The metropolis is an important center for paleontological research, but until now, fossils of plants and fish were the only remains of dinosaur-era life found there

A "staggering array" of markings have been hiding in plain sight carved into the walls of Gainsborough Old Hall, a 500-year-old home in Lincolnshire, England

The votive plaque was found amid the ruins of an ancient Roman fortress. Researchers think a temple dedicated to the mysterious deity may have stood nearby

The 3,800-year-old site near the city of Luxor holds the remains of 11 individuals, who may have been members of the same family. Researchers think the tomb was used for several generations

On this day in 1912, a team found the remains of Robert Falcon Scott and the crew of the "Terra Nova" expedition. A would-be rescuer said he was forever haunted by the "horrible nightmare"

Sławomir and Szymon Milewski were searching for a Roman road when they stumbled upon the cache of coins, which is worth more than $120,000

"Fascinating, Captain"

By raising her son to be curious about the natural world, this mother helped shape the trajectory of the National Museum of Natural History

The Sacro Bosco's meaning is the subject of debate, with scholars alternatively describing the sprawling complex as a memorial, an allegorical site or a tribute to ancient civilizations

‘To design, I use my favorite tool, SOLIDWORKS’

A newly discovered protein naturally houses an unusual binding site that can differentiate between rare earth elements, and researchers at Penn State have made it even better. Rare earth elements are key components used in everything from modern tech to gasoline production. The protein, called LanD, enriches neodymium and praseodymium over other similar rare earth elements and has the potential to revolutionize industrial mining, researchers said.

High school students from the region recently gathered at Penn State DuBois to participate in Discover Engineering Day, an event designed to introduce them to the vast opportunities available within the engineering field.

Discovery Health Medical Scheme's (DHMS) 2023 cancer claims payouts were almost 19% higher than the previous year though the scheme says screening rates in South Africa have mostly returned to pre-pandemic levels.

Through community development projects, workers in Central Asia meet people interested in Jesus.

Scientists have discovered a new fire-resilient, dual-blooming plant species in Indias Northern Western Ghats, which they have named 'Dicliptera polymorpha'.

It's named Bathydevius due to its "devious" nature that fooled the scientists at first, while caudactylus refers to the dactyls -- the fingerlike projections on its tail.

Google DeepMind has silently open-sourced its frontier artificial intelligence (AI) model that can predict the interaction between proteins and other molecules. Dubbed AlphaFold 3, the large language model is the successor of AlphaFold 2, whose research led to the creators of the large language model (LLM) Demis Hassabis and John Jumper getting the Nobel Prize in Chemistry in 2024.

The food festivals happening in November and December 2024 will take you on a wholesome culinary journey like no other!

It's named Bathydevius due to its "devious" nature that fooled the scientists at first, while caudactylus refers to the dactyls -- the fingerlike projections on its tail.

Canada discontinued its Student Direct Stream visa program for international students, amid a push by the country to cope with its housing and resource crisis.

A steady downward trend over the past five years in the landowner discounts of permanent agricultural conservation easements selected for purchase in Delaware shows it’s a great time for landowners to preserve their farms.

Composting food scraps along with yard waste reduces waste going to Delaware’s landfills and produces organic material that can be used to enrich garden soil. DNREC is encouraging residents to try composting by promoting a community sale of compost bins online. Through strategic bulk purchasing, DNREC is able to offer compost bins, rain barrels and accessories at reduced prices, just in time for International Composting Awareness Week, May 6 to 12.

Dover, Del. – July 22, 2024 –The Delaware State Housing Authority (DSHA) and Discover Bank announced a significant milestone in their long-standing partnership to expand homeownership opportunities for low-to-moderate-income residents across the state. Over the past decade, the collaborative lending program has provided more than $500 million in mortgage financing to 2,780 first-time homebuyers with […]

We're already deeply into the discovery phase of the 2025 model year. With it, as usual, have come a stellar crop of new vehicles—everything from the high and mighty Chevy Corvette ZR1 to the cheeky, efficient Honda Civic Hybrid. But on the sadder end of the spectrum, we're tallying the list of vehicles that didn't make the cut—the...

The XT4 compact crossover ends production in January after one generation The Cadillac Optiq electric crossover will take the place as the entry point into the Cadillac brand Production of the XT4 ends not longer after it ended on the Chevy Malibu as GM retools its Fairfax Assembly for the next Bolt EV A year after an interior glow-up, Cadillac...

As of Nov. 11, Chromebook deals are aplenty ahead of Black Friday 2024. Check out our top picks from Lenovo, Asus, Samsung, and others.

As of Nov. 12, a ton of great keayboard deals are live ahead of Black Friday 2024. Check out our top deal picks, from daily-use keyboards to gaming-style keyboards.

Greek divers have discovered the wreckage of an Italian submarine 80 years after it was sunk by the Allied Forces in the Aegean Sea during World War II.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

The Managing Director of Abuja Electricity Distribution Company (AEDC), Ernest Mupwaya said his company has installed 88,000 meters and would install 120,000 units by December 2017 to tackle complaints on estimated billing. upwaya said this at the opening of a two day workshop on energy theft for judges within the Federal Capital Territory (FCT). He […]

Abuja DisCo meters 88,000 customers, targets 120,000 by December

Countries in the East Mediterranean can use gas discoveries as a catalyst for regional cooperation, unlocking the region's production potential.

A member of the team, a water boy, accidentally stumbled upon a stone that turned out to be the first step of an ancient staircase.

to write a discourse community paper

Astronomer Jo Dunkley is planning to use the Simons Observatory to snare evidence for inflation, the theory that the universe expanded at incredible speed after its birth

The atoms within quasicrystals are arranged in repeating forms, but unlike ordinary crystals they have more complex symmetry. It turns out this makes them perfect for producing mazes

A better picture of the hidden landscape beneath the frozen surface of Antarctica could help us understand how the ice will respond to climate change

Once seen as miraculous, these days ice is no longer extraordinary. But in a winter season when Antarctic sea ice hit a historic low, it is clear we should cherish it more, says Max Leonard

An ocean research vessel has just discovered four underwater mountains, the tallest almost 3 kilometres high, that might be hotspots of deep-sea life

Sea-floor nodules raise oxygen levels in the deep ocean, suggesting they may have a valuable role in ecosystems and adding to concerns about the impact of deep-sea mining

Archaeologists have used AI to discover hundreds of large-scale drawings depicting figures like llamas, decapitated human heads and killer whales armed with knives

Title: Discovery May Improve Diagnosis of Alzheimer's, Parkinson's
Category: Health News
Created: 8/29/2012 6:05:00 PM
Last Editorial Review: 8/30/2012 12:00:00 AM

Title: AHA News: Star Wrestler-Turned-Coach Discovers Serious Heart Problem at 24
Category: Health News
Created: 8/24/2021 12:00:00 AM
Last Editorial Review: 8/24/2021 12:00:00 AM

Title: Poliovirus Discovered in New York Wastewater
Category: Health News
Created: 8/12/2022 12:00:00 AM
Last Editorial Review: 8/15/2022 12:00:00 AM

The development of transforming growth factor βreceptor inhibitors (TGFβRi) as new medicines has been affected by cardiac valvulopathy and arteriopathy toxicity findings in nonclinical toxicology studies. PF-06952229 (MDV6058) selected using rational drug design is a potent and selective TGFβRI inhibitor with a relatively clean off-target selectivity profile and good pharmacokinetic properties across species. PF-06952229 inhibited clinically translatable phospho-SMAD2 biomarker (≥60%) in human and cynomolgus monkey peripheral blood mononuclear cells, as well as in mouse and rat splenocytes. Using an optimized, intermittent dosing schedule (7-day on/7-day off/cycle; 5 cycles), PF-06952229 demonstrated efficacy in a 63-day syngeneic MC38 colon carcinoma mouse model. In the pivotal repeat-dose toxicity studies (rat and cynomolgus monkey), PF-06952229 on an intermittent dosing schedule (5-day on/5-day off cycle; 5 cycles, 28 doses) showed no cardiac-related adverse findings. However, new toxicity findings related to PF-06952229 included reversible hepatocellular (hepatocyte necrosis with corresponding clinically monitorable transaminase increases) and lung (hemorrhage with mixed cell inflammation) findings at ≥ targeted projected clinical efficacious exposures. Furthermore, partially reversible cartilage hypertrophy (trachea and femur in rat; femur in monkey) and partially to fully reversible, clinically monitorable decreases in serum phosphorus and urinary phosphate at ≥ projected clinically efficacious exposures were observed. Given the integral role of TGFβ in endochondral bone formation, cartilage findings in toxicity studies have been observed with other TGFβRi classes of compounds. The favorable cumulative profile of PF-06952229 in biochemical, pharmacodynamic, pharmacokinetic, and nonclinical studies allowed for its evaluation in cancer patients using the intermittent dosing schedule (7-day on/7-day off) and careful protocol-defined monitoring.

A nudibranch from the midnight zone has fingers on its tail, collects food with a hood, and glows.

The leak caught national intelligence officials by surprise and led to an embarrassing Air Force Inspector General investigation.

Microsoft and several retailers are currently running a promotion for the standard Xbox Series X in the US.

The Xbox Series X is available for $449, a $50 discount, at the Microsoft Store, GameStop, and Best Buy. It isn't known when this deal will end.

The recently released 1 TB All-Digital Robot White Xbox Series X, 2TB Disc Drive Galaxy Black Xbox Series, and the two Xbox Series S SKUs have not been discounted at this time.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463036/xbox-series-x-discounted-by-50-to-449/