An ongoing threat campaign dubbed VEILDrive has been observed taking advantage of legitimate services from Microsoft, including Teams, SharePoint, Quick Assist, and OneDrive, as part of its modus operandi. "Leveraging Microsoft SaaS services — including Teams, SharePoint, Quick Assist, and OneDrive — the attacker exploited the trusted infrastructures of previously compromised organizations to

An ongoing phishing campaign is employing copyright infringement-related themes to trick victims into downloading a newer version of the Rhadamanthys information stealer since July 2024. Cybersecurity firm Check Point is tracking the large-scale campaign under the name CopyRh(ight)adamantys. Targeted regions include the United States, Europe, East Asia, and South America. "The campaign

Do you remember that one fanfic that kept you reading until dawn for the very first time? Or the fan art or video that led you to dig out all the works its creator shared? Have you ever tried to look into the stories of the authors who wrote fics before you were even born? You can find all this and more on Fanlore - the wiki for fanworks, fan creators, and fannish history!

Fanlore is a project run by the Organization for Transformative Works (OTW) with the goal of providing fans a place to record and share their histories, experiences and traditions. Fanlore records both the history and current state of our fan communities – fan works, fan activities, fan terminology, individual fans and fannish-related events. You can read about what fandoms were like in the olden days and document memorable events in your own fandoms, all on Fanlore! Check out the wiki’s New User Portal or join the Fanlore Discord server to connect with other editors and users.

We would not be able to preserve these cherished pieces of fandom history without the generous donations of our fellow fans and volunteers who work tirelessly behind the scenes to keep all our projects running. As always, we have some shiny new donation gifts!

You can choose to display your love for fandom with some of our new thank-you gifts. For a US$40 donation, we have a new sticker set featuring popular AO3 tags. You can show off a bumper sticker saying "my other car is a ship" for a donation of US$50. For a donation of US$75 or more, you could carry home your groceries with a white and red shopping bag or you can announce your love for AO3 with our rainbow kudos pin.

You can also set up a recurring donation and save towards the gift of your choice. Select the gift you want, and if the total for that donation doesn't reach the amount needed for the gift you selected, future donations will be applied to the gift you’re saving for. Those of you in the U.S. might also be able to double your contribution via employer matching: contact your HR department to find out if this is an option for you.

A donation of US$10 or more will also allow you to become a member of the OTW. OTW members can vote for the Board of Directors – the OTW’s governing board. Donating now and checking the “I wish to be a member” box will make you eligible to vote in the 2025 OTW Board Election.

We hope that many of you will take this opportunity to donate and become a member to support projects like Fanlore, Open Doors, Legal Advocacy, Transformative Works and Cultures, and the Archive of Our Own. Your contributions help keep our projects successful for new and long-time fans alike!

The Organization for Transformative Works's October membership drive is over and we are delighted to say that we are finishing with a total of $214,698.86 raised. We are particularly pleased that 6020 donors chose to either take up or renew OTW membership with their donation, far exceeding our goal of 4,500 members.

These donations came from 6,955 people in 86 countries: thank you to every single one of you, as well as to all of you who posted and shared the news about the drive! The OTW would not exist without its users all around the world, and your continued support for us is our absolute pride and joy! We are so glad to know that our ongoing mission to support, protect, and provide access to the history of fanworks and fan culture continues to resonate with the people that matter most of all: the fans themselves.

If you were intending to donate or join and haven't yet done so, don't worry! The OTW accepts donations year-round, and you can always choose to become a member with a donation of US$10 or more. Memberships run for one calendar year from the date of your donation. If you donate now, you'll be able to vote in next year's OTW Board election, which will take place in August 2025. Our exclusive thank-you gifts are also available whenever you donate!

The Organization for Transformative Works is the non-profit parent organization of multiple projects including Archive of Our Own, Fanlore, Open Doors, Transformative Works and Cultures, and OTW Legal Advocacy. We are a fan-run, entirely donor-supported organization staffed by volunteers. Find out more about us on our website.

Meet McLaren's first female development driver, Bianca Bustamante, who says she shares her hopes and ambitions to become a professional Formula 1 driver.

Ayrton Senna, Michael Schumacher, Lewis Hamilton and Max Verstappen have all mastered treacherous conditions to win F1 races - but which was the best?

Formula 1 drivers urge the sport's governing body to treat them like adults after Max Verstappen and Charles Leclerc were punished for swearing.

With swathes of South Sudan submerged, a whistleblower warns water sources are being polluted by oil.

I have a close circle of clued-on/tech savvy friends whose views I take seriously. For the last few weeks, one of these friends has been sending me emails extolling the merits of something called IOTA – which calls itself as the next generation Blockchain.  At first, I thought of IOTA as yet another cryptocurrency. A [...]

Uber Safari is launching this week, offering riders in Cape Town the opportunity to go on a one-day game drive to a private reserve for $200.

Mobile Ecosystems as a Driver of Innovation and Growth in the Asia-Pacific 19 September 2018 — 12:30PM TO 3:00PM Anonymous (not verified) 18 September 2018 Chatham House, London

Geopolitical corporate responsibility can drive change Expert comment NCapeling 26 July 2022

Russia’s long invasion of Ukraine is testing the commitment of business, but this could see the emergence of a new pillar of support for the rules-based international order.

The massive exit of more than 1,000 international companies from Russia has surpassed – by a factor of nearly ten in merely four months – the number which pulled out of apartheid-led South Africa over an entire decade.

These company exits extend beyond those industries targeted for sanctions – oil and gas, banks and financial services, aerospace, and certain technology sectors – to include hundreds in consumer products ranging from Levi’s and H&M clothing to Coca-Cola and McDonalds. Many of these companies may wish to return to a post-conflict – or post-Putin – Russia, while a few have already sold their Russian operations, as McDonald’s has to an existing Siberian licensee.

Both reputational and operational factors are driving the huge exodus: reputational as companies have chosen to disassociate themselves from Putin’s regime; operational as transportation routes and supply chains have been interrupted.

Few of these companies have made explicit the principles at stake, while many still face ‘tricky legal, operational and ethical considerations’ and some have kept operations in place. But the collective impact of the exit in response to Russia’s affront to international law has sent shockwaves around the world.

Current issues and future implications

Minds now turn to whether this exodus sets a blueprint for the future, and how companies having to make complex and sensitive risk assessments and global business planning decisions can address both current issues as well as similar future challenges.

The new Declaration from the Business for Ukraine Coalition – an international civil society initiative of organizations and individuals – encourages companies to reinforce ‘responsible exit’ from Russia ‘in response to its unprovoked, full-scale war on Ukraine’.

The declaration’s objective is to ‘block access to the economic and financial resources enabling Russian aggression’ and it urgently calls on companies that have terminated or suspended their business operations and relationships to ‘stand by those commitments until the territorial sovereignty of Ukraine within internationally recognized borders is restored.’

It also states companies yet to terminate or suspend operations in Russia should do so unless they can demonstrate through due diligence that their provision of ‘essential’ services or products – such as medicines – meet critical humanitarian needs.

The 2022 Edelman Trust Barometer Special Report: The Geopolitical Business suggests Ukraine represents an inflection point posing ‘a new test’ for business. According to an online survey of 14,000 respondents in 14 countries, including employees, NGOs, and other stakeholders, there is a ‘rising call’ for business to be more engaged in geopolitics, with CEOs ‘expected to shape policy’ on societal and geopolitical issues.

Such expectations have been intensifying with the impetus of the combined stakeholder capitalism and corporate purpose agenda, even as a political backlash in the US against the environmental, social, and governance (ESG) movement linking institutional investors and multinational corporations gains momentum.

The emergence of corporate activism is a further development – partly driven by employees and accelerated during the pandemic – on issues of economic inequality, racial injustice, and gender equality, as well as the climate crisis.

When considering what broader purpose should drive this corporate geopolitical engagement, the Business for Ukraine Declaration offers an answer, calling Russia’s aggression ‘an attack on the rules-based international order which must be protected to ‘safeguard the international community and the global economy.’

This points to broader interests and values at stake in the Russian war on Ukraine because supporting the rules-based international order can become the basis of a new geopolitical corporate responsibility. Business, especially multinational corporations and institutional investors, fundamentally depend on and have enormously benefitted from this order.

Economic development needs a stable rules-based international order

Trade and investment, entrepreneurship, and innovation – the sinews of economic development – depend on predictable, rational behaviour by states at home and abroad. Individual companies and entire industries share a stake in upholding this order at a time when its stability and even legitimacy is undergoing a severe challenge.

The rules-based international order has evolved since the adoption of the UN Charter in 1945, the Universal Declaration of Human Rights in 1948, and the establishment of the standards, norms and institutions that reflect and reinforce these lodestars. It defines the international community, the rule of law, accountable governance, civic freedoms, and human rights within nations. It also supports national self-determination, sovereignty, and the disavowal of the use of force to alter borders among nations, and it provides accountability for genocide, crimes against humanity, and war crimes.

Business has a fundamental stake in the international order as the framework for stability, prosperity, open societies, and markets.

A new geopolitical corporate responsibility does not need to become a doctrine but can instead be an agenda to support the international rules-based order under stress. Such an agenda may help multinationals deal with expectations they already face, such as:

Avoiding situations where they cause, contribute, or are directly linked to human rights abuses. This objective is enshrined in the UN Guiding Principles on Business and Human Rights and companies can be further informed by the new UN Guide to Heightened Human Rights Due Diligence for Business in Conflict-Affected Contexts.

Committing to the ‘shared space’ of the rule of law, accountable governance, civic freedoms, and human rights. These are both the enablers of civil society and the underpinning of sustainable and profitable business and investment environments. The Chatham House synthesis paper The role of the private sector in protecting civic space sets forth the rationale for companies to defend these vital elements.

Supporting peace, justice, and strong institutions both within nations and across the international community as set forth by UN Sustainable Development Goal 16. The SDG 16 Business Framework: Inspiring Transformational Governance shows how companies, as well as national governments and international institutions, can contribute to these building blocks of stability and prosperity.

Demonstrating corporate responsibility at the national and geopolitical levels to enhance equity, transparency, and accountability. Multinationals are already challenged to accept minimum corporate taxation within and across jurisdictions, curb excessive executive compensation, endorse mandatory disclosure of environmental and human rights due diligence, and strengthen corporate governance of ESG risks and responsibilities, including with respect to human rights.

Diminishing inequality by tackling poverty and ensuring sustainability by arresting the climate crisis. Alongside governments and international institutions, the business community already faces increasing pressure to improve its efforts in these areas.

Driven to Extraction: Can Sand Mining be Sustainable? 5 June 2019 — 1:30PM TO 3:00PM Anonymous (not verified) 29 April 2019 Chatham House | 10 St James's Square | London | SW1Y 4LE

Myelination plays an important role in cognitive development and in demyelinating diseases like multiple sclerosis (MS), where failure of remyelination promotes permanent neuro-axonal damage. Modification of cell surface receptors with branched N-glycans coordinates cell growth and differentiation by controlling glycoprotein clustering, signaling, and endocytosis. GlcNAc is a rate-limiting metabolite for N-glycan branching. Here we report that GlcNAc and N-glycan branching trigger oligodendrogenesis from precursor cells by inhibiting platelet-derived growth factor receptor-α cell endocytosis. Supplying oral GlcNAc to lactating mice drives primary myelination in newborn pups via secretion in breast milk, whereas genetically blocking N-glycan branching markedly inhibits primary myelination. In adult mice with toxin (cuprizone)-induced demyelination, oral GlcNAc prevents neuro-axonal damage by driving myelin repair. In MS patients, endogenous serum GlcNAc levels inversely correlated with imaging measures of demyelination and microstructural damage. Our data identify N-glycan branching and GlcNAc as critical regulators of primary myelination and myelin repair and suggest that oral GlcNAc may be neuroprotective in demyelinating diseases like MS.

The Internet is full of cats—and in this case, malware-delivering fake cat websites used for very targeted search engine optimization.

Leandro Xavier Neves
Nov 11, 2020; 0:RA120.002227v1-mcp.RA120.002227
Research

Gα proteins promote dynamic adjustments of cell shape directed by actin-cytoskeleton reorganization via their respective RhoGEF effectors. For example, Gα13 binding to the RGS-homology (RH) domains of several RH-RhoGEFs allosterically activates these proteins, causing them to expose their catalytic Dbl-homology (DH)/pleckstrin-homology (PH) regions, which triggers downstream signals. However, whether additional Gα proteins might directly regulate the RH-RhoGEFs was not known. To explore this question, we first examined the morphological effects of expressing shortened RH-RhoGEF DH/PH constructs of p115RhoGEF/ARHGEF1, PDZ-RhoGEF (PRG)/ARHGEF11, and LARG/ARHGEF12. As expected, the three constructs promoted cell contraction and activated RhoA, known to be downstream of Gα13. Intriguingly, PRG DH/PH also induced filopodia-like cell protrusions and activated Cdc42. This pathway was stimulated by constitutively active Gαs (GαsQ227L), which enabled endogenous PRG to gain affinity for Cdc42. A chemogenetic approach revealed that signaling by Gs-coupled receptors, but not by those coupled to Gi or Gq, enabled PRG to bind Cdc42. This receptor-dependent effect, as well as CREB phosphorylation, was blocked by a construct derived from the PRG:Gαs-binding region, PRG-linker. Active Gαs interacted with isolated PRG DH and PH domains and their linker. In addition, this construct interfered with GαsQ227L's ability to guide PRG's interaction with Cdc42. Endogenous Gs-coupled prostaglandin receptors stimulated PRG binding to membrane fractions and activated signaling to PKA, and this canonical endogenous pathway was attenuated by PRG-linker. Altogether, our results demonstrate that active Gαs can recognize PRG as a novel effector directing its DH/PH catalytic module to gain affinity for Cdc42.

RAS genes are the most commonly mutated in human cancers and play critical roles in tumor initiation, progression, and drug resistance. Identification of targets that block RAS signaling is pivotal to develop therapies for RAS-related cancer. As RAS translocation to the plasma membrane (PM) is essential for its effective signal transduction, we devised a high-content screening assay to search for genes regulating KRAS membrane association. We found that the tyrosine phosphatase PTPN2 regulates the plasma membrane localization of KRAS. Knockdown of PTPN2 reduced the proliferation and promoted apoptosis in KRAS-dependent cancer cells, but not in KRAS-independent cells. Mechanistically, PTPN2 negatively regulates tyrosine phosphorylation of KRAS, which, in turn, affects the activation KRAS and its downstream signaling. Consistently, analysis of the TCGA database demonstrates that high expression of PTPN2 is significantly associated with poor prognosis of patients with KRAS-mutant pancreatic adenocarcinoma. These results indicate that PTPN2 is a key regulator of KRAS and may serve as a new target for therapy of KRAS-driven cancer.

Natalie Bruiners
Dec 1, 2020; 61:1617-1628
Research Articles

Certain tables that are created in SAS Scalable Performance Data (SPD) Server might not be displayed correctly by SAS Federation Server Manager. Tables that have Latin5 characters in column names encounter this

The rise of drug-resistant tuberculosis poses a major risk to public health. Statins, which inhibit both cholesterol biosynthesis and protein prenylation branches of the mevalonate pathway, increase anti-tubercular antibiotic efficacy in animal models. However, the underlying molecular mechanisms are unknown. In this study, we used an in vitro macrophage infection model to investigate simvastatin’s anti-tubercular activity by systematically inhibiting each branch of the mevalonate pathway and evaluating the effects of the branch-specific inhibitors on mycobacterial growth. The anti-tubercular activity of simvastatin used at clinically relevant doses specifically targeted the cholesterol biosynthetic branch rather than the prenylation branches of the mevalonate pathway. Using Western blot analysis and AMP/ATP measurements, we found that simvastatin treatment blocked activation of mechanistic target of rapamycin complex 1 (mTORC1), activated AMP-activated protein kinase (AMPK) through increased intracellular AMP:ATP ratios, and favored nuclear translocation of transcription factor EB (TFEB). These mechanisms all induce autophagy, which is anti-mycobacterial. The biological effects of simvastatin on the AMPK-mTORC1-TFEB-autophagy axis were reversed by adding exogenous cholesterol to the cells. Our data demonstrate that the anti-tubercular activity of simvastatin requires inhibiting cholesterol biosynthesis, reveal novel links between cholesterol homeostasis, the AMPK-mTORC1-TFEB axis, and Mycobacterium tuberculosis infection control, and uncover new anti-tubercular therapy targets.

Protease activity has been associated with pathological processes that can lead to cancer development and progression. However, understanding the pathological unbalance in proteolysis is challenging since changes can occur simultaneously at protease, their inhibitor and substrate levels. Here, we present a pipeline that combines peptidomics, proteomics and peptidase predictions for studying proteolytic events in the saliva of seventy-nine patients and their association with oral squamous cell carcinoma (OSCC) prognosis. Our findings revealed differences in the saliva peptidome of patients with (pN+) or without (pN0) lymph node metastasis and delivered a panel of ten endogenous peptides correlated with poor prognostic factors plus five molecules able to classify pN0 and pN+ patients (ROC-AUC>0.85). In addition, endo- and exopeptidases putatively implicated in the processing of differential peptides were investigated using cancer tissue gene expression data from publicly repositories reinforcing their association with poorer survival rates and prognosis in oral cancer. The dynamics of the OSCC-related proteolysis was further explored via the proteomic profiling of saliva. This revealed that peptidase/endopeptidase inhibitors exhibited reduced levels in the saliva of pN+ patients, as confirmed by SRM-MS, whilst minor changes were detected in the level of saliva proteases. Taken together, our results indicated that proteolytic activity is accentuated in the saliva of OSCC patients with lymph node metastasis and, at least in part, this is modulated by reduced levels of salivary peptidase inhibitors. Therefore, this integrated pipeline provided better comprehension and discovery of molecular features with implications in the oral cancer metastasis prognosis.

Moscow Rules: What Drives Russia to Confront the West Book sysadmin 17 January 2019

Keir Giles surveys Russia’s history and the present day to explain why its current leadership feels it has no choice but to challenge and attack the West. Recognising and accepting that this will not change in the near future will help the West find a way of dealing with Russia without risking a deeper conflict.

This book is for anyone that cannot understand why Russia and its leaders behave as they do.

The relationship between Russia and the West is once again deep in crisis. A major reason is that Western leaders have too often believed or hoped that Russia sees the world as they do — but things look very different from Moscow. This book shows that efforts at engagement with Russia that do not take this into account are a key reason for repeated disappointment and crisis.

In confronting the West, Russia is implementing strategic and doctrinal approaches that have been consistent for centuries. The roots of current Russian behaviour and demands can be traced not just to the Soviet era, but back into Tsarist foreign and domestic policy, and further to the structure and rules of Russian society. But this also gives the US and the West pointers for how to behave — and how not to — in order to manage the challenge of Russia effectively, based on past experience of both successful and unsuccessful engagement with Moscow.

The book recognizes the reality of confrontation and provides an essential introduction to grasping why Russia sees it as inevitable. Consequently, it offers a basis for building a less crisis-prone relationship with Russia.

This book is part of the Insights series.

Praise for Moscow Rules

About the author

Keir Giles is a senior consulting fellow at Chatham House, the Royal Institute of International Affairs. He also works with the Conflict Studies Research Centre (CSRC), a group of subject matter experts in Eurasian security with a particular focus on the wide range of security challenges coming from Russia.

Purchase

• UK (via Amazon)
• Rest of world (via Brookings Institution Press)
• Students (via Browns Books)

AI-driven Personalization in Digital Media: Political and Societal Implications Research paper sysadmin 2 December 2019

The fallout from disinformation and online manipulation strategies have alerted Western democracies to the novel, nuanced vulnerabilities of our information society. This paper outlines the implications of the adoption of AI by the the legacy media, as well as by the new media, focusing on personalization.

Summary

• Machine learning (ML)-driven personalization is fast expanding from social media to the wider information space, encompassing legacy media, multinational conglomerates and digital-native publishers: however, this is happening within a regulatory and oversight vacuum that needs to be addressed as a matter of urgency.
• Mass-scale adoption of personalization in communication has serious implications for human rights, societal resilience and political security. Data protection, privacy and wrongful discrimination, as well as freedom of opinion and of expression, are some of the areas impacted by this technological transformation.
• Artificial intelligence (AI) and its ML subset are novel technologies that demand novel ways of approaching oversight, monitoring and analysis. Policymakers, regulators, media professionals and engineers need to be able to conceptualize issues in an interdisciplinary way that is appropriate for sociotechnical systems.
• Funding needs to be allocated to research into human–computer interaction in information environments, data infrastructure, technology market trends, and the broader impact of ML systems within the communication sector.
• Although global, high-level ethical frameworks for AI are welcome, they are no substitute for domain- and context-specific codes of ethics. Legacy media and digital-native publishers need to overhaul their editorial codes to make them fit for purpose in a digital ecosystem transformed by ML. Journalistic principles need to be reformulated and refined in the current informational context in order to efficiently inform the ML models built for personalized communication.
• Codes of ethics will not by themselves be enough, so current regulatory and legislative frameworks as they relate to media need to be reassessed. Media regulators need to develop their in-house capacity for thorough research and monitoring into ML systems, and – when appropriate –proportionate sanctions for actors found to be employing such systems towards malign ends. Collaboration with data protection authorities, competition authorities and national electoral commissions is paramount for preserving the integrity of elections and of a political discourse grounded on democratic principles.
• Upskilling senior managers and editorial teams is fundamental if media professionals are to be able to engage meaningfully and effectively with data scientists and AI engineers.

BEAVERTON, Ore., Oct. 29, 2024 — Ultra Accelerator Link (UALink) Consortium, led by Board Members from AMD, Amazon Web Services (AWS), Astera Labs, Cisco, Google, Hewlett Packard Enterprise (HPE), Intel, Meta […]

The post Ultra Accelerator Link Consortium Launches with Industry Leaders, Opens Membership to Drive AI Connectivity Standards appeared first on HPCwire.

Nov. 6, 2024 — Harnessing the power artificial intelligence (AI) and the world’s fastest supercomputers, a research team led by the U.S. Department of Energy’s (DOE) Argonne National Laboratory has developed […]

The post Argonne Team Breaks New Ground in AI-driven Protein Design appeared first on HPCwire.

SURREY, British Columbia, Nov. 12, 2024 — Today, the Quantum Algorithms Institute (QAI) announced a partnership with Canadian companies, AbaQus and InvestDEFY Technologies, to solve common challenges in training machine learning […]

The post Quantum Algorithms Institute Drives Predictive Model Accuracy with Quantum Collaboration appeared first on HPCwire.

TROY, Mich., Nov. 12, 2024 — Altair, a global leader in computational intelligence, has entered into collaboration agreement with the European Space Agency (ESA) through the ESA Partnership Initiative for […]

The post Altair Partners with European Space Agency to Advance AI-Driven Aerospace Innovation appeared first on HPCwire.

Discover the hidden force shaping your social habits—and why you’re not even aware of it.

A suburban Indianapolis district is signing up teachers to drive school buses before and after their usual time in the classroom.

Evdokia Menelaou
Aug 8, 2012; 32:10925-10939
BehavioralSystemsCognitive

As hundreds of motorists take to the desert, their tracks damage the massive geoglyphs made by Indigenous groups in northern Chile

A man who fled from police, drove onto a walking trail, triggered a shelter-in-place advisory for the Chateau Nova hotel in Yellowknife and subsequently broke into a home was on bail at the time and under house arrest, police say.

A man from Calgary has been charged in the death of a worker after a 24-year-old woman sustained fatal injuries when a pickup truck crashed into a pizza restaurant in Fort McMurray. 

Drivers are being warned to use caution on Saskatchewan's highways after five separate collisions involving moose were reported to RCMP in a 30-minute window on Friday evening.

A driver killed 35 people and severely injured another 43 when he deliberately rammed his car into people exercising at a sports centre in the southern Chinese city of Zhuhai, police said Tuesday.

Virginia Tech Students Advancing the Possibilities with SolidWorks 3D CAD Software

ioSafe Uses SolidWorks to Design Disaster-Proof Computer Hardware; Company Saves $15,000 and Three Months

Newest Version of Leading 3D CAD Software Eliminates Traditional Performance/Functionality Tradeoffs

U.K.

20th Release of Leading CAD Software Provides More than 200 New Functions to Community

SOLIDWORKS 3D Design Software Delivers the Precision Needed to Shave Milliseconds off Bobsled Finish Times

It is easily possible to double the cost of a new M4 Mac mini by buying Apple storage — but if you know what you're doing, you can buy external drives, and save hundreds of dollars by working off those. Here's how.

Kabir left his hometown after being opposed for his faith but surprisingly was called back.

Just under a quarter of the more than 7 000 independent drivers for Shoprite's newly acquired Pingo last-mile delivery platform are South African.

The Penn State Climate Consortium has awarded funding to four research projects that look to put promising climate solutions into action through interdisciplinary partnerships.