Title: Curbing School Bus Pollution Might Reduce Absences
Category: Health News
Created: 4/29/2015 12:00:00 AM
Last Editorial Review: 4/30/2015 12:00:00 AM

Title: Rock Climbing Goes Mainstream for Exercise Buffs
Category: Health News
Created: 5/1/2018 12:00:00 AM
Last Editorial Review: 5/1/2018 12:00:00 AM

Title: Teens Willing to 'Cash In' on Curbing Cellphone Use While Driving
Category: Health News
Created: 5/2/2018 12:00:00 AM
Last Editorial Review: 5/2/2018 12:00:00 AM

Title: VA Doctors Prescribing Unnecessary Antibiotics, Study Says
Category: Health News
Created: 4/26/2019 12:00:00 AM
Last Editorial Review: 4/29/2019 12:00:00 AM

Title: AHA News: Nearly Killed in OKC Bombing, She Vowed to Change Her Life
Category: Health News
Created: 4/16/2020 12:00:00 AM
Last Editorial Review: 4/17/2020 12:00:00 AM

Background:

In 2015, Vyvanse (lisdexamfetamine) became the first Food and Drug Administration (FDA)-approved treatment for binge-eating disorder (BED), a condition first recognized by the DSM–V in 2013. Because pharmaceutical companies use continuing medical education (CME) to help sell drugs, we explored possible bias in CME modules on BED.

Proteinase-activated receptors (PARs) are a four-member family of G-protein–coupled receptors that are activated via proteolysis. PAR4 is a member of this family that is cleaved and activated by serine proteinases such as thrombin, trypsin, and cathepsin-G. PAR4 is expressed in a variety of tissues and cell types, including platelets, vascular smooth muscle cells, and neuronal cells. In studying PAR4 signaling and trafficking, we observed dynamic changes in the cell membrane, with spherical membrane protrusions that resemble plasma membrane blebbing. Since nonapoptotic membrane blebbing is now recognized as an important regulator of cell migration, cancer cell invasion, and vesicular content release, we sought to elucidate the signaling pathway downstream of PAR4 activation that leads to such events. Using a combination of pharmacological inhibition and CRISPR/CRISPR-associated protein 9 (Cas9)–mediated gene editing approaches, we establish that PAR4-dependent membrane blebbing occurs independently of the Gα_q/11- and Gα_i-signaling pathways and is dependent on signaling via the β-arrestin-1/2 and Ras homolog family member A (RhoA) signaling pathways. Together these studies provide further mechanistic insight into PAR4 regulation of cellular function.

The American Board of Family Medicine routinely surveys its Diplomates in each national graduating cohort 3 years out of training. These data were used to characterize early career family physicians whose services include management of pregnancy and prescribing buprenorphine. A total of 261 (5.1%) respondents both provide maternity care and prescribe buprenorphine. Family physicians who care for pregnant women and also prescribe buprenorphine represented 50.4% of all buprenorphine prescribers. The family physicians in this group were trained in a small number of residency programs, with only 15 programs producing at least 25% of graduates who do this work.

Background:

Unnecessary antibiotic use in the community in Canada is not well defined. Our objective was to quantify unnecessary antibiotic prescribing in a Canadian primary care setting.

BACKGROUND:

Prescribing of levothyroxine and rates of thyroid function testing may be sensitive to minor changes in the upper limit of the reference range for thyroid-stimulating hormone (TSH) that increase the proportion of abnormal results. We evaluated the population-level change in levothyroxine prescribing and TSH testing after a minor planned decrease in the upper limit of the reference range for TSH in a large urban centre with a single medical laboratory.

The Hayabusa-2 spacecraft bombed the asteroid Ryugu in April. Analysing the crater it left behind suggests Ryugu is a relative youngster at 9 million years old

Data leaks of this magnitude are virtually unheard of in Canada

The sixth installment in our weekly series spotlights titles that may have been lost in the news amid the COVID-19 crisis

A 16-year-old boy has suffered serious injuries after he was stabbed in a "senseless" attack in north-east London.

Read our live coronavirus updates HERE Coronavirus: The symptoms

7.45am update: Tragic pregnant mother's baby loses fight for life

A man in his 50s is fighting for his life after a stabbing in Notting Hill.

The 47-year-old officer was knifed in the abdomen while attending reports of disorder at an address in St Vincent Road, Newport, during the early hours of Thursday.

A 44-year-old man has been charged with attempted murder after being allegedly linked to three stabbings in north London.

A young man has died after he was found injured in an east London street.

A mother ran into the street screaming "help me…it's my children" after a baby and a toddler suffered fatal knife wounds at the family home, neighbours said today.

A murder probe has been launched in Putney after a 42-year-old man died after a stabbing in Putney.

A young NHS worker was stabbed to death in east London just days before his father's funeral.

Two young children who were stabbed to death in an attack at their home in east London have been named by police.

A man has been arrested on suspicion of murder after two children were stabbed to death in Ilford.

A north London teenager, 16, has been found guilty of kidnapping a stranger in the street and forcing him to withdraw money from a cash machine.

"He pushed one of the police officers on the ground and I think he was about to lunge at another one of the police with the knife, that's what it looked like to me.

A man and a teenage boy have been stabbed in east London, amid a spate of knife crime in the capital in recent weeks.

Two teenagers have been arrested on suspicion of murder after a young NHS worker was stabbed to death in east London.

Two teenagers have been charged with the murder of NHS worker David Gomoh in east London.

The wife of former Premier League footballer Kevin Phillips has been released without charge after being arrested on suspicion of attempted murder following a stabbing.

Two 20-year-old men were arrested on suspicion of public order offences

A woman has been arrested for suspected murder after a reported stabbing outside a shop in South Wales left an elderly man dead and several others injured.

A man has been found dead after suffering suspected stab wounds in west London.

Police have cordoned off a busy road in south east London after a double stabbing in broad daylight.

A family friend described Mr Rees as a 'pillar of the community'

The company has agreed to launch a new internal data security program and will take other steps to combat hacker disruptions.

While the White House looks ahead to reopening houses of worship, most Americans think in-person religious services should be barred or allowed only with limits during the coronavirus pandemic — and only about a third say that prohibiting in-person services violates religious freedom, a new poll finds. States have taken different approaches to resuming gatherings as the coronavirus continues to spread, raising tough questions for religious leaders and the faithful about the appropriate time to return. Among that group is 54-year-old Andre Harris of Chicago, a onetime Sunday school teacher who has shifted his routine from physical worship to the conference calls his church is holding during the pandemic.

Any big weekend plans? Don't worry, we've got you covered. Every weekend, E! is giving you the top binge picks, including new and old TV series, movies and specials. And this...

He called Exotic 'unbelievably cruel'

As cities and states come out of COVID-19 stay-at-home orders, Uber is working on technologies to ensure both drivers and riders have masks in place.

YouTube has seen a spike in content built on sharing the mundane, often isolating experiences of people's daily lives.

Any big weekend plans? Don't worry, we've got you covered. Every weekend, E! is giving you the top binge picks, including new and old TV series, movies and specials. And this...

MORNING BRIEFING: A truck carrying dry dog food rolls over on a busy western Sydney road, and two men and a woman have been charged over the death of a man in Cartwright.

MORNING BRIEFING: The first non-stop commercial flight between New York and Sydney will depart shortly, and a man is charged over an alleged $170,000 diamond fraud committed in 2002.