12 March 2015 , Volume 91, Number 2

Prime Minister Justin Trudeau called Saturday for caution and expressed concern about loosening lockdown measures in Montreal, the epicenter of Canada's coronavirus outbreak. While several Canadian provinces, including Quebec, are preparing reopening measures and a gradual revival of their economies, Trudeau stressed prudence and said that the country is not yet out of danger. Quebec is the worst-hit province in Canada, with more than half of both the country's 67,000 cases of coronavirus and 4,700 deaths.

β-1,3-d-Glucan is a ubiquitous glucose polymer produced by plants, bacteria, and most fungi. It has been used as a diagnostic tool in patients with invasive mycoses via a highly-sensitive reagent consisting of the blood coagulation system of horseshoe crab. However, no method is currently available for measuring β-1,6-glucan, another primary β-glucan structure of fungal polysaccharides. Herein, we describe the development of an economical and highly-sensitive and specific assay for β-1,6-glucan using a modified recombinant endo-β-1,6-glucanase having diminished glucan hydrolase activity. The purified β-1,6-glucanase derivative bound to the β-1,6-glucan pustulan with a KD of 16.4 nm. We validated the specificity of this β-1,6-glucan probe by demonstrating its ability to detect cell wall β-1,6-glucan from both yeast and hyphal forms of the opportunistic fungal pathogen Candida albicans, without any detectable binding to glucan lacking the long β-1,6-glucan branch. We developed a sandwich ELISA-like assay with a low limit of quantification for pustulan (1.5 pg/ml), and we successfully employed this assay in the quantification of extracellular β-1,6-glucan released by >250 patient-derived strains of different Candida species (including Candida auris) in culture supernatant in vitro. We also used this assay to measure β-1,6-glucan in vivo in the serum and in several organs in a mouse model of systemic candidiasis. Our work describes a reliable method for β-1,6-glucan detection, which may prove useful for the diagnosis of invasive fungal infections.

The exponential growth of international travel since the 1960s has left border management systems worldwide struggling to keep up and has exposed weaknesses in states’ abilities to effectively manage their borders, especially regarding terrorist attacks, human trafficking, and illegal migration.

European dominance in U.S. immigration flows has decreased significantly since World War II, a result of economic, demographic, and policy trends on both sides of the Atlantic. Today, migration from European Union Member States to the United States, while small, is characterized by a substantial numbers of European scientists, professionals, and businesspeople.

This edited volume showcases approaches toward border management in Europe, Central America, and North America, and reflects on the challenges that countries in these regions face in managing their borders. The book brings together perspectives from both sides of the Atlantic on what border security means in practice, the challenges that continue to evade policymakers, and what policies have been the most (and least) successful in achieving “secure” borders.

Testimony of Donald Kerwin, former MPI Vice President for Programs, before the House Homeland Security Committee's Subcommittee on Border, Maritime, and Global Counterterrorism at its hearing: "Moving Toward More Effective Immigration Detention Management." 

On May 9, 1992, Andy Moog powered the Boston Bruins past the Montreal Canadiens with a 2-0 shutout in Game 4 for a sweep of the Adams Division Finals.

(May 5, 2020) On April 11, 2020, Panama published a law allowing its legislative assembly to conduct virtual sessions in cases of a national emergency or other situations that prevent the assembly from meeting in regular fashion. The original bill of this law explained that, in the context of the COVID-19 pandemic, it became necessary […]

Canadians working aboard two cruise ships, who have been prevented from coming ashore due to COVID-19 concerns, have finally been allowed to return home.

With more and more Bollywood celebs taking to social media to interact with their fans amidst the lockdown phase, Kangana Ranaut to Instagram to pour her heart out with a special message which she dedicated to her mother.

OM Czech Republic engaged in a medical mission outreach and evangelism ministry to villages in northern Ghana.

James Dillard, distinguished professor of communication arts and sciences at Penn State, describes strategies to help regulate emotions during the stress and uncertainty of the coronavirus pandemic.

04/13/2020 to 06/12/2020 Daytime intermittent lane closures for milling, patching, paving, and ADA improvements.

The Haryana police on Saturday seized Rs 97 lakh in cash, two pistols and three mobile phones besides a sports utility vehicle following a raid in a house to arrestthe prime accused in the case of a...

Senior Biju Janata Dal (BJD) leader and Chairman of the Western Odisha Development Council (WODC), Subash Chauhan died at a private hospital in Bhubaneswar on Sunday following a prolonged illness. He...

Mother's Day 2020: Yoga can boost overall health and help fight several health issues. This Mother's day, here are some yoga poses for every mother that can help you stay fit.

Mahesh has been with Mahindras for over 20 years and has worked in design and development of engine and vehicle platforms from frugal 3-wheelers to flagship models.

The market share of HUL was up by 50bp in 4QFY20 with 80 per cent of portfolio gaining share in the March quarter, a clear indication of resilient performance in an extraordinarily difficult quarter

Cash flows will be tight and they may also experience delay in the investment cycle, but this is a temporary phase, says Bhaskar Majumdar, managing partner, Unicorn India Ventures (UIV), a Mumbai-based fund house.

There’s absence of catalysts to narrow holdco and conglomerate discount that has risen of late; ‘Hold’ retained with TP of Rs 550.

Margins expected to fall in CY20e; downgraded to ‘Add’ with reduced TP of Rs 330

Varun Beverages (VBL) reported a strong growth in volumes, Ebitda and earnings during Q1CY20. This was, however, led by the acquired territories of south & west not there in the base.

SBI’s focus on the insurance business during a challenging year and SBI Life’s technology push to improve digital agent and client engagements remain crucial.

The bright spot in the Indian real estate market viz leasing is likely to see an abrupt end to its rental uptick cycle.

Lifting of the lockdown would release pent-up demand from incomplete repainting projects but we do not expect much new repainting work (especially in urban markets), nor a pick-up in fresh painting (construction activity).

Team-building and customer-connect are more effective than tall agendas

Shashwati, a news analyst, is able to do research at home, but her effectiveness has dropped in the absence of the right infrastructure.

The near-term outlook is challenging amid economic stress across sectors due to the lockdown, which has added pain to the already weak demand environment and anomalies due to the BS VI transition.

Startups must maintain their financial health by conserving cash, cutting down on costs and renegotiating their existing contracts.

"Students say that they believe in giving exams without cheating" Sharma said.

The Japanese electronics firm has bagged city surveillance projects in Bhopal and Ludhiana. It is now eyeing projects under Smart Cities mission in Guwahati and Jabalpur.

Yes Bank has seen a 30.2% increase in its net profit for the March quarter, due to strong growth in advances and growth in low-cost CASA deposits.

Credit Suisse Asset Management's NEXT Investors has invested an undisclosed amount in Indian software product company Sapience Analytics.

Management continues to focus on liquidating Rs 12,300-crore inventory and scaling up the rental portfolio (DCCDL). We maintain earnings estimates for the erstwhile merged entity (despite demerger of DCCDL) awaiting greater clarity on adjustments/reconciliation between DLF and DCCDL numbers (post-demerger).

The production is based on orders received from the customers and hence management is confident that sales despatches would pick up over the next 2-3 quarters, driving an uptick in sales and normalised inventories.

Overseas subsidiary performance is expected to turn around which coupled with gradual improvement in domestic margins will enable improvement in the overall margins.

As APHS concludes its capex cycle and loss-making ventures breakeven, the stage is set for APHS to double Ebitda and reduce capex to one-third over FY19–21.

VEDL’s H2FY19 operating numbers were mixed. Key highlights, O&G production fell 2% due to natural decline at Mangla field, though gas volumes were better; production at Zn-India was lower due to geo-technical problems at RA mine and FY19 silver volumes missed 650-700t guidance.

Dishwashing has been one of fastest-growing categories for JYL and we expect strong growth to continue on account of market share gains and lower overall penetration in the category.

Even as banks see a rise in core income and a drop in fresh bad loans, they may see a fall in non-interest income, with treasury income falling sharply on a sequential basis.

Banana accounts for as much as 60-65% of the green exports from Kerala and the rest are vegetables. Of the banana varieties, nenthran plantain leads the food preferences of Kerala’s 20 lakh diaspora families fanning out in the GCC countries.

A fully autonomous Russian drone has dived over 10 kilometers deep, reaching the bottom of the Mariana Trench, the deepest part of the Pacific Ocean. It even planted a buoy-like V-Day memorial to forever sway in the deep.
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