Amazon is offering up to 34 percent off Samsung monitors and tablets today. Plus, you can save on the Dell XPS 15 and pre-order Nintendo Switch Animal Crossing: New Horizons Edition.

The SA market is losing favour among international investors.

Roombas, Echo and Ring Alarm devices, and the Apple Watch Series 5 are all still discounted. There's also a great Nintendo Switch deal that includes $20 in Nintendo eShop credit.

Gold ETFs investors can exit only by selling to secondary market participants on the stock exchange.

Charges against US President Donald Trump’s first national security adviser, General Michael Flynn, have been dropped due to new evidence showing they were baseless. Flynn was the first to be targeted in the ‘Russiagate’ probe.
Read Full Article at RT.com

  Recently I was low on battery and needed to conserve it. So I decided to switch to 2G instead of 3G to save some precious minutes of battery. Also, I wanted to limit the data packets being sent and re...

There have been Latest developments for H-1B visa holders in the US in the matter of switching jobs. It deals with the issue of obtaining a new job similar to the old which requires similar skills.Specialty Occupation Clause The US Citizenship and…

This Metasploit module uses the FreeSWITCH event socket interface to execute system commands using the system API command. The event socket service is enabled by default and listens on TCP port 8021 on the local network interface. This module has been tested successfully on FreeSWITCH versions: 1.6.10-17-726448d~44bit on FreeSWITCH-Deb8-TechPreview virtual machine; 1.8.4~64bit on Ubuntu 19.04 (x64); and 1.10.1~64bit on Windows 7 SP1 (EN) (x64).

GNU SIP Witch is a pure SIP-based office telephone call server that supports generic phone system features like call forwarding, hunt groups and call distribution, call coverage and ring groups, holding, and call transfer, as well as offering SIP rver, or an IP-PBX, and does not try to emulate Asterisk, FreeSWITCH, or Yate.

GNU SIP Witch is a pure SIP-based office telephone call server that supports generic phone system features like call forwarding, hunt groups and call distribution, call coverage and ring groups, holding, and call transfer, as well as offering SIP rver, or an IP-PBX, and does not try to emulate Asterisk, FreeSWITCH, or Yate.

GNU SIP Witch is a pure SIP-based office telephone call server that supports generic phone system features like call forwarding, hunt groups and call distribution, call coverage and ring groups, holding, and call transfer, as well as offering SIP rver, or an IP-PBX, and does not try to emulate Asterisk, FreeSWITCH, or Yate.

GNU SIP Witch is a pure SIP-based office telephone call server that supports generic phone system features like call forwarding, hunt groups and call distribution, call coverage and ring groups, holding, and call transfer, as well as offering SIP rver, or an IP-PBX, and does not try to emulate Asterisk, FreeSWITCH, or Yate.

GNU SIP Witch is a pure SIP-based office telephone call server that supports generic phone system features like call forwarding, hunt groups and call distribution, call coverage and ring groups, holding, and call transfer, as well as offering SIP rver, or an IP-PBX, and does not try to emulate Asterisk, FreeSWITCH, or Yate.

GNU SIP Witch is a pure SIP-based office telephone call server that supports generic phone system features like call forwarding, hunt groups and call distribution, call coverage and ring groups, holding, and call transfer, as well as offering SIP rver, or an IP-PBX, and does not try to emulate Asterisk, FreeSWITCH, or Yate.

GNU SIP Witch is a pure SIP-based office telephone call server that supports generic phone system features like call forwarding, hunt groups and call distribution, call coverage and ring groups, holding, and call transfer, as well as offering SIP rver, or an IP-PBX, and does not try to emulate Asterisk, FreeSWITCH, or Yate.

GNU SIP Witch is a pure SIP-based office telephone call server that supports generic phone system features like call forwarding, hunt groups and call distribution, call coverage and ring groups, holding, and call transfer, as well as offering SIP rver, or an IP-PBX, and does not try to emulate Asterisk, FreeSWITCH, or Yate.

GNU SIP Witch is a pure SIP-based office telephone call server that supports generic phone system features like call forwarding, hunt groups and call distribution, call coverage and ring groups, holding, and call transfer, as well as offering SIP rver, or an IP-PBX, and does not try to emulate Asterisk, FreeSWITCH, or Yate.

GNU SIP Witch is a pure SIP-based office telephone call server that supports generic phone system features like call forwarding, hunt groups and call distribution, call coverage and ring groups, holding, and call transfer, as well as offering SIP rver, or an IP-PBX, and does not try to emulate Asterisk, FreeSWITCH, or Yate.

GNU SIP Witch is a pure SIP-based office telephone call server that supports generic phone system features like call forwarding, hunt groups and call distribution, call coverage and ring groups, holding, and call transfer, as well as offering SIP rver, or an IP-PBX, and does not try to emulate Asterisk, FreeSWITCH, or Yate.

GNU SIP Witch is a pure SIP-based office telephone call server that supports generic phone system features like call forwarding, hunt groups and call distribution, call coverage and ring groups, holding, and call transfer, as well as offering SIP rver, or an IP-PBX, and does not try to emulate Asterisk, FreeSWITCH, or Yate.

GNU SIP Witch is a pure SIP-based office telephone call server that supports generic phone system features like call forwarding, hunt groups and call distribution, call coverage and ring groups, holding, and call transfer, as well as offering SIP rver, or an IP-PBX, and does not try to emulate Asterisk, FreeSWITCH, or Yate.

EON SE is now supplying all of its 3.3 million residential customers in Britain with 100% renewable electricity, the first of the U.K.’s “Big Six” utilities to do so.

A significant step to develop the first megawatt from the marine hydrokinetic (MHK) Sotenas Wave Energy Plant off of Sweden’s west coast took place earlier this month when a 120-ton subsea generator switchgear was deployed and connected to the Swedish national power grid via a 10-km-long subsea cable.
 

When Ballarat-based Gekko Systems heard the local medical community was worried about access to ventilators needed to respond to the COVID-19 crisis, the company sprang into action.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

(MENAFN - CDN Newswire) The currently appended report by MarketsandResearch.biz with the title Global Mechanical Time Switches Market 2020 by Manufa... ......

The Nintendo Switch is out of stock everywhere, but the Switch Lite is much easier to find availability. Should you get a Switch Lite if you can't find the main model? It depends. ......

Game-maker sold 21 million of the console units in the year ended March, beating its own estimate and expectations of roughly 20 million.

KSZ8873MLLJ - Integrated 3-Port 10/100 Managed Switch with PHYs

ATA663431/54 LIN SBC including LIN Transceiver, FranVoltage Regulator, Window Watchdog and High-Side Switch

Japan's Nintendo Co Ltd said on Thursday its fourth-quarter profit soared 200% due to surging demand for its Switch games console, and that title Animal Crossing: New Horizons shifted a record 13.4 million units in its first six weeks.

Sentient machines with empathy and morality are coming. We urgently need to make some life-and-death decisions about their rights

Japan's Nintendo said Thursday it sold 21 million Switch units in the year ended March, smashing its forecast of 19.5 million units, with hit title Animal Crossing: New Horizons shifting 13.4 million units in its first six weeks. Ciara Lee reports

Title: Switch From U.S. to African Diet May Lower Colon Cancer Risk in Blacks
Category: Health News
Created: 4/28/2015 12:00:00 AM
Last Editorial Review: 4/29/2015 12:00:00 AM

Title: Could a Cellular Tweak Someday 'Switch Off' Gray Hair?
Category: Health News
Created: 4/28/2016 12:00:00 AM
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Title: Many Smokers Switch to Vaping While Pregnant, But Safety Issues Remain
Category: Health News
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Glycine riboswitches utilize both single- and tandem-aptamer architectures. In the tandem system, the relative contribution of each aptamer toward gene regulation is not well understood. To dissect these contributions, the effects of 684 single mutants of a tandem ON switch from Bacillus subtilis were characterized for the wild-type construct and binding site mutations that selectively restrict ligand binding to either the first or second aptamer. Despite the structural symmetry of tandem aptamers, the response to these mutations was frequently asymmetrical. Mutations in the first aptamer often significantly weakened the K_1/2, while several mutations in the second aptamer improved the amplitude. These results demonstrate that this ON switch favors ligand binding to the first aptamer. This is in contrast to the tandem OFF switch variant from Vibrio cholerae, which was previously shown to have preferential binding to its second aptamer. A bioinformatic analysis of tandem glycine riboswitches revealed that the two binding pockets are differentially conserved between ON and OFF switches. Altogether, this indicates that tandem ON switch variants preferentially utilize binding to the first aptamer to promote helical switching, while OFF switch variants favor binding to the second aptamer. The data set also revealed a cooperative glycine response when both binding pockets were maximally stabilized with three GC base pairs. This indicates a cooperative response may sometimes be obfuscated by a difference in the affinities of the two aptamers. This conditional cooperativity provides an additional layer of tunability to tandem glycine riboswitches that adds to their versatility as genetic switches.

Metabolism and development must be closely coupled to meet the changing physiological needs of each stage in the life cycle. The molecular mechanisms that link these pathways, however, remain poorly understood. Here we show that the Drosophila estrogen-related receptor (dERR) directs a transcriptional switch in mid-pupae that promotes glucose oxidation and lipogenesis in young adults. dERR mutant adults are viable but display reduced locomotor activity, susceptibility to starvation, elevated glucose, and an almost complete lack of stored triglycerides. Molecular profiling by RNA-seq, ChIP-seq, and metabolomics revealed that glycolytic and pentose phosphate pathway genes are induced by dERR, and their reduced expression in mutants is accompanied by elevated glycolytic intermediates, reduced TCA cycle intermediates, and reduced levels of long chain fatty acids. Unexpectedly, we found that the central pathways of energy metabolism, including glycolysis, the tricarboxylic acid cycle, and electron transport chain, are coordinately induced at the transcriptional level in mid-pupae and maintained into adulthood, and this response is partially dependent on dERR, leading to the metabolic defects observed in mutants. Our data support the model that dERR contributes to a transcriptional switch during pupal development that establishes the metabolic state of the adult fly.

Developer Mirari & Co. announced the science-fiction action platformer Dark Light for Windows PC via Steam Early Access on May 8 and later for the Nintendo Switch when the game leaves Steam Early Access. 

Mirari & Co. is looking to release the game within one year of the Steam Early Access release, however, it depends "on how we are taking players suggestions and advice to shaping the game."

View the latest trailer of the game below:

Here is an overview of the game:

Dark Light is a science-fiction action-platformer with unique gameplay. Explore an apocalyptic cyberpunk world full of supernatural beings. Encounter and defeat creatures of darkness invisible to the naked eye, detected only with the light source from your drone. Experience the horror and feel their presence as they surround you.

As a Dark Hunter you were dropped into a wreaked world. To survive, you need to equip yourself, fight your way through, and collect ‘shards’ from killing supernatural creatures to reinforce your energy. Through survival, you will explore the mysterious dark zones of the apocalypse world.

Key Features:

• Cinematic quality graphic, detailed characters and environment design, and vivid animation with lush visual effect.
• A variety of range, melee, and throwable weapons; unique items; and multiple ways to upgrade weapons, special equipment, and the player to shape your own character skills.
• Non-linear map structure for you to choose your own path to explore the dark zones. Encounter horrifying supernatural enemies, fearsome bosses, and friendly NPCs, and fight with invisible creatures that can only be seen in a special light source.
• Detect invisible enemies and reveal hidden paths with the special light source from your drone.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/443411/sci-fi-action-platformer-dark-light-launches-may-8-for-steam-early-access-later-for-switch/