The Union Cabinet today approved the first step towards the Bharatiya Antariksh Station.

Agrochemical makers have seen sales of herbicides going up this kharif season, even though the offtake in other categories such as insecticides and fungicides were muted

Chemjobber on when hoarding chemicals and lab equipment becomes a problem

Pankaj Advani edged closer to his 28th World title, securing a spot in the final of the IBSF World Billiards Championship with a 4-2 win over fellow Indian Sourav Kothari.

The CBDT (Central Board of Direct Taxes) has extended the period of re-registering charitable and religious trusts under the Finance Act 2020 to 1 October. In the view of the unprecedented outbreak of COVID-19 that has caused a humanitarian and economic

The CBDT (Central Board of Direct Taxes) has extended the period of re-registering charitable and religious trusts under the Finance Act 2020 to 1 October. In the view of the unprecedented outbreak of COVID-19 that has caused a humanitarian and economic

At the first sign of trouble, one should exit credit risk funds: Arvind Chari, Head - Fixed Income and Alternatives, Quantum Advisors

Production from PSCs now stands around 30% share of domestic oil, 20% of natural gas

Eminent historian Hari Shankar Vasudevan died at a private hospital here on Sunday. He was 68. Vasudevan had tested positive for novel coronavirus o

Supriyo has shared the picture on May 8, claiming that if Sinha and Banerjee are together then it "raises many questions".

Although a robust inflammatory response is needed to combat infection, this response must ultimately be terminated to prevent chronic inflammation. One mechanism that terminates inflammatory signaling is the production of alternative mRNA splice forms in the Toll-like receptor (TLR) signaling pathway. Whereas most genes in the TLR pathway encode positive mediators of inflammatory signaling, several, including that encoding the MyD88 signaling adaptor, also produce alternative spliced mRNA isoforms that encode dominant-negative inhibitors of the response. Production of these negatively acting alternatively spliced isoforms is induced by stimulation with the TLR4 agonist lipopolysaccharide (LPS); thus, this alternative pre-mRNA splicing represents a negative feedback loop that terminates TLR signaling and prevents chronic inflammation. In the current study, we investigated the mechanisms regulating the LPS-induced alternative pre-mRNA splicing of the MyD88 transcript in murine macrophages. We found that 1) the induction of the alternatively spliced MyD88 form is due to alternative pre-mRNA splicing and not caused by another RNA regulatory mechanism, 2) MyD88 splicing is regulated by both the MyD88- and TRIF-dependent arms of the TLR signaling pathway, 3) MyD88 splicing is regulated by the NF-κB transcription factor, and 4) NF-κB likely regulates MyD88 alternative pre-mRNA splicing per se rather than regulating splicing indirectly by altering MyD88 transcription. We conclude that alternative splicing of MyD88 may provide a sensitive mechanism that ensures robust termination of inflammation for tissue repair and restoration of normal tissue homeostasis once an infection is controlled.

Actinobacillus pleuropneumoniae (App) is the etiological agent of acute porcine pneumonia and responsible for severe economic losses worldwide. The capsule polymer of App serotype 1 (App1) consists of [4)-GlcNAc-β(1,6)-Gal-α-1-(PO4-] repeating units that are O-acetylated at O-6 of the GlcNAc. It is a major virulence factor and was used in previous studies in the successful generation of an experimental glycoconjugate vaccine. However, the application of glycoconjugate vaccines in the animal health sector is limited, presumably because of the high costs associated with harvesting the polymer from pathogen culture. Consequently, here we exploited the capsule polymerase Cps1B of App1 as an in vitro synthesis tool and an alternative for capsule polymer provision. Cps1B consists of two catalytic domains, as well as a domain rich in tetratricopeptide repeats (TPRs). We compared the elongation mechanism of Cps1B with that of a ΔTPR truncation (Cps1B-ΔTPR). Interestingly, the product profiles displayed by Cps1B suggested processive elongation of the nascent polymer, whereas Cps1B-ΔTPR appeared to work in a more distributive manner. The dispersity of the synthesized products could be reduced by generating single-action transferases and immobilizing them on individual columns, separating the two catalytic activities. Furthermore, we identified the O-acetyltransferase Cps1D of App1 and used it to modify the polymers produced by Cps1B. Two-dimensional NMR analyses of the products revealed O-acetylation levels identical to those of polymer harvested from App1 culture supernatants. In conclusion, we have established a protocol for the pathogen-free in vitro synthesis of tailored, nature-identical App1 capsule polymers.

Ravi Zacharias (date: 5/10/2020 - Rank: 6)

Logos Hope crew members share the Gospel in a hair salon with someone who has never before heard about Jesus.

Three patients in a hospital for drug addicts pray a prayer of repentance after hearing testimonies from students in OM Russia’s missions school.

Mikael from Norway is 18 years old and passionate for Jesus. Recently he shared his faith during a sports outreach in London.

OM workers use London charity shop to reach out to surrounding Turkish and Kurdish communities.

Workers with support roles in OM's Near East Field -Lebanon, Jordan, Syria and Iraq - find opportunities to engage locals and share truth with friends.

A long-time resident of Trench Town, Donnette Dowe has seen the trials of urban life up-close and personal. Like many inner-city Jamaican communities, crime, teen pregnancy and poverty are rife.The 50-year-old mother of five children (ages 26, 24, 21, 16 and 12) is director and tour manager for Trench Town Culture Yard, a renovated tenement which was once home to Bob Marley and his family.

Small outreach teams will share the life-changing message of the gospel with hundreds of women in brothels and on the street this Easter.

Small outreach teams will share the life-changing message of the gospel with hundreds of women in brothels and on the street this Easter.

Small outreach teams will share the life-changing message of the gospel with hundreds of women in brothels and on the street this Easter.

The A.J. and Sigismunda Palumbo Charitable Trust has committed an additional $50,000 to a scholarship fund that will help students earn an education at Penn State DuBois. The Palumbo Scholarship at Penn State DuBois was established in 2008 with a $25,000 gift from the Palumbo Charitable Trust. To date, the trust has gifted more than $525,000 to campus scholarship funds.

Personal friendships combined with special events prove effective in sharing Christ with Belgians.

Small outreach teams will share the life-changing message of the gospel with hundreds of women in brothels and on the street this Easter.

Small outreach teams will share the life-changing message of the gospel with hundreds of women in brothels and on the street this Easter.

The sale of fertilisers shot up by 45.1 per cent on-year in April 2020.

All of us here at RenewableEnergyWorld.com would like to wish everyone a very merry Christmas and a happy holiday season.

It’s easy to get caught up in the holiday bustle: shopping, decorating, parties, and preparation. Our to-do lists can seem endless, but we carry on because it is that special time of year, a season of giving.

Cost–sharing for the Local Government Pension Scheme (LGPS) is a subject close to the minds and pockets of all LGPS funds, employers and members. Consultation by the Department for Communities and Local Government (DCLG) on cost–sharing ...

President Muhammadu Buhari has commiserated with the government and people of Sokoto State over the death of Sheikh Haruna Waziri Usman. DAILY POST reported that the 96-year-old uncle of Sokoto State Governor, Aminu Tambuwa, passed away after a prolonged illness. Sheikh Tambuwal was the patriarch of the Waziri Tambuwal family. The President, in a statement […]

Buhari reacts to Sheikh Tambuwal’s death

Creating a safe, online space, where people across the Maltese Islands can come together as a community and combat our society’s greatest challenges

The Special Tribunal for Lebanon has delayed announcing its verdict in the case of the assassination of former Prime Minister Rafik Hariri, previously set for mid-May, due to the coronavirus pandemic, the court said.

John Hillman may have already met his fundraising target, but he says he's determined to complete all planned 101 laps around his residence.

Volunteer Services Lewisham’s food delivery service is a lifeline to vulnerable people suffering under lockdown

• Coronavirus – latest updates
• See all our coronavirus coverage

Brown bread. Baked beans. Tea. And would you happen to have any custard, dear?

Some things stand out in the middle of the prodigiously energetic food-parcel line being run from a community hall in south-east London.

Demi Lovato says she's really happy with Max Ehrich after posting their swoon-worthy moment from the new Ariana Grande and Justin Bieber video, "Stuck with U," directly to her own...

Demi Lovato says she's really happy with Max Ehrich after posting their swoon-worthy moment from the new Ariana Grande and Justin Bieber video, "Stuck with U," directly to her own...

Demi Lovato says she's really happy with Max Ehrich after posting their swoon-worthy moment from the new Ariana Grande and Justin Bieber video, "Stuck with U," directly to her own...

Coronavirus crisis reveals weakness in supply chain as medicines in export ban rise from 29 to 196 this year

• Coronavirus – latest updates
• See all our coronavirus coverage

NHS leaders and medical charities are calling for ministers to bring more drug manufacturing to the UK to reduce the risk of future shortages after the problems seen during the coronavirus crisis.

In addition to the well documented shortages of personal protective equipment, dealing with Covid-19 has placed huge strain on supplies of intensive care medicine, over-the-counter drugs and oxygen. The NHS has been forced to put new rationing measures in place to ensure hospitals do not run out.

The supply chain isn’t as good – isn’t as robust – as it could be

Philippines-based cloud kitchen startup CloudEats has secured $1.4 million in a seed funding round led by an undisclosed local family office.

The post SEA Digest: CloudEats bags seed funding; LinkAja launches sharia service appeared first on DealStreetAsia.