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Neural working memory device

A spiking neuron-based working memory device is provided. The spiking neuron-based working memory device includes an input interface configured to convert input spike signals into respective burst signals having predetermined forms, and output a sequence of the burst signals, the burst signals corresponding to the input spike signals in a burst structure, and two or more memory elements (MEs) configured to sequentially store features respectively corresponding to the outputted sequence of the burst signals, each of the MEs continuously outputting spike signals respectively corresponding to the stored features.




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Systems and methods for making bioproducts

Processes for continuous preparation of bioproducts are described herein. The processes include contacting fatty acid glycerides with alcohols in the presence of an acidic heterogeneous catalyst and separating the fatty acid alkyl esters from the reaction products.




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ZnO nanoparticle catalysts for use in transesterification and esterification reactions and method of making

A method of forming a product from an oil feedstock, such as a biodiesel product, and a heterogeneous catalyst system used to form said product is disclosed. This catalyst system, which has a high tolerance for the presence of water and free fatty acids (FFA) in the oil feedstock, may simultaneously catalyze both the esterification of FAA and the transesterification of triglycerides present in the oil feedstock. The catalyst system is comprised of a mixture of zinc oxide and a second metal oxide. The zinc oxide includes a mixture of amorphous zinc oxide and zinc oxide nanocrystals, the zinc nanocrystals having a mean grain size between about 20 and 80 nanometers with at least one of the nanocrystals including a mesopore having a diameter of about 5 to 15 nanometers. Preferably, the second metal oxide is a lanthanum oxide, the lanthanum oxide being selected as one from the group of La2CO5, LaOOH, and combinations or mixtures thereof.




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Process for making esters

The invention relates to a process for making esters, in particular biodiesel, using heterogeneous catalysts. The invention provides a process for making biodiesel, in particular FAME, which process is versatile and robust. The process of the invention can be carried out continuously, in particular in a fixed bed reactor or a slurry reactor and may be operated in a continuous fashion. In accordance with the invention, the transesterification reaction of triglycerides is carried out using a heterogeneous catalyst that comprises a Group 4 silicate and less than 3 wt. % Na in the presence of at least one acid compound.




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Nitrated lipids and methods of making and using thereof

Described herein are nitrated lipids and methods of making and using the nitrated lipids.




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Dicarboxylate-capped estolide compounds and methods of making and using the same

Described herein are dicarboxylate-capped estolide compound and methods of making the same. Exemplary dicarboxylate-capped estolide compounds include those of the formula x is, independently for each occurrence, an integer selected from 0 to 20; y is, independently for each occurrence, an integer selected from 0 to 20; W is, independently for each occurrence, selected from —CH2— and —CH═CH—; z is an integer selected from 1 to 40; n is an integer equal to or greater than 0; R5 is selected from hydrogen, optionally substituted alkyl that is saturated or unsaturated, and branched or unbranched, and an estolide residue; and R2 is selected from hydrogen and optionally substituted alkyl that is saturated or unsaturated, and branched or unbranched, wherein each fatty acid chain residue of said at least one compound is independently optionally substituted.




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Processes for making compounds useful as inhibitors of ATR kinase

The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole derivatives and related molecules. The present invention also relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I or II: wherein the variables are as defined herein.




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Aqueous cross-linking compositions and methods

Water-borne cross-linking polymeric compositions and related embodiments, such as methods of making and using the compositions, as well as products formed with said compositions are described. The water-borne composition may comprise one or more polymers formulated from one or more monomers of which at least one is a monomer that yields acetaldehyde as a hydrolysis product, and incorporating cross-linking functionality such as, but not limited to, carbonyl or epoxy functionality, and a blocked cross-linking agent, for example, a hydrazone. Neither the cross-linking functionality nor the acetaldehyde reacts with the blocked cross-linking agent; however, the blocked cross-linking agent is capable of conversion to an alternative form cross-linking agent such as, but not limited to, a hydrazide, to yield a cross-linked polymer. The alternative form cross-linking agent may be formed in an equilibrium reaction including the blocked cross-linking agent.




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Metal silicate nanosheets, methods of making metal silicate nanosheets, and methods of use

Embodiments of the present disclosure relate to the preparation of colloidal dispersions or suspensions of inorganic materials with nano-sized and nano-structured morphologies, preferably the nanosheet form, compositions produced by this method, and the like.




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Solid ganaxolone compositions and methods for the making and use thereof

In certain embodiments, the invention is directed to composition comprising stable particles comprising ganaxolone, wherein the volume weighted median diameter (D50) of the particles is from about 50 nm to about 500 nm.




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Non-volatile memory structure containing nanodots and continuous metal layer charge traps and method of making thereof

A memory device includes a semiconductor channel, a tunnel dielectric layer located over the semiconductor channel, a first charge trap including a plurality of electrically conductive nanodots located over the tunnel dielectric layer, dielectric separation layer located over the nanodots, a second charge trap including a continuous metal layer located over the separation layer, a blocking dielectric located over the second charge trap, and a control gate located over the blocking dielectric.




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Rubber-containing bituminous mixtures and methods for making and using same

Disclosed are methods for producing rubber-containing bituminous mixtures by pressurizing mixtures of bituminous materials, crumb rubber, and one or more suspension agents with a gas, and then reducing the pressure, creating bubbles of the gas in the mixture. Also disclosed are methods of introducing gas into such mixture by rapid mixing. Mixtures produced by the disclosed methods, such as rubber-containing asphalt mixtures and paving compositions thereof, and their use are also disclosed.




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Coating/sealant systems, aqueous resinous dispersions, methods for making aqueous resinous dispersions, and methods of electrocoating

A coating/sealant system that includes a coating and a sealant deposited over at least a portion of the coating, in which the coating includes a reaction product formed from reactants comprising a phosphated epoxy resin and a curing agent, and the sealant includes a sulfur-containing polymer.




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Banking of reliability metrics

In one embodiment, a processor includes at least one functional block and banking logic. The banking logic may be to determine an average reliability metric associated with the at least one functional block. The banking logic may also be to, if the average reliability metric exceeds a required level, implement a reduced reliability mode in the at least one functional block, where the reduced reliability mode is associated with a reduction in the average reliability metric. Other embodiments are described and claimed.




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Double data rate memory physical interface high speed testing using self checking loopback

A double data rate memory physical interface having self checking loopback logic on-chip is disclosed. Disposed on the chip is a first linear feedback shift register, which is capable of generating a set of test data values that comprise at least two data bits. Also disposed on the chip is a second linear feedback shift register. The second linear feedback shift register is capable of generating a set of expected data values that match the test data values. Further, an internal loopback error check element is disposed on the chip. The internal loopback error check element is used to compare the set of expected data values with the set of test data values.




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I/O linking, TAP selection and multiplexer remove select control circuitry

Today many instances of IEEE 1149.1 Tap domains are included in integrated circuits (ICs). While all TAP domains may be serially connected on a scan path that is accessible external to the IC, it is generally preferred to have selectivity on which Tap domain or Tap domains are accessed. Therefore Tap domain selection circuitry may be included in ICs and placed in the scan path along with the Tap domains. Ideally, the Tap domain selection circuitry should only be present in the scan path when it is necessary to modify which Tap domains are selected in the scan path. The present disclosure describes a novel method and apparatus which allows the Tap domain selection circuitry to be removed from the scan path after it has been used to select Tap domains and to be replaced back into the scan path when it is necessary to select different Tap domains.




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Method and apparatus for decoding and checking tail-biting convolutional code

A method for decoding and checking a tail-biting convolutional code is provided. The method fully utilizes structural features of the tail-biting convolutional code to re-sort Log-Likelihood Ratio (LLR) values input into a decoder, and by reconstructing a derivative generator polynomial of a convolutional code, allows the decoder to output in serial according to a normal ordering of information bits during backtracking, that is, a first bit of an information sequence is first decoded successfully. Thus, CRC checking may be activated as soon as possible, so that part of the backtracking process and the CRC checking may be performed in parallel, thereby achieving the objective of reducing a processing time delay in decoding and checking the tail-biting convolutional code.




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Method for making a dual curable ethylene propylene diene polymer rubber coating using a photoinitiator and a peroxide

A durable ambient light curable waterproof liquid rubber coating with volatile organic compound (VOC) content of less than 450 grams per liter made from ethylene propylene diene terpolymer (EPDM) in a solvent, a photoinitiator, an additive, pigments, and fillers, and a co-agent and a method for making the formulation, wherein the formulation is devoid of thermally activated accelerators.




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Pressure-sensitive adhesives with mixed photocrosslinking system

The present disclosure provides a method of providing an adhesive composition comprising the steps of combining crosslinkable composition including: a) a (meth)acryloyl monomer mixture with the b) photocrosslinking agent mixture, and irradiating with UVC radiation to polymerize and crosslink the composition.




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Vertex array access bounds checking

Aspects of the invention relate generally to validating array bounds in an API emulator. More specifically, an OpenGL (or OpenGL ES) emulator may examine each array accessed by a 3D graphic program. If the program requests information outside of an array, the emulator may return an error when the graphic is drawn. However, when the user (here, a programmer) queries the value of the array, the correct value (or the value provided by the programmer) may be returned. In another example, the emulator may examine index buffers which contain the indices of the elements on the other arrays to access. If the program requests a value which is not within the range, the emulator may return an error when the graphic is drawn. Again, when the programmer queries the value of the array, the correct value (or the value provided by the programmer) may be returned.




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Managing access to a shared resource by tracking active requestor job requests

The technology of the present application provides a networked computer system with at least one workstation and at least one shared resource such as a database. Access to the database by the workstation is managed by a database management system. An access engine reviews job requests for access to the database and allows job requests access to the resource based protocols stored by the system.




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Reactor and agitator useful in a process for making 1-chloro-3,3,3-trifluoropropene

Disclosed is a reactor and agitator useful in a high pressure process for making 1-chloro-3,3,3-trifluoropropene (1233zd) from the reaction of 1,1,1,3,3-pentachloropropane (240fa) and HF, wherein the agitator includes one or more of the following design improvements: (a) double mechanical seals with an inert barrier fluid or a single seal;(b) ceramics on the rotating faces of the seal;(c) ceramics on the static faces of seal;(d) wetted o-rings constructed of spring-energized Teflon and PTFE wedge or dynamic o-ring designs; and(e) wetted metal surfaces of the agitator constructed of a corrosion resistant alloy.




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Method for crosslinking a colloid, and crosslinked colloid therefrom

The disclosure provides a method for crosslinking a colloid, including: (a) providing a colloid solution; (b) adding a crosslinking agent and solid particles to the colloid solution, wherein the amount of solid particles added is enough to convert the colloid solution into a solid mixture, and wherein a crosslinking reaction proceeds in the solid mixture; and (c) removing the solid particles from the solid mixture.




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Polymer particles, nucleic acid polymer particles and methods of making and using the same

The disclosure relates to methods of making polymer particles, said methods including the steps of: making an aqueous gel reaction mixture; forming an emulsion having dispersed aqueous phase micelles of gel reaction mixture in a continuous phase; adding an initiator oil comprising at least one polymerization initiator to the continuous phase; and performing a polymerization reaction in the micelles. Further, the initiator oil is present in a volume % relative to a volume of the aqueous gel reaction mixture of between about 1 vol % to about 20 vol %. The disclosure also relates to methods of making nucleic acid polymer particles having the same method steps and wherein the aqueous gel reaction mixture includes a nucleic acid fragment, such as a primer.




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Foams of graphene, method of making and materials made thereof

Method for making a liquid foam from graphene. The method includes preparing an aqueous dispersion of graphene oxide and adding a water miscible compound to the aqueous dispersion to produce a mixture including a modified form of graphene oxide. A second immiscible fluid (a gas or a liquid) with or without a surfactant are added to the mixture and agitated to form a fluid/water composite wherein the modified form of graphene oxide aggregates at the interfaces between the fluid and water to form either a closed or open cell foam. The modified form of graphene oxide is the foaming agent.




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Implementation of multi-tasking on a digital signal processor with a hardware stack

The disclosure relates to the implementation of multi-tasking on a digital signal processor. Blocking functions are arranged such that they do not make use of a processor's hardware stack. Respective function calls are replaced with a piece of inline assembly code, which instead performs a branch to the correct routine for carrying out said function. If a blocking condition of the blocking function is encountered, a task switch can be done to resume another task. Whilst the hardware stack is not used when a task switch might have to occur, mixed-up contents of the hardware stack among function calls performed by different tasks are avoided.




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Use of alkamides for masking an unpleasant flavor

An individual alkamide and/or a mixture having two or more different alkamides, is disclosed for changing, masking or reducing the unpleasant flavor impression of an unpleasant-tasting substance or mixture of substances. The alkamide can be trans-pellitorine; cis-pellitorine; 2Z,4Z- or 2Z,4E-decadienoic acid-N-isobutylamide; 2E,4E-decadienoic acid-N-([2S]-2-methylbutyl)amide; 2E,4E-decadienoic acid-N-([2R]-2-methylbutylamide); 2E,4Z-decadienoic acid-N-(2-methylbutyl)amide; achilleamide; sarmentine; 2E- or 3E-decenoic acid-N-isobutylamide; 3E-nonenoic acid-N-isobutylamide; spilanthol; homospilanthol; 2E,6Z,8E-decatrienoic acid-N-([2R]-2-methylbutyl)amide; 2E- or 2Z-decen-4-oic acid-N-isobutylamide; α-sanshool; α-hydroxysanshool; γ-hydroxysanshool; γ-hydroxysanshool; γ-hydroxyisosanshool; γ-dehydrosanshool; γ-sanshool; bungeanool; isobungeanool; dihydrobungeanool; or tetrahydrobungeanool, or combinations thereof.




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Process for making ethanol from acetic acid using acidic catalysts

A process for selective formation of ethanol from acetic acid by hydrogenating acetic acid in the presence of a catalyst comprises a first metal on an acidic support. The acidic support may comprise an acidic support material or may comprise an support having an acidic support modifier. The catalyst may be used alone to produced ethanol via hydrogenation or in combination with another catalyst. In addition, the crude ethanol product is separated to obtain ethanol.




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Process for making polyglycerol ethers of fatty alcohols

Disclosed are processes relating to the production of polyglycerol ethers of fatty alcohols, in particular, one step process using fatty alcohol and glycerine to synthesize polyglycerides of fatty alcohols will provide a 100% renewable surfactant that is cost effective efficient and CMR free. The synthetic methods mentioned in prior art uses hazardous chemicals as glycidyl ethers, epichlorohydrin that are listed as CMR and known carcinogens and hazardous to handle.




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Systems and methods for tracking location of movable target object

An automated process uses a local positioning system to acquire location (i.e., position and orientation) data for one or more movable target objects. In cases where the target objects have the capability to move under computer control, this automated process can use the measured location data to control the position and orientation of such target objects. The system leverages the measurement and image capture capability of the local positioning system, and integrates controllable marker lights, image processing, and coordinate transformation computation to provide tracking information for vehicle location control. The resulting system enables position and orientation tracking of objects in a reference coordinate system.




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Parking assist system and parking assist method

A parking assist system includes: an actuator that drives a back door of a vehicle; an opening degree control unit that controls an opening degree of the back door by controlling the actuator; a storage device that stores an allowable opening degree of the back door at a park position of the vehicle in association with the park position; and a position information acquisition unit that acquires position information of the vehicle. When a position of the vehicle corresponds to the park position stored in the storage device, the opening degree control unit limits the opening degree of the back door on the basis of the allowable opening degree of the back door, stored in the storage device in association with the park position.




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System and method for automated simulator assertion synthesis and digital equivalence checking

A system, method, and computer program product for automatically generating equivalent assertions in different forms for different verification tools, which may be analog or digital. A user submits a set of logic assertions that, if unclocked, are converted to clocked assertions by generating and skewing clocks to ensure simulator uniformity. A stimulus is generated, perhaps at random, or input. A test bench is either input or synthesized. For each verification tool, the test bench is simulated and simulation results are captured. An assertion status difference engine evaluates result differences between the verification tools, and identifies and outputs differences indicating a significant inconsistency. Errors in verification tool implementation and user assertion coding can be detected. The simulators used may include SPICE and Verilog, or any other simulators that differ in type, simulation algorithm, input format, or vendor implementation.




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Foamer composition and methods for making and using same

A new general purpose foaming agent having application as drilling fluid foaming agents or as any foaming agent needed an a wide variety of applications is disclosed, where the agent includes at least one anionic surfactant, at least one cationic surfactant, and mixtures thereof and one or more zwitterionic compounds. A method for using the foaming agent in capillary coiled tubing application is also disclosed. The foaming agents can also include additive to augment the properties of the foaming agent for a given application.




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Voice commands for online social networking systems

In one embodiment, a method includes accessing a social graph that includes a plurality of nodes and edges, receiving from a first user a voice message comprising one or more commands, receiving location information associated with the first user, identifying edges and nodes in the social graph based on the location information, where each of the identified edges and nodes corresponds to at least one of the commands of the voice message, and generating new nodes or edges in the social graph based on the identified nodes or identified edges.




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Handheld electronic device and method for performing spell checking during text entry and for providing a spell-check learning feature

A handheld electronic device includes a reduced QWERTY keyboard and is enabled with a disambiguation routine that is operable to disambiguate text input. In addition to identifying and outputting representations of language objects that are stored in the memory and that correspond with a text input, the device is able to perform a spell check routine during input of a text entry and to learn and automatically correct mistakes typically made by the particular user.




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Isomerized alpha olefin sulfonate and method of making the same

The present invention is directed to an isomerized alpha olefin sulfonate and a method of making the same wherein the isomerized alpha olefin sulfonate is derived from sulfonating an isomerized alpha olefin with sulfur trioxide in the presence of air thereby producing an isomerized alpha olefin sulfonic acid, wherein the isomerized alpha olefin is derived from the isomerization of C12-C20 normal alpha olefins; and neutralizing the isomerized alpha olefin sulfonic acid with a source of an alkali metal or ammonium or substituted ammonium ion.




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Process for making nitriles

An improved multi-reaction zone process provides for improved nitrile product quality and yield. In a first reaction zone, 1,3-butadiene is reacted with hydrogen cyanide in the presence of a catalyst to produce pentenenitriles comprising 3-pentenenitrile and 2-methyl-3-butenenitrile. In a second reaction zone, 2-methyl-3-butenenitrile, recovered from the first reaction zone, is isomerized to 3-pentenenitrile. In an optional third reaction zone, 3-pentenenitrile recovered from the first and second reaction zones is reacted with hydrogen cyanide in the presence of a catalyst and a Lewis acid to produce adiponitrile. A portion of the first catalyst is purified and recycled. Zero valent nickel is added to the purified first catalyst before it is recycled.




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Process for making nitriles

Adiponitrile is made by reacting 3-pentenenitrile with hydrogen cyanide. The 3-pentenenitrile is made by reacting 1,3-butadiene with hydrogen cyanide and by isomerizing 2-methyl-3-butenenitrile. The reaction of 1,3-butadiene with hydrogen cyanide to produce 3-pentenenitrile also produces small amounts of dinitrile compounds, including adiponitrile (ADN) and methylglutaronitrile (MGN). Methylglutaronitrile is removed to provide an adiponitrile-enriched stream, which is used in a catalyst purification step.




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Process for making nitriles

The present invention relates to a process for hydrocyanating 3-pentenenitrile. The process can include feeding 3-pentenenitrile and HCN to a hydrocyanation reaction zone that includes a Lewis acid promoter, nickel, and a phosphorus-containing ligand. In various embodiments, the process can also include controlling water concentration within the hydrocyanation reaction zone sufficient to maintain a high activity of the ligand catalyst complex while recycling at least a portion of the ligand catalyst complex.




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Moon phase menstrual tracking and educational system

A system and method for tracking and informing about a physical, emotional, or physiological cycle, such as a menstrual cycle, includes at least one definition entry and at least one date indicator. Each definition entry defines indicia such as color to represent a stage of a physical, emotional, or physiological cycle. Each date indicator includes a date section and a tracking section corresponding to each date section. The date section of the date indicator indicates at least one date, wherein the tracking section is capable of being marked so as to indicate indicia corresponding to a definition entry to signify the stage of the physical, emotional, or physiological cycle for each date. According to one embodiment, the date indicators are arranged according to phases of the moon to allow correlation of a user's cycle to the lunar cycle.




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Lighter and method for eliminating smoking that includes interactive self-learning software

Smoking cessation lighter is configured for lighting cigarettes for a smoker, and learning software is provided for monitoring smoking behavior of a smoker during a first data collection period and guiding a smoker's smoking cessation by directing the smoker when the smoker is to smoke a cigarette based on data collected during the first data collection period. The learning software monitors user behavior and collects data during use of the lighter by the smoker after the initial data collection period in order to analyze and further guide the smoker based on the smoker's cheating behavior, the smoker's behavior of lighting a cigarette for a friend, and the smoker's behavior of skipping use of the lighter at a time when the smoker has been directed to light a cigarette by the lighter.




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Method and apparatus for optically backing up data

An optical backup apparatus is provided and includes an optical storage device, an interface module to connect with at least one type of external storage medium, and a control unit to back up data from the external storage medium to the optical storage device in response to an external remote control operation.




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L-ornithine phenyl acetate and methods of making thereof

Disclosed herein are forms of L-ornithine phenyl acetate and methods of making the same. A crystalline form may, in some embodiments, be Forms I, II, III and V, or mixtures thereof. The crystalline forms may be formulated for treating subjects with liver disorders, such as hepatic encephalopathy. Accordingly, some embodiments include formulations and methods of administering L-ornithine phenyl acetate.




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Modified carbon material and process of making and using the same

A method of making modified carbon materials for use in fabricating fuel cell components. The modified carbon may comprise pendant fluorocarbon groups bonded covalently bonded thereto. In one embodiment, a mixture is formed and comprises carbon material suitable for use in a fuel cell component, an organic solvent, a compound having the general formula I—R wherein R is a fluorocarbon, and a reductant.




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Resolution programmable dynamic IR-drop sensor with peak IR-drop tracking abilities

A data processing system on an integrated circuit includes a core that performs switching operations responsive to a system clock that draws current from the power supply network. An IR-drop detector includes a resistor ladder having outputs representative of an IR-drop caused by the core during the switching operations. The system further includes a plurality of amplifiers coupled to the outputs indicative of the IR-drop, a plurality of flip-flops coupled to the amplifiers, and a variable clock generator. The variable clock generator outputs a sampling clock comprising a group consisting of a variable phase or a variable frequency to the plurality of flip-flops. The flip-flops are triggered by the sampling clock so that the IR-drop at a time during a clock cycle of the system clock can be detected, and the peak IR-drop value for can be tracked.




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Methods, systems, apparatuses, and computer-readable media for waking a SLIMbus without toggle signal

Arrangements for restarting data transmission on a serial low-power inter-chip media bus (SLIMbus) are presented. A clock signal may be provided in an active mode to a component communicatively coupled with the SLIMbus. Immediately prior to the clock signal in the active mode being provided, the clock signal may have been in a paused mode. While the clock signal was in the paused mode at least until the clock signal is provided in the active mode, the data line may have been inactive (e.g., a toggle on the data line may not have been present). Frame synchronization data for a frame may be transmitted. The frame synchronization data for the frame, as received by the component, may not match expected frame synchronization data. Payload data may be transmitted as part of the frame to the component, wherein the payload data is expected to be read properly by the component.




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Enabling web page tracking

Methods are provided for tracking data corresponding to a mobile device that accesses a web page. Once a mobile device is registered with a network, the mobile device is instructed to request permission before accessing a web page. An access request is received, and based on a user profile, the access request is approved such that the mobile device may access the web page. Access data that corresponds to the mobile device accessing the web page is collected so that it can be added to and stored in a database.




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Method for working up distillation residues from isocyanate production

The present invention relates to a method for working up distillation, residues from isocyanate production in which monomeric isocyanate present in distillation residues is recovered by means of a spray-dry method and the overall yield of monomeric isocyanate is thus significantly increased.




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Organoxysilane compounds having silyl-protected secondary amino group and making method

A silane compound having a secondary amino group protected with a specific silyl group is useful as silane coupling agent, resin additive, textile treating agent, surface treating agent, paint additive, and adhesive.




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Dual end glycerol (meth) acrylate-modified silicone and making method

A dual end glycerol (meth)acrylate-modified silicone having formula (I): R1Me2SiO(R22SiO)aSiMe2R1 is novel. R1 is a mixture of 70-95 mol % of a group having formula (i) and 30-5 mol % of a group having formula (ii) wherein R3 is H or methyl, R2 is a monovalent hydrocarbon group which may be halogenated, Me stands for methyl, and a is an integer of 10-300.