A special state panel in Wisconsin has rejected a financially strapped district's request to dissolve.

A collection of stories from the previous week that you may have missed.

The state's board voted not to open the Common Core to revision, but its commissioner still plans to review them informally, with an eye to future changes.

New Hampshire's education commissioner nominee Frank Edelblut, a businessman, Republican and school choice proponent, has been criticized throughout the state for his lack of education experience.

A collection of articles from this week that you may have missed.

Former Republican Missouri Gov. Eric Greitens appointed enough board members to have Commissioner Margie Vandeven fired last year, but now that he's gone, the state board decided to hire her back.

The search for Missouri's next top education official has begun nearly 10 months after the last one was fired. The state board of education began accepting applications last week.

The state's incoming governor and education commissioner both are former teachers. They face battles over school accountability, funding and the achievement gap between white and minority students.

State Education Secretary Rebecca Holcombe has been officiating over the state's politically thorny district consolidation process, and many are asking for it to be placed on hold until the state board replaces her.

Alaskan schooling developed on many fronts. An illustrated timeline adds historical context for the growth of the state's education system, from the territory’s earliest Native inhabitants to today.

A collection of stories from the week that you may have missed.

A collection of stories from the week that you may have missed.

A collection of articles from this week that you may have missed.

In a case that has drawn the involvement of the Trump administration, a federal judge holds that state rules limiting in-person instruction are not infringing on federal constitutional rights.

A collection of short news stories from the last week.

A collection of stories you may have missed.

Fadel Zeidan
Nov 18, 2015; 35:15307-15325
BehavioralSystemsCognitive

Neuronal cytotoxic edema is implicated in neuronal injury and death, yet mitigating brain edema with osmotic and surgical interventions yields poor clinical outcomes. Importantly, neuronal swelling and its downstream consequences during early brain development remain poorly investigated, and new treatment approaches are needed. We explored Ca²⁺-dependent downstream effects after neuronal cytotoxic edema caused by diverse injuries in mice of both sexes using multiphoton Ca²⁺ imaging in vivo [Postnatal Day (P)12–17] and in acute brain slices (P8–12). After different excitotoxic insults, cytosolic GCaMP6s translocated into the nucleus after a few minutes in a subpopulation of neurons, persisting for hours. We used an automated morphology-detection algorithm to detect neuronal soma and quantified the nuclear translocation of GCaMP6s as the nuclear to cytosolic intensity (N/C ratio). Elevated neuronal N/C ratios occurred concurrently with persistent elevation in Ca²⁺ loads and could also occur independently from neuronal swelling. Electron microscopy revealed that the nuclear translocation was associated with the increased nuclear pore size. The nuclear accumulation of GCaMP6s in neurons led to neocortical circuit dysfunction, mitochondrial pathology, and increased cell death. Inhibiting calpains, a family of Ca²⁺-activated proteases, prevented elevated N/C ratios and neuronal swelling. In summary, in the developing brain, we identified a calpain-dependent alteration of nuclear transport in a subpopulation of neurons after disease-relevant insults leading to long-term circuit dysfunction and cell death. The nuclear translocation of GCaMP6 and other cytosolic proteins after acute excitotoxicity can be an early biomarker of brain injury in the developing brain.

Senior staff at FAO yesterday briefed a delegation of five U.S. Senators on FAO’s work on resilience, nutrition, fisheries, climate change, [...]

26 October 2022, 09.00-16.00 (CEST)

Water is a fundamental resource enabling the production of over 95% of food on land as well the progress of all sustainable development goals [...]

In this episode, the FAO Food Price Index eased in February, driven mostly by lower cereal prices; FAO calls for restoration of humanitarian space to eliminate the risk of famine [...]

In this episode, FAO is distributing fodder to vulnerable families in Gaza to enhance food production to alleviate the catastrophic food security situation; FAO calls for urgent action to prevent [...]

In this episode, FAO calls for more funding and resources for farmers in Sudan to prevent the escalation of the hunger crisis; FAO’s Director-General emphasized Africa’s potential for development at [...]

In this episode, over 282 million people in 59 countries suffered acute food insecurity in 2023, according to the Global Report on Food Crises; FAO warns about the food insecurity [...]

In this episode, high levels of acute food insecurity in Honduras; FAO’s Regional Conference for Europe; and Earth Map receives the Google impact award.

Deteriorating food insecurity in Haiti, The King Hassan II Great World Water Prize; and an updated action plan for mainstreaming biodiversity. 

In this episode, a new report urges immediate action to prevent famine in Gaza and the Sudan; world fisheries and aquaculture production reaches a record high; and the FPI [...]

In this episode, FAO calls for urgent funding to prevent further starvation and suffering in Haiti; FAO’s Director-General underscores that the world should step up efforts and cooperation to tackle [...]

In this episode, FAO welcomed the 'Pact for the Future' in New York, International Food Loss and Waste Day, and an atlas to combat livestock disease.

In this episode, FAO urges immediate access to Gaza; the UN Climate Summit ; the fourth annual World Food Forum 

Uncover the bittersweet story of this ancient treat. Read more at https://www.smithsonianmag.com/arts-culture/a-brief-history-of-chocolate-21860917/

Book-banning might seem like a relic of less enlightened times, but the practice is back in a big way. The American Library Association reports (https://www.smithsonianmag.com/smart-news/american-library-association-names-2022s-most-banned-books-180982048/) that 2022 saw more attempts to have books removed from public libraries than in any prior year this century — indeed, it documented more than twice as many attempted bans in 2022 than in 2021. In schools, attempts to keep certain books out of the hands of students have been even more aggressive and draconian. What’s new about these efforts is the subject that binds the most-challenged titles: Most of them address themes of LGBT+ identity or gender expression. In this episode, we talk with journalist Colleen Connolly about Thomas Morton’s New English Canaan, the first book ever to be suppressed in North America. What did the Puritans find so threatening about it, and how has this book echoed through subsequent centuries? Then we’re joined by Dr. Carla Hayden, Librarian of Congress, for a wide-ranging conversation about the history of book bans in the United States, how a resurgent wave of book bans in many states differs from those of prior eras, and why organized attempts to prevent specific people from reading specific books usually fail. A transcript of this episode can be found here (http://smithsonianmag.com/history/a-brief-history-of-banned-books-in-america-180983011) . Read Colleen’s Smithsonian story about New English Canaan here (https://www.smithsonianmag.com/history/how-americas-first-banned-book-survived-and-became-an-anti-authoritarian-icon-180982971/) . Find prior episodes of our show here (https://www.smithsonianmag.com/podcast/) . There’s More to That is a production of Smithsonian magazine and PRX Productions. From the magazine, our team is Chris Klimek, Debra Rosenberg and Brian Wolly. From PRX, our team is Jessica Miller, Adriana Rosas Rivera, Genevieve Sponsler, Terence Bernardo, and Edwin Ochoa. The Executive Producer of PRX Productions is Jocelyn Gonzales. Fact-checking by Stephanie Abramson. Episode artwork by Emily Lankiewicz. Music by APM Music.

Read more about FDR at http://www.smithsonianmag.com/arts-culture/From-the-Castle-FDRs-Stamps.html A stamp collector since childhood, Franklin Roosevelt designed postage stamps to help promote his presidential agenda.

Investigators discovered that the original print of "The Roaring Lion" had been sold to a buyer in Italy

Officials launched an investigation and recovered the $360,000 print less than a week after it vanished from Grove Gallery. Two men have been charged for the crime

A clinical social worker explains the vital role of the old-fashioned rotary phone for those dealing with death and loss

Hospice Northwest Services is inviting people to visit its third annual photography exhibit, "A Personal Lens on Grief." Here's what the project in Thunder Bay, Ont., entails, and why staff say it's important to find creative ways to express loss.

There is a sign of progress in the effort toward four-laning the final section of Highway 69 that links northern Ontario to the southern part of the province, and improving the safety of the heavily-travelled route.

The re-elected chief of the Tk'emlúps te Secwépemc First Nation says she's hoping to forge connections within her community as she looks ahead to her next term.

Chief Financial Officer Lynne Fitzpatrick Appointed to President and CFO Chief Operating Officer Julie Holzrichter to Step Down and Assume Advisory Role Suzanne Sprague to Succeed Holzrichter CHICAGO,

Product, company, and customers earn additional recognition

Neil Diamond, the president of the SA Chamber of Commerce in the US, said that South Africans with plans for the US should act now

An unexpected connection on a prayer walk leads to multiple opportunities to share spiritual truth with one Muslim family.

A Ukrainian pastor responds to nearly 100 per cent unemployment in his village by starting biofuel and cash crop business enterprises.

A worker shares a story about becoming the fragrance of Christ as she and a team member wash the feet of a local village chief.

A report suggests that the $2.5 billion program should focus more on continuous improvement than on scattershot activities.

A collection of news stories from this week.

A woman whose home was damaged by the tsunami accepts Christ after witnessing the lives and attitudes of the volunteers working in her house.

OM Japan feels honoured to have played a small part in helping bring hope and relief to tsunami survivors.