ign

ADA Practice Transitions offering promotional trial for dentists who sign up through March 1

ADA Practice Transitions, a service offered by the ADA focused on helping dentists make the process of joining or leaving a practice successful, is offering a free three-month trial.




ign

ADA initiates grassroots campaign in response to CARES Act

The ADA is calling on dentists everywhere to contact their legislators today ahead of the Senate’s vote on the Coronavirus Aid, Relief and Economic Security Act.




ign

Prognostic Significance of Long-term HbA1c Variability for All-Cause Mortality in the ACCORD Trial

OBJECTIVE

The association between high glycemic variability and all-cause mortality has been widely investigated in epidemiological studies but rarely validated in glucose-lowering clinical trials. We aimed to identify the prognostic significance of visit-to-visit HbA1c variability in treated patients in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial population.

RESEARCH DESIGN AND METHODS

We studied the risk of all-cause mortality in relation to long-term visit-to-visit HbA1c variability, expressed as coefficient of variation (CV), variability independent of the mean (VIM), and average real variability (ARV), from the 8th month to the transition. Multivariable Cox proportional hazards models were used to estimate adjusted hazard ratio (HR) and 95% CI.

RESULTS

Compared with the standard therapy group (n = 4,728), the intensive therapy group (n = 4,755) had significantly lower mean HbA1c (6.6% [49 mmol/mol] vs. 7.7% [61 mmol/mol], P < 0.0001) and lower CV, VIM, and ARV (P < 0.0001). In multivariate adjusted analysis, all three HbA1c variability indices were significantly associated with total mortality in all patients as well as in the standard- and intensive-therapy groups analyzed separately. The hazard ratios for a 1-SD increase in HbA1c variability indices for the all-cause mortality were 1.19 and 1.23 in intensive and standard therapy, respectively. Cross-tabulation analysis showed the third tertile of HbA1c mean and VIM had significantly higher all-cause mortality (HR 2.05; 95% CI, 1.17–3.61; P < 0.01) only in the intensive-therapy group.

CONCLUSIONS

Long-term visit-to-visit HbA1c variability was a strong predictor of all-cause mortality. HbA1c VIM combined with HbA1c mean conferred an increased risk for all-cause mortality in the intensive-therapy group.




ign

microRNA-21/PDCD4 Proapoptotic Signaling From Circulating CD34+ Cells to Vascular Endothelial Cells: A Potential Contributor to Adverse Cardiovascular Outcomes in Patients With Critical Limb Ischemia

OBJECTIVE

In patients with type 2 diabetes (T2D) and critical limb ischemia (CLI), migration of circulating CD34+ cells predicted cardiovascular mortality at 18 months after revascularization. This study aimed to provide long-term validation and mechanistic understanding of the biomarker.

RESEARCH DESIGN AND METHODS

The association between CD34+ cell migration and cardiovascular mortality was reassessed at 6 years after revascularization. In a new series of T2D-CLI and control subjects, immuno-sorted bone marrow CD34+ cells were profiled for miRNA expression and assessed for apoptosis and angiogenesis activity. The differentially regulated miRNA-21 and its proapoptotic target, PDCD4, were titrated to verify their contribution in transferring damaging signals from CD34+ cells to endothelial cells.

RESULTS

Multivariable regression analysis confirmed that CD34+ cell migration forecasts long-term cardiovascular mortality. CD34+ cells from T2D-CLI patients were more apoptotic and less proangiogenic than control subjects and featured miRNA-21 downregulation, modulation of several long noncoding RNAs acting as miRNA-21 sponges, and upregulation of the miRNA-21 proapoptotic target PDCD4. Silencing miR-21 in control subject CD34+ cells phenocopied the T2D-CLI cell behavior. In coculture, T2D-CLI CD34+ cells imprinted naïve endothelial cells, increasing apoptosis, reducing network formation, and modulating the TUG1 sponge/miRNA-21/PDCD4 axis. Silencing PDCD4 or scavenging reactive oxygen species protected endothelial cells from the negative influence of T2D-CLI CD34+ cells.

CONCLUSIONS

Migration of CD34+ cells predicts long-term cardiovascular mortality in T2D-CLI patients. An altered paracrine signaling conveys antiangiogenic and proapoptotic features from CD34+ cells to the endothelium. This damaging interaction may increase the risk for life-threatening complications.




ign

Do I Have to Sign?

Parents are asked to sign paperwork when services begin, when changes are made, and if services end. Let's not stop there. Parents must sign before any assessments begin. Parents must sign that they attended meetings. Parents sign that they received a copy of special education rights. The reasoning is to protect everyone involved. It gives documentation to show who attended the meetings, shows parental consent for what is outlined in the plan, and documents what has occurred at the meeting.


Should I sign if I don't agree?
You do not have to sign what you do not agree with. That being said- if you attended the meeting, please sign where it says to sign that you attended the meeting. If you received paperwork, please sign that you received it. If you do not agree with the findings or do not agree with the services offered, then do not sign where it asks if you are in agreement. There may also be an area to sign that you do not agree with the findings and you may have an opportunity to write a dissenting opinion.

What will happen if I don't sign?
In general, the answer is nothing. Literally nothing will happen if you don't sign. Services can not begin until the parent signs. Changes can not take place until the parents sign. Services can not end (in most states) until the parent signs. In most cases if the parent refuses to sign, everything will remain basically the same. Laws vary between states on this issue, so make sure to check your own state laws.

Is it okay to think about it overnight before signing?
Absolutely. If you aren't sure, take some time to think things over or check in with an advocate. However, please do so in a timely manner, for the sake of everyone involved.

What if we do not come to an agreement?
There are times when parents and the school system do not agree. Usually, when all parties stop and listen to each other, an agreement can be made that is in the best interest of the child. Remember that schools have very strict guidelines that must be followed and there are restrictions to what a school can do.

Think about exactly what it is you disagree with. If you do not agree with the guidelines the school is following, then there is not much that can be done unless you are willing to go through an expensive and drawn out process in court that will still likely amount to no changes. In this case, it would be my best advice to work with the school to determine what can be done for your child within the guidelines.

If you disagree because you feel the school is not following state or federal guidelines, there are steps you can take. Start by discussing the area you feel is not being followed with the school or the special education administrator. Usually a resolution can be made by providing a second opinion at the cost of the school system or through the use of a mediator.

What is Erin's advice?
Try to reach an agreement, where you can feel comfortable signing as quickly as possible. You don't want to leave this open. If you need time to take it in to discuss it and then suggest some changes, that is within your right. However, I do not suggest refusing to sign for long periods of time. Those battles rarely end well for parents, the school, or the child.



  • IEP
  • Special Education Law

ign

&quot;Merit-Based&quot; Immigration: Designing Successful Selection Systems

With the U.S. administration calling for the United States to adopt a more “merit-based” immigrant selection system, this conversation focused on what policymakers should consider in designing—and managing—immigrant selection systems in a time of intense labor-market and demographic change.




ign

Business as Usual? Regularizing Foreign Labor in Costa Rica

With the growing urbanization and consolidation of Nicaraguan immigrants in sectors such as construction and domestic service, Costa Rica has shifted its focus from immigration enforcement to integration. Tension has emerged between the government and private sector as a new mechanism for regularizing unauthorized immigrant workers has failed to gain traction.




ign

Leadership Visions: A Discussion with Mexican Foreign Minister Claudia Ruiz-Massieu

An MPI Leadership Visions discussion with the Foreign Minister of Mexico, Claudia Ruiz-Massieu, for her first public appearance in Washington, DC. 




ign

&quot;Merit-Based&quot; Immigration: Designing Successful Selection Systems

MPI and OECD experts discuss what policymakers should consider in designing and managing immigrant selection systems in a time of intense labor-market and demographic change.




ign

Signs of Modern Human Cognition Were Found in an Indonesian Cave

Painted images of intriguing human-animal hybrids are signs of modern thought

-- Read more on ScientificAmerican.com




ign

Should You Immerse Yourself in Bad News These Days or Ignore It Completely?

Neither approach is ideal. The best option is to temper your negative emotions by focusing on positive ones

-- Read more on ScientificAmerican.com



  • Mind
  • Behavior & Society

ign

Campaign Contributions Change Priorities, Not Beliefs

There are two ways to think about the staggering amounts of money given by special interest groups to politicians -- the type of contributions that were detailed for the last quarter in reports filed yesterday by presidential candidates and members of Congress.




ign

Does Your Subconscious Think Obama Is Foreign?

A few years ago, psychologists Mahzarin Banaji and Thierry Devos showed the names of a number of celebrities to a group of volunteers and asked them to classify the well-known personalities as American or non-American. The list included television personality Connie Chung and tennis star Michael ...




ign

Preparing for the Unknown: Designing Effective Predeparture Orientation for Resettling Refugees

Refugees encounter a range of challenges after resettlement—from adjusting to a new culture and language, to finding a job. Many resettlement countries invest in predeparture orientation to help refugees develop the knowledge, skills, and attitudes to face these challenges. This report explores the many forms these programs take, highlighting important design questions and key elements that effective programs share.




ign

Reducing Integration Barriers Facing Foreign-Trained Immigrants: Policy and Practice Lessons from Across the United States

Marking the release of an MPI report, researchers and practitioners on this webinar discuss brain waste among college-educated immigrants and initiatives that ease the barriers foreign-educated newcomers confront with regards to credential recognition, employment, and relicensure, as well as recent policy developments and ongoing challenges in the field.




ign

Unlocking Skills: Successful Initiatives for Integrating Foreign-Trained Immigrant Professionals

Nearly 2 million college-educated immigrants in the United States, more than half coming with academic and professional credentials, are unable to fully utilize their professional skills and instead are stuck in low-skilled work or are unemployed. This report explores a range of programs and policies that are providing cutting-edge career navigation, relicensing, gap filling, and job search assistance to remedy this brain waste.




ign

Reducing Integration Barriers Facing Foreign-Trained Immigrants: Policy and Practice Lessons from Across the United States

Marking the release of a report on the barriers foreign-trained high-skilled immigrants face in the United States, this webinar examines programs and initiatives that assist with credential recognition, employment, and relicensure, as well as recent policy developments. Discussants review recommendations for community-based organizations, employers, and policymakers to expand successful efforts aimed at preventing brain waste. 




ign

No-Failure Design and Disaster Recovery: Lessons from Fukushima

One of the striking aspects of the early stages of the nuclear accident at Fukushima-Daiichi last March was the nearly total absence of disaster recovery capability. For instance, while Japan is a super-power of robotic technology, the nuclear authorities had to import robots from France for probing the damaged nuclear plants. Fukushima can teach us an important lesson about technology.

The failure of critical technologies can be disastrous. The crash of a civilian airliner can cause hundreds of deaths. The meltdown of a nuclear reactor can release highly toxic isotopes. Failure of flood protection systems can result in vast death and damage. Society therefore insists that critical technologies be designed, operated and maintained to extremely high levels of reliability. We benefit from technology, but we also insist that the designers and operators "do their best" to protect us from their dangers.

Industries and government agencies who provide critical technologies almost invariably act in good faith for a range of reasons. Morality dictates responsible behavior, liability legislation establishes sanctions for irresponsible behavior, and economic or political self-interest makes continuous safe operation desirable.

The language of performance-optimization  not only doing our best, but also achieving the best  may tend to undermine the successful management of technological danger. A probability of severe failure of one in a million per device per year is exceedingly  and very reassuringly  small. When we honestly believe that we have designed and implemented a technology to have vanishingly small probability of catastrophe, we can honestly ignore the need for disaster recovery.

Or can we?

Let's contrast this with an ethos that is consistent with a thorough awareness of the potential for adverse surprise. We now acknowledge that our predictions are uncertain, perhaps highly uncertain on some specific points. We attempt to achieve very demanding outcomes  for instance vanishingly small probabilities of catastrophe  but we recognize that our ability to reliably calculate such small probabilities is compromised by the deficiency of our knowledge and understanding. We robustify ourselves against those deficiencies by choosing a design which would be acceptable over a wide range of deviations from our current best understanding. (This is called "robust-satisficing".) Not only does "vanishingly small probability of failure" still entail the possibility of failure, but our predictions of that probability may err.

Acknowledging the need for disaster recovery capability (DRC) is awkward and uncomfortable for designers and advocates of a technology. We would much rather believe that DRC is not needed, that we have in fact made catastrophe negligible. But let's not conflate good-faith attempts to deal with complex uncertainties, with guaranteed outcomes based on full knowledge. Our best models are in part wrong, so we robustify against the designer's bounded rationality. But robustness cannot guarantee success. The design and implementation of DRC is a necessary part of the design of any critical technology, and is consistent with the strategy of robust satisficing.

One final point: moral hazard and its dilemma. The design of any critical technology entails two distinct and essential elements: failure prevention and disaster recovery. What economists call a `moral hazard' exists since the failure prevention team might rely on the disaster-recovery team, and vice versa. Each team might, at least implicitly, depend on the capabilities of the other team, and thereby relinquish some of its own responsibility. Institutional provisions are needed to manage this conflict.

The alleviation of this moral hazard entails a dilemma. Considerations of failure prevention and disaster recovery must be combined in the design process. The design teams must be aware of each other, and even collaborate, because a single coherent system must emerge. But we don't want either team to relinquish any responsibility. On the one hand we want the failure prevention team to work as though there is no disaster recovery, and the disaster recovery team should presume that failures will occur. On the other hand, we want these teams to collaborate on the design.

This moral hazard and its dilemma do not obviate the need for both elements of the design. Fukushima has taught us an important lesson by highlighting the special challenge of high-risk critical technologies: design so failure cannot occur, and prepare to respond to the unanticipated.




ign

Six Simple Signs Of A Narcissist (M)

One of the most commonly believed signs of a narcissist is a myth.

Support PsyBlog for just $5 per month. Enables access to articles marked (M) and removes ads.

→ Explore PsyBlog's ebooks, all written by Dr Jeremy Dean:




ign

A campaign for period positivity | Ananya Grover

Having your period is exhausting -- and for many people across the world, menstruation is even more challenging because of stigmas and difficulty getting basic hygiene supplies, says social activist Ananya Grover. In this uplifting, actionable talk, she shares how "Pravahkriti," her campaign to spread period positivity, creatively engages with everyone to promote menstrual health, raise awareness and break taboos around periods.




ign

New Jersey Education Commissioner Resigns

With David Hespe's resignation, announced Friday, New Jersey has had five education commissioners in the last seven years.




ign

Amid Sexual Misconduct Allegations, Pennsylvania State Board Chair Resigns

Several women told local newspapers that Pennsylvania state board chair Larry Wittig pursued sexual relationships with them when they were teenagers.




ign

Atlanta Official Resigns, But Loses Out on Post in Oregon

Atlanta's top school official has resigned and is fighting to keep a report investigating his background secret.




ign

President of Delaware Teachers' Union Resigns Due to Sexist, Racist Posts

Mike Matthews wrote several sexist and racist blog posts a decade ago that were recently unearthed.




ign

Thor's Ranked UDFA Signings by Position

Thor Nystrom ranks the top UDFA signings by position, plus CFL draft picks and the best available unsigned prospects. (Getty Images)




ign

Patriots sign Louisiana Tech quarterback J’Mar Smith

The Patriots didn't draft a quarterback, but they signed two who went undrafted. Michigan State quarterback Brian Lewerke's agent revealed a week ago that Lewerke had signed with the Patriots. Patriots coach Bill Belichick wouldn't confirm the team had signed Louisiana Tech quarterback J'mar Smith as well. But Tuesday's official transactions report brought confirmation of [more]




ign

Jets sign Lamar Jackson (the undrafted DB from Nebraska)

The Jets announced on Wednesday that they have signed Lamar Jackson, but no one start frantically wondering what they missed regarding the 2019 NFL MVP. The Lamar Jackson that the Jets signed is an undrafted defensive back from Nebraska rather than the Ravens quarterback. The Jets' Jackson was second-team All-Big Ten last season after recording [more]




ign

West Virginia signs deal with brand consultant ahead of college athletes' potential ability for endorsements

The NCAA is expected to formally approve rules changes that will allow athletes to get endorsement income in 2021.




ign

South Australian Civil and Administrative Tribunal significant decisions / presented by the Hon. Justice Greg Parker PSM.




ign

Stamp duty foreign ownership surcharge / presented by Bernie Walrut, Murray Chambers.




ign

Not looking for signs / Belinda Broughton.




ign

Designing for resilient energy systems : choices in future engineering / edited by Paul Barnes and Neil Greet.




ign

Australian government response to the Senate Finance and Public Administration References Committee inquiry report : the appropriateness and effectiveness of the objectives, design, implementation and evaluation of the Community Development Program (CDP)




ign

Aligning to aliveness : a simple guide to heart-centred living / Robert Beno.




ign

Evaluating behaviour change communication campaigns in health and safety : a literature review / TJ Bailey [and] LN Wundersitz.




ign

British Empire Cancer Campaign compilation.

Leighton, Margaret., presenter.




ign

Data cities : how satellites are transforming architecture and design / Davina Jackson.

City planning -- Remote sensing.




ign

The death of expertise : the campaign against established knowledge and why it matters / Tom Nichols.

Ability -- United States.




ign

Easy graphic design for librarians : from color to kerning / Diana K. Wakimoto.

Libraries -- Marketing.




ign

Australia Modern : architecture, landscape & design / Hannah Lewi & Philip Goad.

Architecture -- Australia -- History -- 20th century.




ign

She said : breaking the sexual harassment story that helped ignite a movement / Jodi Kantor and Megan Twohey.

Weinstein, Harvey, 1952-




ign

Invisible women : exposing data bias in a world designed for men / Caroline Criado Perez.

Sex discrimination against women.




ign

Managing chaos : digital governance by design / Lisa Welchman.

Business enterprises -- Computer networks -- Management.




ign

Designing the John B Fairfax Learning Centre

The John B Fairfax Learning Centre is officially launched and we look forward to welcoming visitors to this fabulous new




ign

Indiana Superintendent Who Used Her Insurance to Help Sick Student Get Treatment Resigns

Casey Smitherman, the superintendent of the Elwood school district, cited the "negative attention" from the incident, according to the Indianapolis Star.




ign

Des suites eloignees des traumatismes du crane et de leur traitement par la trepanation / par Julien Tellier.

Paris : J.-B. Baillière, 1890.




ign

Des tumeurs synoviales de la partie infërieure de l'avant-bras, de la face palmaire du poignet, et de la main ... / par L.-M. Michon.

Londres : Paris, 1851.




ign

Diagnostic et traitement de la pelade et des teignes de l'enfant / par R. Sabouraud.

Paris : Rueff, 1895.




ign

The diagnostic signs of incompetence of the pulmonary valve / by G. A. Gibson.

Edinburgh : Young J. Pentland, 1894.




ign

Die malignen Geschwülste im Kindesalter / von A. Steffen.

Stuttgart : F. Enke, 1905.