Disparities in outcomes of ethnic minority children have been reported, and have been ascribed to having barriers to access to health care. Minority parents have indicated that difficulties in access are because of problems with transportation and being non-English speaking.

This population-based study of Texas infants with severe congenital heart disease reports that neither home distance from a cardiac center nor Hispanic children having a Latin American–born parent were risk factors for first-year mortality. (Read the full article)

Because pediatric appendicitis is challenging to diagnose, computed tomography (CT) is used frequently. Childhood radiation exposure is associated with increased risk of cancer. Ultrasound avoids radiation exposure but is less sensitive for appendicitis than CT.

Controlling for referral bias, evaluation at a community compared with a children’s hospital is associated with higher CT and lower ultrasound use before appendectomy. CT and ultrasound accuracy for appendicitis in children varies with hospital type. (Read the full article)

Head injuries and concern for skull fracture are common in pediatrics. Point-of-care ultrasound is an imaging tool that can be used to diagnose fractures. However, there are scant data regarding the accuracy of point-of-care ultrasound in skull fracture diagnosis.

Clinicians with focused point-of-care ultrasound training are able to diagnose skull fractures in children with high specificity. Ultrasound may be valuable to diagnose skull fractures in children at the point of care. (Read the full article)

Children with chronic illnesses tend to be sicker during infections than previously healthy children but are triaged in the same way, even though the validity of triage systems has not yet been evaluated in these chronically sick children.

The performance of the Manchester Triage System was lower for children with a chronic illness than for previously healthy children. Children with cardiovascular illnesses, respiratory illnesses, gastrointestinal illnesses, or other congenital or genetic defects were especially at risk of being undertriaged. (Read the full article)

Saturations from pulse oximetry (SpO₂) may overestimate arterial oxygen saturations measured by CO-oximetry (SaO₂). The overestimation can be affected by location of measurement, perfusion, and skin color. Previous studies are limited by small numbers of observations in a hypoxemic range.

This large sample of hypoxemic patients identified that SpO₂ typically overestimates SaO₂. Bias and precision varied throughout the SpO₂ range. The SpO₂ range of 81% to 85% had the greatest bias: median SpO₂ 6% higher than SaO₂ measured by CO-oximetry. (Read the full article)

Studies assessing the accuracy of brief screening tools for postpartum depression have been conducted among adult women; however, no similar validation studies have been conducted among adolescent mothers. Accurate and valid brief depression screening tools are needed for adolescent mothers.

We found that the 10-item Edinburgh Postnatal Depression Scale (EPDS) and 2 subscales, the EPDS-7 and EPDS-2, are highly accurate at identifying postpartum depression among adolescent mothers. In pediatric settings with limited time and resources, these brief scales have potential to be used as effective depression screening tools. (Read the full article)

The sensitivities of ^99mTc-dimercaptosuccinic acid in predicting vesicoureteral reflux reported by different institutions were at different levels for young children with acute febrile urinary tract infection.

An acute ^99mTc-dimercaptosuccinic acid scan is of great value in predicting dilating vesicoureteral reflux in children ≤2 years of age with a febrile urinary tract infection. (Read the full article)

The sensitivity of the urinalysis (UA) traditionally has been considered suboptimal in young infants. Whether the finding of a negative UA and a positive urine culture represents a false-negative UA versus a false-positive urine culture remains unclear.

In infants <3 months with bacteremic urinary tract infection, a condition that represents true infection, the UA sensitivity is higher than previously reported for urinary tract infection in general, suggesting that the UA is reliable even in young infants. (Read the full article)

Our guide to how foul play is dealt with in futsal.

Partick Thistle have released, in full, a letter sent by the club to SPFL chiefs following the news that league reconstruction has been scrapped - confirming the Jags' relegation.

PARTICK Thistle today branded the SPFL a "disgrace" for failing to inform them that league reconstruction had been abandoned and revealed they are "deeply angered" by Ladbrokes Premiership clubs scuppering the plans.

Villavicencio, Colombia, Apr 7, 2020 / 12:00 am (CNA).- The president of the Colombian bishops’ conference, Óscar Urbina, suspended 15 priests of his archdiocese from ministry who have been accused of sexual abuse. Other jurisdictions in the country have removed four other priests.

Archbishop Óscar Urbina of Villavicencio told Colombian media that the accused priests represent 15% of the city’s priests.

The priests are accused of committing sexual abuse in Colombia, Italy and the United States, Caracol Radio reported.

Fr. Carlos Villabón, communications director and chancellor for the archdiocese of Villavicencio, told ACI Prensa, CNA’s Spanish language news partner, that the 15 priests were suspended while a canonical investigation proceeds at the Vatican.

“On March 16, 2020 these 15 priests were notified after a preliminary investigation was carried out. They are neither convicted nor acquitted by this suspension, only asked to relinquish their parish duties, cease celebrating the Eucharist and cease their ministerial service while the complete investigation is conducted,” the priest explained.

The results of the preliminary investigation “are now being sent to the Congregation for the Doctrine of the Faith at the Vatican, and there they will determine the gravity of the facts and what the Church calls a penal canonical process will be conducted,” Villabón said.

“It’s unknown how much time the canonical process will take, but the idea is that it proceed as quickly as possible, considering that in Italy and in many parts of the world there’s a quarantine because of the coronavirus,” the communications director added.
Caracol Radio published a list of the 19 priests, but Villabón told ACI Prensa that the archdiocese would neither confirm nor deny the names reported.

 “According to a witness under protection by the prosecutor’s office, the 19 priests apparently formed a network of abusers, Caracol Radio reported.

In an April 3 statement, the archdiocese of Villavicencio announced that an accusation was received Feb. 14, 2020 concerning “acts against sexual morality by some priests of this archdiocese.”

“Having as a priority the alleged victim, we expressed to him our deep pain and solidarity and have offered him psychological and spiritual accompaniment. We reaffirm our commitment to act with clarity and transparency for his good and that of the Church,” the statement said.

Following the protocols of the Archdiocesan Commission for the Protection of Minors, once the abuse was reported, the regional prosecutor’s office was notified and “we made ourselves completely available to cooperate in the investigations taking place in this case,” the statement said.

The archdiocese said that it has taken steps “to eradicate the terrible evil of abuse within and outside our institution. We ask to be informed of any situations where one of our members has finally betrayed his vocation of service and dedication to the Lord and the community.”

A version of this story was first reported by ACI Prensa, CNA's Spanish-language news partner. It has been translated and adapted by CNA.

 

Right of accused to get bail even if charge sheet is filed

A 25-year-old man was attacked outside a chemist store in Aligarh on suspicions that he was a "coronavirus carrier", police said.

LeBron James has been accused of using the death of a young black man in Georgia to "build a brand" and "sh*t stir," after the NBA icon suggested African Americans were "being hunted" in a tweet about the tragedy.
Read Full Article at RT.com

A court document has surfaced showing that Tara Reade – a former Senate staffer for Joe Biden who has accused him of sexual assault – told her then-husband she was harassed while working in his office.
Read Full Article at RT.com

Democrat Senator Dianne Feinstein is being lambasted for apparent double standards after attacking Tara Reade, the former Joe Biden staffer who alleges the Democrat presidential candidate sexually assaulted her.
Read Full Article at RT.com

The war of words between the White House and the James Comey-era FBI has intensified, with Press Secretary Kayleigh McEnany accusing the agency of “manufacturing” a criminal case against Michael Flynn.
Read Full Article at RT.com

The tests could reveal the true extent of the outbreak and help separate the healthy from the sick. But some scientists have challenged their accuracy.

Hi,

I am currently struggling with measuring the delay between two clocks with a sufficient accuracy. The reference one is a fixed-phase clock, and the other one is a squared clock resulting of a circuit (kind of PLL) synthesis.
As I need to run a large amount of Monte-Carlo simulations in transient noise, I need to improve the simulation speed, while keeping a satisfactory delay measurement accuracy (<0.1ps), more specifically at 0V-crossings of the differential clocks. So I cannot simply set a max timestep <0.1ps as it would be far too long to simulate.
To sum up, I would need a very relaxed timestep on clock up and down levels, and a very short timestep only at rise/fall transitions.

For this purpose, I wrote a Verilog-A script
- using a timmer function to accurately emulate the reference clock 0V-crossing times (and get the related times with $abstime)
- using @(cross to get the 0V-crossing times of the synthesized clock: but this is not accurate enough (I see simulation noise around 3ps in Conservative). Indeed, the "cross" event occures at the simulation time following the effective 0V-crossing time; this could be sometimes >3ps, far not enough accurate for my purpose.
- I have tried to replace the cross with the "above" function, but it hasn't changed anything, whatever the time_tol value I put (<0.1ps for instance), the result is the same as with the "cross" function and the points are larger than >>0.1ps, weirdly.

So I have decided to give up Verilog-A to measure the delay between my two clocks.
I am currently trying to use the "delay" function of the Cadence Calculator as I guess it will "extrapolate" the time between two simulation points and therefore give a more accurate measurement of the 0V-crossing events, but when I try to compute the delay difference between the synthesized clock and the reference clock, it returns "0".

...

Could you please give me hints to dramatically improve my 0V-crossing time measurements while relaxing the simulation time?
- either by helping me in writing a more suitable Verilog-A script
- or by helping me in using the "delay" function of the calculator
- or maybe by providing me a "magic" Skill function?
Using AMS+Multithread simulator...

Thanks a lot in advance for your help and best regards.

Ormat is a successful developer of geothermal energy projects. Two former employees have brought a lawsuit alleging that Ormat made inaccurate 1603 Cash Grant submissions to obtain grants for projects that should not have qualified for such grants.

It is proposed that the rule against perpetuities should no longer apply to property transactions, but only for those entered into after the law has changed.   A Perpetuities and Accumulations Bill has been published and underwent its second re...

Senator representing Adamawa North Senatorial district, Elisha Ishaku Abbo has accused governor Ahmadu Fintiri of making false claims over the donation of transformers to some communities in the State. The lawmaker said the transformers were donated by the newly established Northeast Development Commission (NEDC) through the intervention of his Committee. He frowned at the publication […]

Senator Abbo accuses Adamawa Governor of ‘false claims’ over NEDC projects

Bill Maher is rather frustrated with Democrats and the liberal media . In particular, the talk show host and comedian...

Five teachers at a public school in Mukdahan have been suspended after being charged in connection with repeated sexual assaults against a 14-year-old girl. Two school alumni are also accused of having taken part, and all are said to have taken video of the acts.

It’s alleged that he strangled his wife and two sons and fled

Former US Senate aide Tara Reade said on Thursday that presumptive Democratic presidential nominee Joe Biden should acknowledge her claim that he sexually assaulted her is true and quit the 2020 presidential race.“You and I were there, Joe Biden. Please step forward and be held accountable. You should not be running on character for the president of the United States,” Reade said during her first on-camera interview since Biden appeared on MSNBC last week and denied her accusation for the first…

A series of deadly unrests in the last two weeks that have claimed nearly two dozen lives.

Kenya has accused the UN of bowing to pressure from other countries by setting up an investigation that pins the blame for peacekeeping failures in South Sudan on the Kenyan force commander.

Bomet County Commissioner, Benard Lebarmarai has lambasted Governor Isaac Ruto for falsely accusing the police of causing harm to him.

WASHINGTON: The woman who accused Joe Biden of sexually assaulting her in 1993 called on him to drop out of the US presidential race, saying Thursday she´d take a polygraph about the alleged encounter if he would. Tara Reade said in March that Biden, the Democratic Party´s presumptive...

WASHINGTON: The United States on Friday accused China and Russia of stepping up cooperation to spread false narratives over the coronavirus pandemic, saying Beijing was increasingly adopting techniques honed by Moscow.

“Even before the Covid-19 crisis we assessed a certain level of coordination between Russia and the PRC (Peoples Republic of China) in the realm of propaganda,” said Lea Gabrielle, coordinator of the State Department’s Global Engagement Center, which tracks foreign propaganda.

“But with this pandemic the cooperation has accelerated rapidly,” she told reporters.

“We see this convergence as a result of what we consider to be pragmatism between the two actors who want to shape public understanding of the Covid pandemic for their own purposes,” she said.

The Global Engagement Center earlier said that thousands of Russian-linked social media accounts were spreading conspiracies about the pandemic, including charging that the virus first detected last year in the Chinese metropolis of Wuhan was created by the United States.

China outraged the United States when a foreign ministry spokesman tweeted a conspiracy that the US military brought the virus to Wuhan, but the two countries reached an informal rhetorical truce in late March after telephone talks between President Donald Trump and his counterpart Xi Jinping.

Tensions have again soared as Secretary of State Mike Pompeo pushes the theory that the virus originated in a Chinese laboratory, even though both the World Health Organisation and the US government’s top epidemiologist say there is no evidence of this.

According to the Global Engagement Centre, China has again intensified its online campaign to defend its handling of the pandemic, which has killed some 270,000 people worldwide, and criticise the United States.

“Beijing is adapting in real time and increasingly using techniques that have long been employed by Moscow,” Gabrielle said.

China has increasingly used bot networks to amplify its message, Gabrielle said.

She said that official Chinese diplomatic accounts suddenly witnessed a surge in late March, going from adding around 30 new followers daily to more than 720, often from freshly created accounts.

She said that China was first observed using such online methods to “sow political discord” in its autonomous territory of Hong Kong, which has witnessed major pro-democracy demonstrations.

Published in Dawn, May 9th, 2020

The Weld County GOP chairman has filed a complaint with the local district attorney and the Secretary of State’s Office accusing an aide to Republican U.S. Rep. Ken Buck and three others of election fraud and corruption.

CES 2016, LAS VEGAS – Today, HARMAN International Industries, Incorporated (NYSE:HAR), the premier connected technologies company for automotive, consumer and enterprise markets, announced the newest version of Infinity® Reference Speakers and...

Join Michael De Podesta as he explains how he made the world’s most precise thermometer – and demonstrates its principle live on stage

The “Equal Earth” projection shows the true area of continents such as Africa without greatly distorting their shapes and is already being adopted by NASA

Tara Reade, the woman who alleges Joe Biden sexually assaulted her in 1993, said in a video interview on Thursday that he should withdraw from the White House race. Gloria Tso reports.

Title: Coronavirus Antibody Tests Show Inaccuracies, as Some States Prepare to Reopen
Category: Health News
Created: 4/25/2020 12:00:00 AM
Last Editorial Review: 4/27/2020 12:00:00 AM

ABSTRACT

Lipopolysaccharide (LPS) is an essential glycolipid present in the outer membrane (OM) of many Gram-negative bacteria. Balanced biosynthesis of LPS is critical for cell viability; too little LPS weakens the OM, while too much LPS is lethal. In Escherichia coli, this balance is maintained by the YciM/FtsH protease complex, which adjusts LPS levels by degrading the LPS biosynthesis enzyme LpxC. Here, we provide evidence that activity of the YciM/FtsH protease complex is inhibited by the essential protein YejM. Using strains in which LpxC activity is reduced, we show that yciM is epistatic to yejM, demonstrating that YejM acts upstream of YciM to prevent toxic overproduction of LPS. Previous studies have shown that this toxicity can be suppressed by deleting lpp, which codes for a highly abundant OM lipoprotein. It was assumed that deletion of lpp restores lipid balance by increasing the number of acyl chains available for glycerophospholipid biosynthesis. We show that this is not the case. Rather, our data suggest that preventing attachment of lpp to the peptidoglycan sacculus allows excess LPS to be shed in vesicles. We propose that this loss of OM material allows continued transport of LPS to the OM, thus preventing lethal accumulation of LPS within the inner membrane. Overall, our data justify the commitment of three essential inner membrane proteins to avoid toxic over- or underproduction of LPS.

IMPORTANCE Gram-negative bacteria are encapsulated by an outer membrane (OM) that is impermeable to large and hydrophobic molecules. As such, these bacteria are intrinsically resistant to several clinically relevant antibiotics. To better understand how the OM is established or maintained, we sought to clarify the function of the essential protein YejM in Escherichia coli. Here, we show that YejM inhibits activity of the YciM/FtsH protease complex, which regulates synthesis of the essential OM glycolipid lipopolysaccharide (LPS). Our data suggest that disrupting proper communication between LPS synthesis and transport to the OM leads to accumulation of LPS within the inner membrane (IM). The lethality associated with this event can be suppressed by increasing OM vesiculation. Our research has identified a completely novel signaling pathway that we propose coordinates LPS synthesis and transport.

Plants require a high concentration of ascorbate as a redox buffer for survival under stress conditions, such as high light. Dehydroascorbate reductases (DHARs) are enzymes that catalyze the reduction of DHA to ascorbate using reduced glutathione (GSH) as an electron donor, allowing rapid ascorbate recycling. However, a recent study using an Arabidopsis (Arabidopsis thaliana) triple mutant lacking all three DHAR genes (herein called dhar) did not find evidence for their role in ascorbate recycling under oxidative stress. To further study the function of DHARs, we generated dhar Arabidopsis plants as well as a quadruple mutant line combining dhar with an additional vtc2 mutation that causes ascorbate deficiency. Measurements of ascorbate in these mutants under low- or high-light conditions indicated that DHARs have a nonnegligible impact on full ascorbate accumulation under high light, but that they are dispensable when ascorbate concentrations are low to moderate. Because GSH itself can reduce DHA nonenzymatically, we used the pad2 mutant that contains ~30% of the wild-type GSH level. The pad2 mutant accumulated ascorbate at a wild-type level under high light; however, when the pad2 mutation was combined with dhar, there was near-complete inhibition of high-light–dependent ascorbate accumulation. The lack of ascorbate accumulation was consistent with a marked increase in the ascorbate degradation product threonate. These findings indicate that ascorbate recycling capacity is limited in dhar pad2 plants, and that both DHAR activity and GSH content set a threshold for high-light–induced ascorbate accumulation.

Chronic pain is a highly prevalent disease with poorly understood pathophysiology. In particular, the brain mechanisms mediating the transition from acute to chronic pain remain largely unknown. Here, we identify a subcortical signature of back pain. Specifically, subacute back pain patients who are at risk for developing chronic pain exhibit...

Background

Arteriovenous fistulas placed surgically for dialysis vascular access have a high primary failure rate resulting from excessive inward remodeling, medial fibrosis, and thrombosis. No clinically established pharmacologic or perisurgical therapies currently address this unmet need. Statins’ induction of multiple anti-inflammatory and antithrombotic effects suggests that these drugs might reduce arteriovenous fistula failure. Yet, the in vivo physiologic and molecular effects of statins on fistula patency and maturation remain poorly understood.

Many noncoding RNAs are known to play a role in the cell directly linked to their structure. Structure prediction based on the sole sequence is, however, a challenging task. On the other hand, thanks to the low cost of sequencing technologies, a very large number of homologous sequences are becoming available for many RNA families. In the protein community, the idea of exploiting the covariance of mutations within a family to predict the protein structure using the direct-coupling-analysis (DCA) method has emerged in the last decade. The application of DCA to RNA systems has been limited so far. We here perform an assessment of the DCA method on 17 riboswitch families, comparing it with the commonly used mutual information analysis and with state-of-the-art R-scape covariance method. We also compare different flavors of DCA, including mean-field, pseudolikelihood, and a proposed stochastic procedure (Boltzmann learning) for solving exactly the DCA inverse problem. Boltzmann learning outperforms the other methods in predicting contacts observed in high-resolution crystal structures.