In an annual OM Guatemala outreach, volunteers are challenged to leave their comfort zone and share God’s love in a different way.

London, England, May 5, 2020 / 09:00 am (CNA).- A parish in London’s West End is offering the homeless adoration, access to sacraments, and the rosary -- along with food provided by a five-star restaurant. 

St. Patrick’s Church in Soho, an area known for its nightlife and red-light district, is offering a remarkable ministry to the homeless as the capital struggles to cope with the coronavirus pandemic. 

Pastor Fr. Alexander Sherbrooke said he had “a strong sense that the Holy Spirit is literally building a church on the streets” in response to the crisis. 

When the city began to shut down in mid-March, Westminster City Council turned to Sherbrooke, who has overseen daily outreach to the homeless since he arrived in the parish in 2001.

He told CNA that the council had asked St. Patrick’s to increase its provision of food to the homeless significantly while it tried to house those living on the streets. 

The parish, founded in 1792, had previously fed the homeless in its parish center. But after Catholic churches across the country were ordered to close because of the virus, St. Patrick’s was forced to improvise. It began serving the homeless food on its doorstep twice a day, Monday through Sunday.

“On most days we are providing up to 320 meals,” Sherbrooke explained. “On average, we probably see 220 people a day, some of whom come for both breakfast and dinner.”

Hot food is supplied by the Connaught Hotel, a five-star restaurant in London’s affluent Mayfair district, as well as by Wiltons Restaurant in Jermyn Street. The Pret a Manger chain provides sandwiches. 

“It’s a very sophisticated operation and we fully intend to be diligent in preserving social distancing, personal hygiene, food hygiene, etc,” the priest said. “We have a good number of volunteers. We also continue to provide a shower and lavatory facility.” 

Sherbrooke explained that the homeless in the West End live off the footfall generated by local businesses, restaurants and theaters. 

“There is none of that now,” he said. “It’s amazingly empty and can be quite intimidating, particularly at nighttime.”

”The West End has many who are alcohol and drug dependent and without their normal source of income, this can create a volatile situation. Police are very present, but the West End is very inhospitable, at times threatening and not very pleasant.”

“I’ve been in the parish for some 17 years, throughout which  much of my time has been spent in pastoral care for those who are needy. But nothing has really prepared me for where we are at the moment.”

Volunteers at St. Patrick’s are determined to relieve spiritual as well as physical deprivation. As food is distributed, they pray before the Blessed Sacrament in a nearby adoration tent, while observing social distancing. Sherbrooke is available for visitors seeking a sacramental encounter, sitting at a safe distance and behind a white sheet. There is also a tent offering lectio divina. 

“This enhanced feeding facility has come very much as a response to the request of the local authority,” Sherbrooke said. “We have a long tradition of feeding people happily and well. But in a very strange sort of way, the Church, from being a physical reality behind four walls, is now a reality in the street.”

Sherbrooke, who cites St Damien of Molokai and Mother Teresa as inspirations, continued: “It’s imparting a spiritual, pastoral care, where I have a strong sense that the Holy Spirit is literally building a church on the streets. There’s lectio divina. There’s adoration -- in other words, a prolongation of the Holy Mass -- confession, rosary, etc.”

“We are ministering to the people. We are going to them, speaking to them, giving rosaries and sharing the Gospel. So there is a real work of evangelization going on.”

Volunteers also distribute a sheet each week with reflections, Scripture readings, and advice on how to pray.

“So there’s a kind of catechesis of the poor which is going on,” Sherbrooke said.

“There is a very real sense that in this terrible virus situation that God is creating a very different kind of Church, much more evangelical, and perhaps simpler. All this has happened not through management but I believe through God's providence.”

He noted that despite the present dangers volunteers felt a strong sense of supernatural protection. 

“Personally, I would say that the way that I haven’t caught [the virus] -- given the reality of the situation here -- is that every day I pray that the Precious Blood of Jesus will come into my heart, my veins, my lungs, and protect me from the virus so that I can do this work,” he said. 

In 2011, St. Patrick’s reopened after a £4 million restoration project, which included the excavation of the basement and the creation of the parish center, located beneath the church. Food for the homeless is now prepared there every day.

“It’s almost as though God has crafted this parish for this work at this time,” Sherbrooke said.  

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For me, art galleries have always provided shelter from the storm. The tempest in question might be a literal one, such as Storm Dennis, who buffeted us all from on high last weekend, or it could simply be a sudden squall in the mind. Art in all forms can take us out of ourselves – even if it's for a split-second – and recalibrate the mind.

Data suggest that delivery at high-volume, high-technology hospitals reduces neonatal mortality. No study has examined other complications or compared the effects in multiple states by using a study design to control for unmeasured differences in case mix.

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Despite numerous preventive strategies including prophylaxis with 400 IU/day of vitamin D in recent years, the deficiency of vitamin D in infants is still a global health problem.

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Cerebral edema (CE) occurs frequently during treatment of diabetic ketoacidosis (DKA) in children. Severe, life-threatening CE occurs rarely, but subclinical CE is common. Whether the rate of infusion of intravenous fluids influences the occurrence or severity of CE is unknown.

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Although the metabolic syndrome is associated with obesity, not all obese children have insulin resistance and metabolic syndrome, and nonobese children may develop these abnormalities. Associated factors have not been well described.

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Screen time has risen to unprecedented levels among youth. Greater television time is known to be associated with gains in pediatric adiposity, but few studies have examined the longitudinal relations of other forms of screen-based media with weight gain.

Among adolescents aged 9 to 19 years, television viewing was the type of screen time most consistently associated with gains in BMI. However, time with digital versatile discs/videos and video/computer games was also associated with gains in BMI among girls. (Read the full article)

Restrictive feeding by parents is associated with poorer eating self-regulation and increased child weight status. However, this association could be due to confounding home environmental or genetic factors that are challenging to control.

Differential maternal restrictive feeding is associated with differences in twins' caloric compensation and BMI z score. Controlling for the shared home environment and partially for genetics, these findings further support a true (ie, unconfounded) association between restriction and childhood obesity. (Read the full article)

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Hi All,

I have 1 huge project(day X) which has different reference power supply designs.

Now I start a new project and I require 1 specific reference power supply from X.

What is the easist way to do this, other than a copy paste.

Is there a way to create say symbols or something similar, so that multiple different people could use it if they need, in their projects

Thanks for your help and suggestions.

I’m not talking about carnival funhouse mirrors, but rather the different options for mirroring symbols, vias, and bond fingers in your IC Package layout. The Allegro Package Designer Plus and SiP Layout tools have two distinct styles of m...(read more)

Hello,

I am using Virtuoso 6.1.7.

I am performing the parasitic extraction of a MOM cap array of 32 caps. I use Quantus QRC and I enable field solver. I select “QRCFS” for field solver type and “High” for field solver accuracy. The unit MOM cap is horizontally and vertically symmetric. The array looks like the sketch below and there are no other structures except the unit caps:

Rationally speaking, the capacitance values of the unit caps should be symmetric with respect to a vertical symmetry axis that is between cap16 and cap17 (shown with dashed red line). For example,

the capacitance of cap1 should be equal to the capacitance of cap32

the capacitance of cap2 should be equal to the capacitance of cap31

etc. as there are no other structures around the caps that might create some asymmetry.

Nevertheless, what I observe is the following after the parasitic extraction:

As it can be seen, the result is not symmetric contrary to what is expected. I should also add that I do not observe this when I perform parasitic extraction with no filed solver.

Why do I get this result? Is it an artifact resulting from the field solver tool (my conclusion was yes but still it must be verified)? If not, how can something like this happen?

Many thanks in advance.

Best regards,

Can

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ABSTRACT

Satellite viruses, most commonly found in plants, rely on helper viruses to complete their replication cycle. The only known example of a human satellite virus is the hepatitis D virus (HDV), and it is generally thought to require hepatitis B virus (HBV) to form infectious particles. Until 2018, HDV was the sole representative of the genus Deltavirus and was thought to have evolved in humans, the only known HDV host. The subsequent identification of HDV-like agents in birds, snakes, fish, amphibians, and invertebrates indicated that the evolutionary history of deltaviruses is likely much longer than previously hypothesized. Interestingly, none of the HDV-like agents were found in coinfection with an HBV-like agent, suggesting that these viruses use different helper virus(es). Here we show, using snake deltavirus (SDeV), that HBV and hepadnaviruses represent only one example of helper viruses for deltaviruses. We cloned the SDeV genome into a mammalian expression plasmid, and by transfection could initiate SDeV replication in cultured snake and mammalian cell lines. By superinfecting persistently SDeV-infected cells with reptarenaviruses and hartmaniviruses, or by transfecting their surface proteins, we could induce production of infectious SDeV particles. Our findings indicate that deltaviruses can likely use a multitude of helper viruses or even viral glycoproteins to form infectious particles. This suggests that persistent infections, such as those caused by arenaviruses and orthohantaviruses used in this study, and recurrent infections would be beneficial for the spread of deltaviruses. It seems plausible that further human or animal disease associations with deltavirus infections will be identified in the future.

IMPORTANCE Deltaviruses need a coinfecting enveloped virus to produce infectious particles necessary for transmission to a new host. Hepatitis D virus (HDV), the only known deltavirus until 2018, has been found only in humans, and its coinfection with hepatitis B virus (HBV) is linked with fulminant hepatitis. The recent discovery of deltaviruses without a coinfecting HBV-like agent in several different taxa suggested that deltaviruses could employ coinfection by other enveloped viruses to complete their life cycle. In this report, we show that snake deltavirus (SDeV) efficiently utilizes coinfecting reptarena- and hartmaniviruses to form infectious particles. Furthermore, we demonstrate that cells expressing the envelope proteins of arenaviruses and orthohantaviruses produce infectious SDeV particles. As the envelope proteins are responsible for binding and infecting new host cells, our findings indicate that deltaviruses are likely not restricted in their tissue tropism, implying that they could be linked to animal or human diseases other than hepatitis.

Repeated alcohol experiences can produce long-lasting memories for sensory cues associated with intoxication. These memories can problematically trigger relapse in individuals recovering from alcohol use disorder (AUD). The molecular mechanisms by which ethanol changes memories to become long-lasting and inflexible remain unclear. New methods to analyze gene expression within precise neuronal cell types can provide further insight toward AUD prevention and treatment. Here, we used genetic tools in Drosophila melanogaster to investigate the lasting consequences of ethanol on transcription in memory-encoding neurons. Drosophila rely on mushroom body (MB) neurons to make associative memories, including memories of ethanol-associated sensory cues. Differential expression analyses revealed that distinct transcripts, but not genes, in the MB were associated with experiencing ethanol alone compared to forming a memory of an odor cue associated with ethanol. Adult MB-specific knockdown of spliceosome-associated proteins demonstrated the necessity of RNA-processing in ethanol memory formation. These findings highlight the dynamic, context-specific regulation of transcription in cue-encoding neurons, and the lasting effect of ethanol on transcript usage during memory formation.

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Simian-human immunodeficiency virus (SHIV) infection of rhesus monkeys is an important preclinical model for human immunodeficiency virus type 1 (HIV-1) vaccines, therapeutics, and cure strategies. SHIVs have been optimized by incorporating HIV-1 Env residue 375 mutations that mimic the bulky or hydrophobic residues typically found in simian immunodeficiency virus (SIV) Env to improve rhesus CD4 binding. We applied this strategy to three SHIV challenge stocks (SHIV-SF162p3, SHIV-AE16, and SHIV-325c) and observed three distinct outcomes. We constructed six Env375 variants (M, H, W, Y, F, and S) for each SHIV, and we performed a pool competition study in rhesus monkeys to define the optimal variant for each SHIV prior to generating large-scale challenge stocks. We identified SHIV-SF162p3S/wild type, SHIV-AE16W, and SHIV-325cH as the optimal variants. SHIV-SF162p3S could not be improved, as it already contained the optimal Env375 residue. SHIV-AE16W exhibited a similar replicative capacity to the parental SHIV-AE16 stock. In contrast, SHIV-325cH demonstrated a 2.6-log higher peak and 1.6-log higher setpoint viral loads than the parental SHIV-325c stock. These data demonstrate the diversity of potential outcomes following Env375 modification in SHIVs. Moreover, the clade C SHIV-325cH challenge stock may prove useful for evaluating prophylactic or therapeutic interventions against clade C HIV-1.

IMPORTANCE We sought to enhance the infectivity of three SHIV stocks by optimization of a key residue in human immunodeficiency virus type 1 (HIV-1) Env (Env375). We developed the following three new simian-human immunodeficiency virus (SHIV) stocks: SHIV-SF162p3S/wild type, SHIV-AE16W, and SHIV-325cH. SHIV-SF162p3S could not be optimized, SHIV-AE16W proved comparable to the parental virus, and SHIV-325cH demonstrated markedly enhanced replicative capacity compared with the parental virus.

Although pain is a prevalent nonmotor symptom in Parkinson’s disease (PD), it is undertreated, in part because of our limited understanding of the underlying mechanisms. Considering that the basal ganglia are implicated in pain sensation, and that their synaptic outputs are controlled by the subthalamic nucleus (STN), we hypothesized that...

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