Although there is widespread perception among the public and medical professionals that food allergy prevalence is on the rise, no study in the U.S. has been conducted with sufficient sample size and in various populations to determine the true prevalence of food allergies, and most studies likely overestimate the proportion of the population with this condition, says a new report from the National Academies of Sciences, Engineering, and Medicine.

The U.S. Department of Energy should place a higher priority on developing an accurate and actionable inventory of agency-owned or managed properties that can be leased or sold for energy development, says a new report from the National Academies of Sciences, Engineering, and Medicine.

In light of the present situation in the U.S., we believe that it is essential to explore a wide range of options for treating the increasing numbers of very ill patients with COVID-19 respiratory illness.

Walter Flores was unemployed for 8 months in 2014 but is now working in sales for Workforce Solutions in Compton; Credit: Brian Watt/KPCC

Brian Watt

California's unemployment rate continued its decline in December, ending the year at 7 percent, according to figures released Friday by the state Employment Development Department.

But in Compton, Willowbrook and the Florence-Graham section of Los Angeles County, it remains about double that, data show.

“You might have work this week. But next week, you won’t have work,” said James Hicks, 36, 0f Compton. He's worked in warehouses through staffing agencies, but said the jobs have always been temporary.

Statewide, California has added jobs at a faster rate than the United States for three straight years, according to Robert Kleinhenz, Chief Economist with the Los Angeles County Economic Development Corporation. He pointed out the statewide unemployment rate is now where it was June 2008. 

"All in all, with the recession now five years back in our rearview mirror, we’re finally at the point where we can say that we have shrugged off quite a bit of the pain that occurred back during those times," Kleinhenz said.

The Los Angeles County metro area saw a net gain of almost 71,000 jobs in 2014.  The County's overall unemployment rate has fallen to 7.9 percent from 9.2 percent a year ago.

But Compton's unemployment rate was 13 percent in December.

“I’d rather have a  full-time type of gig, working 40 hours a week, but right now, even if you get 25 hours, it’s a blessing,” said Hicks, the warehouse worker in Compton.

On Thursday, he interviewed to be a guard with a security firm, but was told there weren’t any positions available. He had another security guard job six months ago that he thought might become full time and permanent. 

"It was going all right for about two to three months, until they cut my hours and days," Hicks said. 

Walter Flores lives in La Mirada but currently works as an account executive in the Compton office of Workforce Solutions. He was unemployed for about eight months last year after a car accident.

"Losing what you love to do is a tough one, but I'm back," he said. "2015 is going to be a great year."

Flores said most major warehouse and logistics companies prefer to hire temporary workers through industrial staffing firms like the one where he's working because their needs are sporadic.  

But he said it's still a potential opportunity.

"It doesn't matter that it's a temporary position, as long as you put your foot in the door, and then you let the employer know how much value you are for the company," Flores said.  

Hicks, who's earned a GED, wants to find a program to study physical therapy. But first, he’d like to find a job. 

He said you can't judge Compton’s residents by its unemployment rate.

"Some of us out here who [are] looking for jobs, but sometimes it’s the luck of the draw," he said. "It’s kind of scarce out there.” 

This content is from Southern California Public Radio. View the original story at SCPR.org.

Source: Streetwise Reports   04/27/2020

Avadel Pharmaceuticals' shares traded 25% higher reaching a new 52-week high price after the company reported positive topline results from its Pivotal Phase 3 REST-ON trial of FT218 for the treatment of excessive daytime sleepiness and cataplexy in narcolepsy patients.

Avadel Pharmaceuticals Plc (AVDL:NASDAQ) today announced "positive topline data from its pivotal Phase 3 REST-ON trial assessing the safety and efficacy of FT218, an investigational, once-nightly formulation of sodium oxybate for the treatment of excessive daytime sleepiness and cataplexy in patients with narcolepsy." The firm pointed out that it met all three of the co-primary efficacy endpoints in the study for each of three dosage levels which it claims demonstrates "highly significant, clinically meaningful improvements on the Maintenance of Wakefulness Test, Clinical Global Impression-Improvement and mean weekly cataplexy attacks."

The company's Chief Medical Officer Jordan Dubow, M.D., commented, "We are excited to see these positive topline data from the REST-ON study, where all three dose levels of once-nightly FT218 demonstrated a statistically significant and clinically meaningful improvement on the measures of the two prominent symptoms of narcolepsy, as well as an improvement in overall functioning compared to placebo...Once-nightly FT218 delivered a clinically meaningful response within three weeks of treatment initiation, which was sustained through each treatment period...We think once-nightly FT218, if approved, has the potential to be a meaningful contributor to patient care."

Avadel Pharma's CEO Greg Divis remarked, "The successful outcome of the REST-ON study strengthens our belief that, if approved, once-nightly FT218 has the potential to be a significant advancement for patients in the estimated $1.7 billion twice-nightly sodium oxybate market. Our proprietary market research with physicians and patients informs us that there is a strong interest in a once-nightly sodium oxybate formulation. We look forward to sharing the results from the REST-ON study with the FDA and progressing toward a potential approval that would allow us to bring this important treatment to the patients who need it most. If approved, FT218 would be the first once-nightly therapy to address both excessive daytime sleepiness and cataplexy in patients with narcolepsy."

The REST-ON study is a double-blind, randomized, placebo-controlled Phase 3 trial to assess the efficacy and safety of once-nightly FT218, a formulation of sodium oxybate using Avadel's proprietary Micropump technology for extended-release oral suspension in the treatment of excessive daytime sleepiness and cataplexy in patients suffering from narcolepsy. The company stated that 212 patients were enrolled in the study and result "showed that the 9 g dose of once-nightly FT218 demonstrated a highly significant and clinically meaningful improvement compared to placebo across all three co-primary endpoints."

The company advised that FT218 has been granted Orphan Drug Designation from the U.S. FDA for the treatment of narcolepsy. The firm added that the designation was granted on basis that FT218 may be clinically superior to a formulation of sodium oxybate that is already approved by the FDA for the same indication.

Avadel Pharmaceuticals is biopharmaceutical company headquartered in Dublin, Ireland. The company's primary focus is on the development and potential FDA approval for FT218, which just completed its Phase 3 REST-ON clinical trial for the treatment of narcolepsy patients suffering from excessive daytime sleepiness and cataplexy. The firm also develops and markets sterile injectable drugs for use in hospital settings.

Avadel started off the day with a market capitalization of around $456.2 million with approximately 46.4 million shares outstanding and a short interest of about 14.00%. AVDL shares opened more than 34% higher today at $13.30 (+$3.37, +34.28%) over Friday's $9.83 closing price and reached a new 52-week high price this morning of $13.49. The stock has traded today between $11.90 and $13.49 per share and is currently trading at $12.27 (+$2.44 +24.82%).

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A recap of Parsley Energy's Q1/20 performance and projections for this year and next are given in a Raymond James report.

By ranking the ???hazard potential??? of a wide range of chemicals used to make common plastics, Swedish researchers have highlighted which plastic polymers are made from the most hazardous chemicals. These should be prioritised for assessing the risk of causing human or environmental harm.

Scientists have found that retreating glaciers and melting permafrost in Alaska are releasing up to 70% more methane – a potent greenhouse gas – than previously thought. If this estimate is true for the rest of the Arctic, this could have serious implications for global warming, say the scientists.

Urban agriculture is becoming increasingly popular. A recent assessment of rooftop farming in Barcelona shows differing attitudes towards the practice, and provides important recommendations for the development of agricultural policy for the 21st century, such as including food production as a potential use of rooftops in planning legislation.

‘Product-service systems’ are innovative business models designed to satisfy societal needs in an environmentally sustainable manner. This study explores how government policies could increase the uptake of these systems, outlining five key recommendations to achieve this, including schemes to raise awareness and involve local authorities.

Modern flood risk management is placing more emphasis on improving the resilience of communities prone to flooding. By examining three case studies, a recent investigation has provided insight into how resilience is put into practice, suggesting that clearer identification between the roles of different actors and better communication to the public is needed for successful implementation.

Changing user consumption patterns and rapid adoption of omni-channel models drive demand.

NPCI consecutively reported dismal figures for April 2020 for its UPI, IMPS, NETC and Bharat BillPay platforms – as AePS emerges as an outlier.

By ranking the ‘hazard potential’ of a wide range of chemicals used to make common plastics, Swedish researchers have highlighted which plastic polymers are made from the most hazardous chemicals. These should be prioritised for assessing the risk of causing human or environmental harm.

The 2-month-old cub at the Toronto Zoo hasn't quite nailed walking, but he's definitely got being cute figured out.

Raymond Wang, 17, won prestigious $75,000 award for engineering a system to make cabin air safer.

Space shuttle Endeavour, now a permanent resident of the state of California, has traded its winged chariot for a set of custom wheels.

Consumer Reports’ risk guide helps shoppers make informed decisions when buying fruits and vegetables.

Officials hope the aircraft will help prevent unsafe E. coli counts, which have caused beach closures in the past.

HVAC heavyweight Honeywell unveils Lyric, an attractive and eager-to-adapt household thermostat with GPS-based functionality.

The standard goal of 10,000 steps could do more harm than good for some, says Dr. Greg Hager of Johns Hopkins, and it might not be enough for others.

The EPA unrolls WaterSense labeling for irrigation controllers, the first outdoor product eligible for certification in a program that previously focused only o

Itching to go green and not sure where to start? Try these ten simple ideas.

Kavita Shukla has created a way to keep many other fruits and vegetables fresh two to four times longer with an organic product.

The White House budget proposal for NASA in 2016 calls for a $500 million boost over the 2015 enacted budget and would keep NASA on its path to Mars.

Judges and mentors Anthony Bourdain and Nigella Lawson talk about new food competition 'The Taste'.