The company is showing off its new full-frame SLR, ultra-zoom bridge camera, and a pair of zoom lenses at CES this year.

A studio course for architecture and landscape architecture students in the Stuckeman School prepares students for the collaborative design process they will take part in once they begin careers in their respective fields by blurring the boundaries between the disciplines in the college setting.

Capital structure, or the DNAs of different sectors differ substantially.

A new online newsletter offered by Penn State Extension will give readers “the scoop” on the spotted lanternfly.

KBP-7072 is a semi-synthetic aminomethylcycline with broad-spectrum activity against Gram-positive and Gram-negative pathogens including multidrug resistant bacterial strains. The pharmacokinetics (PK) of KBP-7072 after oral and intravenous (IV) administration of single and multiple doses were investigated in animal models including during fed and fasted states and also evaluated the protein binding and excretion characteristics. In Sprague-Dawley (SD) rats, Beagle dogs, and CD-1 mice, KBP-7072 demonstrated a linear PK profile after administration of single oral and IV and multiple oral doses. Oral bioavailability ranged from 12% to 32%. Mean T_max ranged from 0.5 to 4 hours, and mean half-life ranged from approximately 6 to 11 hours. Administration of oral doses in the fed state resulted in a marked reduction in C_max and AUC compared with dosing in fasted animals. The mean bound fractions of KBP-7072 were 77.5%, 69.8%, 64.5%, 69.3%, and 69.2% in mouse, rat, dog, monkey, and human plasma, respectively. Following a single 22.5 mg/kg oral dose of KBP-7072 in SD rats, cumulative excretion in feces was 64% and in urine was 2.5% of the administered dose. The PK results in animal models are consistent with single and multiple ascending dose studies in healthy volunteers and confirm the suitability of KBP-7072 for once daily oral and IV administration in clinical studies.

Mycobacterium abscessus lung infections remain difficult to treat. Recent studies have recognized the power of new combinations of antibiotics such as bedaquiline and imipenem although in vitro data have questioned this combination. We report that the efficacy of the bedaquiline plus imipenem treatment relies essentially on the activity of bedaquiline in a C3HeB/FeJ mice model of infection with a rough variant of M. abscessus. The addition of imipenem contributed at clearing the infection in the spleen.

Linezolid is the first synthetic oxazolidone agent to treat infections caused by Gram-positive pathogens. Infected patients with liver dysfunction (LD) are more likely to suffer from adverse reactions such as thrombocytopenia when standard-dose linezolid is used than patients with LD who didn't use linezolid. Currently, pharmacokinetics data of linezolid in patients with LD are limited. The study aimed to characterize pharmacokinetics parameters of linezolid in patients with LD, identify the factors influencing the pharmacokinetics, and propose an optimal dosage regimen. We conducted a prospective study and established population pharmacokinetics model with the Phoenix NLME. The final model was evaluated by goodness-of-fit plots, bootstrap analysis, and prediction corrected-visual predictive check. A total of 163 concentration samples from 45 patients with LD were adequately described by a one-compartment model with first-order elimination along with prothrombin activity (PTA) and creatinine clearance as significant covariates. Linezolid clearance (CL) was 2.68 L/h (95% confidence interval [CI]: 2.34-3.03 L/h); the volume of distribution (Vd) was 58.34 L (95% CI: 48.00-68.68 L). Model-based simulation indicated that the conventional dose was at risk for overexposure in patients with LD or severe renal dysfunction; reduced dosage (300 mg/12 h) would be appropriate to achieve safe (C_min, ss at 2-8 ug/mL) and effective targets (the ratio of AUC_0-24 at steady state to MIC, 80-100). In addition, for patients with severe LD (PTA <= 20%), the dosage (400 mg/24 h) was sufficient at an MIC <= 2 ug/mL. This study recommended therapeutic drug monitoring for patients with LD.

In vitro and in vivo interactions of minocycline and azoles including itraconazole, voriconazole, and posaconazole against filamentous pathogenic fungi were investigated. A total of 56 clinical isolates were studied in vitro via broth microdilution checkerboard technique, including 20 strains of Aspergillus fumigatus, 7 strains of A. flavus, 16 strains of Exophiala dermatitidis, 10 strains of Fusarium solani and 3 strain s of F. oxysporum. The results revealed that minocycline individually did not exhibit any significant antifungal activity against all tested strains. However, favorable synergy of minocycline with itraconazole, voriconazole, or posaconazole were observed against 34 (61%), 28 (50%), and 38 (69%) isolates, respectively, including azole resistant A. fumigatus and Fusarium spp. with inherently high MICs of azoles. Synergistic combinations resulted in 4 fold to 16-fold reduction of effective MICs of minocycline and azoles. No antagonism was observed. In vivo effect of minocycline-azole combinations were evaluated by survival assay in Galleria mellonella model infected with E. dermatitidis strain BMU00034, F. solani strain FS9, A. fumigatus strain AF293, AFR1 and AFR2 . Minocycline acted synergistically with azoles and significantly increased larvae survival in all isolates (P<0.001), including azole resistant A. fumigatus and azole-inactive Fusarium spp.. In conclusion, the results suggested that minocycline combined with azoles may help to enhance the antifungal susceptibilities of azoles against pathogenic fungi and had the potential to overcome azole resistance issues.

Clostridioides difficile, the leading cause of nosocomial infections, is an urgent health threat worldwide. The increased incidence and severity of disease, the high recurrence rates, and the dearth of effective anticlostridial drugs have created an urgent need for new therapeutic agents. In an effort to discover new drugs for treatment of Clostridioides difficile infections (CDIs), we investigated a panel of FDA-approved antiparasitic drugs against C. difficile and identified diiodohydroxyquinoline (DIHQ), an FDA-approved oral antiamoebic drug. DIHQ exhibited potent activity against 39 C. difficile isolates, inhibiting growth of 50% and 90% of these isolates at the concentrations of 0.5 μg/mL and 2 μg/mL, respectively. In a time-kill assay, DIHQ was superior to vancomycin and metronidazole, reducing a high bacterial inoculum by 3-log₁₀ within six hours. Furthermore, DIHQ reacted synergistically with vancomycin and metronidazole against C. difficile in vitro. Moreover, at subinhibitory concentrations, DIHQ was superior to vancomycin and metronidazole in inhibiting two key virulence factors of C. difficile, toxin production and spore formation. Additionally, DIHQ did not inhibit growth of key species that compose the host intestinal microbiota, such as Bacteroides, Bifidobacterium and Lactobacillus spp. Collectively, our results indicate that DIHQ is a promising anticlostridial drug that warrants further investigation as a new therapeutic for CDIs.

Omadacycline is a novel aminomethylcycline with activity against Gram-positive and -negative organisms, including Haemophilus influenzae, which is one of the leading causes of community-acquired bacterial pneumonia (CABP). The evaluation of antimicrobial agents against H. influenzae using standard murine infection models is challenging due to the low pathogenicity of this species in mice. Therefore, 24-hour dose-ranging studies using a one-compartment in vitro infection model were undertaken with the goal of characterizing the magnitude of the ratio of the area under the concentration-time curve (AUC) to the MIC (AUC/MIC ratio) associated with efficacy for a panel of five clinical H. influenzae isolates. These five isolates, which had MIC values of 1 or 2 mg/L, were exposed to omadacycline total-drug epithelial lining fluid (ELF) concentration-time profiles based on those observed in healthy volunteers following intravenous omadacycline administration. Relationships between change in log₁₀ colony forming units (CFU) from baseline at 24 hours and total-drug ELF AUC/MIC ratio for each isolate and the isolates pooled together were evaluated using Hill-type models and non-linear least squares regression. As evidenced by the high coefficient of determination (r²) of 0.88 to 0.98, total-drug ELF AUC/MIC ratio described the data well for each isolate and the isolates pooled together. The median total-drug ELF AUC/MIC ratio associated with net bacterial stasis and 1- and 2-log₁₀ CFU/mL reductions from baseline at 24 hours was 6.91, 8.91, and 11.1, respectively. These data were useful to support the omadacycline dosing regimens selected for the treatment of patients with CABP, as well as susceptibility breakpoints for H. influenzae.

Omadacycline, a novel aminomethylcycline antibiotic with activity against Gram-positive and -negative organisms, including tetracycline-resistant pathogens, received FDA approval in October, 2018 for the treatment of patients with acute bacterial skin and skin structure infections (ABSSSI) and community-acquired bacterial pneumonia (CABP). A previously-developed population pharmacokinetic (PK) model based on Phase 1 intravenous and oral PK data was refined using data from infected patients. Data from 10 Phase 1 studies used to develop the previous model were pooled with data from three additional Phase 1 studies, a Phase 1b uncomplicated urinary tract infection study, one Phase 3 CABP study, and two Phase 3 ABSSSI studies. The final population PK model was a three-compartment model with first-order absorption using transit compartments to account for absorption delay following oral dosing and first-order elimination. Epithelial lining fluid (ELF) concentrations were modeled as a sub-compartment of the first peripheral compartment. A food effect on oral bioavailability was included in the model. Sex was the only significant covariate identified, with 15.6% lower clearance for females relative to males. Goodness-of-fit diagnostics indicated a precise and unbiased fit to the data. The final model, which was robust in its ability to predict plasma and ELF exposures following omadacycline administration, was also able to predict the central tendency and variability in concentration-time profiles using an external Phase 3 ABSSSI dataset. A population PK model, which described omadacycline PK in healthy subjects and infected patients, was developed and subsequently used to support pharmacokinetic-pharmacodynamic (PK-PD) and PK-PD target attainment assessments.

Exploring different ways of minimising linezolid toxicity without compromising efficacy is a major quest in the treatment of drug resistant tuberculosis (TB)....

Linezolid has strong antimicrobial activity against the multidrug-resistant (MDR) strains of Mycobacterium tuberculosis. Little is known about the distribution of linezolid in tuberculosis (TB) lesions in patients with MDR-TB. The aim of this study is to evaluate the distribution of linezolid in TB lesions in patients with spinal MDR-TB. Nine patients with spinal MDR-TB were enrolled prospectively from August 2019 to February 2020. The patients received a linezolid-containing anti-TB treatment regimen and needed surgery for the removal of TB lesions. During the operation, nine blood samples, eight diseased bone tissue samples, seven pus samples and four granulation tissue samples were collected simultaneously and 2 h after the oral administration of 600 mg of linezolid. Linezolid concentrations in plasma, diseased bone tissue, pus, and granulation tissue samples were subjected to high-performance liquid chromatography–tandem mass spectrometry. At sample collection, the mean concentrations of linezolid in plasma, diseased bone tissue, pus, and granulation tissue samples of the nine patients were 11.14 ± 5.82, 5.94 ± 4.27, 11.09 ± 4.58, 14.08 ± 10.61 mg/L, respectively. The mean ratios of linezolid concentration in diseased bone/plasma, pus/plasma, and granulation/plasma were 53.84%, 91.69%, and 103.57%, respectively. The mean ratios of linezolid concentration in pus/plasma and granulation/plasma were higher than those in diseased bone/plasma, and the difference was statistically significant (t =-2.810, p = 0.015; t =-4.901, p = 0.001). In conclusion, linezolid had different concentration distributions in different types of TB infected tissues in patients with spinal MDR-TB.

We thank Kim and colleagues for their interest in our study....

Given that GoDaddy's GoCentral Online Store is an add-on service to its web hosting product, you'll find its features a little more limited than much of the competition. But if you're a GoDaddy customer, then it's a great way to start quickly.

Automated EFT payments enabled by technology from fintech company Ozow may be a secure alternative method to transact than card payments.

Metropolitan is sponsoring a financial literacy short course hosted on FunDza, an online literacy portal dedicated to helping South Africans better their skills.

When the novel coronavirus pandemic prompted the transition to remote learning at Penn State, faculty and administrators in the Department of Mechanical Engineering were prepared for the challenge.

Happy Valley LaunchBox powered by PNC Bank is accepting applications through May 15 for its Idea TestLab that will now be hosted virtually in June. Open to the community, the four-week Idea TestLab program is designed to help teams evaluate the viability of their business ideas by coaching them through a proven method of customer discovery and problem analysis.

Not sure which sources to trust when you're online? These browser plug-ins and online tools can help you figure out how to detect fake news sites.

Google Docs, Sheets, and Slides can already be saved and edited offline using the web app, but Google is expanding offline access to all file types, as long as you're using Chrome.

The Z8H 8K LED vibrates the frame of the television to emit audio and give the impression that the sound is coming directly from the screen itself.

The Education Department says federal law should not be used to prevent schools from offering online learning to all students, including those with disabilities.

Holders England, France, Italy, Norway, Portugal, Turkey and Ukraine have won their elite round groups to join hosts Finland.

Czech Republic, France, Italy, Norway, Portugal, Republic of Ireland and Spain have joined Armenia in the finals.

Catch up or get ahead on credits by taking online courses at Penn State Abington this summer. Three sessions are offered and class sizes are small.

Penn State Abington students involved in undergraduate research quickly designed ways to present their findings online. It mirrors a global effort as many academic conferences transitioned to online due to the coronavirus pandemic.

The annual Bertha Lear Art Exhibition showcases the best work by Penn State Abington students during the 2019-20 academic year.

Penn State Extension is extending its free online courses offer through May 10.

Three Penn State Lehigh Valley students majoring in biobehavioral health and working in health care talked to us about the impact of COVID-19 at their jobs.

Lima, Peru, Apr 26, 2020 / 06:18 am (CNA).- An archbishop in Venezuela warned that desperation is growing in the country, as the national coronavirus quarantine measures have compounded a tenuous political and economic situation. He urged people in the country to resist violence and social unrest.

Extreme hunger “does not reason or know rules,” said Archbishop Ulises Gutiérrez of Ciudad Bolívar, adding that this desperate hunger “is becoming a fuel more dangerous than gasoline.”

Gutiérrez spoke with ACI Prensa, CNA’s Spanish language news partner, in an April 23 interview, after looting and protests broke out in seven states in Venezuela.

Protestors objected to price hikes on food and a gasoline shortage exacerbated by the ongoing quarantine that was imposed last month to halt the spread of the COVID-19 pandemic. According to the latest government report, there have been 298 cases and 10 deaths in the country due to the virus.

Even before the coronavirus pandemic, Venezuela has been marred by violence and social upheaval under the socialist administration of Nicolas Maduro, with severe shortages of food and medicine, high unemployment, power outages, and hyperinflation. Some 4.5 million Venezuelans have emigrated since 2015.

The current COVID-19 quarantine is “aggravating the situation,” the archbishop said, noting that the quarantine was implemented without accompanying measures to protect the most vulnerable.

As a result, families are suffering, and many cannot access clean water, electricity or gasoline.

The country is experiencing “a totally destroyed economy in which agricultural producers can’t get their products out because they’re not getting gasoline supplied to them, or they have to buy it on the black market for 2 or 3 dollars a liter,” he said. In some cases, crops are rotting in farmers’ fields due to lack of fuel to transport them to market.

Gutiérrez voiced concern over the hunger-fueled looting and protests throughout the country, as well as the government’s violent suppression of the protests.

“The common denominator in all these protests is hunger,” he stressed.

With equipment in short supply and many of the country’s doctors have already emigrated due to the political and economic crisis, Gutiérrez acknowledged, the pandemic poses a significant threat.

“In short, the outlook is very dark,” he said.

But despite the desperate situation, the archbishop urged people not to resort to looting and violence.

“[S]atisfying hunger short term [by committing robbery] only leads to the destruction of regular commerce,” he said.

“The situation we’re going through is very tough, difficult, and fragile,” Gutiérrez said, likening the conditions to a pressure cooker, “which could lead us to unprecedented explosive social unrest, which nobody wants, and which would bring with it more hunger and greater suffering for the people.”

Still, the archbishop said he has reason for hope: “Our trust is in God and his providence keeps us going, encouraging and accompanying our people, assisting them with our Caritas social programs.”

“We have community soup kitchens, a medicine bank, outpatient medical care, programs for infant nutrition and nursing mothers, etc., which although it’s impossible to reach everyone, is a sign of God’s love through the Church,” he said.

Penn State Brandywine’s Sustainovation Team has partnered with Tyler Arboretum to host an online discussion club for podcasts, offering a creative solution for the local community to stay connected during the coronavirus (COVID-19) pandemic.

Penn State Fayette, The Eberly Campus has introduced a new phone-based resource for area veterans.

In a study published in the latest Proceedings of Computer-Human Interaction, a team of Penn State researchers identified a dozen subtle — but powerful — reasons that may shed light on why people talk a good game about privacy, but fail to follow up in real life.

The staff of Hershey Medical Center is one of only several academic hospitals in the country with specialized infrastructure and and training geared around offering care during a contagion outbreak. But they have another advantage, too. “We are all a family,” says one doctor. “And we look out for one another.”

After two prosecutors recused themselves from investigating Ahmaud Arbery's death, Gregory and Travis McMichael were arrested.

The Coronavirus and International Affairs Roundtable, taking place 9:30 a.m. Friday, April 17, via Zoom, will bring together experts in law and international affairs from Asia, Europe, the Middle East, North America, and the Caribbean to discuss the broader impact of COVID-19.

Visual Art Studies program seniors Andrea Regalbuto and Gary Weyandt are showcasing their respective exhibitions “Flap/Flutter” and “MEDIAted” online via websites, Instagram, and virtual exhibits.

Some of the most important pre-literacy skills begin in infancy. This timeline shows examples of the milestones children meet on their path to fluent reading.

Penn State's College of Education and the State College Area School District have joined forces for 22 years to conduct the Professional Development School.

Holders Spain are among the 15 teams that came through the elite round to join hosts England in May's finals.

Penn State researchers have developed a comprehensive online tutor to educate the general public about the science behind COVID-19 and appropriate steps anyone can take to help reduce its transmission.

School superintendents, principals, and school board members found a lot to like in a draft bill to renew the Elementary and Secondary Education Act.

Belgium, England, France, Germany, Netherlands, Norway and holders Spain will join hosts Scotland in the finals.

Arsenal, Glasgow and Paris have joined Atlético, Barcelona, Bayern, holders Lyon and Wolfsburg in the last eight.

Intel has released some benchmarks for its next-gen Core i9 'Cascade Lake-X' processors, which will be arriving next month with a big price cut. The company is also slightly dropping prices on Core S-series chips that lack GPUs, and preparing to launch the Xeon W-2200 series.

Real Madrid, Chelsea, Liverpool, Atlético Madrid, Tottenham and Porto won their round of 16 ties on Wednesday to join Barcelona and Manchester City in the quarter-finals.

Jane's Skype conversations with Fariha across the world in Bangladesh helped Fariha learn English while providing an opportunity to share the love of Jesus.

Two-time winners Spain will contest the play-offs for the 2016 FIFA Futsal World Cup along 13 other sides, with ten of the 12 UEFA Futsal EURO 2016 finalists through in total.