Saturation of Pilibhit Tiger Reserve with an increasing population of tigers has resulted in man-animal conflicts in the area.

Winds are from the West at 12.7 gusting to 28.8 MPH (11 gusting to 25 KT). The pressure is 1013.2 mb and the humidity is 54%. The wind chill is 29. Last Updated on May 9 2020, 11:53 am EDT.

Winds are from the West at 23.0 gusting to 28.8 MPH (20 gusting to 25 KT). The pressure is 1010.8 mb and the humidity is 49%. The wind chill is 21. Last Updated on May 9 2020, 11:56 am EDT.

Winds are from the Northwest at 15.0 gusting to 24.2 MPH (13 gusting to 21 KT). The pressure is 1011.5 mb and the humidity is 52%. The wind chill is 23. Last Updated on May 9 2020, 11:53 am EDT.

Winds are from the West at 12.7 gusting to 20.7 MPH (11 gusting to 18 KT). The humidity is 75%. The wind chill is 22. Last Updated on May 9 2020, 11:55 am EDT.

Winds are from the Northwest at 17.3 gusting to 31.1 MPH (15 gusting to 27 KT). The pressure is 1014.7 mb and the humidity is 55%. The wind chill is 29. Last Updated on May 9 2020, 11:54 am EDT.

Winds are from the Northwest at 11.5 gusting to 25.3 MPH (10 gusting to 22 KT). The pressure is 1013.0 mb and the humidity is 52%. The wind chill is 31. Last Updated on May 9 2020, 11:53 am EDT.

Winds are from the West at 13.8 gusting to 21.9 MPH (12 gusting to 19 KT). The humidity is 64%. The wind chill is 19. Last Updated on May 9 2020, 11:55 am EDT.

Winds are from the West at 27.6 gusting to 35.7 MPH (24 gusting to 31 KT). The pressure is 1010.6 mb and the humidity is 50%. The wind chill is 25. Last Updated on May 9 2020, 11:53 am EDT.

Tomorrow, September 6, 2019, Haskell XC will compete in Bearcat open against Northwest MIssouri State!

I'm trying to re-install ORCAD 17.2  in a PC from a DVD which I have upgraded from Win 7 to Win 10 and  now has a new 500GB SSD. While installing I got a Windows Application Error  0xc000007b. When I try to run ORCAD I get the same Error.

Looking for ways to fix this problem.

Hello All,

I'm currently using OrCAD PCB Designer Professional w/ PSpice (version 16.6-2015).  In the 'Design Object Find Filter' side bar, all options are grayed out and unselectable.  I did attempt to 'Reset UI to Cadence Default' without any luck.  A colleague has no issues with the identical file on his computer.  Any guidance would be much appreciated.  Thanks!

George

Hi There,

The variant bom I set gone dissapear. Is there any way to recover this back from the old design file? 

This is the second time it happen to me. Not really sure what could cause this. 

Thanks,

Pornchai

AV Arcade version 3 suffers from insecure cookie and SQL injection vulnerabilities.

AV Arcade Pro version 5.4.3 suffers from an insecure cookie vulnerability that allows for access bypass.

Supercars may push automotive design and engineering to the extreme, but they still need to follow the same regulations as ordinary sedans and crossovers. Making a supercar street legal is the hardest part of the development process, Christian von Koenigsegg said in a recent interview with Apex One. Here's why that is so hard. While regulations...

France defender Samuel Umtiti has picked up a calf injury in just the second session since Barcelona returned to training from the coronavirus quarantine, the Spanish champions announced on Saturday. Barca said that Umiti picked up an injury to his right calf during Saturday’s training session at the club’s Joan Gamper facility, but did not
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The post Barca’s Samuel Umtiti suffers calf knock in second training session appeared first on Vanguard News.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

Auteur d'une excellente saison avec le RB Leipzig, Dayot Upamecano est tr�s convoit� sur le march�. ......

The 26-year-old joined Barca from Lyon in 2016.

Bomet Governor, Isaac Ruto was airlifted to Nairobi Hospital on Monday morning after clashing with police officers.

An alligator carcass dropped in the deep ocean reveals the bizarre ecosystems of the seabed - including zombie worms that fed on prehistoric reptiles

An alligator carcass dropped in the deep ocean reveals the bizarre ecosystems of the seabed - including zombie worms that fed on prehistoric reptiles

A number of partial articulated specimens of Cheiracanthus peachi nov. sp. have been collected from the Mey Flagstone Formation and Rousay Flagstone Formation within the Orcadian Basin of northern Scotland. The new, robust-bodied species is mainly distinguished by the scale ornament of radiating grooves rather than ridges. Compared to other Cheiracanthus species in the Orcadian Basin, C. peachi nov. sp. has quite a short range making it a useful zone fossil. As well as describing the general morphology of the specimens, we have also described and figured SEM images of scales and histological sections of all elements, enabling identification of other, isolated remains. Of particular biological interest is the identification of relatively robust, tooth-like gill rakers. Finally, the species has also been identified from isolated scales in Belarus, where it appears earlier and has a longer stratigraphical range, implying the species evolved in the marine deposits of the east and migrated west into the Orcadian Basin via the river systems.

In plants, water use efficiency (WUE) is a complex trait arising from numerous physiological and developmental characteristics. Here, we investigated the involvement of circadian regulation in long-term WUE in Arabidopsis (Arabidopsis thaliana) under light and dark conditions. Circadian rhythms are generated by the circadian oscillator, which provides a cellular measure of the time of day. In plants, the circadian oscillator contributes to the regulation of many aspects of physiology, including stomatal opening, rate of photosynthesis, carbohydrate metabolism, and developmental processes such as the initiation of flowering. We investigated the impact of the misregulation of numerous genes encoding various components of the circadian oscillator on whole plant, long-term WUE. From this analysis, we identified a role for the circadian oscillator in WUE. It appears that the circadian clock contributes to the control of transpiration and biomass accumulation. We also established that the circadian oscillator within guard cells can contribute to long-term WUE. Our experiments indicate that knowledge of circadian regulation will be important for developing crops with improved WUE.

Dependence of drug metabolism on dosing time has long been recognized. However, only recently are the underlying mechanisms for circadian drug metabolism being clarified. Diurnal rhythmicity in expression of drug-metabolizing enzymes is believed to be a key factor determining circadian metabolism. Supporting the notion that biological rhythms are generated and maintained by the circadian clock, a number of diurnal enzymes are under the control of the circadian clock. In general, circadian clock genes generate and regulate diurnal rhythmicity in drug-metabolizing enzymes via transcriptional actions on one or two of three cis-elements (i.e., E-box, D-box, and Rev-erb response element or RAR-related orphan receptor response element). Additionally, cycling or clock-controlled nuclear receptors such as hepatocyte nuclear factor 4α and peroxisome proliferator–activated receptor are contributors to diurnal enzyme expression. These newly discovered mechanisms for each of the rhythmic enzymes are reviewed in this article. We also discuss how the rhythms of enzymes are translated to circadian pharmacokinetics and drug chronotoxicity, which has direct implications for chronotherapeutics. Our discussion is also extended to two diurnal transporters (P-glycoprotein and multidrug resistance-associated protein 2) that have an important role in drug absorption. Although the experimental evidence is lacking in metabolism-based chronoefficacy, circadian genes (e.g., Rev-erbα) as drug targets are shown to account for diurnal variability in drug efficacy.

3-Mercaptopyruvate sulfur transferase (MPST) catalyzes the desulfuration of 3-mercaptopyruvate (3-MP) and transfers sulfane sulfur from an enzyme-bound persulfide intermediate to thiophilic acceptors such as thioredoxin and cysteine. Hydrogen sulfide (H2S), a signaling molecule implicated in many physiological processes, can be released from the persulfide product of the MPST reaction. Two splice variants of MPST, differing by 20 amino acids at the N terminus, give rise to the cytosolic MPST1 and mitochondrial MPST2 isoforms. Here, we characterized the poorly-studied MPST1 variant and demonstrated that substitutions in its Ser–His–Asp triad, proposed to serve a general acid–base role, minimally affect catalytic activity. We estimated the 3-MP concentration in murine liver, kidney, and brain tissues, finding that it ranges from 0.4 μmol·kg−1 in brain to 1.4 μmol·kg−1 in kidney. We also show that N-acetylcysteine, a widely-used antioxidant, is a poor substrate for MPST and is unlikely to function as a thiophilic acceptor. Thioredoxin exhibits substrate inhibition, increasing the KM for 3-MP ∼15-fold compared with other sulfur acceptors. Kinetic simulations at physiologically-relevant substrate concentrations predicted that the proportion of sulfur transfer to thioredoxin increases ∼3.5-fold as its concentration decreases from 10 to 1 μm, whereas the total MPST reaction rate increases ∼7-fold. The simulations also predicted that cysteine is a quantitatively-significant sulfane sulfur acceptor, revealing MPST's potential to generate low-molecular-weight persulfides. We conclude that the MPST1 and MPST2 isoforms are kinetically indistinguishable and that thioredoxin modulates the MPST-catalyzed reaction in a physiologically-relevant concentration range.

A 40-year-old, male non-smoker was diagnosed with asthma 6 years ago. He now presents with a 1-week history of worsening breathlessness with fever, cough, and purulent expectoration. He has had >10 emergency department visits and two admissions to hospital in the last 3 months. At each admission, he received bronchodilators and systemic steroids resulting in rapid improvement within 24 h. However, in the current presentation, the patient has no relief with corticosteroids and bronchodilators. His pulse is 140 per min, respiratory rate is 40 per min, blood pressure is 90/60 mmHg and room air oxygen saturation is 80%. Arterial blood gas (ABG) analysis shows hypercapnic respiratory failure. In view this respiratory failure, the patient is intubated and mechanical ventilation initiated. A chest radiograph is shown in figure 1. The therapy initiated includes bronchodilators, a systemic steroid, antibiotics and supportive care.

BACKGROUND AND PURPOSE:

Endovascular treatment of petrous dural AVFs may carry a risk of iatrogenic facial nerve palsy if the facial nerve arterial arcade, an anastomotic arterial arch that supplies the geniculate ganglion, is not respected or recognized. Our purpose was to demonstrate that the use of a treatment strategy algorithm incorporating detailed angiographic anatomic assessment allows identification of the facial nerve arterial arcade and therefore safe endovascular treatment.

A new study y reveals surprising findings about the function of circadian network neurons that undergo daily structural change. The research could lead to a better understanding of how to address circadian rhythm disruptions in humans and facilitate preventing a host of associated health problems, including increased risk for cancer and metabolic syndrome.

Donations flood in for Margaret Payne's NHS money-raiser as she attempts to mimick a summit of Suilven by making 282 trips upstairs

Donald Trump has said his remarks on injecting disinfectant to treat coronavirus were "sarcastic".

From Matilda the Hun to the first fleet, test your knowledge with the Weekend quiz

1 Which South American was the world’s first female president?
2 What was the destination of the First Fleet?
3 Who lived at 308 Negra Arroyo Lane, Albuquerque?
4 Which epic poem is based on the Battle of Roncevaux?
5 What animal is a sarcastic fringehead?
6 What German car was last made in Mexico in 2019?
7 Pollex is the medical name for what part of the body?
8 Thomas Neuwirth won Eurovision under what stage persona?
What links:
9 Norwich; Newlyn; St Ives; Camden Town; Bloomsbury?
10 Platypus and four species of echidna?
11 Renren; QQ; Sina Weibo; WeChat?
12 Sydenstricker; Stearns; Staples; Surajprasad?
13 Colonel Ninotchka; Mt Fiji; Zelda the Brain; Matilda the Hun?
14 Harmost; satrap; voivode; bey; subahdar?
15 Ridley Scott; James Cameron; David Fincher; Jean-Pierre Jeunet?

Would Kourtney Kardashian have apologized to Kim Kardashian if they didn't have their Armenia trip planned? That very question was addressed in this bonus clip from season 18 of...

Cornwall was considered as a new location for the 2020 series

Hello gentle readers, and welcome to the SwitchArcade Round-Up for May 7th, 2020. Like most Thursdays, today is mostly about …

Continue reading "SwitchArcade Round-Up: ‘Mortal Kombat 11: Aftermath’ Coming May 26th, ‘Slayin 2’ and Today’s Other New Releases, the Latest Sales, and More"

Last week, Apple brought another game to the service in the form of Neversong () from Serenity Forge. Today, we …

Continue reading "Turn Based RPG ‘The Otherside’ from The Label Is This Week’s Apple Arcade Addition"

Hello gentle readers, and welcome to the SwitchArcade Round-Up for May 8th, 2020. Today was basically a nightmare scenario for …

Continue reading "SwitchArcade Round-Up: ‘Fury Unleashed’, ‘Stone’, and Today’s Other New Releases, the Latest Sales Featuring ‘Saints Row IV’ and More"

The idea behind the TouchArcade Game of the Week is that every Friday afternoon we post the one game that …

Continue reading "TouchArcade Game of the Week: ‘Juicy Realm’"

Would Kourtney Kardashian have apologized to Kim Kardashian if they didn't have their Armenia trip planned? That very question was addressed in this bonus clip from season 18 of...

Would Kourtney Kardashian have apologized to Kim Kardashian if they didn't have their Armenia trip planned? That very question was addressed in this bonus clip from season 18 of...

Messi won FIFA's Best Player of the Year award in 2019, as well as his sixth Ballon d'Or, though Barcelona have not achieved the same level of success in recent years that they did on Guardiola's watch

Supercar engineers are taking their skills from the racetrack to the ICU ward by creating a ventilator prototype to help during the coronavirus crisis.

The United States has obtained a $10 million consent judgment against Intercare Health Systems Inc., formerly doing business as City of Angels Medical Center, for a Medicare and Medi-Cal fraud scheme in Los Angeles.