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Wine buying ideas from online specialists | David Williams

Sales from online dealers has shot up during the lockdown. Here’s your chance to find some great deals and also to try some new bottles and grapes

Shaw and Smith Sauvignon Blanc, Adelaide Hills, Australia 2019 (£14.95, slurp.co.uk) With most of us living out most of our lives in the virtual world at the moment, it’s not surprising that a lot of wine buying has migrated online, too. Depending on which statistical data gatherer you believe, sales of alcohol online were up by as much as 50% in the first weeks of the crisis v “normal” times. A lot of those sales went through the virtual tills of the supermarkets, of course. But the online wine specialists have been benefiting, too. If you’re looking to dip a toe into online wine buying for the first time, many retailers are offering discounted mixed cases to get you started. Slurp.co.uk, for example, has a 10-bottle “Indulge in Isolation” case, which at £120 works out as a £50 discount. There are some nice wines in there, although, personally, I’d rather go à la carte on slurp’s extensive list, filling a case with bottles such as Shaw and Smith’s superbly zingy, pristine sauvignon.

De Martino Viejas Tinajas Cinsault, Itata, Chile 2018 (£14.95, virginwines.co.uk) One mixed case that I do like the look of is Virgin Wine’s selection of contemporary German bottles, which, includes pinot blanc and pinot noir as well as a scintillating example of the country’s most famous grape variety, Gunderloch Fritz’s Riesling, Rheinhessen 2017 (a bottle of which is £14.99 on its own; The Best of Modern Germany case of 12 bottles is £140). You could also include any of those Germans in a mixed case with a wine such as the gorgeously light, rosehippy-red fruited, clay amphora-made Viejas Tinajas from Chile. Meanwhile, the UK’s oldest wine retailer, and one of the first to make a success of online, Berry Bros & Rudd, has a tempting 12 for £200 mix and match offer of 30 smart bottles, which is pretty good value for wines from the likes of De Martino, the Loire’s Vincent Carême, Beaujolais’ Julien Sunier and the Douro’s Quinta de la Rosa.

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How to save in lockdown … from buying chairs and laptops to car insurance

We may be spending less by not travelling to work, but with an uncertain future it’s time to take stock of personal finances

With gyms shut, taps turned off in pubs and the prospect of a holiday a distant dream, many people are finding their outgoings have dropped since lockdown. But the shadow of a looming recession and concern about whether jobs will even exist when offices reopen, means many are looking at their finances even more closely.

So what are the best ways to improve them amid extraordinary times and an uncertain future?

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Lockdown brings change in buying behaviour, more older people hop onto digital tech: Survey

New Delhi, May 10 () The coronavirus lockdown has brought a sea change in the buying behaviour of many Indians, such as purchasing vegetables and other consumables without asking for prices, far from the old habit of asking 'dhaniya' or 'mirchi' free from vendors, according to a survey by Enormous Brands. The web-based survey, conducted between March 30 and April 22, took feedback from 3,737 respondents in cities including Delhi-NCR, Mumbai, Bengaluru, Chennai, Pune and Ahmedabad. It found that there has also been a sharp increase in adoption of digital technology by older people to join the e-commerce bandwagon for ordering items like milk, grocery and home essentials and paying through wallets and UPI. The study also found that COVID–19 has helped in forming an opinion for pushing the




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Lockdown brings change in buying behaviour, more older people hop onto digital tech: Survey

The coronavirus lockdown has brought a sea change in the buying behaviour of many Indians, such as purchasing vegetables and other consumables without asking for prices, far from the old habit of asking 'dhaniya' or 'mirchi' free from vendors, according to a survey by Enormous Brands. The web-based survey, conducted between March 30 and April 22, took feedback from 3,737 respondents in cities including Delhi-NCR, Mumbai, Bengaluru, Chennai, Pune and Ahmedabad. It found that there has also been a sharp increase in adoption of digital technology by older people to join the e-commerce bandwagon for ordering items like milk, grocery and home essentials and paying through wallets and UPI. The study also found that COVID19 has helped in forming an opinion for pushing the 'Make in India' agenda, with 42 per cent believing that "there is an active and deliberate attempt by China to spread COVID across the world for economic gains" which has led to a strong anti-China sentiment. "The ...




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Buying ‘China-made’ dreams in Nepal

With China taking greater interest in the internal politics of Nepal and funding several projects in the country, all eyes in the neighbourhood are on the Himalayan nation. However, as most of the projects awarded to Chinese firms lie in limbo and mired in cost-overrun, it is time that Kathmandu pauses to evaluate its engagement with the dragon Nestled in between two gigantic neighbours—India and China—Nepal has often found itself mired in situations when it has to juggle the primacy it places on its ties with the two nations. The Himalayan nation’s allegiance to either an assertive New Delhi and an imperial Beijing has shifted back and forth over the years depending on the powers that be. There is much talk lately about China and its funding to infrastructure projects that would ostensibly bring prosperity to Nepal. A new narrative spun by sections of Nepalese society and political class says that the renewed Chinese support would reduce Nepal’s dependence on its southern neighbour, India. This narrative received an increased impetus subsequent to Madhesi blockade in 2015 against the newly promulgated Constitution that was perceived to be non-inclusive and anti-federalism. The protest movement was projected as India-sponsored ‘economic blockade’ by a section of Nepalese media holding anti-India views and also the then ruling political party, Communist Party of Nepal, (CPN (UML). The attempts thereafter have been to cosy-up to China to attract investments and provide them as much space as they want in Nepalese economy, society and also polity. But one must pause to see the direction the Nepalese are headed in? Are these efforts to seek investment from China actually resulting in robust infrastructure in Nepal, except few cosmetic changes here and there? All major China-supported projects in the Himalayan nation are mired in cost overrun, delayed implementation and compromise on quality, like the West Seti, the Kulekhani 3 and the Budhigandaki hydropower projects. Various projects taken over by Chinese companies continue to remain incomplete as neither the agreed terms and conditions were honoured by the Chinese nor the time schedule on which they were supposed to be completed. A study of the actual on-the-ground situation in each of the five mega infrastructure projects funded by the Chinese is highly revelatory. It was not only the norms of awarding a project to a foreign entity that were flouted in favour of China but also major compromises were made in the process. Nepal’s impatience to grab Chinese investments has been fully exploited by China, which has been trying to wean them away from India’s sphere of influence like a pied piper. Take the example of West Seti hydropower project which was awarded to a sub-group of China, Three Gorges International Corporation (CTGC), in 2012 without any international bidding. The plan was to create a 750MW power generation unit but the project did not see any progress till 2016. Last year, after the Nepalese government threatened to scrap the deal, CTGC signed a framework agreement with Nepal Electricity Authority in January 2017 but the project still hangs in limbo because the agreement is yet to be ratified. The original idea of the project was to export the electricity generated from the plant to India. However, at the behest of China, Nepal eliminated that clause and inserted one which said that the electricity will be consumed domestically. It was not only the norms of awarding a project to a foreign entity that were flouted in favour of China but also major compromises were made in the process. Nepal’s impatience to grab Chinese investments has been fully exploited by China Another instance of delayed implementation relates to Kulekhani 3 hydropower project which has missed its fourth revised completion deadline set for July 2017. It was awarded to awarded to Chinese companies Zhejiang Jiahi and Sino Hydro in 2008 and was scheduled to be completed in 2012. The project faced not only time overruns but also cost escalation due to delays. The Initial estimated cost which was NR 2.43 billion is now doubled to NR 4.22 billion. The inordinate delay in the completion of the project prompted the National Planning Commission of Nepal to declare Kulekhani 3 a “troubled hydropower project.” The fate of Gautam Buddha Airport upgradation project, awarded to North West Civil Aviation Airport Construction Group of China in 2014, appears to be steeped in uncertainty just like the others. The airport infrastructure was to be improved as part of Nepal’s national pride project so that it could function as an international airport to serve the fast-rising business and industrial hub of Bhairahawa and facilitate international pilgrimage tourism to Lumbini, the birthplace of the Buddha. The upgradation work which was to be completed by December 2017 is now revised to be finished by 2019. Nepalese authorities have attributed slow progress on the project to very low bidding price and the weak cash flow situation in the Chinese company which grabbed the tender. Exasperated at the lack of desired progress, the Civil Aviation Authority of Nepal is contemplating measures to terminate the contract of the Chinese firm. They have also hired international contract management experts to resume the upgradation work at the airport. After remaining mired in troubled relating to funding problems, Pokhara Regional International Airport witnessed some progress in August 2017 when the Chinese company, which was awarded the contract, started the construction work. The project, which was formulated at the cost of NR 22 billion, will be financed by China’s Export and Import Bank under a loan agreement with Nepal government. The airport, which was to be ready by July 2020, is now planned to be completed by July 2021 on paper at least. Whether it will happen or not remains to be seen. Likewise, Solar Power Project has run into controversy with the PAC directing the government to scrap the contract awarded to a Chinese company. The committee contended that the decision was against procurement law. On May 16, China’s Risen Co Energy Limited had bagged the contract from the Nepal Electricity Authority (NEA) management at the price of approximately NR 3.88 billion, despite the fact that the bidder ranked fourth in the financial proposal. An English daily in Nepal quoted PAC chairman Dor Prasad Upadhyaya as saying, “There (were) other bidders with equally good technical qualifications as that of the selected bidder, but the contract was given to this company in a premeditated way.” The committee has now asked the authorities to start a fresh tender to install solar power plants in the premises of Kulekhani reservoir in Makwanpur district and Devighat Hydropower Project in Nuwakot district. The project is already one and a half year behind its schedule and the NEA has stated that it could be abandoned if the World Bank decides to withdraw from financing due to overrun. The Budhi Gandaki hydropower project, awarded in June 2017 to China Gezhouba Group Corporation without any international bidding, has also run into troubles. A joint meeting of the parliament’s Agriculture and Water Resources Committee (AWRC) and Finance Committee has instructed the government to scrap the contract awarded to the Chinese firm to build the 1,200-megawatt hydroelectric project because the tender was awarded without bidding in violation of the Public Procurement Act. An English daily quoted Prakash Jwala, chairperson of the Finance Committee, as saying that the government made a blunder by awarding the project to a firm whose track record has been abysmal. He had said, “This project was handed over to a controversial Chinese company whose track record is so bad in Nepal by flouting various laws like Public Procurement Act. The intention behind selecting this Chinese firm is only to hold the project. How can a company, which could not build even a 30-megawatt project (Chameliya), build such a mega project?” Opposition to the project has also come up from political parties citing provisions in the Nepalese Constitution which ensures compulsory local investment in the development of natural resources. Experts are of the view that if the Chinese company proceeds with the development of the project, the cost is bound to inflate. Taking into account this viewpoint, the PAC of Nepal has summoned the concerned government officials involved in the deal. Opposition to the project has also come up from political parties citing provisions in the Nepalese Constitution which ensures compulsory local investment in the development of natural resources After the two-month-long standoff with India in Doklam plateau, China has accelerated its engagement with Nepal. The country’s foreign minister Wang Yi has promised to take the ties between Kathmandu and Beijing to a new level and the sentiment got a major boost when Nepal’s deputy prime minister Krishna Bahadur Mahara visited Beijing in September first week and met several high-level officials, including Premier Li Keqiang. To show that China approved of Nepal’s neutral stand during the Doklam standoff, Li had also said, “China is ready to provide support within its due capacity toNepal’s economic and social development.” Because of the growing bonhomie between the two nations, quite obviously, the developments in Nepal are being watched keenly by the neighbourhood. With the Left parties coming together to form a pre-poll alliance in October first week, the rumour mill is churning various kinds of news as to how the tieup will impact India and China. While some experts allege India’s role in forging the alliance, others claim that the tieup had received Beijing’s nod. The opinion is divided over how it will benefit or harm India’s interests. Considering that New Delhi has had its share of troubles with the CPN (UML) chief K.P. Sharma Oli in the past, a unity government under Oli’s leadership will be in Beijing’s favour. However, Nepal needs to tread the ground carefully. While seeking closeness to and investments from Beijing, Nepal will have to seek answers to a few questions: Why is China interested in Nepal? By helping Nepal, is Beijing serving its own nationalistic interests? Could the funds coming in from China land Nepal in a debt trap like Sri Lanka (which was forced to lease its Hambantota port to China for 99 years in order to pay back the debt)? Nepalese must ask themselves what are the commonalities between China and Nepal, in terms of religion, language, food, dress, culture and identity? China, as of now, is like a new toy being held in high esteem. Once its glitter is gone and it shows its true nature, it might be too late for Nepal.  
From HardNews print issue: 
Lead Image: 




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Stemline Shares Take Off on $677 Million Buyout Offer by Global Pharmaceutical Firm

Source: Streetwise Reports   05/04/2020

Shares of Stemline Therapeutics traded 150% higher after the company reported that it has entered into a definitive agreement to be acquired by Italy's Menarini Group in a deal valued at up to $677 million.

Stemline Therapeutics Inc. (STML:NASDAQ), which is focused on developing and commercializing novel oncology therapeutics, today announced that it has entered into a definitive agreement to be acquired by private Italian pharmaceutical and diagnostics company Menarini Group in a transaction valued up to $677 million.

The companies advised that the transaction has already been unanimously approved by both companies' Boards of Directors and that the transaction is expected to close in Q2/20 subject to customary closing conditions, regulatory approvals and a tender of at least 50% of the outstanding Stemline shares by shareholders. Menarini stated that it plans to fund the purchase by using existing cash resources.

The firms outlined that purchase details and advised that "under the terms of the agreement, a wholly owned subsidiary of the Menarini Group will commence a tender offer for all outstanding shares of Stemline, whereby Stemline shareholders will be offered a total potential consideration of $12.50 per share, consisting of an upfront payment of $11.50 in cash and one non-tradeable Contingent Value Right (CVR) that will entitle each holder to an additional $1.00 in cash per share upon completion of the first sale of ELZONRIS in any EU5 country after European Commission approval."

The report explained that ELZONRIS is a novel targeted therapy directed to the interleukin-3 (IL-3) receptor-α (CD123) and was developed by Stemline for treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN) in adult and pediatric patients. The firm stated that the U.S. Food and Drug Administration (FDA) approved that drug in the U.S. in December 2018. A marketing authorization application (MAA) has already been submitted and is presently under review by the European Medicines Agency. Post acquisition, Menarini expects to obtain approvals and expand distribution of ELZONRIS to Europe and emerging markets.

Stemline Therapeutics' Chairman, CEO and Founder Ivan Bergstein, M.D., commented, "Joining Menarini represents a unique opportunity for Stemline to advance the commercialization of ELZONRIS across the globe and to accelerate the development of our pipeline of oncology assets. ...We are excited to be combining with a like-minded organization in Menarini, in a transaction that will deliver immediate and significant cash value to our shareholders, while also allowing our shareholders to participate in the future upside of ELZONRIS's European launch."

Elcin Barker Ergun, CEO of Menarini Group, remarked, "Stemline is an excellent fit for Menarini, enabling us to expand our presence in the U.S. with an established biopharmaceutical company focused on developing oncology therapeutics. Through this acquisition, we will continue to strengthen our portfolio and pipeline of oncology assets and deliver novel therapies around the world."

The company described BPDCN, formerly blastic NK-cell lymphoma, as "an aggressive hematologic malignancy, often with cutaneous manifestations, with historically poor outcomes which typically presents in the bone marrow and/or skin and may also involve lymph nodes and viscera."

Stemline Therapeutics is a commercial-stage biopharmaceutical company headquartered in New York that develops and markets oncology therapeutics. The firm stated that its "ELZONRIS® (tagraxofusp) is a targeted therapy directed to CD123 and is FDA-approved and commercially available in the U.S. for the treatment of adult and pediatric patients, two years and older, with BPDCN." Stemline noted that ELZONRIS is also being currently being evaluated in clinical studies for other indications including chronic myelomonocytic leukemia, myelofibrosis and acute myeloid leukemia.

The Menarini Group is an international pharmaceutical company based in Italy which operates and sells its products in more than 100 countries. The company stated that it has $4.2 billion in sales annually. The company's medicines address many areas of illnesses including cardiovascular, gastroenterology, metabolic, infectious diseases and anti-inflammatory/analgesic therapeutic areas and oncology.

Stemline Therapeutics began the day with a market capitalization of around $249.2 million with approximately 54.27 million shares outstanding and a short interest of about 11.3%. STML shares opened nearly 150% higher today at $11.81 (+$7.06, +148.63%) over Friday's closing price of $4.75. The stock has traded today between $1.81 and $12.35 per share and is currently trading at $12.10 (+$7.35, +154.74%).

Sign up for our FREE newsletter at: www.streetwisereports.com/get-news

Disclosure:
1) Stephen Hytha compiled this article for Streetwise Reports LLC and provides services to Streetwise Reports as an independent contractor. He or members of his household own securities of the following companies mentioned in the article: None. He or members of his household are paid by the following companies mentioned in this article: None.
2) The following companies mentioned in this article are billboard sponsors of Streetwise Reports: None. Click here for important disclosures about sponsor fees.
3) Comments and opinions expressed are those of the specific experts and not of Streetwise Reports or its officers. The information provided above is for informational purposes only and is not a recommendation to buy or sell any security.
4) The article does not constitute investment advice. Each reader is encouraged to consult with his or her individual financial professional and any action a reader takes as a result of information presented here is his or her own responsibility. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. This article is not a solicitation for investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company mentioned on Streetwise Reports.
5) From time to time, Streetwise Reports LLC and its directors, officers, employees or members of their families, as well as persons interviewed for articles and interviews on the site, may have a long or short position in securities mentioned. Directors, officers, employees or members of their immediate families are prohibited from making purchases and/or sales of those securities in the open market or otherwise from the time of the interview or the decision to write an article until three business days after the publication of the interview or article. The foregoing prohibition does not apply to articles that in substance only restate previously published company releases.
6) This article does not constitute medical advice. Officers, employees and contributors to Streetwise Reports are not licensed medical professionals. Readers should always contact their healthcare professionals for medical advice.

( Companies Mentioned: STML:NASDAQ, )




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Alexion's Buyout of Portola Pharmaceuticals Gets Investors' Blood Flowing

Source: Streetwise Reports   05/05/2020

Shares of Portola Pharmaceuticals traded 130% higher after the company reported that it has received an $18 per share buyout offer from Alexion Pharmaceuticals.

Commercial-stage biotechnology company Portola Pharmaceuticals Inc. (PTLA:NASDAQ), which focuses on blood-related disorders, and global biopharmaceuticals firm Alexion Pharmaceuticals Inc. (ALXN:NASDAQ) announced that they have entered into a definitive merger agreement for Portola to be acquired by Alexion.

The acquisition is said to provide a key addition to Alexion's diversified commercial portfolio. The report indicated that the merger agreement has already been unanimously approved each of the company's boards of directors.

The report explained that "Portola's commercialized medicine, Andexxa® [coagulation factor Xa (recombinant), inactivated-zhzo], marketed as Ondexxya® in Europe, is the first and only approved Factor Xa inhibitor reversal agent, and has demonstrated transformative clinical value by rapidly reversing the anticoagulant effects of Factor Xa inhibitors rivaroxaban and apixaban in severe and uncontrolled bleeding."

Portola's President and CEO Scott Garland commented, "In developing and launching Andexxa, Portola has established a strong foundation for changing the standard of care for patients receiving Factor Xa inhibitors that experience a major, life-threatening bleed. Andexxa rapidly reverses the pharmacologic effect of rivaroxaban and apixaban within two minutes, reducing anti-Factor Xa activity by 92 percent...Given their enhanced resources, global footprint and proven commercial expertise, we look forward to working with Alexion to maximize the value of Andexxa. With their commitment to commercial excellence, together, we will be able to drive stronger utilization of Andexxa, increase penetration and accelerate adoption in the critical care setting."

Ludwig Hantson, Ph.D., CEO of Alexion, remarked, "The acquisition of Portola represents an important next step in our strategy to diversify beyond C5. Andexxa is a strategic fit with our existing portfolio of transformative medicines and is well-aligned with our demonstrated expertise in hematology, neurology and critical care...We believe Andexxa has the potential to become the global standard of care for patients who experience life-threatening bleeds while taking Factor Xa inhibitors apixaban and rivaroxaban. By leveraging Alexion's strong operational and sales infrastructure and deep relationships in hospital channels, we are well positioned to expand the number of patients helped by Andexxa, while also driving value for shareholders."

The firms advised that "under the terms of the merger agreement, a subsidiary of Alexion will commence a tender offer to acquire all of the outstanding shares of Portola's common stock at a price of $18 per share in cash." Alexion plans to fund the purchase with existing cash on hand and the transaction is expected to close in Q3/20. The purchase is subject to approval by a majority interest of Portola's common stockholders tendering their shares along with ordinary closing conditions and regulatory approvals. The company noted that "following successful completion of the tender offer, Alexion will acquire all remaining shares not tendered in the offer at the same price of $18 per share through a merger."

Alexion is a global biopharmaceutical company based in Boston, Mass., with offices in 50 countries worldwide. The company states that it has been "the global leader in complement biology and inhibition for more than 20 years and that it has developed and commercializes two approved complement inhibitors to treat patients with paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome, as well as the first and only approved complement inhibitor to treat anti-acetylcholine receptor antibody-positive generalized myasthenia gravis and neuromyelitis optica spectrum disorder."

Portola is headquartered in South San Francisco, Calif., and is a commercial-stage biopharmaceutical company focused on treating patients with serious blood-related disorders. Specifically, the company is engaged in developing and commercializing novel therapeutics in order to advance the fields of thrombosis and other hematologic conditions. The firm listed that its first two commercialized products are Andexxa® and Bevyxxa® (betrixaban), and that it is also advancing and developing cerdulatinib, a SYK/JAK inhibitor for use in treatment of hematologic cancers.

Portola Pharmaceuticals started off the day with a market capitalization of around $609.0 million with approximately 78.5 million shares outstanding and a short interest of about 23.0%. PTLA shares opened 130% higher today at $17.85 (+$10.09, +130.03%) over yesterday's $7.85 closing price. The stock has traded today between $17.71 and $17.91 per share and is currently trading at $17.83 (+$10.07, +129.77%).

Sign up for our FREE newsletter at: www.streetwisereports.com/get-news

Disclosure:
1) Stephen Hytha compiled this article for Streetwise Reports LLC and provides services to Streetwise Reports as an independent contractor. He or members of his household own securities of the following companies mentioned in the article: None. He or members of his household are paid by the following companies mentioned in this article: None.
2) The following companies mentioned in this article are billboard sponsors of Streetwise Reports: None. Click here for important disclosures about sponsor fees.
3) Comments and opinions expressed are those of the specific experts and not of Streetwise Reports or its officers. The information provided above is for informational purposes only and is not a recommendation to buy or sell any security.
4) The article does not constitute investment advice. Each reader is encouraged to consult with his or her individual financial professional and any action a reader takes as a result of information presented here is his or her own responsibility. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. This article is not a solicitation for investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company mentioned on Streetwise Reports.
5) From time to time, Streetwise Reports LLC and its directors, officers, employees or members of their families, as well as persons interviewed for articles and interviews on the site, may have a long or short position in securities mentioned. Directors, officers, employees or members of their immediate families are prohibited from making purchases and/or sales of those securities in the open market or otherwise from the time of the interview or the decision to write an article until three business days after the publication of the interview or article. The foregoing prohibition does not apply to articles that in substance only restate previously published company releases.
6) This article does not constitute medical advice. Officers, employees and contributors to Streetwise Reports are not licensed medical professionals. Readers should always contact their healthcare professionals for medical advice.




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Stemline Shares Take Off on $677 Million Buyout Offer by Global Pharmaceutical Firm

Source: Streetwise Reports   05/04/2020

Shares of Stemline Therapeutics traded 150% higher after the company reported that it has entered into a definitive agreement to be acquired by Italy's Menarini Group in a deal valued at up to $677 million.

Stemline Therapeutics Inc. (STML:NASDAQ), which is focused on developing and commercializing novel oncology therapeutics, today announced that it has entered into a definitive agreement to be acquired by private Italian pharmaceutical and diagnostics company Menarini Group in a transaction valued up to $677 million.

The companies advised that the transaction has already been unanimously approved by both companies' Boards of Directors and that the transaction is expected to close in Q2/20 subject to customary closing conditions, regulatory approvals and a tender of at least 50% of the outstanding Stemline shares by shareholders. Menarini stated that it plans to fund the purchase by using existing cash resources.

The firms outlined that purchase details and advised that "under the terms of the agreement, a wholly owned subsidiary of the Menarini Group will commence a tender offer for all outstanding shares of Stemline, whereby Stemline shareholders will be offered a total potential consideration of $12.50 per share, consisting of an upfront payment of $11.50 in cash and one non-tradeable Contingent Value Right (CVR) that will entitle each holder to an additional $1.00 in cash per share upon completion of the first sale of ELZONRIS in any EU5 country after European Commission approval."

The report explained that ELZONRIS is a novel targeted therapy directed to the interleukin-3 (IL-3) receptor-α (CD123) and was developed by Stemline for treatment of blastic plasmacytoid dendritic cell neoplasm (BPDCN) in adult and pediatric patients. The firm stated that the U.S. Food and Drug Administration (FDA) approved that drug in the U.S. in December 2018. A marketing authorization application (MAA) has already been submitted and is presently under review by the European Medicines Agency. Post acquisition, Menarini expects to obtain approvals and expand distribution of ELZONRIS to Europe and emerging markets.

Stemline Therapeutics' Chairman, CEO and Founder Ivan Bergstein, M.D., commented, "Joining Menarini represents a unique opportunity for Stemline to advance the commercialization of ELZONRIS across the globe and to accelerate the development of our pipeline of oncology assets. ...We are excited to be combining with a like-minded organization in Menarini, in a transaction that will deliver immediate and significant cash value to our shareholders, while also allowing our shareholders to participate in the future upside of ELZONRIS's European launch."

Elcin Barker Ergun, CEO of Menarini Group, remarked, "Stemline is an excellent fit for Menarini, enabling us to expand our presence in the U.S. with an established biopharmaceutical company focused on developing oncology therapeutics. Through this acquisition, we will continue to strengthen our portfolio and pipeline of oncology assets and deliver novel therapies around the world."

The company described BPDCN, formerly blastic NK-cell lymphoma, as "an aggressive hematologic malignancy, often with cutaneous manifestations, with historically poor outcomes which typically presents in the bone marrow and/or skin and may also involve lymph nodes and viscera."

Stemline Therapeutics is a commercial-stage biopharmaceutical company headquartered in New York that develops and markets oncology therapeutics. The firm stated that its "ELZONRIS® (tagraxofusp) is a targeted therapy directed to CD123 and is FDA-approved and commercially available in the U.S. for the treatment of adult and pediatric patients, two years and older, with BPDCN." Stemline noted that ELZONRIS is also being currently being evaluated in clinical studies for other indications including chronic myelomonocytic leukemia, myelofibrosis and acute myeloid leukemia.

The Menarini Group is an international pharmaceutical company based in Italy which operates and sells its products in more than 100 countries. The company stated that it has $4.2 billion in sales annually. The company's medicines address many areas of illnesses including cardiovascular, gastroenterology, metabolic, infectious diseases and anti-inflammatory/analgesic therapeutic areas and oncology.

Stemline Therapeutics began the day with a market capitalization of around $249.2 million with approximately 54.27 million shares outstanding and a short interest of about 11.3%. STML shares opened nearly 150% higher today at $11.81 (+$7.06, +148.63%) over Friday's closing price of $4.75. The stock has traded today between $1.81 and $12.35 per share and is currently trading at $12.10 (+$7.35, +154.74%).

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Disclosure:
1) Stephen Hytha compiled this article for Streetwise Reports LLC and provides services to Streetwise Reports as an independent contractor. He or members of his household own securities of the following companies mentioned in the article: None. He or members of his household are paid by the following companies mentioned in this article: None.
2) The following companies mentioned in this article are billboard sponsors of Streetwise Reports: None. Click here for important disclosures about sponsor fees.
3) Comments and opinions expressed are those of the specific experts and not of Streetwise Reports or its officers. The information provided above is for informational purposes only and is not a recommendation to buy or sell any security.
4) The article does not constitute investment advice. Each reader is encouraged to consult with his or her individual financial professional and any action a reader takes as a result of information presented here is his or her own responsibility. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. This article is not a solicitation for investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company mentioned on Streetwise Reports.
5) From time to time, Streetwise Reports LLC and its directors, officers, employees or members of their families, as well as persons interviewed for articles and interviews on the site, may have a long or short position in securities mentioned. Directors, officers, employees or members of their immediate families are prohibited from making purchases and/or sales of those securities in the open market or otherwise from the time of the interview or the decision to write an article until three business days after the publication of the interview or article. The foregoing prohibition does not apply to articles that in substance only restate previously published company releases.
6) This article does not constitute medical advice. Officers, employees and contributors to Streetwise Reports are not licensed medical professionals. Readers should always contact their healthcare professionals for medical advice.

( Companies Mentioned: STML:NASDAQ, )




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Alexion's Buyout of Portola Pharmaceuticals Gets Investors' Blood Flowing

Source: Streetwise Reports   05/05/2020

Shares of Portola Pharmaceuticals traded 130% higher after the company reported that it has received an $18 per share buyout offer from Alexion Pharmaceuticals.

Commercial-stage biotechnology company Portola Pharmaceuticals Inc. (PTLA:NASDAQ), which focuses on blood-related disorders, and global biopharmaceuticals firm Alexion Pharmaceuticals Inc. (ALXN:NASDAQ) announced that they have entered into a definitive merger agreement for Portola to be acquired by Alexion.

The acquisition is said to provide a key addition to Alexion's diversified commercial portfolio. The report indicated that the merger agreement has already been unanimously approved each of the company's boards of directors.

The report explained that "Portola's commercialized medicine, Andexxa® [coagulation factor Xa (recombinant), inactivated-zhzo], marketed as Ondexxya® in Europe, is the first and only approved Factor Xa inhibitor reversal agent, and has demonstrated transformative clinical value by rapidly reversing the anticoagulant effects of Factor Xa inhibitors rivaroxaban and apixaban in severe and uncontrolled bleeding."

Portola's President and CEO Scott Garland commented, "In developing and launching Andexxa, Portola has established a strong foundation for changing the standard of care for patients receiving Factor Xa inhibitors that experience a major, life-threatening bleed. Andexxa rapidly reverses the pharmacologic effect of rivaroxaban and apixaban within two minutes, reducing anti-Factor Xa activity by 92 percent...Given their enhanced resources, global footprint and proven commercial expertise, we look forward to working with Alexion to maximize the value of Andexxa. With their commitment to commercial excellence, together, we will be able to drive stronger utilization of Andexxa, increase penetration and accelerate adoption in the critical care setting."

Ludwig Hantson, Ph.D., CEO of Alexion, remarked, "The acquisition of Portola represents an important next step in our strategy to diversify beyond C5. Andexxa is a strategic fit with our existing portfolio of transformative medicines and is well-aligned with our demonstrated expertise in hematology, neurology and critical care...We believe Andexxa has the potential to become the global standard of care for patients who experience life-threatening bleeds while taking Factor Xa inhibitors apixaban and rivaroxaban. By leveraging Alexion's strong operational and sales infrastructure and deep relationships in hospital channels, we are well positioned to expand the number of patients helped by Andexxa, while also driving value for shareholders."

The firms advised that "under the terms of the merger agreement, a subsidiary of Alexion will commence a tender offer to acquire all of the outstanding shares of Portola's common stock at a price of $18 per share in cash." Alexion plans to fund the purchase with existing cash on hand and the transaction is expected to close in Q3/20. The purchase is subject to approval by a majority interest of Portola's common stockholders tendering their shares along with ordinary closing conditions and regulatory approvals. The company noted that "following successful completion of the tender offer, Alexion will acquire all remaining shares not tendered in the offer at the same price of $18 per share through a merger."

Alexion is a global biopharmaceutical company based in Boston, Mass., with offices in 50 countries worldwide. The company states that it has been "the global leader in complement biology and inhibition for more than 20 years and that it has developed and commercializes two approved complement inhibitors to treat patients with paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome, as well as the first and only approved complement inhibitor to treat anti-acetylcholine receptor antibody-positive generalized myasthenia gravis and neuromyelitis optica spectrum disorder."

Portola is headquartered in South San Francisco, Calif., and is a commercial-stage biopharmaceutical company focused on treating patients with serious blood-related disorders. Specifically, the company is engaged in developing and commercializing novel therapeutics in order to advance the fields of thrombosis and other hematologic conditions. The firm listed that its first two commercialized products are Andexxa® and Bevyxxa® (betrixaban), and that it is also advancing and developing cerdulatinib, a SYK/JAK inhibitor for use in treatment of hematologic cancers.

Portola Pharmaceuticals started off the day with a market capitalization of around $609.0 million with approximately 78.5 million shares outstanding and a short interest of about 23.0%. PTLA shares opened 130% higher today at $17.85 (+$10.09, +130.03%) over yesterday's $7.85 closing price. The stock has traded today between $17.71 and $17.91 per share and is currently trading at $17.83 (+$10.07, +129.77%).

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Disclosure:
1) Stephen Hytha compiled this article for Streetwise Reports LLC and provides services to Streetwise Reports as an independent contractor. He or members of his household own securities of the following companies mentioned in the article: None. He or members of his household are paid by the following companies mentioned in this article: None.
2) The following companies mentioned in this article are billboard sponsors of Streetwise Reports: None. Click here for important disclosures about sponsor fees.
3) Comments and opinions expressed are those of the specific experts and not of Streetwise Reports or its officers. The information provided above is for informational purposes only and is not a recommendation to buy or sell any security.
4) The article does not constitute investment advice. Each reader is encouraged to consult with his or her individual financial professional and any action a reader takes as a result of information presented here is his or her own responsibility. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. This article is not a solicitation for investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company mentioned on Streetwise Reports.
5) From time to time, Streetwise Reports LLC and its directors, officers, employees or members of their families, as well as persons interviewed for articles and interviews on the site, may have a long or short position in securities mentioned. Directors, officers, employees or members of their immediate families are prohibited from making purchases and/or sales of those securities in the open market or otherwise from the time of the interview or the decision to write an article until three business days after the publication of the interview or article. The foregoing prohibition does not apply to articles that in substance only restate previously published company releases.
6) This article does not constitute medical advice. Officers, employees and contributors to Streetwise Reports are not licensed medical professionals. Readers should always contact their healthcare professionals for medical advice.




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