The most aerodynamic car ever to wear a Volkswagen emblem on its nose isn't the newest Golf GTI or an ID-badged electric model. It's a forward-thinking prototype named Aerodynamic Research Volkswagen (ARVW) developed and built in 1980 in response to the oil shortages that rocked the global economy in the 1970s. Volkswagen initiated the project because it wanted to learn more about aerodynamics and fuel efficiency.

Don't take it to the bank, but it is starting to look like the last flakes have flown across much of Colorado for the winter.

(US 2nd Circuit) - 19-1058-cv

Don't take it to the bank, but it is starting to look like the last flakes have flown across much of Colorado for the winter.

Hearing loss caused by the death of sensory hair cells of the inner ear is an unfortunate side effect for many patients treated with aminoglycoside antibiotics or platinum-containing chemotherapy agents. In animal models, induction of heat shock confers substantial otoprotection against aminoglycoside- and cisplatin-induced hair cell death. In this issue of the JCI, Breglio et al. demonstrate that inner ear tissue released exosomes carrying heat shock protein 70 (HSP70) in response to heat stress. HSP70 acted by a paracrine mechanism that engaged the Toll-like receptor 4 (TLR4) on hair cells to protect them from death. Exosomes and the HSP70/TLR4 pathway could thus provide treatment targets for the protection of hair cells from chemically induced death or from other insults, such as noise.

Curing HIV infection will require the elimination of a reservoir of infected CD4+ T cells that persists despite HIV-specific cytotoxic T cell (CTL) responses. Although viral latency is a critical factor in this persistence, recent evidence also suggests a role for intrinsic resistance of reservoir-harboring cells to CTL killing. This resistance may have contributed to negative outcomes of clinical trials, where pharmacologic latency reversal has thus far failed to drive reductions in HIV reservoirs. Through transcriptional profiling, we herein identified overexpression of the prosurvival factor B cell lymphoma 2 (BCL-2) as a distinguishing feature of CD4+ T cells that survived CTL killing. We show that the inducible HIV reservoir was disproportionately present in BCL-2hi subsets in ex vivo CD4+ T cells. Treatment with the BCL-2 antagonist ABT-199 was not sufficient to drive reductions in ex vivo viral reservoirs when tested either alone or with a latency-reversing agent (LRA). However, the triple combination of strong LRAs, HIV-specific T cells, and a BCL-2 antagonist uniquely enabled the depletion of ex vivo viral reservoirs. Our results provide rationale for novel therapeutic approaches targeting HIV cure and, more generally, suggest consideration of BCL-2 antagonism as a means of enhancing CTL immunotherapy in other settings, such as cancer.

Systemic sclerosis (SSc) is an autoimmune fibrotic disease whose pathogenesis is poorly understood and lacks effective therapies. We undertook quantitative analyses of T cell infiltrates in the skin of 35 untreated patients with early diffuse SSc and here show that CD4+ cytotoxic T cells and CD8+ T cells contribute prominently to these infiltrates. We also observed an accumulation of apoptotic cells in SSc tissues, suggesting that recurring cell death may contribute to tissue damage and remodeling in this fibrotic disease. HLA-DR–expressing endothelial cells were frequent targets of apoptosis in SSc, consistent with the prominent vasculopathy seen in patients with this disease. A circulating effector population of cytotoxic CD4+ T cells, which exhibited signatures of enhanced metabolic activity, was clonally expanded in patients with systemic sclerosis. These data suggest that cytotoxic T cells may induce the apoptotic death of endothelial and other cells in systemic sclerosis. Cell loss driven by immune cells may be followed by overly exuberant tissue repair processes that lead to fibrosis and tissue dysfunction.

Millions of consumers depend on The Weather Channel and weather.com for their daily forecasts, breaking weather news, and the latest in health and travel. And, on August 21, they will be able to experience a solar eclipse like never before. The Weather Channel digital properties and Twitter have teamed up for a live stream of this once-in-a lifetime celestial event, which will allow consumers to chase the total solar eclipse in real time as it moves from coast-to-coast.

• Con vigencia de 10 años, Banorte e IBM firman alianza estratégica que permitirá establecer las bases de un nuevo modelo de banca enfocado al cliente, y mejorar sustancialmente sus índices de eficiencia para alcanzar niveles cercanos al 40%, así como retornos sobre capital superiores al 20%. El acuerdo incluye servicios de consultoría y de tecnología, investigación y desarrollo. • “Estamos plenamente satisfechos con el acuerdo logrado, pues este suma el mejor talento humano, tanto de IBM, como de Banorte Ixe, y está en línea con nuestra búsqueda de herramientas tecnológicas para servir a nuestros clientes de manera individualizada”: Alejandro Valenzuela.

There's a new addition to the Starfighter Shop: custom tote bags! These 12 oz. cotton canvas deluxe totes feature a screen print of a brand new illustration. Measures 14"x13", perfect for carrying comics and showing your Starfighter love! On sale now!

Also, Starfighter Chapeter 02: Page 39 has just been posted! Thank you all so much! -HamletMachine

Kvůli koronavirové pandemii lze očekávat silnou recesi. Česká národní banka proto v březnu dvakrát snížila základní úrokovou sazbu z 2,25 procenta na jedno procento. Některé banky na to už zareagovaly razantním snižováním úrokových sazeb na spořicích účtech, což zamíchalo žebříčkem nejlepších spořicích účtů. Ve spolupráci s Finparádou jsme zmapovali aktuální trend a sestavili nový žebříček.

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1. Covid-19 Delhi latest figures- 224 new cases take capital’s total to 8,630, India tally at 59,662  Hindustan Times
2. Confusion over Delhi's Covid-19 toll as govt data, figures from hospitals don't match  Times of India
3. 3 More Private Hospitals To Treat COVID-19 Patients In Delhi  NDTV
4. Delhi Covid-19 tally tops 6,000 with 338 new cases in last 24 hours  Livemint
5. 100 rooms in Delhi's five-star hotels now hospitals  Times of India
6. View Full coverage on Google News

Minister Muylle wil tijdelijke werkloosheid verlengen tot 1 ...  Het NieuwsbladHele verhaal bekijken via Google Nieuws

Becky Lynch has become the Superstar with the most total days as Raw Women’s Champion, surpassing Alexa Bliss.

Last night's democratic debate in Nevada got pretty damn spicy to say the least. So much so that many are calling it the most entertaining debate of the election cycle so far. Pete spoke Spanish, Warren (and every other candidate, for that matter) came out swinging against Bloomberg, and many, many other things that warranted a monumental cringe fest. 

So please enjoy the following roast-y memes from the night and you can watch a more in-depth recap of it here!

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The Spring Sale is now here with fresh offers across a range of top content! Don't forget, Epic Coupons acquired in our Holiday Sale are expiring May 1, 2020 2:59am EST and able to be used on any eligible purchase $14.99 or above!

Spring Sale - ends 4/16