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The difficult search for the right recipe in cancer immunotherapy

With so many ingredients on hand, can the oncology community figure out how to sensibly and efficiently combine checkpoint inhibitors with other drugs?




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Isotopes could sniff out fake truffles

The abundance of carbon-13 relative to carbon-12 reveals whether the key component of white truffle aroma originates from a natural or synthetic source




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Chemistry in Pictures: Call of Cthulhu




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Scientists push back against Trump administration’s proposed visa rules




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Conservators consult Forbes Pigment Collection to solve artwork mysteries

Library of 2,500 samples offers clues about hues, both old and new




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Colorful hair dyes from blackcurrants

Semipermanent color from anthocyanins in fruit skins are a natural alternative to petroleum-derived dyes




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Fire-retardant electrolyte could usher in practical lithium metal batteries

Solution containing lithium salt-solvent clusters makes lithium metal batteries safer and long-lasting




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Double oxadiazole could replace TNT

As the military looks to phase out toxic TNT, chemists have created a new nitrogen-packed molecule with promising properties




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Sensing molecules released from single cells without labels

Combination of microfluidics and a nanosensor achieves label-free detection of cytokines from individual cells




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Bleach activator could lead to greener whites

Cationic molecule helps bleach cotton faster with less energy




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Copper regulates sleep in zebrafish

Metal may play sleep role through an enzyme responsible for synthesis of norepinephrine




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Hallan antiguas moléculas orgánicas en Marte

El rover Curiosity proporciona datos sobre las misteriosas plumas de metano del planeta rojo




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Ancient organic molecules found on Mars

Curiosity rover also reports data on the red planet’s mysterious methane plumes




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U.S. Chemical Safety Board’s internal woes could thwart its mission




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Sensing molecules released from single cells without using labels

Combination of microfluidics and a nanosensor achieves label-free detection of cytokines from individual cells




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Fire-retardant electrolyte could usher in practical lithium-metal batteries

Solution containing lithium salt-solvent clusters makes lithium-metal batteries safer and long lasting




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Double oxadiazole could replace TNT

As the military looks to phase out toxic TNT, chemists have created a new nitrogen-packed molecule with promising properties




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Multilayer coating helps plastic dental devices stay clear of bacteria

A superhydrophilic film made of two sugar molecules could help prevent bacterial growth on the mouthpieces




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Nobel Laureates Paul D. Boyer and Jens C. Skou die at 99

Biochemists were two of three who shared 1997 prize for work related to adenosine triphosphate




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Kristen Kulinowski to lead Chemical Safety Board




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Nobel laureates Jens C. Skou and Paul D. Boyer die at 99

Biochemists were two of three who shared 1997 prize for work related to adenosine triphosphate




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Broad could receive $125 million in sponsored research agreement with Editas




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Chemists synthesize Saturn-shaped molecule

Flat, macrocyclic host captures fullerene guest with CH–π interactions




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Multilayer coating could fight bacterial growth on plastic dental devices

Superhydrophilic film made of two sugar molecules could lead to cleaner retainers or tooth aligners




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Synthetic biology could enable bioweapons development

A new National Academies report names and classifies the kinds of biological weapons that could emerge from techniques like CRISPR gene editing and DNA synthesis




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Existing treaty could help manage global plastic waste trade, researchers suggest

Basel Convention would help control flow of used material displaced by China’s ban




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Some Chinese power plants may underreport sulfur dioxide emissions

Data from air pollution monitors don’t jibe with satellite measurements




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Cellulose derivative accelerates organic chemistry in water

Additive facilitates numerous pharmaceutically relevant reactions through unknown mechanism




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Human enzyme makes antiviral small molecule

Naturally occurring compound inhibits replication of Zika virus in living cells




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Celgene partners with Skyhawk Therapeutics to drug RNA with small molecules

Skyhawk will receive $60 million up front to develop drug candidates that target RNA in neurological diseases




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Ocean geysers on Enceladus harbor large organic molecules

Moon is a good candidate to host extraterrestrial life, but this find isn’t proof that it does




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Modified enzyme could make bioprocessing zippier

Adding positively charged molecules and a surfactant to β-glucosidase makes the enzyme work 30 times as fast




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3 siloxanes, lead, and a phthalate are candidates for tight regulation in EU




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Human enzyme makes antiviral small molecule

Naturally occurring compound inhibits replication of Zika virus in living cells




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Raman spectra of bloodstains could reveal age range of suspects or victims

Study with blood donors pinpoints age-related intensity differences of particular peaks




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Reversing rules of arene chemistry

New norbornene compound overcomes ring substitution limitation




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Canada moving to update environmental protection regulations

Actions may include requiring industry to demonstrate safety of substances, akin to Europe’s REACH program




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Chemistry in Pictures: Simulating cancer




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Canada moves to update environmental protection regulations




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Multifunctional nanofibers filter dust and fight fire

Nylon 6 nanofibers contain flame-retardant core




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Calculations suggest flea and tick medications for pets could benefit people by controlling mosquitoes

These drugs could have beneficial population-wide effects in areas at risk for malaria and Zika, according to modeling study




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The unwritten rules of sharing in the laboratory

Chemjobber on when hoarding chemicals and lab equipment becomes a problem




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U.S. Supreme Court nominee Brett Kavanaugh likely to limit regulatory authority

Current district judge is viewed as reliably conservative, deferent to presidential power




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Regulus cuts jobs after oligonucleotide safety setback




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Molecule from fungi might whack weeds

Genome scan turns up aspterric acid, which has a new mode of herbicidal action




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These new textile dyeing methods could make fashion more sustainable

Large and small suppliers vow to help a resource-intensive, cost-sensitive industry change with the times




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Fetal gene therapy could treat genetic diseases in the womb

Researchers are working to fix genetic conditions like Gaucher disease before birth by testing experimental therapies on fetal animals




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Targeting immune cells could relieve chronic pain

Study finds macrophages talk to sensory nerves to elicit chronic pain caused by nerve damage




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Warmer world could feed the oceans

Higher temperatures allow nitrogen-fixing microbe to work better even when iron is scarce




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Deadly blast in China highlights uneven enforcement of safety regulations

Facilities where 19 died had not been inspected or approved