Todd Colvin, Ambrosino Brothers

Dan Deming, KKM Financial

Todd Colvin, Ambrosino Brothers

Dan Deming, KKM Financial

Todd Colvin, Ambrosino Brothers

Dan Deming, KKM Financial

Larry Shover, Efficient Advisors

Todd Colvin, Ambrosino Brothers

Todd Colvin, Ambrosino Brothers

Dan Deming, KKM Financial

Larry Shover, Efficient Advisors

Dan Deming, KKM Financial

Todd Colvin, Ambrosino Brothers

Todd Colvin, Ambrosino Brothers

Larry Shover, Efficient Advisors

Dan Deming, KKM Financial

Dan Deming, KKM Financial

Todd Colvin, Ambrosino Brothers

In India and China, indigenous drug manufacturers market arbitrarily combined parenteral β-lactam and β-lactamase inhibitors (BL-BLIs). In these fixed-dose combinations, sulbactam or tazobactam is indiscriminately combined with parenteral cephalosporins, with BLI doses kept in ratios similar to those for the approved BL-BLIs. Such combinations have been introduced into clinical practice without mandatory drug development studies involving pharmacokinetic/pharmacodynamic, safety, and efficacy assessments being undertaken. Such unorthodox combinations compromise clinical outcomes and also potentially contribute to resistance development.

The International Journal of Forecasting has published its 2020-Q1 issue, guest edited by Spyros Makridakis and Fotios Petropoulos, and dedicated entirely to results and commentary on the M4 Forecasting Competition. This issue should be of great interest and value to business forecasting practitioners, and you get online access to it [...]

The post M4 Forecasting Competition: Results and Commentary appeared first on The Business Forecasting Deal.

Once while eating dinner in Montreal, our friendly, intoxicated waitress plopped herself in my lap and proceeded to tell us about how obsessed she was with the CD that was playing - singing out the lyrics at an ungodly volume and flinging her arms about. Wow, I thought to myself, people who listen to Morcheeba sure seem to have a lot of fun, and promised to check them out.

Several CDs later, they are firmly one of my favorites. And their trip hop meditation, 2003’s Charango remains one of my most played CDs.

Morcheeba (Mor = more, Cheeba = pot) are brothers Ross and Paul Godfrey with singer Skye Edwards (who has since been replaced). Part trance, part ambience, Charango is full of smooth, snogworthy jams. And just as you surrender to its seductive groove, Slick Rick shows up with a rap called “Women Lose Weight”.

Lamenting his wife putting on weight after having kids and stalled by his mistress who wants a clean break before she shacks up with him, he decides the easiest way out of it all is to kill the spouse. Considering different ways to do the deed, he finally rams his car into her Chevy over a long lunch break one fine day. It is an unexpected, stunning, tongue-in-cheek social commentary that makes it a CD you won’t forget easily.

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Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Introduction The Competition and Markets Authority (“CMA”), the authority responsible for operating and enforcing the UK merger control regime, has published its updated Retail Mergers Commentary (“New Commentary”).1 The CMA ...

The case of So Sau Lai Connie v DBS Bank (Hong Kong) Ltd [2017] HKEC 29 is a typical letter of credit fraud case. This case illustrates whether certain “red flags” may constitute discrepant presentation or a fraud indication. Background ...

(MENAFN - Caribbean News Global) OLDWICK, N.J.-(BUSINESS WIRE)-Life/health-related catastrophe bonds face the greatest threat of losses from the COVID... ......

The prime minister will hopefully continue to ignore those who claim the oil and gas industry is dead, Rob Breakenridge says.

Medscape thanks nurses around the world during International Year of the Nurse and the Midwife and National Nurses Week. Please join us.

After a week seeing cancer patients with COVID-19 as the inpatient consult attending, Don Dizon finds himself more emotionally exhausted than he's ever been before.

Calls to relax social distancing policies emphasize the need for increased testing, but a closer look at current SARS-CoV-2 tests leaves Anish Koka, MD, doubtful that more tests will be the solution.

Dr Harpreet Bajaj summarizes the known and unknown links between diabetes and COVID-19, focusing on three clinical questions.

Dr Aaron Holley warns against following 'false prophets' as we confront treatment decisions for patients with COVID-19.

Just as an imperfect ruler can measure accurately if its error is constant and known, serology need not have perfect sensitivity and specificity to estimate COVID's prevalence, write Drs Jha and Murthy.

Select agents (SA) pose unique challenges for licensing vaccines and therapies. In the case of toxin-mediated diseases, HHS assigns guidelines for SA use, oversees vaccine and therapy development, and approves animal models and approaches to identify mechanisms for toxin neutralization. In this commentary, we discuss next-generation vaccines and therapies against ricin toxin and botulinum toxin, which are regulated SA toxins that utilize structure-based approaches for countermeasures to guide rapid response to future biothreats.

Cushing syndrome results from chronic excessive exposure to glucocorticoids, impacting virtually every organ system with the most dominant effects on fat metabolism, immune function, and musculoskeletal systems. Endogenous Cushing syndrome is rare, most usually due to excess ACTH secretion from pituitary, and less frequently from ectopic tumors. Other cases result from ACTH-independent adrenal overproduction of cortisol.

Lai et al. report the case of an elderly gentleman who presented with resolving neurologic findings from a transient ischemic attack and who was found to have hyponatremia with a serum sodium concentration of 123 mmol/L. Hypoosmolality was confirmed, and a diluting defect identified with a urine osmolality that ranged between 167 and 285 mOsm/kg. As the urine osmolality rose to > 400 mOsm/kg with water deprivation, a diagnosis of syndrome of inappropriate antidiuresis (SIAD) from reset osmostat was entertained.

This interesting case report from South Africa focuses on a difficult diagnostic challenge: apparent Cushing syndrome with inconsistent laboratory findings.

Hyponatremia, the most common electrolyte disorder, is present in 2%–4% of ambulatory patients and up to 22% of geriatric inpatients (1). Clinicians classify hyponatremia into three main categories: hypovolemic (decreased intravascular volume from salt and water loss with inadequate replacement), euvolemic (normal intravascular volume, but increased water dilutes sodium), and hypervolemic (total body water is increased, usually causing edema, while intravascular volume is often decreased). Less frequent causes are pseudohyponatremia (due to decreased water in a fixed volume of plasma, usually due to increased lipids or protein) and water shifting due to increased osmolality (most commonly due to glucose). While the most extreme examples of hypovolemic and hypervolemic states can be determined by physical examination, in many cases the patient is euvolemic clinically.

In India and China, indigenous drug manufacturers market arbitrarily combined parenteral β-lactam and β-lactamase inhibitors (BL-BLIs). In these fixed-dose combinations, sulbactam or tazobactam is indiscriminately combined with parenteral cephalosporins, with BLI doses kept in ratios similar to those for the approved BL-BLIs. Such combinations have been introduced into clinical practice without mandatory drug development studies involving pharmacokinetic/pharmacodynamic, safety, and efficacy assessments being undertaken. Such unorthodox combinations compromise clinical outcomes and also potentially contribute to resistance development.

Welcome to Standard Sport's LIVE coverage of the K-League openers between Jeonbuk Hyundai Motors and the Suwon Samsung Bluewings

The Sky Blues make it two from two with a against the Phoenix, following Melbourne City's 2-1 win over Adelaide United.

Sculptures commemorating plagues were common in Europe. Our art critic suggests America could build its own, and Trump provides inspiration for where.

Risk guides much of our medical care system. COVID-19 is showing us, unless we have developed immunity, we are all at risk.

The OECD's Committee on Fiscal Affairs (CFA) invites public comments on the draft Commentary on the International VAT Neutrality Guidelines. This draft Commentary provides guidance on the practical implementation of the six International VAT Neutrality Guidelines approved by the CFA in July 2011. Public comments should be sent before 26 September 2012 to vat@oecd.org.

A hilarious video has emerged of a pitchside correspondent reporting on a Russian Premier League game despite being drenched by a sprinkler. 

Rafael Nadal has endured a series of injuries during his illustrious career but the latest setback appeared to happen in the comfort of his own home.