England : Society of Medical Officers of Health, [192-?]

England : League of Nations, 1925.

Rockville, Maryland : National Institute on Drug Abuse, 1979.

Yichong Wu, Tiejun Li, Xiaoping Liu, Luonan Chen.

Source: Electronic Journal of Statistics, Volume 14, Number 1, 1269--1301.

Abstract:
Detecting the change of biological interaction networks is of great importance in biological and medical research. We proposed a simple loss function, named as CrossFDTL, to identify the network change or differential network by estimating the difference between two precision matrices under Gaussian assumption. The CrossFDTL is a natural fusion of the D-trace loss for the considered two networks by imposing the $ell _{1}$ penalty to the differential matrix to ensure sparsity. The key point of our method is to utilize the cross variables, which correspond to the sum and difference of two precision matrices instead of using their original forms. Moreover, we developed an efficient minimization algorithm for the proposed loss function and further rigorously proved its convergence. Numerical results showed that our method outperforms the existing methods in both accuracy and convergence speed for the simulated and real data.

Over the past decades, numerous loss functions have been been proposed for a variety of supervised learning tasks, including regression, classification, ranking, and more generally structured prediction. Understanding the core principles and theoretical properties underpinning these losses is key to choose the right loss for the right problem, as well as to create new losses which combine their strengths. In this paper, we introduce Fenchel-Young losses, a generic way to construct a convex loss function for a regularized prediction function. We provide an in-depth study of their properties in a very broad setting, covering all the aforementioned supervised learning tasks, and revealing new connections between sparsity, generalized entropies, and separation margins. We show that Fenchel-Young losses unify many well-known loss functions and allow to create useful new ones easily. Finally, we derive efficient predictive and training algorithms, making Fenchel-Young losses appealing both in theory and practice.

We present new excess risk bounds for general unbounded loss functions including log loss and squared loss, where the distribution of the losses may be heavy-tailed. The bounds hold for general estimators, but they are optimized when applied to $eta$-generalized Bayesian, MDL, and empirical risk minimization estimators. In the case of log loss, the bounds imply convergence rates for generalized Bayesian inference under misspecification in terms of a generalization of the Hellinger metric as long as the learning rate $eta$ is set correctly. For general loss functions, our bounds rely on two separate conditions: the $v$-GRIP (generalized reversed information projection) conditions, which control the lower tail of the excess loss; and the newly introduced witness condition, which controls the upper tail. The parameter $v$ in the $v$-GRIP conditions determines the achievable rate and is akin to the exponent in the Tsybakov margin condition and the Bernstein condition for bounded losses, which the $v$-GRIP conditions generalize; favorable $v$ in combination with small model complexity leads to $ ilde{O}(1/n)$ rates. The witness condition allows us to connect the excess risk to an 'annealed' version thereof, by which we generalize several previous results connecting Hellinger and Rényi divergence to KL divergence.

Mohd Arshad, Omer Abdalghani.

Source: Brazilian Journal of Probability and Statistics, Volume 34, Number 1, 167--182.

Abstract:
Suppose that $pi_{1},pi_{2},ldots ,pi_{k}$ be $k(geq2)$ independent exponential populations having unknown location parameters $mu_{1},mu_{2},ldots,mu_{k}$ and known scale parameters $sigma_{1},ldots,sigma_{k}$. Let $mu_{[k]}=max {mu_{1},ldots,mu_{k}}$. For selecting the population associated with $mu_{[k]}$, a class of selection rules (proposed by Arshad and Misra [ Statistical Papers 57 (2016) 605–621]) is considered. We consider the problem of estimating the location parameter $mu_{S}$ of the selected population under the criterion of the LINEX loss function. We consider three natural estimators $delta_{N,1},delta_{N,2}$ and $delta_{N,3}$ of $mu_{S}$, based on the maximum likelihood estimators, uniformly minimum variance unbiased estimator (UMVUE) and minimum risk equivariant estimator (MREE) of $mu_{i}$’s, respectively. The uniformly minimum risk unbiased estimator (UMRUE) and the generalized Bayes estimator of $mu_{S}$ are derived. Under the LINEX loss function, a general result for improving a location-equivariant estimator of $mu_{S}$ is derived. Using this result, estimator better than the natural estimator $delta_{N,1}$ is obtained. We also shown that the estimator $delta_{N,1}$ is dominated by the natural estimator $delta_{N,3}$. Finally, we perform a simulation study to evaluate and compare risk functions among various competing estimators of $mu_{S}$.

Abbas Pak, M. E. Ghitany, Mohammad Reza Mahmoudi.

Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 4, 894--914.

Abstract:
This paper focuses on Bayesian estimation of the parameters and reliability function of the power Lindley distribution by using various symmetric and asymmetric loss functions. Assuming suitable priors on the parameters, Bayes estimates are derived by using squared error, linear exponential (linex) and general entropy loss functions. Since, under these loss functions, Bayes estimates of the parameters do not have closed forms we use lindley’s approximation technique to calculate the Bayes estimates. Moreover, we obtain the Bayes estimates of the parameters using a Markov Chain Monte Carlo (MCMC) method. Simulation studies are conducted in order to evaluate the performances of the proposed estimators under the considered loss functions. Finally, analysis of a real data set is presented for illustrative purposes.

Gregory J. Matthews, Ofer Harel

Source: Statist. Surv., Volume 5, 1--29.

Abstract:
There is an ever increasing demand from researchers for access to useful microdata files. However, there are also growing concerns regarding the privacy of the individuals contained in the microdata. Ideally, microdata could be released in such a way that a balance between usefulness of the data and privacy is struck. This paper presents a review of proposed methods of statistical disclosure control and techniques for assessing the privacy of such methods under different definitions of disclosure.

References:
Abowd, J., Woodcock, S., 2001. Disclosure limitation in longitudinal linked data. Confidentiality, Disclosure, and Data Access: Theory and Practical Applications for Statistical Agencies, 215–277.

Adam, N.R., Worthmann, J.C., 1989. Security-control methods for statistical databases: a comparative study. ACM Comput. Surv. 21 (4), 515–556.

Armstrong, M., Rushton, G., Zimmerman, D.L., 1999. Geographically masking health data to preserve confidentiality. Statistics in Medicine 18 (5), 497–525.

Bethlehem, J.G., Keller, W., Pannekoek, J., 1990. Disclosure control of microdata. Jorunal of the American Statistical Association 85, 38–45.

Blum, A., Dwork, C., McSherry, F., Nissam, K., 2005. Practical privacy: The sulq framework. In: Proceedings of the 24th ACM SIGMOD-SIGACT-SIGART Symposium on Principles of Database Systems. pp. 128–138.

Bowden, R.J., Sim, A.B., 1992. The privacy bootstrap. Journal of Business and Economic Statistics 10 (3), 337–345.

Carlson, M., Salabasis, M., 2002. A data-swapping technique for generating synthetic samples; a method for disclosure control. Res. Official Statist. (5), 35–64.

Cox, L.H., 1980. Suppression methodology and statistical disclosure control. Journal of the American Statistical Association 75, 377–385.

Cox, L.H., 1984. Disclosure control methods for frequency count data. Tech. rep., U.S. Bureau of the Census.

Cox, L.H., 1987. A constructive procedure for unbiased controlled rounding. Journal of the American Statistical Association 82, 520–524.

Cox, L.H., 1994. Matrix masking methods for disclosure limitation in microdata. Survey Methodology 6, 165–169.

Cox, L.H., Fagan, J.T., Greenberg, B., Hemmig, R., 1987. Disclosure avoidance techniques for tabular data. Tech. rep., U.S. Bureau of the Census.

Dalenius, T., 1977. Towards a methodology for statistical disclosure control. Statistik Tidskrift 15, 429–444.

Dalenius, T., 1986. Finding a needle in a haystack - or identifying anonymous census record. Journal of Official Statistics 2 (3), 329–336.

Dalenius, T., Denning, D., 1982. A hybrid scheme for release of statistics. Statistisk Tidskrift.

Dalenius, T., Reiss, S.P., 1982. Data-swapping: A technique for disclosure control. Journal of Statistical Planning and Inference 6, 73–85.

De Waal, A., Hundepool, A., Willenborg, L., 1995. Argus: Software for statistical disclosure control of microdata. U.S. Census Bureau.

DeGroot, M.H., 1962. Uncertainty, information, and sequential experiments. Annals of Mathematical Statistics 33, 404–419.

DeGroot, M.H., 1970. Optimal Statistical Decisions. Mansell, London.

Dinur, I., Nissam, K., 2003. Revealing information while preserving privacy. In: Proceedings of the 22nd ACM SIGMOD-SIGACT-SIGART Symposium on Principlesof Database Systems. pp. 202–210.

Domingo-Ferrer, J., Torra, V., 2001a. A Quantitative Comparison of Disclosure Control Methods for Microdata. In: Doyle, P., Lane, J., Theeuwes, J., Zayatz, L. (Eds.), Confidentiality, Disclosure and Data Access - Theory and Practical Applications for Statistical Agencies. North-Holland, Amsterdam, Ch. 6, pp. 113–135.

Domingo-Ferrer, J., Torra, V., 2001b. Disclosure control methods and information loss for microdata. In: Doyle, P., Lane, J., Theeuwes, J., Zayatz, L. (Eds.), Confidentiality, Disclosure and Data Access - Theory and Practical Applications for Statistical Agencies. North-Holland, Amsterdam, Ch. 5, pp. 93–112.

Duncan, G., Lambert, D., 1986. Disclosure-limited data dissemination. Journal of the American Statistical Association 81, 10–28.

Duncan, G., Lambert, D., 1989. The risk of disclosure for microdata. Journal of Business & Economic Statistics 7, 207–217.

Duncan, G., Pearson, R., 1991. Enhancing access to microdata while protecting confidentiality: prospects for the future (with discussion). Statistical Science 6, 219–232.

Dwork, C., 2006. Differential privacy. In: ICALP. Springer, pp. 1–12.

Dwork, C., 2008. An ad omnia approach to defining and achieving private data analysis. In: Lecture Notes in Computer Science. Springer, p. 10.

Dwork, C., Lei, J., 2009. Differential privacy and robust statistics. In: Proceedings of the 41th Annual ACM Symposium on Theory of Computing (STOC). pp. 371–380.

Dwork, C., Mcsherry, F., Nissim, K., Smith, A., 2006. Calibrating noise to sensitivity in private data analysis. In: Proceedings of the 3rd Theory of Cryptography Conference. Springer, pp. 265–284.

Dwork, C., Nissam, K., 2004. Privacy-preserving datamining on vertically partitioned databases. In: Advances in Cryptology: Proceedings of Crypto. pp. 528–544.

Elliot, M., 2000. DIS: a new approach to the measurement of statistical disclosure risk. International Journal of Risk Assessment and Management 2, 39–48.

Federal Committee on Statistical Methodology (FCSM), 2005. Statistical policy working group 22 - report on statistical disclosure limitation methodology. U.S. Census Bureau.

Fellegi, I.P., 1972. On the question of statistical confidentiality. Journal of the American Statistical Association 67 (337), 7–18.

Fienberg, S.E., McIntyre, J., 2004. Data swapping: Variations on a theme by Dalenius and Reiss. In: Domingo-Ferrer, J., Torra, V. (Eds.), Privacy in Statistical Databases. Vol. 3050 of Lecture Notes in Computer Science. Springer Berlin/Heidelberg, pp. 519, http://dx.doi.org/10.1007/ 978-3-540-25955-8_2

Fuller, W., 1993. Masking procedurse for microdata disclosure limitation. Journal of Official Statistics 9, 383–406.

General Assembly of the United Nations, 1948. Universal declaration of human rights.

Gouweleeuw, J., P. Kooiman, L.W., de Wolf, P.-P., 1998. Post randomisation for statistical disclosure control: Theory and implementation. Journal of Official Statistics 14 (4), 463–478.

Greenberg, B., 1987. Rank swapping for masking ordinal microdata. Tech. rep., U.S. Bureau of the Census (unpublished manuscript), Suitland, Maryland, USA.

Greenberg, B.G., Abul-Ela, A.-L.A., Simmons, W.R., Horvitz, D.G., 1969. The unrelated question randomized response model: Theoretical framework. Journal of the American Statistical Association 64 (326), 520–539.

Harel, O., Zhou, X.-H., 2007. Multiple imputation: Review and theory, implementation and software. Statistics in Medicine 26, 3057–3077.

Hundepool, A., Domingo-ferrer, J., Franconi, L., Giessing, S., Lenz, R., Longhurst, J., Nordholt, E.S., Seri, G., paul De Wolf, P., 2006. A CENtre of EXcellence for Statistical Disclosure Control Handbook on Statistical Disclosure Control Version 1.01.

Hundepool, A., Wetering, A. v.d., Ramaswamy, R., Wolf, P.d., Giessing, S., Fischetti, M., Salazar, J., Castro, J., Lowthian, P., Feb. 2005. τ-argus 3.1 user manual. Statistics Netherlands, Voorburg NL.

Hundepool, A., Willenborg, L., 1996. μ- and τ-argus: Software for statistical disclosure control. Third International Seminar on Statistical Confidentiality, Bled.

Karr, A., Kohnen, C.N., Oganian, A., Reiter, J.P., Sanil, A.P., 2006. A framework for evaluating the utility of data altered to protect confidentiality. American Statistician 60 (3), 224–232.

Kaufman, S., Seastrom, M., Roey, S., 2005. Do disclosure controls to protect confidentiality degrade the quality of the data? In: American Statistical Association, Proceedings of the Section on Survey Research.

Kennickell, A.B., 1997. Multiple imputation and disclosure protection: the case of the 1995 survey of consumer finances. Record Linkage Techniques, 248–267.

Kim, J., 1986. Limiting disclosure in microdata based on random noise and transformation. Bureau of the Census.

Krumm, J., 2007. Inference attacks on location tracks. Proceedings of Fifth International Conference on Pervasive Computingy, 127–143.

Li, N., Li, T., Venkatasubramanian, S., 2007. t-closeness: Privacy beyond k-anonymity and l-diversity. In: Data Engineering, 2007. ICDE 2007. IEEE 23rd International Conference on. pp. 106–115.

Liew, C.K., Choi, U.J., Liew, C.J., 1985. A data distortion by probability distribution. ACM Trans. Database Syst. 10 (3), 395–411.

Little, R.J.A., 1993. Statistical analysis of masked data. Journal of Official Statistics 9, 407–426.

Little, R.J.A., Rubin, D.B., 1987. Statistical Analysis with Missing Data. John Wiley & Sons.

Liu, F., Little, R.J.A., 2002. Selective multiple mputation of keys for statistical disclosure control in microdata. In: Proceedings Joint Statistical Meet. pp. 2133–2138.

Machanavajjhala, A., Kifer, D., Abowd, J., Gehrke, J., Vilhuber, L., April 2008. Privacy: Theory meets practice on the map. In: International Conference on Data Engineering. Cornell University Comuputer Science Department, Cornell, USA, p. 10.

Machanavajjhala, A., Kifer, D., Gehrke, J., Venkitasubramaniam, M., 2007. L-diversity: Privacy beyond k-anonymity. ACM Trans. Knowl. Discov. Data 1 (1), 3.

Manning, A.M., Haglin, D.J., Keane, J.A., 2008. A recursive search algorithm for statistical disclosure assessment. Data Min. Knowl. Discov. 16 (2), 165–196.

Marsh, C., Skinner, C., Arber, S., Penhale, B., Openshaw, S., Hobcraft, J., Lievesley, D., Walford, N., 1991. The case for samples of anonymized records from the 1991 census. Journal of the Royal Statistical Society 154 (2), 305–340.

Matthews, G.J., Harel, O., Aseltine, R.H., 2010a. Assessing database privacy using the area under the receiver-operator characteristic curve. Health Services and Outcomes Research Methodology 10 (1), 1–15.

Matthews, G.J., Harel, O., Aseltine, R.H., 2010b. Examining the robustness of fully synthetic data techniques for data with binary variables. Journal of Statistical Computation and Simulation 80 (6), 609–624.

Moore, Jr., R., 1996. Controlled data-swapping techniques for masking public use microdata. Census Tech Report.

Mugge, R., 1983. Issues in protecting confidentiality in national health statistics. Proceedings of the Section on Survey Research Methods.

Nissim, K., Raskhodnikova, S., Smith, A., 2007. Smooth sensitivity and sampling in private data analysis. In: STOC ’07: Proceedings of the thirty-ninth annual ACM symposium on Theory of computing. pp. 75–84.

Paass, G., 1988. Disclosure risk and disclosure avoidance for microdata. Journal of Business and Economic Statistics 6 (4), 487–500.

Palley, M., Simonoff, J., 1987. The use of regression methodology for the compromise of confidential information in statistical databases. ACM Trans. Database Systems 12 (4), 593–608.

Raghunathan, T.E., Reiter, J.P., Rubin, D.B., 2003. Multiple imputation for statistical disclosure limitation. Journal of Official Statistics 19 (1), 1–16.

Rajasekaran, S., Harel, O., Zuba, M., Matthews, G.J., Aseltine, Jr., R., 2009. Responsible data releases. In: Proceedings 9th Industrial Conference on Data Mining (ICDM). Springer LNCS, pp. 388–400.

Reiss, S.P., 1984. Practical data-swapping: The first steps. CM Transactions on Database Systems 9, 20–37.

Reiter, J.P., 2002. Satisfying disclosure restriction with synthetic data sets. Journal of Official Statistics 18 (4), 531–543.

Reiter, J.P., 2003. Inference for partially synthetic, public use microdata sets. Survey Methodology 29 (2), 181–188.

Reiter, J.P., 2004a. New approaches to data dissemination: A glimpse into the future (?). Chance 17 (3), 11–15.

Reiter, J.P., 2004b. Simultaneous use of multiple imputation for missing data and disclosure limitation. Survey Methodology 30 (2), 235–242.

Reiter, J.P., 2005a. Estimating risks of identification disclosure in microdata. Journal of the American Statistical Association 100, 1103–1112.

Reiter, J.P., 2005b. Releasing multiply imputed, synthetic public use microdata: An illustration and empirical study. Journal of the Royal Statistical Society, Series A: Statistics in Society 168 (1), 185–205.

Reiter, J.P., 2005c. Using CART to generate partially synthetic public use microdata. Journal of Official Statistics 21 (3), 441–462.

Rubin, D.B., 1987. Multiple Imputation for Nonresponse in Surveys. John Wiley & Sons.

Rubin, D.B., 1993. Comment on “Statistical disclosure limitation”. Journal of Official Statistics 9, 461–468.

Rubner, Y., Tomasi, C., Guibas, L.J., 1998. A metric for distributions with applications to image databases. Computer Vision, IEEE International Conference on 0, 59.

Sarathy, R., Muralidhar, K., 2002a. The security of confidential numerical data in databases. Information Systems Research 13 (4), 389–403.

Sarathy, R., Muralidhar, K., 2002b. The security of confidential numerical data in databases. Info. Sys. Research 13 (4), 389–403.

Schafer, J.L., Graham, J.W., 2002. Missing data: Our view of state of the art. Psychological Methods 7 (2), 147–177.

Singh, A., Yu, F., Dunteman, G., 2003. MASSC: A new data mask for limiting statistical information loss and disclosure. In: Proceedings of the Joint UNECE/EUROSTAT Work Session on Statistical Data Confidentiality. pp. 373–394.

Skinner, C., 2009. Statistical disclosure control for survey data. In: Pfeffermann, D and Rao, C.R. eds. Handbook of Statistics Vol. 29A: Sample Surveys: Design, Methods and Applications. pp. 381–396.

Skinner, C., Marsh, C., Openshaw, S., Wymer, C., 1994. Disclosure control for census microdata. Journal of Official Statistics 10, 31–51.

Skinner, C., Shlomo, N., 2008. Assessing identification risk in survey microdata using log-linear models. Journal of the American Statistical Association 103, 989–1001.

Skinner, C.J., Elliot, M.J., 2002. A measure of disclosure risk for microdata. Journal of the Royal Statistical Society. Series B (Statistical Methodology) 64 (4), 855–867.

Smith, A., 2008. Efficient, dfferentially private point estimators. arXiv:0809.4794v1 [cs.CR].

Spruill, N.L., 1982. Measures of confidentiality. Statistics of Income and Related Administrative Record Research, 131–136.

Spruill, N.L., 1983. The confidentiality and analytic usefulness of masked business microdata. In: Proceedings of the Section on Survey Reserach Microdata. American Statistical Association, pp. 602–607.

Sweeney, L., 1996. Replacing personally-identifying information in medical records, the scrub system. In: American Medical Informatics Association. Hanley and Belfus, Inc., pp. 333–337.

Sweeney, L., 1997. Guaranteeing anonymity when sharing medical data, the datafly system. Journal of the American Medical Informatics Association 4, 51–55.

Sweeney, L., 2002a. Achieving k-anonymity privacy protection using generalization and suppression. International Journal of Uncertainty, Fuzziness and Knowledge Based Systems 10 (5), 571–588.

Sweeney, L., 2002b. k-anonymity: A model for protecting privacy. International Journal of Uncertainty, Fuzziness and Knowledge Based Systems 10 (5), 557–570.

Tendick, P., 1991. Optimal noise addition for preserving confidentiality in multivariate data. Journal of Statistical Planning and Inference 27 (2), 341–353.

United Nations Economic Comission for Europe (UNECE), 2007. Manging statistical cinfidentiality and microdata access: Principles and guidlinesof good practice.

Warner, S.L., 1965. Randomized response: A survey technique for eliminating evasive answer bias. Journal of the American Statistical Association 60 (309), 63–69.

Wasserman, L., Zhou, S., 2010. A statistical framework for differential privacy. Journal of the American Statistical Association 105 (489), 375–389.

Willenborg, L., de Waal, T., 2001. Elements of Statistical Disclosure Control. Springer-Verlag.

Woodward, B., 1995. The computer-based patient record and confidentiality. The New England Journal of Medicine, 1419–1422.

Introducing common shocks is a popular dependence modelling approach, with some recent applications in loss reserving. The main advantage of this approach is the ability to capture structural dependence coming from known relationships. In addition, it helps with the parsimonious construction of correlation matrices of large dimensions. However, complications arise in the presence of "unbalanced data", that is, when (expected) magnitude of observations over a single triangle, or between triangles, can vary substantially. Specifically, if a single common shock is applied to all of these cells, it can contribute insignificantly to the larger values and/or swamp the smaller ones, unless careful adjustments are made. This problem is further complicated in applications involving negative claim amounts. In this paper, we address this problem in the loss reserving context using a common shock Tweedie approach for unbalanced data. We show that the solution not only provides a much better balance of the common shock proportions relative to the unbalanced data, but it is also parsimonious. Finally, the common shock Tweedie model also provides distributional tractability.

People learn to discriminate between classes without explicit exposure to negative examples. On the contrary, traditional machine learning algorithms often rely on negative examples, otherwise the model would be prone to collapse and always-true predictions. Therefore, it is crucial to design the learning objective which leads the model to converge and to perform predictions unbiasedly without explicit negative signals. In this paper, we propose a Collectively loss function to learn from only Positive and Unlabeled data (cPU). We theoretically elicit the loss function from the setting of PU learning. We perform intensive experiments on the benchmark and real-world datasets. The results show that cPU consistently outperforms the current state-of-the-art PU learning methods.

A free manuscripts workshop for PhD students at Wellcome Collection, 01 June 2018 Engaging with an artefact from the past is often a powerful experience, eliciting emotional and sensory, as well as analytical, responses. Researchers in the library at Wellcome… Continue reading

Members of the future American workforce could see losses of earnings that add up to trillions of dollars, depending on how long coronavirus-related school closures persist.

The post Economists Expect Huge Future Earnings Loss for Students Missing School Due to COVID-19 appeared first on Market Brief.

U.S. Chief Justice John Roberts on Friday put a temporary hold on the disclosure to a Democratic-led House of Representatives committee of grand jury material redacted from former Special Counsel Robert Mueller's report on Russian interference in the 2016 election. The U.S. Court of Appeals for the District of Columbia Circuit ruled in March that the materials had to be disclosed to the House Judiciary Committee and refused to put that decision on hold. The appeals court said the materials had to be handed over by May 11 if the Supreme Court did not intervene.

Cristiano Villa, Jeong Eun Lee.

Source: Bayesian Analysis, Volume 15, Number 2, 533--558.

Abstract:
In this work we propose a novel model prior for variable selection in linear regression. The idea is to determine the prior mass by considering the worth of each of the regression models, given the number of possible covariates under consideration. The worth of a model consists of the information loss and the loss due to model complexity. While the information loss is determined objectively, the loss expression due to model complexity is flexible and, the penalty on model size can be even customized to include some prior knowledge. Some versions of the loss-based prior are proposed and compared empirically. Through simulation studies and real data analyses, we compare the proposed prior to the Scott and Berger prior, for noninformative scenarios, and with the Beta-Binomial prior, for informative scenarios.

Adam J. Krause
Mar 20, 2019; 39:2291-2300
BehavioralSystemsCognitive

Ben Warren
Apr 8, 2020; 40:3130-3140
Neurobiology of Disease

Michele Bellesi
May 24, 2017; 37:5263-5273
Cellular

Spanish translation of the BIS press release about the BIS Quarterly Review, March 2018

Spanish version of Press release about CPMI and the Markets Committee issuing a report on "Central bank digital currencies" (12 March 2018)

Spanish translation of press release - the Basel Committee on Banking Supervision is finalising stress-testing principles, reviews ways to stop regulatory arbitrage behaviour, agrees on annual G-SIB list, discusses leverage ratio, crypto-assets, market risk framework and implementation, 20 September 2018.

Spanish translation of the BIS press release about the BIS Quarterly Review, September 2018

Spanish translation of the BIS press release about the BIS Quarterly Review, March 2019

Spanish translation of the speech by Mr Agustín Carstens, General Manager of the BIS, on the occasion of the Bank's Annual General Meeting, Basel, 30 June 2019.

Spanish translation of the BIS press release on the presentation of the Annual Economic Report 2019, 30 June 2019.

To view more press releases, please visit http://www.snl.com/irweblinkx/news.aspx?iid=1024452.

To view more press releases, please visit http://www.snl.com/irweblinkx/news.aspx?iid=1024452.

Speech by Mr Agustín Carstens, General Manager of the BIS, at the Fourteenth ASBA-BCBS-FSI High-level Meeting on Global and Regional Supervisory Priorities, Lima, 1 October 2019.

Acoustic overexposure, such as listening to loud music too often, results in noise-induced hearing loss. The pathologies of this prevalent sensory disorder begin within the ear at synapses of the primary auditory receptors, their postsynaptic partners and their supporting cells. The extent of noise-induced damage, however, is determined by overstimulation of primary auditory receptors, upstream of where the pathologies manifest. A systematic characterization of the electrophysiological function of the upstream primary auditory receptors is warranted to understand how noise exposure impacts on downstream targets, where the pathologies of hearing loss begin. Here, we used the experimentally-accessible locust ear (male, Schistocerca gregaria) to characterize a decrease in the auditory receptor's ability to respond to sound after noise exposure. Surprisingly, after noise exposure, the electrophysiological properties of the auditory receptors remain unchanged, despite a decrease in the ability to transduce sound. This auditory deficit stems from changes in a specialized receptor lymph that bathes the auditory receptors, revealing striking parallels with the mammalian auditory system.

SIGNIFICANCE STATEMENT Noise exposure is the largest preventable cause of hearing loss. It is the auditory receptors that bear the initial brunt of excessive acoustic stimulation, because they must convert excessive sound-induced movements into electrical signals, but remain functional afterward. Here we use the accessible ear of an invertebrate to, for the first time in any animal, characterize changes in auditory receptors after noise overexposure. We find that their decreased ability to transduce sound into electrical signals is, most probably, due to changes in supporting (scolopale) cells that maintain the ionic composition of the ear. An emerging doctrine in hearing research is that vertebrate primary auditory receptors are surprisingly robust, something that we show rings true for invertebrate ears too.

Neural plasticity due to hearing loss results in tonotopic map changes. Several studies have suggested a relation between hearing loss-induced tonotopic reorganization and tinnitus. This large fMRI study on humans was intended to clarify the relations between hearing loss, tinnitus, and tonotopic reorganization. To determine the differential effect of hearing loss and tinnitus, both male and female participants with bilateral high-frequency hearing loss, with and without tinnitus, and a control group were included. In a total of 90 participants, bilateral cortical responses to sound stimulation were measured with loudness-matched pure-tone stimuli (0.25-8 kHz). In the bilateral auditory cortices, the high-frequency sound-evoked activation level was higher in both hearing-impaired participant groups, compared with the control group. This was most prominent in the hearing loss group without tinnitus. Similarly, the tonotopic maps for the hearing loss without tinnitus group were significantly different from the controls, whereas the maps of those with tinnitus were not. These results show that higher response amplitudes and map reorganization are a characteristic of hearing loss, not of tinnitus. Both tonotopic maps and response amplitudes of tinnitus participants appear intermediate to the controls and hearing loss without tinnitus group. This observation suggests a connection between tinnitus and an incomplete form of central compensation to hearing loss, rather than excessive adaptation. One implication of this may be that treatments for tinnitus shift their focus toward enhancing the cortical plasticity, instead of reversing it.

SIGNIFICANCE STATEMENT Tinnitus, a common and potentially devastating condition, is the presence of a "phantom" sound that often accompanies hearing loss. Hearing loss is known to induce plastic changes in cortical and subcortical areas. Although plasticity is a valuable trait that allows the human brain to rewire and recover from injury and sensory deprivation, it can lead to tinnitus as an unwanted side effect. In this large fMRI study, we provide evidence that tinnitus is related to a more conservative form of reorganization than in hearing loss without tinnitus. This result contrasts with the previous notion that tinnitus is related to excessive reorganization. As a consequence, treatments for tinnitus may need to enhance the cortical plasticity, rather than reverse it.

FAO and its partners have launched an initiative aimed at cutting food waste across the Asia-Pacific region. Save Food Asia-Pacific Campaign targets losses both straight after harvest and between the market and people’s plates. FAO estimates that reducing global food waste by just one quarter would be sufficient to feed the 870 million people suffering from chronic hunger in the world. [...]

Whether we categorize uneaten food as “lost” or “wasted” depends on where it goes out of the food supply chain. Imagine how everything we eat travels across a food supply chain, a complex journey that stretches from farm to table. Studies show that an astounding 1/3 of all the food we produce for human consumption never actually reaches our plates. Most [...]

The National Cherry Blossom Festival has moved online due to the novel coronavirus pandemic

Titles related to "home-life" subjects—like preserving and canning—have also experienced a boost in sales

The country has shut down its museums and archaeological sites in an effort to slow the spread of coronavirus

The 18th-century Edinburgh factory once produced a million bottles a week

The solitary species is hard to spot on camera, and they're the only canine that lives in the Amazon rainforest

The quarantined felines of the world are coming for your screens

Each night, the institution will post an encore showing of an opera from its "Met Live in HD" series

In an official statement, the Institution announced temporary closures beginning Saturday, March 14

View these vivid illustrations by Japanese artist Kōkichi Tsunoi of the varieties of trees presented to the United States in 1912