, analysts at a China Institute event said.




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What can COVID-19 teach us about strengthening education systems?

As cases of coronavirus (COVID-19) in the United States rise, more and more states have adopted shelter-in-place orders to curtail the pandemic. The disruption to most Americans’ daily lives has been drastic and sudden—and perhaps one of the most dramatic shifts was education’s move to a virtual setting. Even before the current pandemic forced school closures,…

       




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Coronavirus Crisis Shows Cracks in the U.S. Governing System, Analysts Say

China’s autocratic system has performed better in some aspects than America’s democracy so far in responding to the coronavirus pandemic, but it is too early to write off the United States despite its many early missteps, analysts at a China Institute event said.




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The End of Sykes-Picot? Reflections on the Prospects of the Arab State System


During much of the past three years, the Syrian civil war has been the most prominent item on the Middle Eastern political agenda and has dominated the political-diplomatic discourse in the region and among policy makers, analysts and pundits interested in its affairs. 

Preoccupation with the Syrian crisis has derived from the sense, apparent since its early phases, that it was much more than a domestic issue. It has, indeed, become a conflict by-proxy between Iran and its regional rivals and the arena of American-Russian competition. It has also had a spillover effect on several neighboring countries and has been a bellwether for the state of the Arab Spring.

As the conflict festered it also prompted a broader discussion and debate over the future of the Arab State system. The collapse of Syria, the ongoing fighting in Iraq, and the general instability in the Middle East has led some observers to question whether the very geography of the region will be changed. Robin Wright, a journalist and scholar at the Woodrow Wilson International Center for Scholars, argues that “the map of the modern Middle East, a political and economic pivot in the international order, is in tatters.” Wright also warns that competing groups and ideologies are pulling the region apart: “A different map would be a strategic game changer for just about everybody, potentially reconfiguring alliances, security challenges, trade and energy flows for much of the world, too.”  Similarly, Parag Khanna, a senior fellow at the New America Foundation, argues, “Nowhere is a rethinking of “the state” more necessary than in the Middle East.” He contends that “The Arab world will not be resurrected to its old glory until its map is redrawn to resemble a collection of autonomous national oases linked by Silk Roads of commerce.” Lt. Colonel Joel Rayburn, writing from the Hoover Institution, points out that the alternative may not be new states but rather simply collapse. “If watching the fall or near-fall of half a dozen regimes in the Arab Spring has taught us anything, it should be that the Arab states that appeared serenely stable to outsiders for the past half century were more brittle than we have understood,” warning darkly, “This conflict could very well touch us all, perhaps becoming an engine of jihad that spews forth attackers bent on bombing western embassies and cities or disrupting Persian Gulf oil markets long before the fire burns out.” 

This discussion touches on a key question: Will the collapse of one or several other Arab states produce a new order in the region? 

The regional order has been threatened before, but today’s challenge is unique. Syria is what has prompted the latest reevaluation of the Skyes-Picot borders, but many of the problems predated the Syrian civil war. Ambitious monarchs in the 1930s and 1940s challenged the order after the colonial period. The doctrine of Pan-Arab Nationalism and Gamal Abd al-Nasir’s messianic leadership in the 1950s and by Saddam Hussein in 1990 again posed a threat. Now it is now challenged not by a powerful state or a sweeping ideology but by the weakness of several Arab states that seem to be on the verge of implosion or disintegration.

This paper assesses the situation in Syria, with an emphasis on what might lead to its de facto partition or lasting collapse. It then examines Syria’s neighbors and their prospects for stability. The paper concludes by exploring how the United States, Israel and Iran might affect this tenuous balance.

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Image Source: © Muzaffar Salman / Reuters
      
 
 




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Why AI systems should disclose that they’re not human

       




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After COVID-19—thinking differently about running the health care system

       




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Why AI systems should disclose that they’re not human

       




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Regulating Systemic Risk

EXECUTIVE SUMMARY

The ongoing financial crisis that began in 2007 has revealed a fundamental weakness in our financial regulatory system: the absence of a regulator charged with overseeing and preventing “systemic risk,” or the risks to the health of the entire financial system posed by the failure of one or more “systemically important financial institutions” (SIFIs).

On March 26, the Treasury Department released the first part of its plan to fix the financial system, which concentrates on reducing systemic risk. The Treasury’s suggestions, if enacted into law, would go a long a way toward achieving this objective. One of the central elements in the plan is to establish a systemic risk regulator. Treasury did not identify which agency or agencies should assume this job. I address this issue, among others, in this essay on systemic risk.

Ideally, all federal financial regulatory activities should be consolidated in two agencies, a financial solvency regulator and a federal consumer protection regulator, with systemic risk responsibilities being assigned to the solvency regulator. As a second-best option, clear systemic risk oversight authority should be assigned to the Fed. Either of these options is superior to creating a new agency or regulating systemic risk through a “college” of existing financial regulators.

The systemic risk regulator (SRR) should supervise all SIFIs, although the nature and details of this supervision should take account of the differences in types of such institutions (banks, large insurers, hedge funds, private equity funds, and financial conglomerates). The SRR should also regularly analyze and report to Congress on the systemic risks confronting the financial system.

There are legitimate concerns about vesting such large responsibilities with any financial regulator. But as long as there are financial institutions whose failure could lead to calamitous financial and economic consequences, and thus invite all-but-certain federal rescue efforts if the threat of failure is real, then some arm of the federal government must oversee systemic risk and do the best it can to make that oversight work.

While the United States should continue to cooperate with governments of other countries in reforming financial systems, notably through the G-20 process, policymakers here should not wait for international agreements to be in place before putting our own financial house in order.

Read the full paper » (pdf)

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Our employment system has failed low-wage workers. How can we rebuild?

Surging unemployment claims show that our labor market, built for efficiency, can crumble in times of crisis at huge human and economic costs. The pandemic has exposed a weak point in the country’s economy: the precarity of low-wage workers. Many have adapted to unimaginable circumstances, risking their own well-being, implementing public health protocols, and keeping…

       




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COVID-19 has revealed a flaw in public health systems. Here’s how to fix it.

To be capable of surveilling, preventing, and managing disease outbreaks, public health systems require trustworthy, community-embedded public health workers who are empowered to undertake their tasks as professionals. The world has not invested in this cadre of health workers, despite the lessons from Ebola. In a new paper, my co-authors and I discuss why, and…

       




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Procedure Price Lookup: A step toward transparency in the health care system

The Centers for Medicare and Medicaid Services (CMS) recently launched a new initiative to curb the costs of health care services and empower patients to make more informed decisions about their medical care. The newly launched website, Procedure Price Lookup, increases the transparency of prices by allowing users to compare the total and out-of-pocket costs…

       




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Our employment system has failed low-wage workers. How can we rebuild?

Surging unemployment claims show that our labor market, built for efficiency, can crumble in times of crisis at huge human and economic costs. The pandemic has exposed a weak point in the country’s economy: the precarity of low-wage workers. Many have adapted to unimaginable circumstances, risking their own well-being, implementing public health protocols, and keeping…

       




stem

Our employment system has failed low-wage workers. How can we rebuild?

Surging unemployment claims show that our labor market, built for efficiency, can crumble in times of crisis at huge human and economic costs. The pandemic has exposed a weak point in the country’s economy: the precarity of low-wage workers. Many have adapted to unimaginable circumstances, risking their own well-being, implementing public health protocols, and keeping…

       




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The value of systemwide, high-quality data in early childhood education

High-quality early learning experiences—those filled with stimulating and supportive interactions between children and caregivers—can have long-lasting impacts for children, families, and society. Unfortunately, many families, particularly low-income families, struggle to find any affordable early childhood education (ECE) program, much less programs that offer engaging learning opportunities that are likely to foster long-term benefits. This post…

       




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After COVID-19—thinking differently about running the health care system

       




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COVID-19 has revealed a flaw in public health systems. Here’s how to fix it.

To be capable of surveilling, preventing, and managing disease outbreaks, public health systems require trustworthy, community-embedded public health workers who are empowered to undertake their tasks as professionals. The world has not invested in this cadre of health workers, despite the lessons from Ebola. In a new paper, my co-authors and I discuss why, and…

       




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Appointments, Vacancies and Government IT: Reforming Personnel Data Systems

John Hudak argues for reforming personnel data systems – more carefully tracking both appointments and vacancies within government offices ­– in order to ensure that agency efficacy is not compromised. Hudak recommends several revisions that would immediately recognize vacancies, track government positions and personnel more carefully, and eliminate long-standing vacancies that reduce the efficiency within a department or agency. He asks Congress to stop its cries of “waste” and “inefficiency” and instead push data system improvements that will limit these issues.

      
 
 




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Unmanned aircraft systems: Key considerations regarding safety, innovation, economic impact, and privacy


Good afternoon Chair Ayotte, Ranking Member Cantwell, and Members of the Subcommittee. Thank you very much for the opportunity to testify today on the important topic of domestic unmanned aircraft systems (UAS).

I am a nonresident senior fellow in Governance Studies and the Center for Technology Innovation at the Brookings Institution. I am also a National Fellow at the Hoover Institution at Stanford, and a professor at UCLA, where I hold appointments in the Electrical Engineering Department and the Department of Public Policy. The views I am expressing here are my own, and do not necessarily represent those of the Brookings Institution, Stanford University or the University of California.

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Authors

Image Source: © Mike Segar / Reuters
     
 
 




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How early colleges can make us rethink the separation of high school and postsecondary systems

The COVID-19 pandemic has caused a historic spike in unemployment insurance claims, and there is growing consensus that the economy is headed for a potentially deep and protracted recession. In the past, postsecondary credentials or degrees have helped mitigate the impact of an economic downturn. Of all new jobs created after the Great Recession, 99%…

       




stem

Our employment system has failed low-wage workers. How can we rebuild?

Surging unemployment claims show that our labor market, built for efficiency, can crumble in times of crisis at huge human and economic costs. The pandemic has exposed a weak point in the country’s economy: the precarity of low-wage workers. Many have adapted to unimaginable circumstances, risking their own well-being, implementing public health protocols, and keeping…

       




stem

COVID-19 has revealed a flaw in public health systems. Here’s how to fix it.

To be capable of surveilling, preventing, and managing disease outbreaks, public health systems require trustworthy, community-embedded public health workers who are empowered to undertake their tasks as professionals. The world has not invested in this cadre of health workers, despite the lessons from Ebola. In a new paper, my co-authors and I discuss why, and…

       




stem

The value of systemwide, high-quality data in early childhood education

High-quality early learning experiences—those filled with stimulating and supportive interactions between children and caregivers—can have long-lasting impacts for children, families, and society. Unfortunately, many families, particularly low-income families, struggle to find any affordable early childhood education (ECE) program, much less programs that offer engaging learning opportunities that are likely to foster long-term benefits. This post…

       




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A Congressional Oversight Office: A proposed early warning system for the United States Congress


A central function of the United States Congress is oversight of the executive branch. Congressional oversight, as exercised from the beginning of the nation, is an essential tool in making the separation of powers real by empowering Congress to check the executive. In recent years, however, as polarization has reached paralyzing levels, Congress has largely gotten out of the business of routine and prospective “police-patrol” oversight.  In the absence of the will and the capacity to do prospective oversight, Congress is at risk of losing its power to the executive branch and thus failing one of its most important constitutional roles.

This paper assesses whether or not anything can be done to get Congress back into the oversight business. Specifically, author Elaine Kamarck examines the following question: Assuming that future Congresses develop the political will to conduct oversight, do they have the capacity to do oversight of a large, modern, and complex executive branch?

As Kamarck illustrates, mismatched resources may make it difficult for Congress to resume its oversight function. The modern federal government is a complex and enormous enterprise. But as the executive branch has grown considerably over the past decades, Congress has adopted budget cuts that make the legislative branch less and less capable of undertaking the kinds of systemic oversight that can solve or prevent problems. Congress employs a mere 17,272 professional staff to oversee an executive branch consisting of 4.2 million civil servants and uniformed military. 

“The existing infrastructure that is supposed to help Congress be on top of the executive branch has fallen prey to a mindless dumbing down of Congress,” Kamarck states. She details the five entities that are meant to support Congress in its oversight role: committee staff, the Congressional Research Service, the Government Accountability Office, the Congressional Budget Office, and the Inspectors General, all of which are understaffed and under-budgeted. Kamarck recommends the first thing Congress should do to fix its oversight problem is to properly staff the agencies it already has and to stop nickel and diming and degrading its own capacity.

Furthermore, Kamarck calls for a “Congressional Oversight Office,” a body charged with evaluating governmental performance before a crisis arises. This office should be staffed by implementation professionals who can gather the signals from all the other oversight organizations annually and in sync with the budget cycle.

“Congress needs to get back into the business of productive executive branch oversight,” concludes Kamarck. A Congressional Oversight Office is certainly a step in that direction.

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Authors

Image Source: © Kevin Lamarque / Reuters